CN206285924U - A kind of micro-fluidic chip based on MHD controls - Google Patents
A kind of micro-fluidic chip based on MHD controls Download PDFInfo
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- CN206285924U CN206285924U CN201621189618.8U CN201621189618U CN206285924U CN 206285924 U CN206285924 U CN 206285924U CN 201621189618 U CN201621189618 U CN 201621189618U CN 206285924 U CN206285924 U CN 206285924U
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- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 14
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 14
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims abstract description 10
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical group C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims abstract description 9
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 3
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Abstract
The utility model discloses a kind of micro-fluidic chip based on MHD controls, the micro-fluidic chip is based on exchange MHD actuation techniques, and using three-decker, ground floor is PDMS cover plates layer 16, leaves electrode connecting pole 12, inlet 19 and the hole of observation port 20；The second layer is miniflow channel layer 17, including exchange MHD transfer tubes 11, fluid channel 15, fluid reservoir 21 and sensing chamber 22, wherein exchange MHD transfer tubes 11 include the miniature solenoid 14 immediately below electrode connecting pole 12, electrode 13 and runner 15；Third layer is quartz glass plate 18, and the groove for placing miniature solenoid 14 is carved with above.Predetermined sensing chamber 22 is flowed under the control of exchange MHD transfer tubes 11 after the different injection samples of fluid reservoir 21 or reagent and analyzes detection, or can be with multipath, while detection, improves detection efficiency, with very actual application value.
Description
Technical field
The utility model is related to a kind of micro-fluidic chip based on MHD controls, belongs to field of mechanical technique.
Background technology
Microfluidic chip technology is sample preparation, reaction, separation, detection biological, chemistry and medical analysis process etc.
Basic operation unit is integrated on the chip of micro-meter scale, completes analysis all processes.To sample on the chip of micron level
The analysis detection sample and reagent that only need to microlitre even nanoliter, its cost greatly reduces relative to high throughput analysis systems
, not only energy-conserving and environment-protective, and create good condition for analysis detects family.Micro-fluidic chip in the market is mostly
Simple sample analysis and detection can only be carried out, Mechanical Driven mode is used, sensitivity is not high, volume it is excessive be unfavorable for it is integrated
Change development.
Chinese Patent Application No.：201510191236.2nd, it is micro- disclosed in entitled " nucleic acid automatically extracts micro fluidic device "
Flow control apparatus are made up of micro-fluidic chip and drive device, drive device include chip tray, locating slot, magnet frame, upper magnet,
Lower magnet, optocoupler frame, slot optical coupling, motor fixing plate, stepper motor, support frame, base plate are constituted.This kind of sensitivity is not high, knot
Structure is complicated, volume is excessive is unfavorable for integrated development.Chinese Patent Application No.：200980120537.9th, it is entitled " to utilize capillary
Device and Chinese Patent Application No. disclosed in the analytical equipment and analysis method of electrophoresis tube method "：201410355409.5th, it is entitled
Chip disclosed in " a kind of new big passage electrophoretic microchip " in implementation process using to voltage respectively reach 600V and
1000V, voltage so high not only has influence on the activity of detected sample, it is also possible to which electrochemical reaction occurs, or even to behaviour
Make human life to constitute a threat to safely.And the utility model can be solved the problems, such as above well.
The content of the invention
The utility model is for above-mentioned the deficiencies in the prior art, it is proposed that a kind of micro-fluidic core based on MHD controls
Piece, the micro-fluidic chip can realize monocyte sample analysis detection, it is also possible to realize Multi-example while analyzing detection.The utility model
In order to reduce volume, beneficial to integrated and raising accuracy, exchange MHD drivings are applied in micro-fluidic chip.Therefore, it is possible to
Problem above is overcome well, is improved efficiency and is reduced cost.
