CN110433012A - It is a kind of to facilitate bone to recycle pressurized casing for large segmental bone defect treatment - Google Patents
It is a kind of to facilitate bone to recycle pressurized casing for large segmental bone defect treatment Download PDFInfo
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- CN110433012A CN110433012A CN201910678911.2A CN201910678911A CN110433012A CN 110433012 A CN110433012 A CN 110433012A CN 201910678911 A CN201910678911 A CN 201910678911A CN 110433012 A CN110433012 A CN 110433012A
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- bar
- strip structure
- bone
- large segmental
- bone defect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
It is disclosed by the invention it is a kind of for large segmental bone defect treatment facilitate bone recycle pressurized casing, it includes cyclic structure and the strip structure that is arranged between a pair of of cyclic structure, the cyclic structure and strip structure form the cavity of a relative closure, and the ectopic osteogenesis material is arranged in the cavity;The strip structure retractable is to pressurize to the ectopic osteogenesis material in cavity.It is provided by the invention it is a kind of for large segmental bone defect treatment facilitate bone recycle pressurized casing, large segmental bone defect is treated suitable for ectopic osteogenesis, its is structurally reasonable, it is ingenious in design, the strip structure being arranged between cyclic structure has retractility, so that the ectopic osteogenesis material pressurization between setting cyclic structure, to promote the speed and quality of skeletonization.
Description
Technical field
The present invention relates to the field of medical instrument technology more particularly to it is a kind of for large segmental bone defect treatment facilitate bone to recycle
Pressurized casing.
Background technique
It is current hair using bone tissue engineer technology treatment bone defect recently as the rapid development of bone tissue engineer
Exhibition trend, ectopic osteogenesis model can reduce the variable for influencing skeletonization in experiment relative to skeletonization in situ, can assess thin at backbone
Born of the same parents, osteogenic induction material effect.Ectopic ossification (HO) refers to the ectopic teratism in normal soft group betided other than bone tissue
Skeletonization is the process of an active development;Ectopic ossification is one kind of ectopic osteogenesis.
Circulating pressure is of great significance to osteanagenesis and remodeling, treats big section bone especially with ectopic osteogenesis technology and lacks
Damage, quality and the speed for how effectively improving internal ectopic osteogenesis are particularly significant.There is presently no mature to lack for big section bone
Damage treatment facilitates bone to recycle pressurized casing.
Patent CN100571662C discloses a kind of prosthesis and preparation method thereof for repairing defect of maxilla, and one
The silicon rubber outer layer adapted to maxilla coloboma section is equipped in cylindricality skin tissue expander in the silicon rubber outer layer
Layer, the cylindricality skin tissue expander internal layer are connected with the air charging system extended to outside the silicon rubber outer layer, institute
It the silicon rubber outer layer stated and is provided on the cylindricality skin tissue expander internal layer or the air charging system corresponding
Magnetic attachment.The invention is only applicable to the reparation of jaw defect.
Patent CN103992947A discloses the loading device of bone cells compression and load in a kind of porous titanium alloy
Method, loading device include servo motor, movement chamber, movement piston, pressurised chamber, movable siding, drive rod, pressure, temperature
Sensor etc. is spent, servo motor is connect by PC by motion control card control, and with drive rod, and drive rod and movement piston connect
It connects, servo motor drives piston up-down by drive rod.The front side wall of pressurised chamber sets retractable movable siding.The device
Sterilized disinfecting action is placed in cell incubator, bone cells suspension is planted in porous titanium alloy, compression system is to more
Cell in the titanium alloy of hole carries out the stimulation of compressive load.A kind of experimental rig of the disclosure of the invention can not carry out clinical bone
Defect treatment.
Therefore, need to design it is a kind of facilitate bone to recycle pressurized casing for large segmental bone defect treatment, effectively improve in vivo
The quality and speed of ectopic osteogenesis.
Summary of the invention
The purpose of the present invention is in view of the above technical problems, a kind of rush for large segmental bone defect treatment provided by the invention
Skeletonization recycles pressurized casing, is suitable for ectopic osteogenesis and treats large segmental bone defect, structurally reasonable, ingenious in design, is arranged in ring-type
Strip structure between structure has retractility, so that the ectopic osteogenesis material pressurization between setting cyclic structure, to promote
The speed and quality of skeletonization.
