CN105125317B - Segmented nano coating modified artificial rotator cuff patch - Google Patents
Segmented nano coating modified artificial rotator cuff patch Download PDFInfo
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- CN105125317B CN105125317B CN201510593692.XA CN201510593692A CN105125317B CN 105125317 B CN105125317 B CN 105125317B CN 201510593692 A CN201510593692 A CN 201510593692A CN 105125317 B CN105125317 B CN 105125317B
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Abstract
The invention provides a segmented nano coating modified artificial rotator cuff patch which comprises a humerus woven section 1, a tendon free fiber section 2 and a pull ring 900. A capitulum hole 3 is formed in the upper portion of the humerus woven section 1 and penetrates through the inner surface and the outer surface of the humerus woven section 1. The lower end of the humerus woven section 1 is connected with the upper end of the tendon free fiber section 2. A tendon end hole 4 is formed in the lower portion of the tendon free fiber section 2 and penetrates through the inner surface and the outer surface of the tendon free fiber section 2. By means of the segmented nano coating modified artificial rotator cuff patch, mechanical properties of rotator cuff tissue can be improved after a rotator cuff injury repair operation. Meanwhile, in the aspect of biological performance, the features of tendon-bone healing tissue through which a rotator cuff and a bone are connected can be simulated. The structure can enhance the inherent healing potential of tendons, and accordingly the success rate of the rotator cuff injury repair operation is increased.
Description
Technical field
The present invention relates to surgical patch field, in particular it relates to artificial bone-head for shoulder's sleeve sticking patch of stagewise nano coating modification.
Background technology
Rotator cuff tear is common Shoulder joint, and sickness rate increases with advancing age and gradually.Rotator cuff tear is
Cause shoulder arthralgia, mobility reduction, the common cause of miopragia, account for the 60% of shoulder pathological changes.To Jing expectant treatments
Invalid Patients with Rotator Cuff Injury After and shoulder sleeve mass lesions patient, are usually taken surgical operation therapy and repair tear tendon, so as to
Mitigate pain, and rebuild function of joint.
Tendon is the weak spot in shoulder sleeve repair process, when especially defect is larger, pulls and attempt to tear bulk in art
The former attachment point that the shoulder tissue sleeve for splitting is fixed on before injury is more difficult, now needs to be solved with shoulder sleeve structure enhancement techniques huge
During rotator cuff tear, head of humerus covers not enough problem, it is ensured that the mechanical property of kposthesiss back porch tissue sleeve, maintains stablizing for shoulder joint
Property and function.
The material that enhancement techniques are repaired currently used for shoulder sleeve is a lot, including autologous tissue, allohisto compatibility, heteroplasm
And synthetic tissue etc., but all there is respective and application limitation in clinical practice.Autograft material
Material is mainly derived from the tissue such as autologous fascia lata, tendon of long head of biceps brachii, and autograft class sticking patch great advantage is
With good biological attribute, typically not causing one of the inflammatory reaction of body, major defect to be may be to certainly when drawing materials
Body brings extra wound, belongs to " tearing down the east wall to repair the west wall ", can affect shoulder joint stability for area's disease damage.Allogeneic is undressed
Tissue graft material is typically derived from homologous shoulder tissue sleeve, allosome kneecap tendinous tissue, with tendinous tissue and quadriceps femoris tendon tissue etc..
This kind of stable mechanical property of material shortage ensures, easily makes body produce immunoreation, there is infection infectiousness disease after transplanting
The risk of disease, and limited source.Acellular tissue graft material class sticking patch mainly includes two kinds:Heteroplasm transplants:Mainly
Corium, small intestinal, pericardium from animal etc. are organized, such as Restore, Cuffpatch, Conexa, TissueMen etc..②
Allograft:It is mainly derived from the dermal tissue or fascia lata of human skin.Jing physical methods or chemical method are de-
After cellularised operation, although the mechanical characteristic with good biocompatibility and stretch-proof, but because of its tissue-derived, processing side
The difference of method, sterilizing methods, its mechanical strength is well below the Mechanical loading intensity carried by the primary tendon of human body or ligament.From
Biomechanicss and biology angle say that it does not have the inherent character of tendon itself.