The technical scheme in the invention for solving the technical problem is：A kind of micro-fluidic core based on MHD controls
Piece, the micro-fluidic chip is based on exchange MHD actuation techniques, and using three-decker, ground floor is PDMS cover plates layer 16, leaves electrode
Connecting pole 12, inlet 19 are (i.e.：Fluid reservoir one, fluid reservoir two, fluid reservoir three, fluid reservoir four and fluid reservoir five have inlet
19) with the hole of observation port 20 (i.e.：Sensing chamber A, sensing chamber B, sensing chamber C, sensing chamber D and sensing chamber E have observation port 20)；Second
Layer is miniflow channel layer 17, including exchange MHD transfer tubes 11, fluid channel 15, fluid reservoir 21 and sensing chamber 22, wherein exchange MHD drives
Dynamic pump 11 includes the miniature solenoid 14 immediately below electrode connecting pole 12, electrode 13 and runner 15；Third layer is quartz glass plate
18, the groove for placing miniature solenoid 14 is carved with above.Needed to inject sample in different fluid reservoirs 21 according to different detections
Or after reagent, by changing the direction in the electric field and magnetic field being applied in exchange MHD transfer tubes 11, sample or reagent will be subject to
The effect of Lorentz force flows to the predetermined analysis of sensing chamber 22 detection, without the other places of flow direction, can with multipath, while
Detection.
Further, the utility model micro-fluidic chip includes basalis, miniflow channel layer, cover plate layer, sample room, reagent
Room, microfluidic channel, analysis sensing chamber, MHD drive valve.The material that the basalis of the micro-fluidic chip is used is quartz glass
Piece, coats one layer of SU-8 optical cement on the quartz glass plate of wash clean, and microchannel, Ran Houzai are made by lithography with exposure machine after drying
Material is the cover plate layer of dimethyl silicone polymer (i.e. PDMS) in covering.Wherein, the section of fluid channel is rectangle, sprue
Width is 120~150 microns, and depth is 50~80 microns, and the width of branch flow passage is highly micro- 50~80 at 100~120 microns
Rice；The electrode of MHD transfer tubes is the metal material of the chemical stabilization in the plating of fluid channel two side, is below miniature spiral shell at it
Coil, the electric current of change produces magnetic field by miniature solenoid, and liquid is subject to Lip river under the collective effect in electric field and magnetic field
Lun Zili, is applied to the electric current at electrode and miniature solenoid two ends with frequency, by changing both phase differences so as to reach change
The direction of Lorentz force, i.e., the Lorentz force that produces is in opposite direction when with phase difference being 180 degree when with phase.Therefore it is micro- by controlling
Sample, the flowing of reagent and flow direction reach the required sensing chamber for analyzing during stream pump can control micro-fluidic chip.
Further, exchange MHD transfer tubes of the present utility model are made up of electrode connecting pole, electrode and miniature solenoid,
Using Theory of Electromagnetic Field, conducting liquid is acted in electromagnetic field and flowed by Lorentz force.
Further, miniature solenoid of the present utility model is located at the lower section of electrode and runner, and electromagnetic field is time-varying field, electricity
Pole is formed in the plating of fluid channel side wall using electroplating technology, the electrochemical corrosion resistant metal such as platinum, gold that electrode material is.
Further, the fluid channel in miniflow channel layer of the present utility model is that SU-8 optical cements expose under exposure machine and form,
The section of fluid channel is rectangle, and the width of sprue is 120~150 microns, and depth is 50~80 microns, the width of branch flow passage
At 100~120 microns, highly at 50~80 microns.
Further, cover plate layer of the present utility model is one layer of fexible film, by dimethyl silicone polymer (i.e. PDMS) material
Material is made, and thickness is at 500~8000 microns.
Beneficial effect：
1st, the utility model sample or reagent are acted on by Lorentz force, flow to predetermined sensing chamber (22) analysis inspection
Survey, without the other places of flow direction, multipath is realized well, while detection.
2nd, the utility model can well improve detection efficiency, with very actual application value.
3rd, the utility model is driven using exchange MHD, and required voltage is low, and electrochemical reaction will not occur.
4th, the utility model small volume, facilitates integrated development well.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model.
