CN105125317B - The segmented modified nano-coating artificial rotator cuff patch - Google Patents

The segmented modified nano-coating artificial rotator cuff patch Download PDF

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CN105125317B
CN105125317B CN201510593692.XA CN201510593692A CN105125317B CN 105125317 B CN105125317 B CN 105125317B CN 201510593692 A CN201510593692 A CN 201510593692A CN 105125317 B CN105125317 B CN 105125317B
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self
tendon
expanding stent
coating
section
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CN201510593692.XA
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CN105125317A (en
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陈世益
张鹏
智云龙
蒋佳
陈天午
李云霞
陈疾忤
李宏
吴子英
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复旦大学附属华山医院
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Abstract

本发明提供了一种分段式纳米涂层修饰的人工肩袖补片,包括:肱骨编织段1、肌腱自由纤维段2、拉环900;肱骨编织段1的上部设置有骨端孔3,骨端孔3贯穿肱骨编织段1的内表面、外表面;肱骨编织段1的下端连接肌腱自由纤维段2的上端;肌腱自由纤维段2的下部设置有腱端孔4,腱端孔4贯穿肌腱自由纤维段2的内表面、外表面。 The present invention provides a segmented modified nano-coating artificial rotator cuff patch, comprising: a woven segments humerus, tendon segment 2 consisting of fibers, pull ring 900; knit upper humerus bone segment end 1 is provided with a hole 3, bone end opening 3 through humeral woven segments inner surface of an outer surface; a lower humeral braided section 1 is connected to the tendon free fiber segment upper 2; tendon free fiber section the lower portion 2 is provided with a tendon end hole 4, tendon end aperture 4 through tendon fiber section consisting of the inner surface 2, outer surface. 本发明所提供的肩袖补片可提高肩袖损伤修补术后肩袖组织的力学性能,同时在生物性能方面可模拟肩袖与骨连接的腱骨愈合组织特性,该结构可增强肌腱内在的愈合潜能,进而提高肩袖损伤修复手术的成功率。 Rotator cuff patch provided by the present invention can improve the mechanical properties of rotator cuff repair surgery rotator cuff tissue, while in terms of biological properties can be simulated rotator cuff tendon-bone healing and bone connecting tissue properties, the structure may enhance the intrinsic tendon healing potential, thus improving the success rate of surgery to repair a rotator cuff injury.

Description

分段式纳米涂层修饰的人工肩袖补片 The segmented modified nano-coating artificial rotator cuff patch

技术领域 FIELD

[0001] 本发明涉及外科补片领域,具体地,涉及分段式纳米涂层修饰的人工肩袖补片。 [0001] The present invention relates to a surgical patch, and in particular, to a segmented modified nano-coating artificial rotator cuff patch.

背景技术 Background technique

[0002]肩袖撕裂是常见的肩关节疾病,发病率随着年龄的增长而逐渐增加。 [0002] rotator cuff tear shoulder is a common disease, the incidence with age gradually increases. 肩袖撕裂是导致肩关节疼痛、活动度降低、功能减弱的常见原因,约占肩部病变的60%。 Rotator cuff tear is a common cause of shoulder pain, reduced activity, weakened, accounting for about 60% of shoulder lesions. 对经保守治疗无效的肩袖损伤患者及肩袖大面积损伤患者,通常采取外科手术治疗修补撕裂肌腱,从而减轻疼痛,并重建关节功能。 For conservative treatment fails in patients with rotator cuff injuries and shoulder sleeves patients with large areas of damage, usually take torn tendon repair surgery, thus reducing the pain and rebuild joint function.

[0003] 肌腱是肩袖修复过程中的薄弱点,尤其是缺损较大时,术中牵拉并试图将大块撕裂的肩袖组织固定于受伤前的原附着点较为困难,此时需要用肩袖结构增强技术解决巨大肩袖撕裂时肱骨头覆盖不足问题,保证修补术后肩袖组织的力学性能,维持肩关节的稳定性和功能。 [0003] rotator cuff tendon repair is a weak point in the process, especially in larger defects, the surgery and tried to pull chunks torn rotator cuff tissue fixation to the original attachment points before the injury more difficult at this time need enhancement technology to solve the stability and function of the shoulder joint of the humeral head covering when huge shortage rotator cuff tear, to ensure that the mechanical properties after repair of rotator cuff tissue, to maintain the structure with rotator cuff.

