CN205339654U - 3D prints peripheral nerve pipe - Google Patents
3D prints peripheral nerve pipe Download PDFInfo
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- CN205339654U CN205339654U CN201521140198.XU CN201521140198U CN205339654U CN 205339654 U CN205339654 U CN 205339654U CN 201521140198 U CN201521140198 U CN 201521140198U CN 205339654 U CN205339654 U CN 205339654U
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- growth factor
- nerve
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- nerve growth
- peripheral nerve
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Abstract
The utility model discloses a 3D prints peripheral nerve pipe, including the sleeve pipe, overlap the intraductal six prismatic pipes of one or more that are provided with, six prismatic intraductal a plurality of neural growth factor carrier balls that are provided with, the load has neural growth factor in the neural growth factor carrier ball, the utility model discloses a 3D prints peripheral nerve pipe structure is stable more, the integration, can the gradient supply with neural growth factor simultaneously, more is favorable to promoting the nerve regneration.
Description
Technical field
This utility model relates to medical instruments field, particularly relates to a kind of 3D and prints peripheral nerve conduit.
Background technology
Peripheral nerve major injury (especially the most serious SunderlandV type neurologic defect wound), is common in avulsion, incision, and serious tension injury and squeezing is hindered., owing to not only existing the fracture completely of nerve trunk, and there is gap in various degree in the peripheral nerve injury of this kind of type, the possibility therefore at all do not recovered voluntarily between the broken ends of fractured bone.So far, the repairing and treating of peripheral nerve defection is focused primarily upon nerve autograft by domestic and international medical needles and artificial neuron is transplanted, but due to many deficiencies that nerve autograft exists, such as donor nerve is limited, increase wound, dysfunction and operation risk etc., and therefore the research and development one of artificial neuron are directly subordinate to the study hotspot in this field.The artificial neuron of official listing and entrance clinical trial both at home and abroad mainly has two big classes at present, one class is allogeneic nerve, source includes people's corpse, amputation, animal etc., the major defect of this type of artificial neuron include limited source, expensive, implant after be likely to result in infection and immunologic rejection etc., therefore greatly limit the application of allogeneic nerve.Another big class artificial neuron is tissue engineering nerve, namely by all kinds of safe, study more ripe macromolecule organic material be made, but it is limited to processing technology thereof, the outer layer of this type of conduit is generally individually cylindrical, only there are some differences in internal structure, for instance has irregular filament, single or multiple hollow cylindricals etc..No matter tissue engineering nerve is made by what material, no matter also its internal structure why, it is both needed to reach common purpose, namely space support reliable, effective and the function such as guiding, neural (especially performing the nerve tract of the difference in functionality) growth of promotion are provided for regenerating nerve under complicated internal milieu.
No matter previously existing artificial nerve catheter conduit is worked out material, why is constructed both at home and abroad; all regenerated nervous fibers can only be played passive protective effect; namely enough mechanical support are provided as far as possible in nerve fiber regeneration is by proximate regenerative process; to guarantee that regenerated nervous fibers is not subsided or hard pressed guide-tube structure and in-vivo tissue stop, thus by the remote broken ends of fractured bone continuity of energy for growth neurad of self.After nerve trachea previously implants, nerve fiber regeneration mode remains unordered and chaotic, proximal movement, Sensory nerve fibre itself are grow in corresponding perineurium, but good order and directivity will be lost in the past conduit, in mixing growth, it is substantially reduced the efficiency of neuranagenesis, even and if regenerated nervous fibers reaches the remote broken ends of fractured bone, correctly dock with the motion of far-end, Sensory nerve fibre Shu Buneng, therefore there is bigger nerve fiber misconnection rate, had a strong impact on the effect of neuranagenesis.Additionally, nerve regeneration itself is slowly, and therefore previously all nerve tracheas are limited to repair the neurologic defect within 3cm, the neurologic defect of superelevation 3cm, owing to long-term denervation occurs the effector organ of distal nerve fiber tip, corresponding function has been unable to reach efficient recovery.Therefore, in prior art, several tissue engineering nerves all fail to reach satisfied therapeutic effect in above-mentioned key performance, more can not solve to repair the different phase different demands to nerve growth factor in neural growth course in vivo.
Utility model content
This utility model is solve a kind of 3D printing peripheral nerve conduit that the problems referred to above of the prior art propose, it is intended to provide a kind of structure more stable, integrated, gradient can supply nerve growth factor simultaneously, be more beneficial for promoting the artificial conduit of neuranagenesis.
In order to solve above-mentioned technical problem, the technical measures that this utility model is taked are:
A kind of 3D prints peripheral nerve conduit, includes sleeve pipe, is provided with one or more six prism pipes in sleeve pipe, is provided with multiple nerve growth factor carrier ball, is loaded with nerve growth factor in nerve growth factor carrier ball in six prism pipes.
