CN206285925U - A kind of chemical reaction rate teaching microchip - Google Patents
A kind of chemical reaction rate teaching microchip Download PDFInfo
- Publication number
- CN206285925U CN206285925U CN201621202340.3U CN201621202340U CN206285925U CN 206285925 U CN206285925 U CN 206285925U CN 201621202340 U CN201621202340 U CN 201621202340U CN 206285925 U CN206285925 U CN 206285925U
- Authority
- CN
- China
- Prior art keywords
- pipeline
- chemical reaction
- reaction rate
- sample
- teaching
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 29
- 238000010438 heat treatment Methods 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 9
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 description 15
- 238000005516 engineering process Methods 0.000 description 10
- 238000013461 design Methods 0.000 description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 description 5
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 5
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 5
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 229910000679 solder Inorganic materials 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 239000005864 Sulphur Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010022524 Intentional self-injury Diseases 0.000 description 1
- 239000007832 Na2SO4 Substances 0.000 description 1
- 208000005560 Self Mutilation Diseases 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- JZZIHCLFHIXETF-UHFFFAOYSA-N dimethylsilicon Chemical compound C[Si]C JZZIHCLFHIXETF-UHFFFAOYSA-N 0.000 description 1
- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Landscapes
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The utility model discloses a kind of chemical reaction rate teaching microchip, including chip body, sample channel and inlet channel are provided with the chip body, the sample channel and inlet channel are gone out sample pipeline and are connected by several of cross pipeline and its lower end, and the outlet that sample pipeline is gone out described in any one is equipped with two reservoirs of connection；This chip is by concentration gradient chip and integral heating element so as to build concentration gradient and thermograde on microchip, the suitable reaction system of selection can easily allow student to understand the influence of concentration and temperature to chemical reaction rate, intuitively it was observed that phenomenon, reaches more preferable teaching efficiency.
Description
Technical field
The utility model is related to chemistry teaching fixture technology field, and in particular to a kind of to be made based on microfluidic chip technology
Chemical reaction rate teaching microchip.
Background technology
This technology belongs to the crossing domain of miniaturization chemical reaction equipment and microfluidic chip technology, and its main thought is profit
With the manufacturing technology of micro-fluidic chip, new microization Teaching of Analytical Chemistry utensil, Manz A et al. are made in 90 years 20th century
In generation, just proposes the concept of micro-full analytical system (miniaturized total analysis system, μ-TAS) first.
Micro-fluidic chip therein combine analytical chemistry, MEMS (mi-cro-electro-mechanical system,
MEMS), the multidisciplinary field such as computer, materialogy, biomedicine, by such as sample pretreatment of the various functions of chemical laboratory,
Sample introduction, separation and detection etc., are integrated on the chip of credit card-sized, realize the miniaturization in laboratory, can greatly shorten whole
Time required for individual analysis process；Also the consumption of reagent can be reduced to microlitre even nanoliter level, it is possible to achieve various analyses
Function.Since the beginning of this century, microfluidic chip technology is developed rapidly, and has been widely used for chip capillary electricity
Swimming, materials synthesis, immunoassay, cell operation, crystallization of protein research etc. various fields, be analysis science research focus it
One.But the technology is presently mainly to apply in terms of scientific research, and teaching and research aspect applies less, but microchip method consumptive material is few, just
The features such as property taken is good exactly meets the requirement of Green Chemistry, Microscale chemical experiment, is also convenient for realizing teaching combining theory with practice, because
This its also there is application prospect widely in teaching field.On the other hand, the technology such as MEMS skills that current microchip makes
Art etc. costly, which also limits its teaching field application.
Microscale experiment is to emerge the eighties in 20th century, the generally acknowledged chemical experiment that can embody green chemical concept in the world
New technology and method.It has saving medicine, time-consuming, reduce experiment " three wastes " the advantages of, cause both at home and abroad
The most attention of experimental teaching personnel.But in general miniaturized devices need remain for the facilities such as supporting water power, it is impossible to
Really bring classroom into be tested, while instrument and equipment needs are special therefore also more expensive in price, it is impossible to realize teacher or even
The raw self-mutilation behavior to reaction unit.
If chemical reaction rate is important Chemistry Teaching Content, but comparatively its knowledge is more uninteresting and abstract,
Although classmate can be allowed to understand the shadow of concentration, temperature, pressure, catalyst to chemical reaction rate by certain concrete instance etc.