[0004]目前用于肩袖修补增强技术的材料很多,包括自体组织、同种异体组织、异种组织以及人工合成组织等,但在临床应用上都存在各自的问题及应用局限性。 [0004] rotator cuff repair materials currently used for many enhancement techniques, including autologous tissue, allogeneic tissue, xenogeneic tissue and synthetic organization, but in clinical applications there own problems and limitations apply. 自体组织移植材料主要来源于自体的阔筋膜、肱二头肌长头肌腱等组织,自体组织移植类补片最大优点是具有良好的生物属性,一般不引起机体的炎症反应,主要缺点之一在于取材时可能会给自体带来额外创伤,属于“拆东墙,补西墙”,供区病损会影响肩关节稳定性。 Autologous tissue graft material is primarily derived from autologous fascia lata, biceps tendon and other tissues, autologous tissue graft patch type big advantage is good biological properties, generally do not cause inflammation of the body, one of the main drawbacks could have drawn that when autologous bring additional trauma, are "split the east wall, pay Paul," the donor lesions affect the stability of the shoulder joint. 同种异体未加工组织移植材料通常来源于同源肩袖组织、异体髌腱组织、跟腱组织及股四头肌肌腱组织等。 Allogeneic tissue transplantation raw material usually derived from homologous rotator cuff tissue allograft patella tendon, Achilles tendon and quadriceps tendon organizations. 该种材料缺乏稳定的力学性能保证,移植后容易使机体产生免疫反应,存在感染传染性疾病的风险,且来源有限。 Lack of stable mechanical properties to ensure that this kind of material, post-transplant easily make the body produce immune responses, there is a risk of infectious disease, and limited sources. 脱细胞化组织移植材料类补片主要包括两种:异种组织移植:主要来源于动物的真皮、小肠、心包膜等组织,如Restore ,Cuffpatch,Conexa,TissueMen等。 Decellularized tissue patch graft material mainly include two categories: xenogeneic tissue transplantation: mainly derived from animal leather, small intestine, film pericardial tissue, such as Restore, Cuffpatch, Conexa, TissueMen like. ②同种异体组织移植:主要来源于人类皮肤的真皮组织或阔筋膜。 ② allogeneic tissue transplantation: mainly from human skin dermal tissue or fascia lata. 经物理方法或化学方法脱细胞化操作后,虽然具有良好的生物相容性及抗拉伸的力学特性,但因其组织来源、加工方法、灭菌方法的不同,其力学强度远远低于人体原生肌腱或韧带所承载的力学负荷强度。 Physically or chemically acellular operation, while having good biocompatibility and mechanical properties of tensile, but because of different tissue origin, processing method, sterilization methods, which is much lower than the mechanical strength mechanical load intensity human native tendon or ligament carried. 从生物力学和生物学角度讲,它并不具备肌腱本身的固有特性。 Biomechanical and biological perspective, it does not have the inherent characteristics of the tendon itself.

[0005]目前的肩袖补片材料,生物力学强度、组织相容性、取材来源问题、安全性和费用等因素均限制其在临床上的应用。 [0005] The current rotator cuff patch materials, biomechanics, tissue compatibility, drawn source of the problem, and security costs and other factors limit its use in the clinic. 因此设计力学强度优良,模拟肩袖组织、生物相容性好的肩袖补片对于治疗肩袖损伤有重要的临床应用价值。 So excellent mechanical strength design, simulation rotator cuff tissue, biocompatibility good rotator cuff patch has important clinical value in the treatment of rotator cuff injury.

发明内容 SUMMARY

[0006] 针对现有技术中的缺陷,本发明的目的是提供一种分段式纳米涂层修饰的人工肩袖补片。 [0006] For the prior art drawbacks, an object of the present invention is to provide a segmented modified nano-coating artificial rotator cuff patch.