In order to solve the above technical problems, it is provided by the invention it is a kind of for large segmental bone defect treatment facilitate bone circulation pressurization
Shell, including cyclic structure and the strip structure being arranged between a pair of of cyclic structure, the cyclic structure and strip structure shape
At the cavity of a relative closure, the ectopic osteogenesis material is arranged in the cavity;The strip structure retractable with
To the ectopic osteogenesis material pressurization in cavity.
In some embodiments, the strip structure is adhesively fixed by multilayer bar.
In some embodiments, the bar is hydrogel or high polymer, is provided with biogum between adjacent bar.
In some embodiments, the bar is scalable.
In some embodiments, the strip structure includes the different bar of multiple length, and the bar is along length
Direction is stretched to isometric rear be adhesively fixed by biogum and is integrated.
In some embodiments, the strip structure includes multiple bars of different size, and the bar is along width
Direction is stretched to isometric rear be adhesively fixed by biogum and is integrated.
In some embodiments, the strip structure is uniformly distributed centered on the axis of cyclic structure.
In some embodiments, the strip structure it is adjacent between gap it is adjustable.
In some embodiments, the section of the strip structure is any one of rectangle, triangle, ellipse, circle.
In some embodiments, the sequence that the different bar of the length successively decreases or is incremented by according to length be adhesively fixed for
One.
In some embodiments, the sequence that the bar of different size successively decreases or is incremented by according to width be adhesively fixed for
One.
The invention has the advantages that:
Facilitate bone to recycle pressurized casing provided by the present invention for large segmental bone defect treatment, is suitable for ectopic osteogenesis and treats
Large segmental bone defect, structurally reasonable, ingenious in design, the strip structure being arranged between cyclic structure has retractility, so that setting
Set between cyclic structure ectopic osteogenesis material pressurization, and can in contraction of muscle, under the compression of muscle, make cyclic structure it
Between distance increase, axial compressive force becomes smaller, and radial pressure becomes larger, change by the flexible generation intermediate pressure of muscle itself,
Gap between strip structure is adjustable, facilitate nutriment enter, blood vessel is grown into and the discharge of metabolite, to promote
The speed and quality of skeletonization.
Detailed description of the invention
It will be apparent and be easier reason by made detailed description, above-mentioned advantage of the invention in conjunction with the following drawings
Solution, these attached drawings are only schematical, are not intended to limit the present invention, in which:
Fig. 1 is the structural schematic diagram of the present invention that facilitate bone circulation pressurized casing for large segmental bone defect treatment;
Fig. 2 to Fig. 3 is the sectional view of the strip structure of the present invention along its length;
Fig. 4 is the sectional view of the strip structure of the present invention in the width direction;
Fig. 5 is the application schematic diagram of the present invention that facilitate bone circulation pressurized casing for large segmental bone defect treatment;
Fig. 6 a and Fig. 6 b are Alizarin red staining comparison of test results figures;
Fig. 7 a and Fig. 7 b be it is of the present invention for large segmental bone defect treatment facilitate bone circulation pressurized casing dystopy at
Bone comparative result figure.
In figure:
10. cyclic structure;20. strip structure;21. bar;F1, axial pressure;F2, through to pressure.
Specific embodiment
Combined with specific embodiments below and attached drawing, a kind of bone is facilitated to follow for large segmental bone defect treatment to herein described
Ring pressurized casing is described in detail.
The embodiment recorded herein is specific specific embodiment of the invention, for illustrating design of the invention,
Be it is explanatory and illustrative, should not be construed as the limitation to embodiment of the present invention and the scope of the invention.Except what is recorded herein
Outside embodiment, those skilled in the art can also based on the claim of this application book and specification disclosure of that using aobvious and
The other technical solutions being clear to, these technical solutions include using any obvious to making for the embodiment recorded herein
The technical solution of substitutions and modifications.