Ring, but not enough concrete image.Therefore design the microchip of a chemical reaction rate teaching, construct concentration gradient and
Thermograde, selects suitable reaction system, so as to intuitively allow student to understand concentration and temperature to chemical reaction rate
Influence, is significantly.
Utility model content
The technical problems to be solved in the utility model be design it is a kind of it is portable, chemistry can be directly demonstrated on classroom
The microchip of reaction rate principle, reaches more preferable teaching efficiency.
To reach above-mentioned purpose, the technical solution adopted in the utility model is：Micro- core is used in a kind of chemical reaction rate teaching
Piece, including chip body, are provided with sample channel and inlet channel in the chip body, the sample channel and inlet channel are logical
Several for crossing cross pipeline and its lower end go out sample pipeline and are connected, and the outlet that sample pipeline is gone out described in any one is equipped with two companies
Logical reservoir.
Further, it is described go out sample pipeline quantity be five, the reservoir going out sample pipeline exit be in two rows
Five row arrangements.
Further, go out in sample pipeline to be formed the hypo solution of various concentrations gradient described in five.
Further, lower end reservoir is integrated with the heating element heater of available battery heating.
Further, the thickness all same of any one reservoir.
Further, the multiple pipe tunnels of the pipeline by three horizontal pipelines and between horizontal pipeline that cross
It is interconnected and constitutes.
Further, the sample channel entrance is provided with injection port, and the inlet channel entrance is provided with water inlet.
The beneficial effects of the utility model are：
1st, this chip passes through concentration gradient chip and integral heating element so as to build concentration gradient and temperature on microchip
Degree gradient, the suitable reaction system of selection can easily allow student to understand the shadow of concentration and temperature to chemical reaction rate
Ring, intuitively observe phenomenon, reach more preferable teaching efficiency.
2nd, cost of manufacture is cheap, without any large-scale instrument and equipment, is conveniently mass produced, and meets teaching and uses,
Processing can be designed in common lab simultaneously, without special instrument and equipment, facilitate teacher or even student to enter relevant apparatus
Row makes.
3rd, the chip good portability prepared, can be carried to classroom carries out teaching combining theory with practice.
4th, the chip pipeline that the printing template that compares method the method is obtained is wide, and area of display is big, and phenomenon becomes apparent from.It is simultaneously real
The chip for having showed the preparation of printing template method is difficult to the chip with three-dimensional structure for preparing.
The structure and its preparation process of the utility model microchip are done into one below in conjunction with the drawings and specific embodiments
Step detailed description, so as to help it is further understood that the microchip of the design offer.
Brief description of the drawings
Accompanying drawing is, for providing a further understanding of the present invention, and to constitute the part of specification, with following tool
Body implementation method is used to explain the present invention together, but is not construed as limiting the invention.In the accompanying drawings：
Fig. 1 is the schematic diagram of the utility model microchip；
Fig. 2 is the preparation process schematic diagram of microchip；
In figure：Sample channel 1；Inlet channel 2；Horizontal pipeline 30；Pipe tunnel 31；Go out sample pipeline 4；Reservoir 5；Chip
Body 6；Culture dish 7；PDMS lower master films 8；Heating element heater 9；Injection port 10；Battery 11；Water inlet 20.
Specific embodiment
As shown in figure 1, the schematic diagram of the teaching microchip for chemical reaction rate provided for the design, including core
Sample channel 1 and inlet channel 2 are provided with piece body 6, the chip body 6, the entrance of sample channel 1 is provided with injection port 10, institute
State the entrance of inlet channel 2 and be provided with water inlet 20, the sample channel 1 and inlet channel 2 are by the pipeline and the five of its lower end that crosses
It is individual go out sample pipeline 4 be connected, go out described in any one sample pipeline 4 outlet be equipped with two connection reservoirs 5 so that reservoir
Arrange arrangement in two row five the exit of sample pipeline is gone out, and any one reservoir thickness all same, a line storage of lower end
Liquid bath is integrated with the heating element heater 9 of available battery heating, and the heating element heater in the design uses heating plate, under heating element heater 9 pairs
The reservoir 5 at end is heated, so as to form thermograde between upper end reservoir and lower end reservoir；The pipeline that crosses
Multiple pipe tunnels 31 by three horizontal pipelines 30 and between horizontal pipeline are interconnected and constitute, three horizontal strokes
From top to bottom arranged successively to pipeline 30, three pipe tunnels 31 are provided between upper end and the horizontal pipeline of centre, centre is with
Four pipe tunnels 31 are provided between the horizontal pipeline at end, the horizontal pipeline of upper end is connected with sample channel 1 and inlet channel 2
Logical, the horizontal pipeline of lower end is connected with sample pipeline 4 is gone out.