[0007] 根据本发明提供的一种分段式纳米涂层修饰的人工肩袖补片,包括:肱骨编织段 [0007] According to one segmented nano-coating of the present invention provides a modified artificial rotator cuff patch, comprising: a woven segments humerus

1、肌腱自由纤维段2; 1, the tendon segment 2 consisting of fibers;

[0008] 肱骨编织段I的上部设置有骨端孔3,骨端孔3贯穿肱骨编织段I的内表面、外表面; [0008] The upper portion of the knitting section I humerus bone ends is provided with a hole 3, 3 through the bone hole inner surface of the end of the knitting section I of the humerus, the outer surface;

[0009] 肱骨编织段I的下端连接肌腱自由纤维段2的上端; [0009] the lower end I humeral woven segments connecting the upper end of the tendon section 2 consisting of fibers;

[0010] 肌腱自由纤维段2的下部设置有腱端孔4,腱端孔4贯穿肌腱自由纤维段2的内表面、外表面; [0010] Tendon fiber section consisting of the lower portion 2 is provided with an end hole 4 tendons, tendon end hole 4 through the inner surface 2, outer surface of the fiber section consisting of the tendon;

[0011] 肱骨编织段I的上端设置有牵引拉环900;肌腱自由纤维段2的下端设置有牵引拉环900; [0011] The upper section I is knit disposed humerus traction pull ring 900; consisting of lower tendon fiber section 2 is provided with a pulling tab 900;

[0012] 肱骨编织段I与肌腱自由纤维段2所构成的整体为矩形或者圆角矩形形状。 Whole is rectangular or rounded rectangular shape [0012] I and the free segment of the humerus woven fiber section composed of two tendon.

[0013] 优选地,骨端孔3系有牵引线A,腱端孔4系有牵引线B。 [0013] Preferably, the end of the bone hole 3 is tied with pull wire A, tendon end tied with pull wire holes 4 B.

[0014] 优选地,肱骨编织段I采用纤维编织而成的网状结构。 [0014] Preferably, the fibers employed humerus segments I weave woven mesh structure.

[0015] 优选地,骨端孔3和腱端孔4采用如下任一种方式: [0015] Preferably, the end of the bone bore hole 3 and the terminal 4 as follows tendon any way:

[0016]-骨端孔3为螺钉孔,腱端孔4为穿针孔; [0016] - end of the bone screw holes of the hole 3, 4 for the tendon end hole through the pinhole;

[0017]-骨端孔3为带线锚钉孔,腱端孔4为穿针孔; [0017] - bone bore 3 is an end strip line anchor hole through the tendon end of the pinhole aperture 4;

[0018]-骨端孔3为穿针孔,腱端孔4为穿针孔。 [0018] - end of the bone hole 3 through the pinhole, tendon end of bore 4 through the pinhole.

[0019] 优选地,肱骨编织段I的上部表面或全部表面设置有涂层I,肌腱自由纤维段2的下部表面或全部表面设置有涂层II,在肱骨编织段I与肌腱自由纤维段2的连接处涂覆有涂层III; [0019] Preferably, the upper surface or the entire surface of the humeral woven segments is provided with a coating I I, a lower surface, or the entire surface of the tendon free fibers 2 is provided with a coating section II, I and humerus woven segments consisting of fiber segments tendon 2 coated with a coating junction III;

[0020] 进一步地,具体为: [0020] Further, in particular:

[0021]-所述涂层III是由涂层I的材料与涂层II的材料所构成的复合涂层; [0021] - the coating is a composite coating of a material III I coating the coating material consisting of a II;

[0022]-与涂层I和/或涂层II相比,所述涂层III含有不同的成骨生长因子、成骨生长药物、成肌生长因子或者成肌生长药物; [0022] - the coating I and / or II as compared to a coating, the coating III contain various osteogenic growth factors, osteogenic growth drugs, growth factors myoblasts into muscle growth or drugs;

[0023]-所述涂层1、涂层I1、涂层III均为纳米涂层。 [0023] - the coating 1, coating I1, III are coated nano-coating.

[0024] 优选地,所述肱骨编织段I的下端连接所述肌腱自由纤维段2的上端所形成的接合界线D呈锯齿状。 [0024] Preferably, the lower end of the humerus braided section I is connected to the upper end of the tendon fiber section consisting of the two joining line D formed serrated.

[0025] 优选地,所述肱骨编织段I与肌腱自由纤维段2的连接处,是指:由肱骨编织段1、肌腱自由纤维段2所构成的整体在高度方向上包含有所述接合界线D的一段。 [0025] Preferably, said knitting section I humeral joint and the free tendon fiber section 2 refers to: woven segments humeral whole by 1, the tendon free fiber segment 2 is comprised in the height direction of the line joining paragraph D of.

