CN206621456U - A kind of bone repairing support - Google Patents
A kind of bone repairing support Download PDFInfo
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- CN206621456U CN206621456U CN201620808823.1U CN201620808823U CN206621456U CN 206621456 U CN206621456 U CN 206621456U CN 201620808823 U CN201620808823 U CN 201620808823U CN 206621456 U CN206621456 U CN 206621456U
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Abstract
The utility model belongs to technical field of biomedical materials, and in particular to a kind of bone repairing support.A kind of bone repairing support, the support are the loose structure to match with the size at the Cranial defect position of patient.Support described in the utility model can be used for repairing bone defect, skeletonization can be strengthened into the ability of blood vessel, in the cavity formed at implantable large segmental bone defect or after early ischemic necrosis of femoral head focal cleaning, play a part of biomethanics support and promote blood vessel and bone tissue to grow into.
Description
Technical field
The utility model belongs to technical field of biomedical materials, and in particular to a kind of bone repairing support.
Background technology
Large segmental bone defect caused by the diseases such as wound, infection, tumour is still the great challenges of clinical treatment, therapeutic effect
One of the reason for bad is exactly the avascular of bone graft or bone alternate material：And effective disperse of oxygen and nutriment in vivo
Distance only 200um.Traditional bone graft and organizational project bone alternate material is no microcirculqtory system mostly.Graft
Central area can not obtain required oxygen and nutriment, so as to easily causing Bone graft healing to fail.
Caput femoris necrosis is the common and refractory disease of field of orthopaedics.If without effectively treatment, about 80% patient's meeting
Collapse of femoral head, subsequent articular dysfunction occurred in 4 years, final patient has to receive artificial joint replacement, manually
The high cost of joint replacement brings huge financial burden to patient and society, and because joint prosthesis has certain longevity
Life, the problem of often also facing joint mobilization after the joint replacement of middle-young patients, joint prosthesis, which will be overhauled, further to be aggravated
Financial burden and the quality of life for reducing patient.Therefore early treatment caput femoris necrosis, to retain the treatment in patient itself joint
Method receives much concern always.
Early stage removes focus, the use of be implanted into material filling support defect area and promote osteanagenesis is current research and clinic
One of focus for the treatment of.Stem-cell therapy, artificial filling material of bone and stent in the treatment etc. are taken in the investigation of materials of the past, so
And gratifying therapeutic effect is not obtained.Because the Important cause of disease of caput femoris necrosis be in its lesion region blood supply it is impaired or
Interrupt, although these materials are with good support or promote bone formation performance, it can be difficult to rebuilding the microcirculation system of lesion region
System, therefore necessary nutrition and removing metabolic waste can not be provided for the stem cell of injection or the bone tissue of new life, so that can not
Obtain preferable therapeutic effect.
In summary, that repairs large segmental bone defect and femoral head osteonecrosis focuses on solving following three problems：
1st, the biomethanics support in Cranial defect region；2nd, the reconstruction of local microcirculation system；3rd, the regeneration of bone tissue is promoted
Repair.
Utility model content
In view of the above-mentioned problems, the utility model proposes a kind of bone repairing support and preparation method thereof, the support can use
In repairing bone defect, skeletonization can be strengthened into the ability of blood vessel.
A kind of bone repairing support, the support are the loose structure to match with the size at the Cranial defect position of patient.
Further, the material of the support is bone biologic material.
Further, the internal stent has the duct that one or two run through support.
Further, the porosity of the loose structure is 70-90%.
Further, the size in the duct of the loose structure is：Post a width of 100-1000um, aperture 300-
3000um。
Further, a width of 300um of the post in the duct, the aperture in duct is 1000um.
Further, the support is columned porous titanium alloy support, a diameter of 10-12mm of support, support
Length is 70-130mm, and internal stent is provided with a duct for running through cylindrical-shaped structure, and the internal diameter in duct is 5-10mm.
Further, the support is columned porous titanium alloy support, a diameter of 10-12mm of support, support
Length is 70-130mm, and internal stent is provided with two ducts for running through cylindrical-shaped structure, and the internal diameter in duct is 3-4mm.
Further, the support is the porous titanium alloy support of column shape, and the size of support is 15 × 25 × 15mm3,
Internal stent is provided with one through the duct of vertical column structure, and the internal diameter in duct is 5-10mm.
Further, the support is the porous titanium alloy support of column shape, and the size of support is 15 × 25 × 15mm3,
Internal stent is provided with two through the duct of vertical column structure, and the internal diameter in duct is 3-5mm.