The principle that the microchip provided using the utility model demonstrates chemical reaction rate is as follows：By the thio of 0.5mol/L
Metabisulfite solution and pure water are injected in sample channel 1 and inlet channel 2 from injection port 10 and water inlet 20 respectively, thiosulfuric acid
Flowed into out in sample pipeline 4 by the pipeline that crosses after sodium solution and pure water mixing, led to after mixing with pure water because of hypo solution
Cross the pipeline that crosses to arrive separately at each to go out the stroke that sample pipeline 4 experienced different, form different so as to go out at five in sample pipeline 4
The hypo solution of concentration gradient, meanwhile, in the exit that any one goes out sample pipeline, the reservoir 5 being arranged in order is by shape
Into the absorption cell of different temperatures.And in each group reservoir in advance add 0.1mol/L sulfuric acid solution, so in each groove will
There is following reaction：
Na2S2O3+H2SO4==Na2SO4+S↓+SO2+H2O
Because it is different with the temperature of groove that any one goes out hypo solution concentration in the reservoir in the exit of sample pipeline 4,
Such that it is able to observe that the big speed for sulphur precipitation occur of concentration of sodium thiosulfate is fast in each row, while the storage after being heated in each row
The speed for occurring sulphur precipitation in liquid bath is fast, and chemical reaction rate will be run away with concentration and the pass of temperature by observing classmate
System.
During the microchip of above-mentioned chemical reaction rate teaching is prepared, this seminar used various methods,
The method for being used is printing template method, solder stick-flour hybrid template method, and printing template the method device therefor is simple and imitates
Fruit substantially, there is certain practical value, but be limited to printer to limit its area of display relatively thin, phenomenon be not it is obvious that and
X-Y scheme can only be obtained, the ability of Three-dimensional thickness is there is no.Solder stick-flour hybrid template method template is easily destroyed, and is
Disposable template, solder stick is not fixed easily, and these methods have certain defect.
For above-mentioned defect, it is template that the microchip in the utility model uses PUR, culture dish, magnetite, is used
Prepared by poly dimethyl silicon rubber (i.e. PDMS), reference picture 2, and preparation method is as follows：
1) sample channel, inlet channel are designed in the smooth square plastic culture dish in bottom, crossing pipeline and goes out sample
The position of pipeline, depicts the pipeline model of projection at the corresponding pipeline with PUR in culture dish, i.e., with PUR along pipe
The shape in road is coated, and waits it to solidify；
2) go out sample pipe outlet at each and be sequentially placed two blocks of thickness identical magnetites, used between this two blocks of magnetites
PUR is connected；Can surface is can be placed in below culture dish, so as to by the position of magneticaction fixed magnet stone, complete
Template with three-D space structure；
3) by PDMS glue according to monomer：Curing agent=10:1 ratio is prepared, well mixed to pour into culture dish, more than magnetic
Surface where iron-stone, after standing drains bubble, dries two hours at a temperature of 60 °；
4) the PDMS colloids for completing will be dried to be stripped down from culture dish, magnetite is removed；
5) lower surface in chip body is adjacent to using the sealing-in of PDMS lower master films 8 of other one piece of integrated heating piece, it is ensured that
Heating plate is directed at the reservoir of bottom, so that chip body is formed, in injection port and water inlet etc. punching, you can for reality
Test, the chip body for preparing can copy pattern and prepare new template by thermosol, it is ensured that the reappearance of chip.
Schematically the utility model and embodiments thereof are described above, the description does not have restricted, accompanying drawing
Shown in be also one of implementation method of the present utility model, actual structure is not limited thereto.So, if this area
Those of ordinary skill enlightened by it, do not departing from the case that the utility model creates objective, designed without creative
The frame mode similar to the technical scheme and embodiment, all should belong to protection domain of the present utility model.
Claims (7)
1. a kind of chemical reaction rate teaching microchip, including chip body (6), it is characterised in that：The chip body (6)
Sample channel (1) and inlet channel (2) are inside provided with, the sample channel (1) and inlet channel (2) are by crossing under pipeline and its
Several of end go out sample pipeline (4) and are connected, and the outlet that sample pipeline (4) is gone out any one described in is equipped with two reservoirs for connecting
(5)。
2. a kind of chemical reaction rate teaching microchip according to claim 1, it is characterised in that：It is described go out sample pipeline
(4) quantity is five, and the reservoir (5) arranges arrangement in the exit for going out sample pipeline in two row five.