[0026] 优选地,还包括:自展开支架A501、自展开支架B502、自展开支架C601、自展开支架D602; [0026] Preferably, further comprising: a self-expanding stent A501, B502 self-expanding stents, self-expanding stents C601, D602 self-expanding stent;

[0027] 肱骨编织段I设置有通孔A7; [0027] I humerus woven segments is provided with a through hole the A7;

[0028]自展开支架A501与自展开支架B502交叉设置,且均穿过通孔A7; [0028] The self-expanding stents and self-expanding stent A501 B502 crossover settings, and both the A7 through the through holes;

[0029]自展开支架A501、自展开支架B502的上端均紧固连接于肱骨编织段I的外表面; [0029] The self-expanding stent A501, B502 self-expanding stents are an upper end fastened to the outer surface of the humeral woven segments I;

[0030]自展开支架A501、自展开支架B502的下端均紧固连接于肱骨编织段I的内表面; [0030] The self-expanding stent A501, B502 self-expanding stents are lower end fastened to the inner surface of the humeral woven segments I;

[0031] 肌腱自由纤维段2设置有通孔B8; [0031] 2 fiber section consisting of the tendon is provided with a through hole B8;

[0032]自展开支架C601与自展开支架D602交叉设置,且均穿过通孔B8; [0032] The self-expanding stents and self-expanding stent D602 C601 crossover settings, and both B8 through the through holes;

[0033]自展开支架C601、自展开支架D602的下端均紧固连接于肌腱自由纤维段2的外表面;自展开支架C601、自展开支架D602的上端均紧固连接于肌腱自由纤维段2的内表面。 [0033] The self-expanding stent C601, D602 self-expanding stent lower end are fastened to the outer surface of the tendon fiber section consisting of 2; self-expanding stent C601, D602 self-expanding stents are an upper end fastened to the tendon fibers consisting section 2 The inner surface.

[0034] 优选地,自展开支架A501、自展开支架B502、自展开支架C601、自展开支架D602均为采用记忆合金制成的长条形片状结构或者杆状结构; [0034] Preferably, A501 self-expanding stents, self-expanding stents B502, C601 self-expanding stents, self-expanding stents are employed D602 elongated rod-like structure or a sheet-like structure made of a memory alloy;

[0035]自展开支架A501、自展开支架B502的具体结构均为:除了上端与下端之外,其余部分与肱骨编织段I的表面相分离; [0035] A501 self-expanding stents, self-expanding stent structure B502 are specifically: in addition upper and lower ends, and the remaining surface portion of the knitting section I humeral phase separation;

[0036]自展开支架C601、自展开支架D602的具体结构均为:除了上端与下端之外,其余部分与肌腱自由纤维段2的表面相分离。 [0036] C601 self-expanding stents, self-expanding stent D602 specific configuration are: in addition to upper and lower ends, and the free surface of the rest of the fiber segments 2 separated tendon.

[0037] 优选地,还包括:外保护层901、内保护层902; [0037] Preferably, further comprising: an outer protective layer 901, the protective layer 902;

[0038] 外保护层901、内保护层902均由一编织片1001和一自由纤维片1002构成; [0038] The outer protective layer 901, the protective layer 902 by a woven sheet consisting of a fibrous sheet 1001 and 1002 configured;

[0039]外保护层901的编织片1001覆盖住肱骨编织段I的外表面,且位于自展开支架A501、自展开支架B502的外侧; [0039] The outer protective layer 901 is woven around the outer surface of the cover sheet 1001 humeral braided section I, and self-expanding stent located A501, B502 of the self-expanding outer stent;

[0040]外保护层901的自由纤维片1002覆盖住肌腱自由纤维段2的外表面,且位于自展开支架C601、自展开支架D602的外侧; [0040] The outer protective layer 901 free fiber sheet 1002 covers the outer surface of the tendon segment 2 consisting of fibers, and the self-expanding stent located C601, D602 of self-expanding outer stent;

[0041]内保护层902的编织片1001覆盖住肱骨编织段I的内表面,其位于自展开支架A501、自展开支架B502的内侧; The protective layer 902 [0041] 1001 the woven sheet covering the inner surface of the humeral knitting section I, which is self-expanding stent located A501, B502 of the self-expanding inner stent;

[0042]内保护层902的自由纤维片1002覆盖住肌腱自由纤维段2的内表面,且位于自展开支架C601、自展开支架D602的内侧。 [0042] The inner protective layer 902 consisting of fibrous sheet 1002 covers an inner surface of the tendon segment 2 consisting of fibers, and the self-expanding stent located C601, D602 of self-expanding inner stent.