Support described in the utility model is porous support, and at implantable large segmental bone defect or Femoral head ischemic is bad
In the cavity formed after dead focal cleaning, play a part of biomethanics support and promote blood vessel and bone tissue to grow into；Porous knot
Bioactivity growth factor (such as BMP-2/VEGF) or stem cell can be loaded inside structure and promotes bone again so as to further strengthen it
Raw ability；The single through hole being provided with the support can carry out bone collection or vasotransplantation, strengthen bone tissue and blood
Pipe repair ability；Two ducts run through are provided with the support, arteriovenous combined transplantation can be achieved, to promote support and disease
The blood vessel become in region is grown into, and realizes the reconstruction of necrotic zone microcirculqtory system, and required nutrients is provided for freshman bone tissue
Matter and the metabolic waste for removing part.
Brief description of the drawings
Fig. 1 is a kind of embodiment of cylindric porous titanium alloy support of the present utility model.
Fig. 2 is the another embodiment of cylindric porous titanium alloy support of the present utility model.
Fig. 3 is a kind of embodiment of column shape porous titanium alloy support of the present utility model.
Fig. 4 is the another embodiment of column shape porous titanium alloy support of the present utility model.
Fig. 5 is the another embodiment of column shape porous titanium alloy support of the present utility model.
Fig. 6 is the schematic diagram of loose structure in Fig. 1 medium-height trestles.
Fig. 7 is the schematic diagram of loose structure in Fig. 2 medium-height trestles.
Fig. 8 is the schematic diagram of loose structure in Fig. 3 medium-height trestles.
Fig. 9 is the schematic diagram of loose structure in Fig. 4 medium-height trestles.
Figure 10 is the schematic diagram of loose structure in Fig. 5 medium-height trestles.
Figure 11 is the structure chart of porous matrix structure unit in the utility model.
Figure 12 is another structure chart of porous matrix structure unit in the utility model.
Figure 13 is the schematic diagram that the utility model medium-height trestle carries out duct in bone collection fore-stock.
Figure 14 is the schematic diagram that the utility model medium-height trestle carries out duct in bone collection after-poppet.
Embodiment
Embodiment of the present utility model, wherein identical part identical reference table are described with reference to the accompanying drawings
Show.
Support described in the utility model can be used for repairing bone defect, such as large segmental bone defect and femoral head osteonecrosis.
Some embodiments that the support is column structure are only provided below, and certain support is not limited only to column structure, described
The appearance and size of support should be depending on the appearance and size at Cranial defect position, such as large segmental bone defect region, caput femoris necrosis subtract
The size of cavity and femoral head neck windowed regions is remained after pressure treatment, can be using CT scan as foundation.
Fig. 1-2 is two kinds of embodiments that support described in the utility model is cylindric porous titanium alloy support.The branch
The appearance and size of frame is depending on Cranial defect position, length and profile, for example, when repairing large segmental bone defect, the size of support should
Match with the size in large segmental bone defect region；When reparation carries out caput femoris necrosis focus in a manner of core decompression removes,
The size of support should match with remaining cavity after patient femur's head necrosis decompression treatment.In Fig. 1-2, the chi of cylinder racks
It is very little to be：A diameter of 10-12mm of support, the length of support is 70-130mm.In Fig. 1, it is provided with one in the inside of support
The cylindrical vent of longitudinal direction, duct internal diameter can be 5-10mm.In fig. 2, it is provided with the cylindric of two longitudinal directions in the inside of support
Duct, duct internal diameter can be 3-4mm.
Fig. 3-5 is three kinds of embodiments that support described in the utility model is column shape porous titanium alloy support.The branch
The appearance and size of frame is depending on Cranial defect position, length and profile, for example, when repairing large segmental bone defect, the size of support should
Match with the size in large segmental bone defect region；Caput femoris necrosis focus is carried out in a manner of femoral head neck decompression by fenestration when repairing
During removing, the size of support should be depending on the size of patient femur's neck windowed regions.In figs. 3-5, columnar bracket is found
Size can be：15×25×15mm3.In figure 3, the duct of a straight is provided with the inside of support, duct internal diameter can be 5-
10mm.In Fig. 4, two cylindrical vents are provided with the inside of support, duct internal diameter can be 3-5mm.In Figure 5, in support
Inside be provided with the ducts of two arcs, duct internal diameter is 3-5mm.