Identifier declaration：1- fluid reservoirs one；2- fluid reservoirs two；3- fluid reservoirs three；4- fluid reservoirs four；5- fluid reservoirs five；6- is examined
Survey room A；7- sensing chamber B；8- sensing chamber C；9- sensing chamber D；10- sensing chamber E；11- exchanges MHD transfer tubes；12- electrodes are connected
Post；13- electrodes；The miniature solenoids of 14-；15- fluid channels；16-PDMS cover plates layer；17- miniflow channel layer；18- quartz glass plates；
19- inlets；20- observation ports；21- fluid reservoirs；22- sensing chamber.
Fig. 2 is that the utility model exchanges MHD transfer tube cross section of fluid channel structural representations.
Identifier declaration：12- electrode connecting poles；13- electrodes；The miniature solenoids of 14-；15- fluid channels；16-PDMS cover plates layer；
17- miniflow channel layer；18- quartz glass plates.
Fig. 3 is the utility model fluid reservoir cross section structure schematic diagram.
Identifier declaration：15- fluid channels；16-PDMS cover plates layer；17- miniflow channel layer；18- quartz glass plates；19- inlets；
21- fluid reservoirs；
Fig. 4 is the utility model sensing chamber cross section structure schematic diagram.
Identifier declaration：1- fluid reservoirs one；2- fluid reservoirs two；3- fluid reservoirs three；4- fluid reservoirs four；5- fluid reservoirs five；6- is examined
Survey room A；7- sensing chamber B；8- sensing chamber C；9- sensing chamber D；10- sensing chamber E；11- exchanges MHD transfer tubes；12- electrodes are connected
Post；13- electrodes；The miniature solenoids of 14-；15- fluid channels；16-PDMS cover plates layer；17- miniflow channel layer；18- quartz glass plates；
19- inlets；20- observation ports；21- fluid reservoirs；22- sensing chamber.
Specific embodiment
The utility model is described in further detail with reference to Figure of description.
Embodiment one
As shown in figure 1, the utility model provides a kind of micro-fluidic chip based on MHD controls, the micro-fluidic chip is adopted
With three-decker, ground floor is quartz glass plate 18, as shown in Figure 2；The second layer is miniflow channel layer 17, and this layer is in wash clean
One layer of SU-8 optical cement is coated on quartz glass plate, fluid channel 15 is made by lithography with exposure machine after drying, be electroplate with fluid channel 15
Electrode 13, electrode 13 is connected with electrode connecting pole 12, and the quartz glass plate 18 immediately below fluid channel 15 is fluted can be embedded in
One miniature solenoid 14, miniflow channel layer 17 also includes fluid reservoir 21 and sensing chamber 22；Third layer is PDMS cover plates layer 16, at this
Left on layer electrode connecting pole 12 export, inlet 19 and observation port 20.Specifically include：
Micro-fluidic chip of the present utility model is based on exchange MHD actuation techniques, and using three-decker, ground floor is covered for PDMS
Lamella 16, leaves electrode connecting pole 12, inlet 19 (i.e.：Fluid reservoir one, fluid reservoir two, fluid reservoir three, fluid reservoir four and liquid storage
There is inlet 19 room five) and the hole of observation port 20 is (i.e.：Sensing chamber A, sensing chamber B, sensing chamber C, sensing chamber D and sensing chamber E have
Observation port 20)；The second layer is miniflow channel layer 17, including exchange MHD transfer tubes 11, fluid channel 15, fluid reservoir 21 and sensing chamber 22,
Wherein exchange MHD transfer tubes 11 include the miniature solenoid 14 immediately below electrode connecting pole 12, electrode 13 and runner 15；Third layer
It is quartz glass plate 18, the groove for placing miniature solenoid 14 is carved with above.Needed in different liquid storages according to different detections
After sample or reagent are injected in room 21, by changing the direction in the electric field and magnetic field being applied in exchange MHD transfer tubes 11, sample or
Reagent will be acted on by Lorentz force flows to the predetermined analysis detection of sensing chamber 22, without the other places of flow direction, can
With multipath, while detection.