3. a kind of chemical reaction rate teaching microchip according to claim 2, it is characterised in that：Go out sample described in five
The hypo solution of various concentrations gradient can be formed in pipeline.
4. a kind of chemical reaction rate teaching microchip according to claim 2, it is characterised in that：Lower end reservoir collection
Into the heating element heater (9) for having available battery heating.
5. a kind of chemical reaction rate teaching microchip according to claim 1, it is characterised in that：Any one described storage
The thickness all same of liquid bath.
6. a kind of chemical reaction rate teaching microchip according to claim 1, it is characterised in that：The pipeline that crosses
Multiple pipe tunnels (31) by three horizontal pipelines (30) and between horizontal pipeline are interconnected and constitute.
7. a kind of chemical reaction rate teaching microchip according to claim 1, it is characterised in that：The sample channel
Entrance is provided with injection port (10), and the inlet channel entrance is provided with water inlet (20).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621202340.3U CN206285925U (en) | 2016-11-08 | 2016-11-08 | A kind of chemical reaction rate teaching microchip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621202340.3U CN206285925U (en) | 2016-11-08 | 2016-11-08 | A kind of chemical reaction rate teaching microchip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206285925U true CN206285925U (en) | 2017-06-30 |
Family
ID=59100774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621202340.3U Expired - Fee Related CN206285925U (en) | 2016-11-08 | 2016-11-08 | A kind of chemical reaction rate teaching microchip |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206285925U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108597335A (en) * | 2018-06-15 | 2018-09-28 | 安徽中医药高等专科学校 | A kind of preparation method of green multifunctional teaching microchip |
-
2016
- 2016-11-08 CN CN201621202340.3U patent/CN206285925U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108597335A (en) * | 2018-06-15 | 2018-09-28 | 安徽中医药高等专科学校 | A kind of preparation method of green multifunctional teaching microchip |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105457695B (en) | Reversible micro-fluidic chip clamp | |
| CN102174388B (en) | Surface-electrode-technology-based high-throughput cell electrofusion chip device | |
| CN105170208A (en) | Preparation method of microarray chip and product thereof | |
| CN105296348A (en) | Genotyping detection-based microfluidic chip, detection system and device | |
| CN106824317A (en) | A kind of method that drop is manipulated using micro- electromagnetic wand | |
| CN109682962A (en) | Immunofluorescence test system and detection method based on micro-fluidic chip | |
| CN108300640A (en) | A kind of micro-fluidic chip for nucleic acid automation extraction and detection | |
| CN101498704A (en) | Valveless micro-flow control gradient real-time reaction chip and reaction control method | |
| CN206285925U (en) | A kind of chemical reaction rate teaching microchip | |
| CN106563516B (en) | A kind of teaching preparation method of microchip | |
| CN209727963U (en) | Immunofluorescence test system based on micro-fluidic chip | |
| CN206293074U (en) | A kind of langbobier law teaching microchip | |
| CN208366832U (en) | Complex water body multi-parameter based on microflow control technique examines equipment fastly | |
| CN206441437U (en) | A kind of microchip imparted knowledge to students for TLC | |
| CN206404699U (en) | A kind of AC field promoted type micro-mixer | |
| CN107469745A (en) | A kind of micro-fluidic combinatorial chemistry reaction chip | |
| CN107661784A (en) | After a kind of quantitative shunting be pre-stored in liquid hybrid detection micro-fluidic chip | |
| CN210022179U (en) | High-efficient extraction integrated device that mixes | |
| CN208449339U (en) | A kind of MHD micro-fluidic chip of star-tree-shaped composite construction | |
| CN106959332B (en) | The automatic fine sampling device and its control method of electrophoresis detection instrument | |
| CN108597335A (en) | A kind of preparation method of green multifunctional teaching microchip | |
| CN206232739U (en) | The device of biomolecule is extracted by magnetic bead | |
| CN109865539A (en) | Micro-fluidic chip of integrated electrochemical sensor and manufacturing method and application thereof | |
| CN209373894U (en) | A kind of green multifunctional teaching microchip | |
| CN110841728B (en) | Manufacturing method of 3D micro-channel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170630 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |