CN208449339U - A kind of MHD micro-fluidic chip of star-tree-shaped composite construction - Google Patents
A kind of MHD micro-fluidic chip of star-tree-shaped composite construction Download PDFInfo
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- CN208449339U CN208449339U CN201820666917.9U CN201820666917U CN208449339U CN 208449339 U CN208449339 U CN 208449339U CN 201820666917 U CN201820666917 U CN 201820666917U CN 208449339 U CN208449339 U CN 208449339U
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Abstract
The utility model discloses a kind of star-tree-shaped composite construction MHD micro-fluidic chip, sample to be tested inlet, MHD transfer tube, detection zone, No. two sprues, No. three sprues, No. four sprues, No. five sprues, the first branch flow passage, the second branch flow passage, third branch flow passage and the 4th branch flow passages.Ionic liquid can be sent into final sensing chamber and carry out reaction detection by the utility model by changing the potential difference of different runners to control the Lorentz force of different runners.
Description
Technical field
The present invention relates to chemical reagent or biological medicine detection technique field, especially a kind of star-tree-shaped composite construction
MHD micro-fluidic chip.
Background technique
The preparation, reaction, detection of chemical reagent or biological medicine are integrated on the chip of micron dimension by micro-fluidic chip,
Ionic liquid is driven by Lorentz force, different sensing chamber is sent to and carries out reaction detection.On micro-fluidic chip, only need
It wants microlitre reagent sample even nanoliter that can complete testing process in high precision, examination is greatly saved compared to other detection methods
The consumption of agent sample.Micro-fluidic chip currently on the market uses Mechanical Driven mode mostly, can only carry out simple sample
Detection, and it is unfavorable for integrated development at the excessive disadvantage of volume.
Summary of the invention
Technical problem to be solved by the present invention lies in, a kind of MHD micro-fluidic chip of star-tree-shaped composite construction is provided,
Ionic liquid can be sent into final inspection by changing the potential difference of different runners to control the Lorentz force of different runners
It surveys room and carries out reaction detection.
In order to solve the above technical problems, the present invention provides a kind of MHD micro-fluidic chip of star-tree-shaped composite construction, comprising:
Sample to be tested inlet 1, MHD transfer tube 2, the master of sprue 6, five of sprue 5, four of sprue 4, three of detection zone 3, two
Runner 7, the first branch flow passage 8, the second branch flow passage 9, third branch flow passage 10 and the 4th branch flow passage 11；Sample to be tested inlet 1 and MHD
Transfer tube 2 is located at No.1 sprue, No.1 sprue, No. two 6, No. five mainstreams of sprue of sprue 5, four of sprue 4, three
Road 7 is connected, and No.1 sprue end branches into the first branch flow passage 8, the second branch flow passage 9, and 8 end of the first branch flow passage is divided into third again
Branch flow passage 10 and the 4th branch flow passage 11, every branch flow passage are all connected with a detection zone 3, are reacted in detection zone 3.
Preferably, MHD transfer tube 2 include: quartz glass plate 12, permanent magnet 13, miniflow channel layer 14, electrode connecting column 15,
Electrode 16, fluid channel 17, PDMS coating 18, test sample inlet 19, fluid reservoir 20, sensing chamber 21 and observation port 22；From
It is made of under three-decker, first layer is PDMS coating 18, and there are the outlets of electrode connecting column 15, detection on this layer
Sample injection port 19 and observation port 22；The second layer is miniflow channel layer 14, is carved with fluid channel 17 in this layer of glazing, is electroplated on tube wall
There is electrode 16 to be connected with electrode connecting column 15, one permanent magnet 13 of just side's insertion below of fluid channel 17 also includes in the layer
There are fluid reservoir 20 and sensing chamber 21；Third layer is quartz glass plate 12, is carved with the groove of permanent magnet 13.
Preferably, micro-fluidic chip uses quartz glass as substrate, uses exposure machine photoetching fluid channel on it, runner
Section is square, it is wide and it is high be 600 microns.
Preferably, the material of electrode 16 is platinum or gold.
Preferably, PDMS coating 18 is one layer of fexible film, and material is dimethyl silicone polymer.
The invention has the benefit that the present invention only needs microlitre reagent sample even nanoliter that can complete to examine in high precision
Flow gauge can carry out various samples detection, and small in size be easily integrated.
Detailed description of the invention
Fig. 1 is chip structure schematic diagram of the invention.
Fig. 2 is MHD transfer tube structural schematic diagram of the invention.
Fig. 3 is fluid reservoir structural schematic diagram of the invention.
Fig. 4 is sensing chamber's structural schematic diagram of the invention.
Specific embodiment
As shown in Figure 1, a kind of star-tree-shaped composite construction MHD micro-fluidic chip, comprising: sample to be tested inlet 1,
MHD transfer tube 2, detection zone 3, two sprue 4, three sprue 5, four sprue 6, five sprue 7, the first branch flow passage
8, the second branch flow passage 9, third branch flow passage 10 and the 4th branch flow passage 11；Sample to be tested inlet 1 and MHD transfer tube 2 are located at No.1
Sprue, No.1 sprue, No. two 6, No. five sprues 7 of sprue of sprue 5, four of sprue 4, three are connected, No.1 master
Runner end branches into the first branch flow passage 8, the second branch flow passage 9, and 8 end of the first branch flow passage is divided into third branch flow passage 10 and the 4th again
Branch flow passage 11, every branch flow passage are all connected with a detection zone 3, are reacted in detection zone 3.
The present invention sprue end up Chu You branch, by next stage branch flow passage apply opposite Lorentz force drive from
Sub- liquid enters different runners, forms MHD fluid switch, N grades can be divided into transverse direction, centre is hub-and-spoke configuration, at runner end
The runner of place's addition tree structure, expansion in layer are gone down, and space can be saved.
As in Figure 2-4, MHD transfer tube 2 includes: quartz glass plate 12, permanent magnet 13, miniflow channel layer 14, electrode connection
Column 15, electrode 16, fluid channel 17, PDMS coating 18, test sample inlet 19, fluid reservoir 20, sensing chamber 21 and observation port
22；It is made of from top to bottom three-decker, first layer is PDMS coating 18, the going out there are electrode connecting column 15 on this layer
Mouth, test sample inlet 19 and observation port 22；The second layer is miniflow channel layer 14, fluid channel 17 is carved in this layer of glazing, in pipe
It is electroplate with electrode 16 on wall to be connected with electrode connecting column 15, one permanent magnet 13 of just side's insertion below of fluid channel 17, at this
Layer also includes fluid reservoir 20 and sensing chamber 21；Third layer is quartz glass plate 12, is carved with the groove of permanent magnet 13.
MHD fluid switch is applied to micro-fluidic chip by the present invention, by changing the potential difference of different runners to control
Ionic liquid is sent into final sensing chamber and carries out reaction detection by the Lorentz force of different runners.Micro-fluidic chip includes detection
The inlet of liquid, observation port, MHD transfer tube, sensing chamber, fluid reservoir, basal layer, coating and the fluid channel for detecting liquid
Layer.Micro-fluidic chip uses quartz glass as substrate, uses fluid channel as shown in Figure 1 in exposure machine photoetching on it, then
The coating that material is dimethyl silicone polymer (PDMS) is covered again.The interface of runner be square, it is wide and it is high be all 600
Microns, the electrode of MHD transfer tube are that the metal material of upper chemical stabilization is electroplated in fluid channel two sidewalls, are on the downside of it
Permanent magnet, Miniature permanent magnet iron generate uniform magnetic field, and liquid passes through under the collective effect of electric and magnetic fields and by Lorentz force
The sensing chamber that sample, the flowing of reagent and flow direction are analyzed required for reaching in the potential difference control micro-fluidic chip of coordination electrode.
The sample of fluid reservoir 20 is set to flow to detection zone 3: firstly, injecting sample to detection zone 3 by test sample inlet 19
Then product open the fluid switch on No. two sprues, are closed at the fluid switch of remaining four sprue 4,5,6,7, make
Testing liquid flows into No. two sprues.Similarly, the fluid switch of the first branch flow passage 8 and third branch flow passage 10 is opened, closure cannot
Fluid switch on runner the second branch flow passage 9 flowed through and the 4th branch flow passage 11, so that fluid be prevented to flow to the runner, most Zhongdao
Up to detection zone 3, fluid flow direction is set to want the sensing chamber for reaching it with this.