In order to optimize technique scheme further, the technical measures that this utility model is taked also include:
Preferably, conduit both sides are additionally provided with neural overlap joint passage, and this space is used for disposing injured nerve fiber.
Preferably, above-mentioned nerve growth factor carrier ball is inscribed within described six prism pipes and arranges, and quantity is 5-200, more preferably 18-90.
Preferably, above-mentioned nerve growth factor carrier ball is equidistantly arranged in six prism pipes, is namely evenly spaced distributed in six prism pipes.
Preferably, above-mentioned nerve growth factor carrier ball arranging distance in six prism pipes is gradually reduced from six prism pipe one end to other end, namely tapers into from six prism pipe one end to other end distribution density.
Preferably, the quantity of above-mentioned six prism pipes is 1-19.
Preferably, above-mentioned conduit integral diameter is 3-10mm, and length is 25-35mm, more preferably diameter 5mm, length 30mm.
Preferably, the diameter of above-mentioned six prism pipes is 0.5mm-10mm, and length is 11-29mm, more preferably diameter 1-3mm, and length is 15-25mm；
Preferably, the length of above-mentioned neural overlap joint passage is 3-7mm, and more preferably length is 5mm.
Preferably, above-mentioned sleeve pipe, six prism pipes and nerve growth factor carrier ball are PGA and PLA composite material and make, wherein, in the composite material of forming sleeves, six prism pipes and nerve growth factor carrier ball, the content of PGA raises successively, namely form the content of PGA in the composite material of sleeve pipe minimum, form the content of PGA in the composite material of nerve growth factor carrier ball the highest.
Preferably, above-mentioned nerve growth factor includes NGF, NT-3 (neurotrophin-3), NT-4 (neurotrophin-4) and BDNF (Brain Derived Neurotrophic Factor).
This utility model adopts above technical scheme, compared with prior art, has the following technical effect that
First, inside subject structure of the present utility model is based on six prism pipes (six angle pipes), and can multiple six prism pipe superpositions, the design synthesis of hexagonal structure considers nerve growth space and stable mechanical support, not only can provide sufficient space for nerve growth, be conducive to conduit to keep good spatial stability and crushing resistance in complicated internal milieu simultaneously, thering is provided safer external environment condition for neuranagenesis, effectively preventing from nerve regeneration suffering, card is pressed thus affecting regeneration；And being arranged in of the design of six prism pipes is similar with the arrangement of the internal each function bundle of human peripheral nerve to a certain extent, all has a limit adjacent, thus being greatly increased the stability of entirety between each adjacent column jecket.
Secondly, the nerve trachea being compared to prior art uses catheter body absorption and release nerve growth factor, this utility model introduces the structure of nerve growth factor carrier ball in a creative way, inscribe it is placed in six prism pipes, and can the different arrangement of density, what this allowed for the release amount of nerve growth factor and gradient is precisely controlled to for possibility so that in repair process, the release of nerve growth factor more conforms to demand.
Finally, nerve trachea of the present utility model is in conjunction with 3D printing technique, the production efficiency not only making complicated nerve trachea improves, simultaneously, 3D printer is equipped with nerve growth factor catheter needle, the perfusion nerve growth factor when nerve growth factor carrier ball prints and do not seal, the nerve growth factor making liquid phase dexterously combines with integral duct, PGA content in conjunction with different nerve growth factor carrier balls, it is achieved that neural factor carries out the gradient release of variable concentrations at different time in six prism pipes.
Accompanying drawing explanation
Accompanying drawing 1 is the 3D of the present utility model cross cut structure schematic diagram printing peripheral nerve conduit (single six prism pipes).
Accompanying drawing 2 is the 3D of the present utility model cross cut structure schematic diagram printing peripheral nerve conduit (three six prism pipes).
Accompanying drawing 3 is the 3D of the present utility model cross cut structure schematic diagram printing peripheral nerve conduit (four six prism pipes).
Accompanying drawing 4 is the 3D of the present utility model cross cut structure schematic diagram printing peripheral nerve conduit (five six prism pipes).
Accompanying drawing 5 is the 3D of the present utility model cross cut structure schematic diagram printing peripheral nerve conduit (seven six prism pipes).
Accompanying drawing 6 is the 3D of the present utility model side view printing peripheral nerve conduit (7 six prism pipes).
Accompanying drawing 7 is the 3D of the present utility model side perspective printing peripheral nerve conduit (4 six prism pipes, and arranging distance difference).
Accompanying drawing therein is labeled as: sleeve pipe 1, six prism pipe 2, nerve growth factor carrier ball 3, nerve growth factor 4, neural overlap joint passage 5.