[0043]与现有技术相比,本发明具有如下的有益效果: [0043] Compared with the prior art, the present invention has the following advantages:

[0044] 本发明所设计的纳米涂层修饰的肩袖补片可提高肩袖损伤修补术后肩袖组织的力学性能,同时在生物性能方面可模拟肩袖与骨连接的腱骨愈合组织特性,该结构可增强肌腱内在的愈合潜能,进而提高肩袖损伤修复手术的成功率。 [0044] The present invention is designed rotator cuff modified nano-coating may improve the mechanical properties patch rotator cuff injury rotator cuff repair tissues after surgery, while in terms of biological properties can be simulated rotator cuff tendon-bone healing and bone connecting tissue properties the internal structure can enhance tendon healing potential, thus improving the success rate of surgery to repair a rotator cuff injury.

附图说明 BRIEF DESCRIPTION

[0045] 通过阅读参照以下附图对非限制性实施例所作的详细描述,本发明的其它特征、目的和优点将会变得更明显: [0045] By reading the following detailed description of non-limiting embodiments given with reference to the following figures, other features of the present invention, objects and advantages will become more apparent:

[0046]图1示出本发明第一实施例的结构示意图。 [0046] Figure 1 shows a schematic structural view of a first embodiment of the present invention.

[0047]图2、图3示出本发明第一实施例的优选例的结构示意图。 [0047] FIG. 2, FIG. 3 shows a structural diagram of a preferred embodiment according to the first embodiment of the present invention.

[0048]图4示出本发明第一实施例的优选例的收拢及展开的原理示意图。 [0048] Figure 4 shows a schematic principle retracted according to the first preferred embodiment and the embodiment of the present invention is deployed.

[0049]图5示出本发明第一实施例的变化例的结构示意图。 [0049] FIG. 5 shows a structural diagram of a first embodiment variant of the embodiment of the present invention.

[0050]图中:D表示接合界线,E表示由肱骨编织段1、肌腱自由纤维段2所构成的整体在高度方向上包含有所述接合界线D的一段。 [0050] FIG: D represents a boundary engagement, E represents a 1, consisting of the entire tendon fiber section 2 is comprised of the engagement section has a D line in the height direction from the humeral woven segments.

具体实施方式 Detailed ways

[0051]下面结合具体实施例对本发明进行详细说明。 Specific embodiments of the present invention will be described in detail [0051] below in conjunction. 以下实施例将有助于本领域的技术人员进一步理解本发明,但不以任何形式限制本发明。 The following examples will assist those skilled in the art a further understanding of the invention, but do not limit the present invention in any way. 应当指出的是,对本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变化和改进。 It should be noted that one of ordinary skill in the art, without departing from the spirit of the present invention, can make various changes and modifications. 这些都属于本发明的保护范围。 All these fall within the scope of the present invention.

[0052]如图1所示,根据本发明提供的一种分段式纳米涂层修饰的人工肩袖补片,包括:肱骨编织段1、肌腱自由纤维段2; [0052] 1, according to one segmented nano-coating of the present invention provides a modified artificial rotator cuff patch, comprising: a woven segments humerus, tendon segment 2 consisting of fibers;

[0053] 肱骨编织段I的上部设置有骨端孔3,骨端孔3贯穿肱骨编织段I的内表面、外表面; [0053] The upper portion of the knitting section I humerus bone ends is provided with a hole 3, 3 through the bone hole inner surface of the end of the knitting section I of the humerus, the outer surface;

[0054] 肱骨编织段I的下端连接肌腱自由纤维段2的上端; [0054] the lower end I humeral woven segments connecting the upper end of the tendon section 2 consisting of fibers;

[0055] 肌腱自由纤维段2的下部设置有腱端孔4,腱端孔4贯穿肌腱自由纤维段2的内表面、外表面。 [0055] Tendon fiber section consisting of a lower portion 2 is provided with an end hole 4 tendons, tendon end hole 4 through the inner surface 2, outer surface of the fiber section consisting of the tendon.