Current shoulder sleeve patching material, biomechanical strength, histocompatibility, source of drawing material problem, safety and expense
Its application clinically is limited etc. factor.Therefore design mechanical strength is excellent, simulates shoulder tissue sleeve, good biocompatibility
Shoulder tucks inside the sleeve sticking patch for treatment rotator cuff injury has important clinical value.
The content of the invention
For defect of the prior art, it is an object of the invention to provide a kind of artificial bone-head for shoulder of stagewise nano coating modification
Sleeve sticking patch.
A kind of artificial bone-head for shoulder's sleeve sticking patch of the stagewise nano coating modification provided according to the present invention, including:Humerus weaves section
1st, tendon free-fiber section 2;
The top of humerus braiding section 1 is provided with epiphysis hole 3, and epiphysis hole 3 weaves the inner surface of section 1, outer surface through humerus;
The lower end of humerus braiding section 1 connects the upper end of tendon free-fiber section 2;
The bottom of tendon free-fiber section 2 is provided with tendon stomidium 4, interior table of the tendon stomidium 4 through tendon free-fiber section 2
Face, outer surface;
The upper end of humerus braiding section 1 is provided with traction draw ring 900;The lower end of tendon free-fiber section 2 is provided with traction and draws
Ring 900;
Generally rectangle or rounded rectangle shape that humerus braiding section 1 is constituted with tendon free-fiber section 2.
Preferably, epiphysis hole 3 is have draught line A, and tendon stomidium 4 is have draught line B.
Preferably, network structure of the humerus braiding section 1 using fibrage.
Preferably, epiphysis hole 3 and tendon stomidium 4 are using following any one mode:
- epiphysis hole 3 is screw hole, and tendon stomidium 4 is hole of threading a needle;
- epiphysis hole 3 is band wire holdfast hole, and tendon stomidium 4 is hole of threading a needle;
- epiphysis hole 3 is hole of threading a needle, and tendon stomidium 4 is hole of threading a needle.
Preferably, the upper face or all surfaces of humerus braiding section 1 is provided with coating I, under tendon free-fiber section 2
Portion surface or all surfaces are provided with coating II, weave section 1 in humerus and are coated with coating with the junction of tendon free-fiber section 2
III;
Further, specially:
- coating III is the composite coating being made up of the material of coating I and the material of coating II;
- compared with coating I and/or coating II, coating III contains different osteogenic growth factors, osteogenic growth medicine
Thing, into flesh somatomedin or into flesh grow medicine;
- coating I, coating II, coating III are nano coating.
Preferably, the lower end of the humerus braiding section 1 connects the engagement formed by the upper end of the tendon free-fiber section 2
Boundary line D is serrated.
Preferably, the humerus braiding section 1 and the junction of tendon free-fiber section 2, refer to:Section 1, flesh is woven by humerus
The entirety constituted by tendon free-fiber section 2 includes a section of engagement boundary line D in the height direction.
Preferably, also include:Support A501 is self-deployed, support B502 is self-deployed, is self-deployed support C601, self-deploys support
D602;
Humerus braiding section 1 is provided with through hole A7;
Support A501 is self-deployed with to self-deploy support B502 arranged in a crossed manner, and both passes through through hole A7;
Self-deploy support A501, self-deploy support B502 upper end be fastenedly connected in humerus weave section 1 outer surface;
Self-deploy support A501, self-deploy support B502 lower end be fastenedly connected in humerus weave section 1 inner surface;
Tendon free-fiber section 2 is provided with through hole B8;
Support C601 is self-deployed with to self-deploy support D602 arranged in a crossed manner, and both passes through through hole B8;
The lower end for self-deploy support C601, self-deploying support D602 is fastenedly connected in the appearance of tendon free-fiber section 2
Face;The upper end for self-deploy support C601, self-deploying support D602 is fastenedly connected in the inner surface of tendon free-fiber section 2.
Preferably, self-deploy support A501, self-deploy support B502, self-deploy support C601, to self-deploy support D602 equal
It is using strip laminated structure or rod-like structure made by memorial alloy;
The concrete structure for self-deploy support A501, self-deploying support B502 is:In addition to top and bottom, its remaining part
The surface for weaving section 1 with humerus is divided to be separated;
The concrete structure for self-deploy support C601, self-deploying support D602 is:In addition to top and bottom, its remaining part
The surface with tendon free-fiber section 2 is divided to be separated.
Preferably, also include:External protection 901, inner protective layer 902;
External protection 901, inner protective layer 902 are constituted by a pieces of fabric 1001 and a free-fiber piece 1002;
The pieces of fabric 1001 of external protection 901 cover humerus weave section 1 outer surface, and be located at self-deploy support
A501, the outside for self-deploying support B502;
The free-fiber piece 1002 of external protection 901 covers the outer surface of tendon free-fiber section 2, and is located at and self-deploys
Support C601, the outside for self-deploying support D602;
The pieces of fabric 1001 of inner protective layer 902 covers the inner surface that humerus weaves section 1, and which is located at and self-deploys support
A501, the inner side for self-deploying support B502;
The free-fiber piece 1002 of inner protective layer 902 covers the inner surface of tendon free-fiber section 2, and is located at and self-deploys
Support C601, the inner side for self-deploying support D602.
Compared with prior art, the present invention has following beneficial effect:
The shoulder sleeve sticking patch of the nano coating modification designed by the present invention can improve rotator cuff injury kposthesiss back porch tissue sleeve
Mechanical property, while the tendon-bone healing tissue characteristics that shoulder sleeve is connected with bone can be simulated in terms of biological property, the structure can strengthen
In tendon healing potential, and then improve the success rate of rotator cuff injury prosthesis.
Description of the drawings
Detailed description non-limiting example made with reference to the following drawings by reading, the further feature of the present invention,
Objects and advantages will become more apparent upon:
Fig. 1 illustrates the structural representation of first embodiment of the invention.
Fig. 2, Fig. 3 illustrate the structural representation of the preference of first embodiment of the invention.
Fig. 4 illustrates the principle schematic of the gathering and expansion of the preference of first embodiment of the invention.
Fig. 5 illustrates the structural representation of the change case of first embodiment of the invention.
In figure:D represents engagement boundary line, and E represents the entirety being made up of humerus braiding section 1, tendon free-fiber section 2 in height
Include one section of engagement boundary line D on degree direction.
Specific embodiment
With reference to specific embodiment, the present invention is described in detail.Following examples will be helpful to the technology of this area
Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill to this area
For personnel, without departing from the inventive concept of the premise, some changes and improvements can also be made.These belong to the present invention
Protection domain.
As shown in figure 1, a kind of artificial bone-head for shoulder's sleeve sticking patch of the stagewise nano coating modification provided according to the present invention, including:
Humerus braiding section 1, tendon free-fiber section 2;
The top of humerus braiding section 1 is provided with epiphysis hole 3, and epiphysis hole 3 weaves the inner surface of section 1, outer surface through humerus;
The lower end of humerus braiding section 1 connects the upper end of tendon free-fiber section 2;
The bottom of tendon free-fiber section 2 is provided with tendon stomidium 4, interior table of the tendon stomidium 4 through tendon free-fiber section 2
Face, outer surface.
The upper end of humerus braiding section 1 is provided with traction draw ring 900;The lower end of tendon free-fiber section 2 is provided with traction and draws
Ring 900;So, in positioning and expansion can using apparatus draw in the vertical direction pulling humerus braiding section 1 and tendon from
By segment of fiber 2.
Generally rectangle or rounded rectangle shape that humerus braiding section 1 is constituted with tendon free-fiber section 2.
Preferably, epiphysis hole 3 is have draught line A, and tendon stomidium 4 is have draught line B.
Preferably, network structure of the humerus braiding section 1 using fibrage.For example, humerus weaves the braiding material of section 1
Material can be constituted using PET, ultra-high molecular weight polyethylene, nylon material.
Preferably, epiphysis hole 3 is screw hole, and tendon stomidium 4 is hole of threading a needle.In change case, epiphysis hole 3 can be band wire anchor
Nail or hole of threading a needle.
Preferably, the upper face or all surfaces of humerus braiding section 1 is provided with coating I, under tendon free-fiber section 2
Portion surface or all surfaces are provided with coating II, weave section 1 in humerus and are coated with coating with the junction of tendon free-fiber section 2
III;
Further, specially:
- coating III is the composite coating being made up of the material of coating I and the material of coating II, wherein, preferably
Ground, in the composite coating, the ratio of the material of the material and coating II of coating I is 1:1;
- compared with coating I and/or coating II, coating III contains different osteogenic growth factors, osteogenic growth medicine
Thing, into flesh somatomedin or into flesh grow medicine;
- coating I, coating II, coating III are nano coating.
Wherein, coating I can be made up of following any one material material or by appointing multiple material to constitute as follows
Composite:Collagen, gelatin, shitosan, hyaluronic acid, fibroin, Polyethylene Glycol (PEG), polylactic acid (PLA) etc..Coating I
Can be nanometer silver, nano-titanium, nano aluminium oxide, nanometer calcium triphosphate (TCP), nano-calcium phosphate, sodium carbonate calcium granule etc..
The somatomedin of skeletonization can be added in coating I, such as:BMP-2、BMP-7、BMP-9;TGF-β 1 (transforminggrowthfactor-β1) etc.
Deng.
Coating II can be the material or compound by appoint multiple material to constitute as follows being made up of following any one material
Material:Shitosan, glucosan, polylactic acid, hyaluronic acid, polyvinyl alcohol (PVA), etc..Can add in coating II blood red
Albumen etc. adds somatomedin or medicine, such as VEGF (VEGF), transforming growth factor-β etc. into flesh.
As shown in Fig. 2 as the preferred technical scheme of Fig. 1, according to a kind of stagewise nano coating that the present invention is provided
Artificial bone-head for shoulder's sleeve sticking patch of modification also includes:Support A501 is self-deployed, support B502 is self-deployed, is self-deployed support C601, self-deploys
Support D602;
Humerus braiding section 1 is provided with through hole A7;
Support A501 is self-deployed with to self-deploy support B502 arranged in a crossed manner, and both passes through through hole A7;
Self-deploy support A501, self-deploy support B502 upper end be fastenedly connected in humerus weave section 1 outer surface;
Self-deploy support A501, self-deploy support B502 lower end be fastenedly connected in humerus weave section 1 inner surface;
Tendon free-fiber section 2 is provided with through hole B8;
Support C601 is self-deployed with to self-deploy support D602 arranged in a crossed manner, and both passes through through hole B8;
The lower end for self-deploy support C601, self-deploying support D602 is fastenedly connected in the appearance of tendon free-fiber section 2
Face;The upper end for self-deploy support C601, self-deploying support D602 is fastenedly connected in the inner surface of tendon free-fiber section 2.
Preferably, self-deploy support A501, self-deploy support B502, self-deploy support C601, to self-deploy support D602 equal
It is using strip laminated structure or rod-like structure made by memorial alloy;
The concrete structure for self-deploy support A501, self-deploying support B502 is:In addition to top and bottom, its remaining part
The surface for weaving section 1 with humerus is divided to be separated;
The concrete structure for self-deploy support C601, self-deploying support D602 is:In addition to top and bottom, its remaining part
The surface with tendon free-fiber section 2 is divided to be separated.
As shown in figure 4, by self-deploying support A501, self-deploying support B502, self-deploy support C601, self-deploy support
D602, artificial bone-head for shoulder's sleeve sticking patch of the stagewise nano coating modification can be changed between rounding state and deployed condition.Please
Referring in Fig. 4, towards the arrow on the right of paper, the artificial bone-head for shoulder of the stagewise nano coating modification tucks inside the sleeve sticking patch from being fully deployed shape
State (i.e. naturalness) is gradually compressed height, then artificial bone-head for shoulder's sleeve sticking patch in the width direction to the modification of stagewise nano coating
It is crimped so that artificial bone-head for shoulder's sleeve sticking patch of the stagewise nano coating modification can be stuffed into conduit, to be sent to along conduit
Affected area, after affected area is reached, by support A501 being self-deployed by made by memorial alloy, support B502 being self-deployed, is bootstrapped
Spending frame C601, self-deploy support D602 and self-deploy from the state of batching, then being pulled by doctor makes the stagewise nano coating
The height of artificial bone-head for shoulder's sleeve sticking patch of modification becomes greatly until its fully unfolded position.
As shown in Figure 3, it is preferable that artificial bone-head for shoulder's sleeve sticking patch of the stagewise nano coating modification can be stuffed into conduit also
Including:External protection 901, inner protective layer 902;
External protection 901, inner protective layer 902 are constituted by a pieces of fabric 1001 and a free-fiber piece 1002;
The pieces of fabric 1001 of external protection 901 cover humerus weave section 1 outer surface, and be located at self-deploy support
A501, the outside for self-deploying support B502;
The free-fiber piece 1002 of external protection 901 covers the outer surface of tendon free-fiber section 2, and is located at and self-deploys
Support C601, the outside for self-deploying support D602;
The pieces of fabric 1001 of inner protective layer 902 covers the inner surface that humerus weaves section 1, and which is located at and self-deploys support
A501, the inner side for self-deploying support B502;
The free-fiber piece 1002 of inner protective layer 902 covers the inner surface of tendon free-fiber section 2, and is located at and self-deploys
Support C601, the inner side for self-deploying support D602.
As shown in figure 5, the lower end of humerus braiding section 1 connects the tendon described in the change case of embodiment illustrated in fig. 1
Engagement boundary line D formed by the upper end of free-fiber section 2 is serrated.The lower edge of humerus braiding section 1 is serrated, tendon
The zigzag that the upper end-face edge of free-fiber section 2 is matched in the lower edge that section 1 is woven with humerus.
Preferably, the humerus braiding section 1 and the junction of tendon free-fiber section 2, refer to:Section 1, flesh is woven by humerus
The entirety constituted by tendon free-fiber section 2 includes a section of engagement boundary line D in the height direction.
Above the specific embodiment of the present invention is described.It is to be appreciated that the invention is not limited in above-mentioned
Particular implementation, those skilled in the art can make a variety of changes within the scope of the claims or change, this not shadow
Ring the flesh and blood of the present invention.In the case where not conflicting, the feature in embodiments herein and embodiment can any phase
Mutually combine.
Claims (9)
1. artificial bone-head for shoulder's sleeve sticking patch that a kind of stagewise nano coating is modified, it is characterised in that include:Humerus braiding section (1), tendon
Free-fiber section (2);
The top of humerus braiding section (1) is provided with epiphysis hole (3), and epiphysis hole (3) weave the inner surface of section (1), outer through humerus
Surface;
The upper end of lower end connection tendon free-fiber section (2) of humerus braiding section (1);
The bottom of tendon free-fiber section (2) is provided with tendon stomidium (4), and tendon stomidium (4) is interior through tendon free-fiber section (2)
Surface, outer surface;
The upper end of humerus braiding section (1) is provided with traction draw ring (900);The lower end of tendon free-fiber section (2) is provided with traction
Draw ring (900);
Generally rectangle or rounded rectangle shape that humerus braiding section (1) is constituted with tendon free-fiber section (2);
Also include:Support A (501) is self-deployed, support B (502) is self-deployed, is self-deployed support C (601), self-deploys support D
(602);
Humerus braiding section (1) is provided with through hole A (7);
Support A (501) is self-deployed with to self-deploy support B (502) arranged in a crossed manner, and both passes through through hole A (7);
Self-deploy support A (501), self-deploy support B (502) upper end be fastenedly connected in humerus weave section (1) outer surface;
Self-deploy support A (501), self-deploy support B (502) lower end be fastenedly connected in humerus weave section (1) inner surface;
Tendon free-fiber section (2) is provided with through hole B (8);
Support C (601) is self-deployed with to self-deploy support D (602) arranged in a crossed manner, and both passes through through hole B (8);
The lower end for self-deploy support C (601), self-deploying support D (602) is fastenedly connected in the outer of tendon free-fiber section (2)
Surface;The upper end for self-deploy support C (601), self-deploying support D (602) is fastenedly connected in the interior of tendon free-fiber section (2)
Surface.
2. artificial bone-head for shoulder's sleeve sticking patch that stagewise nano coating according to claim 1 is modified, it is characterised in that epiphysis hole
(3) there is draught line A in system, and there is draught line B in tendon stomidium (4) system.
3. artificial bone-head for shoulder's sleeve sticking patch that stagewise nano coating according to claim 1 is modified, it is characterised in that humerus weaves
Network structure of the section (1) using fibrage.
4. artificial bone-head for shoulder's sleeve sticking patch that stagewise nano coating according to claim 1 is modified, it is characterised in that epiphysis hole
And tendon stomidium (4) is using following any one mode (3):
- epiphysis hole (3) is screw hole, and tendon stomidium (4) is hole of threading a needle;
- epiphysis hole (3) is band wire holdfast hole, and tendon stomidium (4) is hole of threading a needle;
- epiphysis hole (3) is hole of threading a needle, and tendon stomidium (4) is hole of threading a needle.