The attached drawing of this specification is schematic diagram, aids in illustrating design of the invention, it is schematically indicated the shape of each section
And its correlation.It note that for the ease of clearly showing the structure of each component of the embodiment of the present invention, identical reference
Label is for indicating identical part.
A kind of structural schematic diagram for facilitating bone circulation pressurized casing for large segmental bone defect treatment of the present invention, such as schemes
1 to shown in Fig. 4 comprising cyclic structure 10 and the strip structure 20 being arranged between a pair of of cyclic structure 10, the cyclic annular knot
Structure 10 and strip structure 20 form the cavity of a relative closure, and the ectopic osteogenesis material is arranged in the cavity;The item
20 retractable of shape structure is to pressurize to the ectopic osteogenesis material in cavity.
As an embodiment of the present invention, the strip structure 20 is adhesively fixed by multilayer bar 21.In Fig. 2
To in embodiment shown in Fig. 4, the quantity of the bar 21 is three layers, the quantity of the bar 21 may be three layers,
The quantity such as four layers, five layers.
As the one aspect of the present embodiment, the bar 21 is hydrogel or high polymer, and hydrogel and high polymer are not
It can occur to exclude react with human body, be unfavorable for merging for ectopic osteogenesis material and tissue in this way.As the another of the present embodiment
On one side, it is provided with biogum between adjacent bar 21, to guarantee the rapid fusion of ectopic osteogenesis material and tissue.
As an embodiment of the present invention, the bar 21 is scalable, and multilayer bar 21 during the bonding process, will
Bar 21 along its length and/or width direction stretch after it is Nian Jie with other bars 21 again, such multilayer bar 21 glue
The strip structure 20 to be formed is connect with retractility, can along its length and/or width direction is flexible, cyclic annular to be tied to described
Position osteogenic materials pressurization in the cavity for the relative closure that structure 10 and strip structure 20 are formed.
As the one aspect of the present embodiment, the strip structure 20 includes the different bar 21 of multiple length, described
Bar 21 is stretched to isometric rear be adhesively fixed by biogum along its length and is integrated;As shown in Fig. 2, dotted line table in diagram
Show the state after bar 21 stretches along its length, solid line indicates the non-stretched state of bar 21, by the shorter item of length
Shape object 21 be stretched to along its length with the corresponding equal length of the longer bar 21 of length, reuse biogum and be adhesively fixed
It is integrated, being thusly-formed the strip structure 20 that the bonding of multilayer bar 21 is formed has retractility, can stretch along its length
Contracting is pressurizeed with the position osteogenic materials in the cavity of the relative closure to the cyclic structure 10 and the formation of strip structure 20.
The strip structure 20 includes multiple bars 21 of different size, and the bar 21 is stretched in the width direction
It is adhesively fixed and is integrated by biogum after isometric;As shown in figure 4, dotted line indicates that bar 21 stretches in the width direction in diagram
State afterwards, solid line indicate the non-stretched state of bar 21, by the shorter bar 21 of width be stretched in the width direction with
The correspondence width of the longer bar 21 of width is equal, reuses biogum and is adhesively fixed and is integrated, and is thusly-formed multilayer strip
The strip structure 20 that the bonding of object 21 is formed has retractility, can stretch in the width direction, with to the cyclic structure 10 and
Position osteogenic materials pressurization in the cavity for the relative closure that strip structure 20 is formed.
In the embodiment shown in fig. 1, the strip structure 20 is uniformly distributed centered on the axis of cyclic structure 10, item
20 retractable of shape structure is to pressurize to the ectopic osteogenesis material in cavity, as a variant of the present embodiment, the item
Shape structure 20 can also be center uneven distribution along the axis of cyclic structure 10, as long as guaranteeing between adjacent strip structure 20
Gap is in 1mm-5mm, and 20 retractable of strip structure is to pressurize to the ectopic osteogenesis material in cavity.
In the present invention, the gap between the strip structure 20 is adjacent is adjustable.Specifically, in the embodiment shown in fig. 4,
The strip structure 20 is scalable in the width direction, passes through the adjacent strip of flexible realization of strip structure 20 in the width direction in this way
The gap of structure 20 adjusts.