[0056] 肱骨编织段I的上端设置有牵引拉环900;肌腱自由纤维段2的下端设置有牵引拉环900;这样,在定位和展开时可以利用器械在上下方向上牵引拉拽肱骨编织段I和肌腱自由纤维段2。 [0056] an upper end disposed humerus knitting section I of traction pull ring 900; the lower end of the tendon free fiber section 2 is provided with a pulling tab 900; Thus, during positioning and deployment can be utilized instrument traction pull humeral woven segments in the vertical direction I freely and tendon fiber segment 2.

[0057] 肱骨编织段I与肌腱自由纤维段2所构成的整体为矩形或者圆角矩形形状。 Whole is rectangular or rounded rectangular shape [0057] I and the free segment of the humerus woven fiber section composed of two tendon.

[0058] 优选地,骨端孔3系有牵引线A,腱端孔4系有牵引线B。 [0058] Preferably, the end of the bone hole 3 is tied with pull wire A, tendon end tied with pull wire holes 4 B.

[0059] 优选地,肱骨编织段I采用纤维编织而成的网状结构。 [0059] Preferably, the fibers employed humerus segments I weave woven mesh structure. 例如,肱骨编织段I的编织材料可采用PET、超高分子量聚乙烯、尼龙材料构成。 For example, the humeral segment I weave woven material can be PET, ultrahigh molecular weight polyethylene, nylon material.

[0060] 优选地,骨端孔3为螺钉孔,腱端孔4为穿针孔。 [0060] Preferably, the bone screw hole of the end holes 3, 4 as a through hole tendon end pinholes. 在变化例中,骨端孔3可以为带线锚钉孔或者穿针孔。 In variations, the ends of the bones through a pinhole aperture 3 may be a belt or a wire anchor hole.

[0061] 优选地,肱骨编织段I的上部表面或全部表面设置有涂层I,肌腱自由纤维段2的下部表面或全部表面设置有涂层II,在肱骨编织段I与肌腱自由纤维段2的连接处涂覆有涂层III; [0061] Preferably, the upper surface or the entire surface of the humeral woven segments is provided with a coating I I, a lower surface, or the entire surface of the tendon free fibers 2 is provided with a coating section II, I and humerus woven segments consisting of fiber segments tendon 2 coated with a coating junction III;

[0062] 进一步地,具体为: [0062] Further, in particular:

[0063]-所述涂层III是由涂层I的材料与涂层II的材料所构成的复合涂层,其中,优选地,所述复合涂层中,涂层I的材料与涂层II的材料的比例为1:1; [0063] - the coating of composite III is a coating material coating the coating material I, II composed, wherein, preferably, the composite coating layer, the coating material to the coating I II the proportion of material is 1: 1;

[0064]-与涂层I和/或涂层II相比,所述涂层III含有不同的成骨生长因子、成骨生长药物、成肌生长因子或者成肌生长药物; [0064] - the coating I and / or II as compared to a coating, the coating III contain various osteogenic growth factors, osteogenic growth drugs, growth factors myoblasts into muscle growth or drugs;

[0065]-所述涂层1、涂层I1、涂层III均为纳米涂层。 [0065] - the coating 1, coating I1, III are coated nano-coating.

[0066] 其中,涂层I可以是由如下任一种材料构成的材料或者由如下任多种材料构成的复合材料:胶原、明胶、壳聚糖、透明质酸、丝蛋白、聚乙二醇(PEG),聚乳酸(PLA)等等。 [0066] wherein the coating material I may be formed of any of the following materials or a composite material composed of a plurality of any of the following materials: collagen, gelatin, chitosan, hyaluronic acid, silk protein, polyethylene glycol (PEG), polylactic acid (PLA) and the like. 涂层I可以是纳米银、纳米钛、纳米氧化铝、纳米三磷酸钙(TCP)、纳米磷酸钙、碳酸钠钙颗粒等。 I may be a nano-silver coating, nano titanium, nano alumina, nano-tricalcium phosphate (TCP), nano-calcium phosphate, calcium carbonate particles and the like. 在涂层I中可以加入成骨的生长因子,如:BMP-2、BMP-7、BMP-9;TGF-βI (转化生长因子βI)等等。 I may be added in the coating osteogenic growth factors, such as: BMP-2, BMP-7, BMP-9; TGF-βI (TGF BETA I) and the like.