The utility model micro-fluidic chip includes that basalis, miniflow channel layer, cover plate layer, sample room, reagent chamber, microfluid lead to
Road, analysis sensing chamber, MHD drive valve.The material that the basalis of the micro-fluidic chip is used is quartz glass plate, in wash clean
One layer of SU-8 optical cement is coated on quartz glass plate, microchannel is made by lithography with exposure machine after drying, material is then covered again is
The cover plate layer of dimethyl silicone polymer (i.e. PDMS).Wherein, the section of fluid channel is rectangle, the width of sprue is 120~
150 microns, depth is 50~80 microns, the width of branch flow passage at 100~120 microns, highly at 50~80 microns；MHD drives
The electrode of pump is the metal material of the chemical stabilization in the plating of fluid channel two side, is below miniature solenoid at it, change
Electric current magnetic field is produced by miniature solenoid, liquid is subject to Lorentz force under the collective effect in electric field and magnetic field, applies
The electric current at electrode and miniature solenoid two ends is added in frequency, change Lorentz force is reached by changing both phase differences
Direction, i.e., the Lorentz force that produces is in opposite direction when with phase difference being 180 degree when with phase.Therefore can be controlled by controlling miniflow pump
The sensing chamber of analysis required for sample, the flowing of reagent and flow direction are reached in micro-fluidic chip processed.
Exchange MHD transfer tubes of the present utility model are made up of electrode connecting pole, electrode and miniature solenoid, using electromagnetic field
Theory, conducting liquid is acted in electromagnetic field and flowed by Lorentz force.
Miniature solenoid of the present utility model is located at the lower section of electrode and runner, and electromagnetic field is time-varying field, and electrode is to use
Electroplating technology is formed in the plating of fluid channel side wall, the electrochemical corrosion resistant metal such as platinum, gold that electrode material is.
Fluid channel in miniflow channel layer of the present utility model is that SU-8 optical cements expose under exposure machine and form, and fluid channel is cut
Face is rectangle, and the width of sprue is 120~150 microns, and depth is 50~80 microns, and the width of branch flow passage is 100~120
Micron, highly at 50~80 microns.
Cover plate layer of the present utility model is one layer of fexible film, by the making of dimethyl silicone polymer (i.e. PDMS) material
Into thickness is at 500~8000 microns.
Embodiment two
The sample flow detection room D9 of fluid reservoir of the present utility model 22：Sample is injected to fluid reservoir 22 by inlet 19
Product, regulation is applied to fluid reservoir 22, fluid reservoir 33, fluid reservoir 44, fluid reservoir 55, sensing chamber A6, sensing chamber B7, sensing chamber
The electric field of MHD transfer tubes 11 and the direction in magnetic field, the Lorentz that sample is subject under electromagnetic field effect are exchanged on tributary where E10
Point to sprue in the direction of power；And sample flows through long-range navigation suffered during the exchange MHD transfer tubes 11 on tributary where sensing chamber D9
Hereby power direct detection room D9；Regulation makes liquid flow near the electric field of exchange MHD transfer tubes 11 of fluid reservoir 1 and the direction in magnetic field
Out-of-date Lorentz force points to the right；Electric field and the direction in magnetic field of the regulation near the exchange MHD transfer tubes 11 of sensing chamber C8, make
The out-of-date Lorentz force of liquid flow points to the left side, and others exchange MHD transfer tubes 11 do not need applied voltage.So sample is with regard to energy
Enough sample flow detection room D9 from fluid reservoir 22 are without flowing to other fluid reservoirs or sensing chamber.Again may be by regulation
The phase difference of the exchange MHD transfer tubes 11 on different tributaries, can reach any required detection approach.