5. artificial bone-head for shoulder's sleeve sticking patch that stagewise nano coating according to claim 1 is modified, it is characterised in that humerus weaves
The upper face or all surfaces of section (1) is provided with coating I, and the lower surface or all surfaces of tendon free-fiber section (2) set
Coating II is equipped with, and section (1) is woven in humerus and is coated with coating III with the junction of tendon free-fiber section (2);
Further, specially:
- coating III is the composite coating being made up of the material of coating I and the material of coating II;
- compared with coating I and/or coating II, coating III contain different osteogenic growth factors, osteogenic growth medicine, into
Flesh somatomedin grows medicine into flesh;
- coating I, coating II, coating III are nano coating.
6. artificial bone-head for shoulder's sleeve sticking patch that stagewise nano coating is modified according to claim 1 or 5, it is characterised in that described
The engagement boundary line formed by the upper end of the lower end connection tendon free-fiber section (2) of humerus braiding section (1) is serrated.
7. artificial bone-head for shoulder's sleeve sticking patch that stagewise nano coating according to claim 6 is modified, it is characterised in that the humerus
Braiding section (1) and the junction of tendon free-fiber section (2), refer to:Section (1), tendon free-fiber section (2) institute are woven by humerus
The entirety of composition includes a section of the engagement boundary line in the height direction.
8. artificial bone-head for shoulder's sleeve sticking patch that stagewise nano coating according to claim 1 is modified, it is characterised in that spending of bootstrapping
Frame A (501), support B (502) is self-deployed, support C (601) is self-deployed, is self-deployed support D (602) and be using memorial alloy system
Into strip laminated structure or rod-like structure;
The concrete structure for self-deploy support A (501), self-deploying support B (502) is:In addition to top and bottom, its remaining part
The surface for weaving section (1) with humerus is divided to be separated;
The concrete structure for self-deploy support C (601), self-deploying support D (602) is:In addition to top and bottom, its remaining part
The surface with tendon free-fiber section (2) is divided to be separated.
9. artificial bone-head for shoulder's sleeve sticking patch that stagewise nano coating according to claim 8 is modified, it is characterised in that also include:
External protection (901), inner protective layer (902);
External protection (901), inner protective layer (902) are constituted by a pieces of fabric (1001) and a free-fiber piece (1002);
The pieces of fabric (1001) of external protection (901) cover humerus braiding section (1) outer surface, and be located at self-deploy support A
(501), self-deploy the outside of support B (502);
The free-fiber piece (1002) of external protection (901) covers the outer surface of tendon free-fiber section (2), and is located at and bootstraps
Spending frame C (601), the outside for self-deploying support D (602);
The pieces of fabric (1001) of inner protective layer (902) covers the inner surface of humerus braiding section (1), and which is located at and self-deploys support A
(501), self-deploy the inner side of support B (502);
The free-fiber piece (1002) of inner protective layer (902) covers the inner surface of tendon free-fiber section (2), and is located at and bootstraps
Spending frame C (601), the inner side for self-deploying support D (602).
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CN201510593692.XA CN105125317B (en) | 2015-09-17 | 2015-09-17 | Segmented nano coating modified artificial rotator cuff patch |
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CN106901868B (en) * | 2017-02-24 | 2018-08-14 | 丁少华 | A kind of upper joint capsule rebuilds reparation sticking patch and preparation method thereof |
CN107928837B (en) * | 2017-10-23 | 2023-06-13 | 上海利格泰生物科技股份有限公司 | Partially absorbable patch for rotator cuff repair and method of manufacture |
CN114949353B (en) * | 2022-01-24 | 2023-05-30 | 东华大学 | Biological function differentiated adaptive musculoskeletal system prosthesis and preparation method thereof |
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CN203195798U (en) * | 2013-04-07 | 2013-09-18 | 复旦大学附属华山医院 | Easy molding folding suspension type artificial ligament |
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CN204995611U (en) * | 2015-09-17 | 2016-01-27 | 复旦大学附属华山医院 | Artifical shoulder sleeve patch of type is woven in segmentation that nanometer coating was decoratied |
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