As illustrated in figures 6-10, the support in Fig. 1-5 is the support with loose structure, has duct in support, duct
The a width of 100-1000um (intermediate value 300um) of post, aperture are 300-3000um (intermediate value 1000um), and the porosity of support is
70-90%, it is to be imitated with what the filling of porous matrix structure unit, extension obtained with what Cranial defect region profile matched with mechanics
The above-mentioned support of natural disposition energy.Wherein, porous matrix structure unit as depicted in figs. 11-12, the knot being of course not solely limited in Figure 11-12
Structure unit.
Support described in the utility model is porous titanium alloy support, the material of certain support be alternatively pure titanium, cobalt alloy,
Tantalum, titanium tantalum alloy, calcium phosphate, PLA (PLA), poly lactic coglycolic acid (PLGA), poly- acetic acid lactones (PCL), coral
The bone biologic materials such as coral, bioceramic, as long as there can be the material of the bionical performance of mechanics.It is of the present utility model described
The implantable large segmental bone defect of support at or early ischemic necrosis of femoral head focal cleaning after in the cavity that is formed, play life
Thing mechanical support and the effect for promoting blood vessel and bone tissue to grow into.Bone Ingrowth is promoted by the design of loose structure, and can be more
Load bioactivity growth factor (such as BMP-2/VEGF) or stem cell promote bone again so as to further strengthen it in pore structure
Raw ability.
In figures 1 and 3, internal stent has a duct, and the both ends in duct are above support and following, duct
Inside can be used for carrying out bone implantation or vasotransplantation (as illustrated in figs. 13-14), to strengthen the local Bone Defect Repari ability in lesion, branch
Frame can then play a part of biomethanics support and promote blood vessel and bone tissue to grow into.As shown in Fig. 2, Fig. 4 and Fig. 5, in support
Portion has two ducts, and the both ends in duct are above cylinder racks and following in fig. 2, in Fig. 4 the both ends in duct
Above vertical columnar bracket and below, in Figure 5 duct both ends stand columnar bracket above and side, wherein, one
Transplanting and the blood vessel of arterial anastomosis are used as blood supply passage in duct, and the blood vessel of transplanting and venous anastomosis is as blood in another duct
The outlet of confession.By two ducts that blood vessel (such as great saphenous vein or neighbouring arteriolovenular beam) is implanted into insertion in support
It is interior, and with blood supply system existing near large segmental bone defect or around hip joint (before such as shin/shin after arteriovenous system, outside rotation stock
Side arteriovenous system) it coincide, the vascularization of support is realized, is stent area to promote the reconstruction of focus local microcirculation system
Stem cell and freshman bone tissue provide needed for nutriment and remove metabolic waste in time.It is pointed out that in support
The size in portion duct should match with the bone tissue or blood vessel for needing to be implanted into, thus the size knot being not limited only in accompanying drawing
Structure.
The utility model also proposes a kind of preparation method of bone repairing support, and this method can be used for preparing above-mentioned support, when
So it is not limited only to the support of above-mentioned size.
In one embodiment, step includes：
1) by proe Three-dimensional Design Softwares, the design entity (such as Fig. 1-5) of above-mentioned supporting structure is established in a computer；
2) threedimensional model (such as Fig. 6-10) of porous matrix structure construction unit is built, the unit key element of construction unit is more
Hole matrix structure (such as Figure 11-12), the duct of porous matrix structure is 100-1000um (intermediate value 300um), aperture 200-
3000um (intermediate value 1000um), the porosity 70-90% of support；
3) according to the three-dimensional construction unit in step 2), step is filled with construction unit by magics Three-dimensional Design Softwares
1) design entity of medium-height trestle, design entity is produced as porous matrix structure；
4) according to the porous matrix structure in step 3), using 3D printer, with the bone biology material such as titanium alloy (Ti6Al4V)
Material is printed, and printing thickness is 0.025mm；
5) printout that step 4) obtains is heat-treated in stove, under argon gas protective condition, heated up in 4 hours
To 840 degrees Celsius, and kept for 2 hours, take out printout after in-furnace temperature then is cooled into 500 degrees Celsius, be put in workbench
Go up and naturally cool to room temperature；
6) printout that step 5) obtains is used into wire cutting, cut from workbench；
7) printout that step 6) obtains is used into blasting treatment, removes print surface and glue molten unnecessary raw material；
8) printout that step 7) obtains is cleaned using ultrasonic wave, removes surface impurity；
9) printout is put into high temperature and high pressure steam sterilizer and sterilized, and independent packing is handled.