Embodiment three
The sample of fluid reservoir of the present utility model 1 mixes flow direction with the reagent of fluid reservoir 33, the reagent of fluid reservoir 44
Sensing chamber A6 and sensing chamber E10：By inlet 19 to the injection of fluid reservoir 1 sample, to the injection of fluid reservoir 33 reagent, to storage
Reagent is injected in liquid room 44.Regulation be applied to fluid reservoir 22, fluid reservoir 33, fluid reservoir 44, on the place tributary of fluid reservoir 55
The electric field of exchange MHD transfer tubes 11 and the direction in magnetic field, make the direction of the Lorentz force that sample is subject to when flowing through point to sprue；
Electric field and the direction in magnetic field of the regulation near the exchange MHD transfer tubes 11 of fluid reservoir 1, Lorentz force when flowing liquid through refer to
To the right；And flow through sensing chamber A6 and divide with the Lorentz force suffered when exchanging MHD transfer tubes 11 on tributary where sensing chamber E10
Other direct detection room A6, sensing chamber E10；Near tributary where regulation sensing chamber A6 and sensing chamber E10 and sprue intersection
The electric field of exchange MHD transfer tubes 11 and the direction in magnetic field, Lorentz force suffered when flowing liquid through point to the left side, others exchange
MHD transfer tubes 11 do not need applied voltage.This makes it possible to the sample and reagent, the fluid reservoir of fluid reservoir 33 that make fluid reservoir 1
44 reagent mixing flows to sensing chamber A6 and sensing chamber E10.Again may be by adjusting the exchange being applied on different tributaries
The electric field of MHD transfer tubes 11 and the direction in magnetic field, to meet different detection demands.
Claims (5)
1. it is a kind of based on MHD control micro-fluidic chip, it is characterised in that：The micro-fluidic chip uses three-decker, first
Layer is PDMS cover plates layer (16), leaves electrode connecting pole (12), inlet (19) and observation port (20) hole；The second layer is fluid channel
Layer (17), including exchange MHD transfer tubes (11), fluid channel (15), fluid reservoir (21) and sensing chamber (22), wherein exchange MHD drives
Dynamic pump (11) includes the miniature solenoid (14) immediately below electrode connecting pole (12), electrode (13) and runner (15)；Third layer is
Quartz glass plate (18), is carved with the groove for placing miniature solenoid (14) above, in different fluid reservoir (21) injection samples or
After reagent, by changing the direction in the electric field and magnetic field being applied in exchange MHD transfer tubes (11), sample or reagent flow direction are predetermined
Sensing chamber (22).
2. it is according to claim 1 it is a kind of based on MHD control micro-fluidic chip, it is characterised in that：The exchange MHD drives
Dynamic pump (11) is made up of electrode connecting pole (12), electrode (13) and miniature solenoid (14).
3. it is according to claim 2 it is a kind of based on MHD control micro-fluidic chip, it is characterised in that the miniature helical
Positioned at electrode and the lower section of runner, electromagnetic field is time-varying field to circle (14), and electrode (13) is in fluid channel side wall using electroplating technology
Plating is formed, and the material of electrode (13) is platinum or the electrochemical corrosion resistant metal of gold.
4. it is according to claim 1 it is a kind of based on MHD control micro-fluidic chip, it is characterised in that the miniflow channel layer
(17) fluid channel (15) in is that SU-8 optical cements expose under exposure machine and form, and the section of fluid channel (15) is rectangle, main flow
The width in road is 120~150 microns, and depth is 50~80 microns, the width of branch flow passage at 100~120 microns, highly 50~
80 microns.
5. a kind of micro-fluidic chip based on MHD controls according to claim 1, it is characterised in that cover plate layer is
One layer of fexible film, is made by polydimethyl siloxane material, and thickness is at 500~8000 microns.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201621189618.8U CN206285924U (en) | 2016-11-01 | 2016-11-01 | A kind of micro-fluidic chip based on MHD controls |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201621189618.8U CN206285924U (en) | 2016-11-01 | 2016-11-01 | A kind of micro-fluidic chip based on MHD controls |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106622408A (en) * | 2016-11-01 | 2017-05-10 | 南京邮电大学 | Micro-fluidic chip based on MHD control |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106622408A (en) * | 2016-11-01 | 2017-05-10 | 南京邮电大学 | Micro-fluidic chip based on MHD control |
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Granted publication date: 20170630 |