Detailed description of the invention
This utility model provides a kind of 3D and prints peripheral nerve conduit, include sleeve pipe 1, it is provided with one or more six prism pipes 2 in sleeve pipe 1, is provided with multiple nerve growth factor carrier ball 3 in described six prism pipes 2, in nerve growth factor carrier ball 3, is loaded with nerve growth factor 4.
Below in conjunction with accompanying drawing, the technical solution of the utility model is described in further detail.
Embodiment 1
When preparing peripheral nerve conduit by 3D printing, ratio respectively 5:5 and the 8:2 of PGA and PLA in the composite material of forming sleeves 1, six prism pipe 2, six prism pipes 2 are set to four, each six prism pipes 2 are internal arranges nine nerve growth factor carrier balls 3 (such as accompanying drawing 7), and the arrangement of nerve growth factor carrier ball 3 is for be gradually reduced from six prism pipe 2 one end to other end；Simultaneously, when printing nine nerve growth factor carrier balls 3, in composite material used, the content of PGA diminishes from one end that nerve growth factor carrier ball 3 density is high successively to low density one end, eventually becomes the same with the ratio of PGA and the PLA of six prism pipes 2, is 8:2.In the present embodiment, the degraded order of whole conduit various piece is: the nerve growth factor carrier ball → six prism pipe 2 → sleeve pipe 1 at the loose place of nerve growth factor carrier ball → arrangement at arrangement closely place.Therefore in actual application, the nerve trachea of the present embodiment is placed in after in the patient, injured nerve is after growing into six prism pipes 2, and the nerve growth factor carrier ball at arrangement closely place is high due to PGA content, and take the lead in degraded, release nerve growth factor, meanwhile, in this part of conduit, the density of carrier ball is higher, therefore the nerve growth factor amount check and correction of release, meet the neural fast-growth at reparation initial stage；When nerve growth to the other end, nerve growth factor carrier ball 3 degraded that PGA relative amount is the highest discharges last nerve growth factor, and each six prisms pipe 2 is also correspondingly degraded simultaneously, and after whole CO2 laser weld and overlap joint complete, sleeve pipe 1 is finally degraded.
Embodiment 2
First the present embodiment have chosen the patient of an example left upper arm nervus radialis superficialis defect damage and carries out the clinical repair of 3D peripheral nerve conduit.Patient's neurologic defect reaches 2.5cm.Making a peripheral nerve conduit by the preparation method of the present invention, the design parameter of conduit is as follows: length 3.0cm, diameter 0.3cm, built-in six prism pipes, is uniformly distributed the hollow ball injecting mouse nerve growth factor in conduit.This case is followed up a case by regular visits to after accessing nerve trachea conduit prothesis by operation for 2 weeks, 1 month, 3 months, 6 months.Being confirmed by high-frequency ultrasonography, during 3 months after operation, in conduit, neuranagenesis aixs cylinder has reached the neural distally broken ends of fractured bone.
On the basis of above-mentioned first case, successively completing the reparation of 15 example nervus radialis superficialis defect cases, all cases are the built-in six prism conduits that 3D printing technique makes, and all cases have completed 6 months follow up a case by regular visits to all.Pass through high-frequency ultrasonography, all case month after operations and comparing for 3 months, 3 months after operation catheter diameter is decreased slightly as low, but does not have obvious significant difference, illustrates that the 3D that inventor adopts prints nerve trachea and has good internal compressive property (table 1).In actual applications, six prism Guan Yue are many, and compressive property is more good.
Table 13D prints the internal diameter of nerve trachea and compares
It addition, all cases carry out high-frequency ultrasonography, month after operation is in 3 months, and the neural axon growth of all visible regeneration reaches the neural distally broken ends of fractured bone.By carrying out electromyography inspection, during postoperative 6 months of all cases, the sensory nerve action potential of nervus radialis superficialis reappears, and sensory nerve conduction velocity also progressively recovers.All cases are carried out clinical examination by inventor, including monofilament sense of touch inspection, discovery has two cases to reappear monofilament sense of touch in month after operation the earliest, during to 3 months after operation, all cases all reappear monofilament sense of touch, wherein 4 example monofilament senses of touch recover to 2 grades, and 3 example monofilament senses of touch of remaininging recover to 3 grades (see tables 2).
After table 2 conduit prothesis, monofilament sense of touch checks
By the above embodiments, those skilled in the art are able to know that, relative to the nerve trachea of prior art, nerve trachea of the present utility model has the advantage that
First, inside subject structure of the present utility model is based on six prism pipes (six angle pipes), and can multiple six prism pipe superpositions, the design synthesis of hexagonal structure considers nerve growth space and stable mechanical support, not only can provide sufficient space for nerve growth, be conducive to conduit to keep good spatial stability and crushing resistance in complicated internal milieu simultaneously, thering is provided safer external environment condition for neuranagenesis, effectively preventing from nerve regeneration suffering, card is pressed thus affecting regeneration；And being arranged in of the design of six prism pipes is similar with the arrangement of the internal each function bundle of human peripheral nerve to a certain extent, all has a limit adjacent, thus being greatly increased the stability of entirety between each adjacent column jecket.