Embodiment described above, simply the utility model more preferably embodiment, those skilled in the art
The usual variations and alternatives carried out in the range of technical solutions of the utility model should all be included in the scope of protection of the utility model
It is interior.
Claims (8)
- A kind of 1. bone repairing support, it is characterised in that：The support is the porous matrix structure to match with the size at the Cranial defect position of patient, and the internal stent has one Individual or two ducts for running through support, the duct are used for bone implantation or vasotransplantation.
- 2. bone repairing support according to claim 1, it is characterised in that：The porosity of the loose structure is 70-90%.
- 3. bone repairing support according to claim 1, it is characterised in that：The size in the duct of the loose structure is：Post a width of 100-1000um, aperture 300-3000um.
- 4. bone repairing support according to claim 3, it is characterised in that：The a width of 300um of post in the duct, the aperture in duct is 1000um.
- 5. bone repairing support according to claim 1, it is characterised in that：The support is columned porous titanium alloy support, and a diameter of 10-12mm of support, the length of support is 70- 130mm, internal stent are provided with a duct for running through cylindrical-shaped structure, and the internal diameter in duct is 5-10mm.
- 6. bone repairing support according to claim 1, it is characterised in that：The support is columned porous titanium alloy support, and a diameter of 10-12mm of support, the length of support is 70- 130mm, internal stent are provided with two ducts for running through cylindrical-shaped structure, and the internal diameter in duct is 3-4mm.
- 7. bone repairing support according to claim 1, it is characterised in that：The support is the porous titanium alloy support of column shape, and the size of support is 15 × 25 × 15mm3, internal stent is provided with one The individual duct for running through vertical column structure, the internal diameter in duct is 5-10mm.
- 8. bone repairing support according to claim 1, it is characterised in that：The support is the porous titanium alloy support of column shape, and the size of support is 15 × 25 × 15mm3, internal stent is provided with two The individual duct for running through vertical column structure, the internal diameter in duct is 3-5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620808823.1U CN206621456U (en) | 2016-07-29 | 2016-07-29 | A kind of bone repairing support |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620808823.1U CN206621456U (en) | 2016-07-29 | 2016-07-29 | A kind of bone repairing support |
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| Publication Number | Publication Date |
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| CN206621456U true CN206621456U (en) | 2017-11-10 |
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ID=60212101
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| CN201620808823.1U Active CN206621456U (en) | 2016-07-29 | 2016-07-29 | A kind of bone repairing support |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108158697A (en) * | 2017-12-25 | 2018-06-15 | 中国人民解放军第四军医大学 | bone defect filling bracket structure |
| CN110433012A (en) * | 2019-07-25 | 2019-11-12 | 中国人民解放军总医院 | It is a kind of to facilitate bone to recycle pressurized casing for large segmental bone defect treatment |
| CN112206076A (en) * | 2020-09-15 | 2021-01-12 | 北京科技大学 | Porous implant structure for bone repair and preparation method |
| WO2022099444A1 (en) * | 2020-11-10 | 2022-05-19 | 北京积水潭医院 | Femoral isthmus forming porous steel plate system |
| CN116832222A (en) * | 2023-06-21 | 2023-10-03 | 北京幸福益生再生医学科技有限公司 | Artificial cartilage bracket and preparation method thereof |
-
2016
- 2016-07-29 CN CN201620808823.1U patent/CN206621456U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108158697A (en) * | 2017-12-25 | 2018-06-15 | 中国人民解放军第四军医大学 | bone defect filling bracket structure |
| CN110433012A (en) * | 2019-07-25 | 2019-11-12 | 中国人民解放军总医院 | It is a kind of to facilitate bone to recycle pressurized casing for large segmental bone defect treatment |
| CN112206076A (en) * | 2020-09-15 | 2021-01-12 | 北京科技大学 | Porous implant structure for bone repair and preparation method |
| WO2022099444A1 (en) * | 2020-11-10 | 2022-05-19 | 北京积水潭医院 | Femoral isthmus forming porous steel plate system |
| CN116832222A (en) * | 2023-06-21 | 2023-10-03 | 北京幸福益生再生医学科技有限公司 | Artificial cartilage bracket and preparation method thereof |
| CN116832222B (en) * | 2023-06-21 | 2024-02-23 | 北京幸福益生再生医学科技有限公司 | Artificial cartilage bracket and preparation method thereof |
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