As an embodiment of the present invention, the section of the strip structure 20 is rectangle, triangle, ellipse, circle
Any one of.It is understood that the section of the strip structure 20 may be other closed shapes, such as trapezoidal, square
The shape etc. that shape is combined with semicircle, as long as strip structure 20 is conveniently adhesively fixed and guarantees that the strip structure 20 that bonding is formed has
There is good retractility.
As an embodiment of the present invention, the sequence that the different bar 21 of the length successively decreases or is incremented by according to length
It is adhesively fixed and is integrated, as shown in Figure 2;As a variant of the present embodiment, the bar 21 can also be according to other arrangements
Mode is adhesively fixed, such as symmetrical according to the sequence successively decreased or be incremented by, as shown in figure 3, the length of the bar 21 of two sides in this way
Degree is shorter, and the shorter bar 21 of two side lengths is fixed with the longer bar 21 of intermediate length using biogum switching after stretching
It is integrated, can similarly guarantee good retractility.
The sequence that the bar 21 of different size successively decreases or is incremented by according to width, which is adhesively fixed, to be integrated, such as Fig. 4 institute
Show;As a kind of variant of the present embodiment, the bar 21 can also be adhesively fixed according to other arrangement modes, such as according to successively decreasing
Or incremental sequence is symmetrical, the width of the bar 21 of such two sides is shorter, and width shorter bar 21 in two sides stretches
It is fixed as one, can similarly be guaranteed good flexible using biogum switching with the longer bar 21 of intermediate width afterwards
Property.
It is of the present invention to facilitate bone circulation pressurized casing to move towards setting along muscle for large segmental bone defect treatment, then exist
When contraction of muscle, the strip structure 20 realizes length under the action of muscle squeezes power, along the axis of ectopic osteogenesis material
To pressure F1 reduce, and radial pressure F2 increases, can be in ectopic osteogenesis material in this way as the interval of muscle is shunk
The radial and axial circulating pressure for forming interval, accelerates comprehensive exchange of substance, promotes osteogenesis speed and quality, such as Fig. 5
Shown, double-head arrow direction is contraction of muscle direction in figure.In the present invention, Fig. 1 shows the embodiment of a pair of of cyclic structure 10,
Also it may include multiple cyclic structures 10, multiple strip structures 20 be set between adjacent annular structure 10, length can be formed in this way
Longer cycle pressure device is spent, to be suitable for the treatment of different form bone defect.
It is of the present invention to facilitate the use step of bone circulation pressurized casing and process as follows for large segmental bone defect treatment:
Ectopic osteogenesis operation is carried out in the experimental animal Special surgical operation room by ultraviolet light irradiation, to anesthesia onset
Afterwards, preserved skin is carried out to art area using animal specific shaver;
By new zealand white rabbit prostrate in surgical console, carried out disinfection using the medical tincture of iodine to range inner skin, it is conventional
Drape, exposure experimental animal back;
Make two notch for being about 2cm in back backbone two sides, it is subcutaneous with vessel forceps and tissue shear separation after starting skin
Tissue and fascia superficialis, as deep as fatty deep layer, until appearing muscle fascia superficialis;
Pocket-like flesh bag is isolated using blunt separation device, after carrying tissue engineering bracket in the device, with physiology salt
Water infiltration, then lay flat in flesh bag, cycle pressure device moves towards setting along muscle, then layer-by-layer suture wound, and marks.
Fig. 6 a is the Alizarin red staining result figure of simple ectopic osteogenesis culture, and Fig. 6 b is in device of the present invention
It is put into the Alizarin red staining result figure of the bone tissue engineering scaffold of 3D printing, compared with simple ectopic osteogenesis culture (Fig. 6 a);2 weeks
Afterwards, the Alizarin red staining result that the bone tissue engineering scaffold of 3D printing is put into device of the present invention is good, Neng Gouda
To good skeletonization effect (Fig. 6 b).