Secondly, the nerve trachea being compared to prior art uses catheter body absorption and release nerve growth factor, this utility model introduces the structure of nerve growth factor carrier ball in a creative way, inscribe it is placed in six prism pipes, and can the different arrangement of density, what this allowed for the release amount of nerve growth factor and gradient is precisely controlled to for possibility so that in repair process, the release of nerve growth factor more conforms to demand.
Finally, nerve trachea of the present utility model is in conjunction with 3D printing technique, the production efficiency not only making complicated nerve trachea improves, simultaneously, 3D printer is equipped with nerve growth factor catheter needle, the perfusion nerve growth factor when nerve growth factor carrier ball prints and do not seal, the nerve growth factor making liquid phase dexterously combines with integral duct, PGA content in conjunction with different nerve growth factor carrier balls, it is achieved that neural factor carries out the gradient release of variable concentrations at different time in six prism pipes.
Above specific embodiment of the utility model being described in detail, but it is only used as example, this utility model is not restricted to particular embodiments described above.To those skilled in the art, any equivalent modifications that this practicality is carried out and replacement are also all among category of the present utility model.Therefore, the impartial conversion made under without departing from spirit and scope of the present utility model and amendment, all should be encompassed in scope of the present utility model.
Claims (8)
1. a 3D prints peripheral nerve conduit, include sleeve pipe (1), it is characterized in that, one or more six prism pipes (2) it are provided with in described sleeve pipe (1), it is provided with multiple nerve growth factor carrier ball (3) in described six prism pipes (2), in described nerve growth factor carrier ball (3), is loaded with nerve growth factor (4).
2. peripheral nerve conduit according to claim 1, it is characterised in that conduit both sides are additionally provided with neural overlap joint passage (5).
3. peripheral nerve conduit according to claim 1, it is characterised in that described nerve growth factor carrier ball (3) is inscribed within described six prism pipes (2) and arranges, quantity is 5-200.
4. peripheral nerve conduit according to claim 3, it is characterised in that described nerve growth factor carrier ball (3) is equidistant arrangement in described six prism pipes (2).
5. peripheral nerve conduit according to claim 3, it is characterized in that, the described nerve growth factor carrier ball (3) arranging distance in described six prism pipes (2) is gradually reduced from described six prism pipe (2) one end to other end.
6. peripheral nerve conduit according to claim 1, it is characterised in that the quantity of described six prism pipes (2) is 1-19.
7. peripheral nerve conduit according to claim 2, it is characterised in that conduit diameter is 3-10mm, length is 25-35mm, the diameter of described six prism pipes (2) is 0.5mm-10mm, and length is 11-29mm, and the length of described neural overlap joint passage (5) is 3-7mm.
8. the peripheral nerve conduit according to claim 1-7 any one, it is characterised in that described nerve growth factor (4) includes NGF, NT-3, NT-4 and BDNF.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521140198.XU CN205339654U (en) | 2015-12-31 | 2015-12-31 | 3D prints peripheral nerve pipe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521140198.XU CN205339654U (en) | 2015-12-31 | 2015-12-31 | 3D prints peripheral nerve pipe |
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| Publication Number | Publication Date |
|---|---|
| CN205339654U true CN205339654U (en) | 2016-06-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201521140198.XU Expired - Fee Related CN205339654U (en) | 2015-12-31 | 2015-12-31 | 3D prints peripheral nerve pipe |
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| Country | Link |
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| CN (1) | CN205339654U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105457103A (en) * | 2015-12-31 | 2016-04-06 | 复旦大学附属华山医院 | 3D-printed peripheral nerve conduit and preparing method thereof |
| CN106215245A (en) * | 2016-07-21 | 2016-12-14 | 青岛三帝生物科技有限公司 | Method and the artificial nerve catheter of artificial nerve catheter is prepared based on 3D printing |
-
2015
- 2015-12-31 CN CN201521140198.XU patent/CN205339654U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105457103A (en) * | 2015-12-31 | 2016-04-06 | 复旦大学附属华山医院 | 3D-printed peripheral nerve conduit and preparing method thereof |
| CN106215245A (en) * | 2016-07-21 | 2016-12-14 | 青岛三帝生物科技有限公司 | Method and the artificial nerve catheter of artificial nerve catheter is prepared based on 3D printing |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160629 Termination date: 20181231 |
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| CF01 | Termination of patent right due to non-payment of annual fee |