Claims (5)
1. a kind of star-tree-shaped composite construction MHD micro-fluidic chip characterized by comprising sample to be tested inlet (1),
MHD transfer tube (2), detection zone (3), No. two sprues (4), No. three sprues (5), No. four sprues (6), No. five sprues
(7), the first branch flow passage (8), the second branch flow passage (9), third branch flow passage (10) and the 4th branch flow passage (11)；Sample to be tested inlet
(1) it is located at No.1 sprue, No.1 sprue, No. two sprues (4), No. three sprues (5), No. four masters with MHD transfer tube (2)
Runner (6), No. five sprues (7) are connected, and No.1 sprue end branches into the first branch flow passage (8), the second branch flow passage (9), the
One branch flow passage (8) end is divided into third branch flow passage (10) and the 4th branch flow passage (11) again, every branch flow passage all with a detection zone
(3) it is connected, is reacted in detection zone (3).
2. star as described in claim 1-tree-shaped composite construction MHD micro-fluidic chip, which is characterized in that MHD transfer tube (2)
It include: quartz glass plate (12), permanent magnet (13), miniflow channel layer (14), electrode connecting column (15), electrode (16), fluid channel
(17), PDMS coating (18), test sample inlet (19), fluid reservoir (20), sensing chamber (21) and observation port (22)；From upper
It is made of under three-decker, first layer is PDMS coating (18), and there are the outlets of electrode connecting column (15), inspection on the layer
Sample inlet (19) and observation port (22)；The second layer is miniflow channel layer (14), is carved with fluid channel (17) in this layer of glazing,
It is electroplate with electrode (16) on tube wall to be connected with electrode connecting column (15), one permanent magnet of just side's insertion below of fluid channel (17)
It (13), also include fluid reservoir (20) and sensing chamber (21) in the layer；Third layer is quartz glass plate (12), is carved with permanent magnet
(13) groove.
3. star as described in claim 1-tree-shaped composite construction MHD micro-fluidic chip, which is characterized in that micro-fluidic chip makes
Use quartz glass as substrate, use exposure machine photoetching fluid channel on it, the section of runner is square, it is wide and it is high be 600
Micron.
4. star as claimed in claim 2-tree-shaped composite construction MHD micro-fluidic chip, which is characterized in that the material of electrode (16)
Material is platinum or gold.
5. star as claimed in claim 2-tree-shaped composite construction MHD micro-fluidic chip, which is characterized in that PDMS coating
It (18) is one layer of fexible film, material is dimethyl silicone polymer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820666917.9U CN208449339U (en) | 2018-05-04 | 2018-05-04 | A kind of MHD micro-fluidic chip of star-tree-shaped composite construction |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820666917.9U CN208449339U (en) | 2018-05-04 | 2018-05-04 | A kind of MHD micro-fluidic chip of star-tree-shaped composite construction |
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| CN208449339U true CN208449339U (en) | 2019-02-01 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110713900A (en) * | 2019-11-05 | 2020-01-21 | 深圳先进技术研究院 | Micro-fluidic chip for separating and capturing single cell and preparation method and application thereof |
| CN112916062A (en) * | 2021-01-29 | 2021-06-08 | 哈尔滨医科大学 | Driving method for liquid flow of microfluidic chip |
-
2018
- 2018-05-04 CN CN201820666917.9U patent/CN208449339U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110713900A (en) * | 2019-11-05 | 2020-01-21 | 深圳先进技术研究院 | Micro-fluidic chip for separating and capturing single cell and preparation method and application thereof |
| WO2021088936A1 (en) * | 2019-11-05 | 2021-05-14 | 深圳先进技术研究院 | Microfluidic chip for isolating and capturing single cell, manufacturing method for same, and applications thereof |
| CN112916062A (en) * | 2021-01-29 | 2021-06-08 | 哈尔滨医科大学 | Driving method for liquid flow of microfluidic chip |
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