Fig. 7 a and Fig. 7 b are the comparative result figures that the ectopic osteogenesis bracket that the device obtains is used for internal skeletonization, in rabbit oar
In bone defect model, using cycle pressure device of the present invention, tissue engineering bracket ectopic osteogenesis first is replanted after 2 weeks
Defect (as shown in Figure 7a) to the marrow, than directly by tissue engineering bracket implantation bone defect position (shown in Fig. 7 a) at 16 weeks
With better skeletonization effect.
It is provided by the invention it is a kind of for large segmental bone defect treatment facilitate bone recycle pressurized casing, be suitable for ectopic osteogenesis
Large segmental bone defect is treated, structurally reasonable, ingenious in design, the strip structure being arranged between cyclic structure has retractility, makes
The ectopic osteogenesis material pressurization that must be arranged between cyclic structure has and preferably pushes away to promote the speed and quality of skeletonization
Wide value.
The present invention is not limited to the above-described embodiments, anyone can obtain other various forms under the inspiration of the present invention
Product, it is all that there is technical side identical or similar to the present application however, make any variation in its shape or structure
Case is within the scope of the present invention.
Claims (11)
1. a kind of facilitate bone to recycle pressurized casing, including cyclic structure and setting a pair of cyclic annular for large segmental bone defect treatment
Strip structure between structure, the cyclic structure and strip structure form the cavity of a relative closure, the ectopic osteogenesis material
Material is arranged in the cavity;The strip structure retractable is to pressurize to the ectopic osteogenesis material in cavity.
2. according to claim 1 facilitate bone to recycle pressurized casing for large segmental bone defect treatment, which is characterized in that institute
Strip structure is stated to be adhesively fixed by multilayer bar.
3. according to claim 2 facilitate bone to recycle pressurized casing for large segmental bone defect treatment, which is characterized in that institute
Stating bar is hydrogel or high polymer, is provided with biogum between adjacent bar.
4. according to claim 1 facilitate bone to recycle pressurized casing for large segmental bone defect treatment, which is characterized in that institute
It is scalable to state bar.
5. according to claim 1 facilitate bone to recycle pressurized casing for large segmental bone defect treatment, which is characterized in that institute
Stating strip structure includes the different bar of multiple length, the bar be stretched to along its length it is isometric after pass through biogum
It is adhesively fixed and is integrated.
6. according to claim 1 facilitate bone to recycle pressurized casing for large segmental bone defect treatment, which is characterized in that institute
Stating strip structure includes multiple bars of different size, the bar be stretched in the width direction it is isometric after pass through biogum
It is adhesively fixed and is integrated.
7. according to claim 1 facilitate bone to recycle pressurized casing for large segmental bone defect treatment, which is characterized in that institute
Strip structure is stated to be uniformly distributed centered on the axis of cyclic structure.
8. according to claim 1 facilitate bone to recycle pressurized casing for large segmental bone defect treatment, which is characterized in that institute
State strip structure it is adjacent between gap it is adjustable.
9. according to claim 1 facilitate bone to recycle pressurized casing for large segmental bone defect treatment, which is characterized in that institute
The section for stating strip structure is any one of rectangle, triangle, ellipse, circle.
10. according to claim 5 facilitate bone to recycle pressurized casing for large segmental bone defect treatment, which is characterized in that
The sequence that the different bar of the length successively decreases or is incremented by according to length, which is adhesively fixed, to be integrated.
11. according to claim 6 facilitate bone to recycle pressurized casing for large segmental bone defect treatment, which is characterized in that
The sequence that the bar of different size successively decreases or is incremented by according to width, which is adhesively fixed, to be integrated.
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CN201910678911.2A CN110433012A (en) | 2019-07-25 | 2019-07-25 | It is a kind of to facilitate bone to recycle pressurized casing for large segmental bone defect treatment |
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CN201910678911.2A CN110433012A (en) | 2019-07-25 | 2019-07-25 | It is a kind of to facilitate bone to recycle pressurized casing for large segmental bone defect treatment |
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CN201910678911.2A Pending CN110433012A (en) | 2019-07-25 | 2019-07-25 | It is a kind of to facilitate bone to recycle pressurized casing for large segmental bone defect treatment |
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