[0067] 涂层11可以是由如下任一种材料构成的材料或者由如下任多种材料构成的复合材料:壳聚糖、葡聚糖、聚乳酸、透明质酸、聚乙烯醇(PVA)、等等。 [0067] The coating material 11 may be composed of any of the following materials or a composite material made of any of a variety of materials as follows: chitosan, dextran, polylactic acid, hyaluronic acid, polyvinyl alcohol (PVA) ,and many more. 在涂层II中可以加入血红蛋白等成肌,加入生长因子或者药物,如VEGF (血管内皮生长因子)、转化生长因子_β等等。 II can be added in the coating hemoglobin myoblasts added growth factors or drugs, such as VEGF (vascular endothelial growth factor), transforming growth factor _β like.

[0068]如图2所示,作为图1的优选的技术方案,根据本发明提供的一种分段式纳米涂层修饰的人工肩袖补片还包括:自展开支架Α501、自展开支架Β502、自展开支架C601、自展开支架D602; [0068] 2, as a preferred aspect of FIG. 1, according to one segmented nano-coating of the present invention provides a modified patch of artificial rotator cuff further comprising: a self-expanding stent Α501, self-expanding stents Β502 , self-expanding stents C601, self-expanding stents D602;

[0069] 肱骨编织段I设置有通孔Α7; [0069] humerus woven segments I [alpha] 7 is provided with a through hole;

[0070]自展开支架Α501与自展开支架Β502交叉设置,且均穿过通孔Α7; [0070] The self-expanding stents and self-expanding stent Β502 Α501 crossover settings, and both [alpha] 7 through the through-hole;

[0071]自展开支架Α501、自展开支架Β502的上端均紧固连接于肱骨编织段I的外表面; [0071] The self-expanding stent Α501, self-expanding stents Β502 upper end are fastened to the outer surface of the humeral woven segments I;

[0072]自展开支架Α501、自展开支架Β502的下端均紧固连接于肱骨编织段I的内表面; [0072] The self-expanding stent Α501, self-expanding stents Β502 lower end are fastened to the inner surface of the humeral woven segments I;

[0073] 肌腱自由纤维段2设置有通孔Β8; [0073] 2 fiber section consisting of the tendon is provided with a through hole Β8;

[0074]自展开支架C601与自展开支架D602交叉设置,且均穿过通孔Β8; [0074] The self-expanding stents and self-expanding stent D602 C601 crossover settings, and are passed through the through hole Β8;

[0075]自展开支架C601、自展开支架D602的下端均紧固连接于肌腱自由纤维段2的外表面;自展开支架C601、自展开支架D602的上端均紧固连接于肌腱自由纤维段2的内表面。 [0075] The self-expanding stent C601, D602 self-expanding stent lower end are fastened to the outer surface of the tendon fiber section consisting of 2; self-expanding stent C601, D602 self-expanding stents are an upper end fastened to the tendon fibers consisting section 2 The inner surface.

[0076] 优选地,自展开支架Α501、自展开支架Β502、自展开支架C601、自展开支架D602均为采用记忆合金制成的长条形片状结构或者杆状结构; [0076] Preferably, the self-expanding stent Α501, self-expanding stents Β502, C601 self-expanding stents, self-expanding stents are employed D602 elongated rod-like structure or a sheet-like structure made of a memory alloy;

[0077]自展开支架Α501、自展开支架Β502的具体结构均为:除了上端与下端之外,其余部分与肱骨编织段I的表面相分离; [0077] The self-expanding stent Α501, self-expanding stent Β502 specific configuration are: In addition to the upper and lower ends, and the remaining surface portion of the knitting section I humeral phase separation;

[0078]自展开支架C601、自展开支架D602的具体结构均为:除了上端与下端之外,其余部分与肌腱自由纤维段2的表面相分离。 [0078] C601 self-expanding stents, self-expanding stent D602 specific configuration are: in addition to upper and lower ends, and the free surface of the rest of the fiber segments 2 separated tendon.

[0079] 如图4所示,通过自展开支架A501、自展开支架B502、自展开支架C601、自展开支架D602,所述分段式纳米涂层修饰的人工肩袖补片可以在收拢状态与展开状态之间转换。 [0079] As shown in FIG. 4, the self-expanding stent A501, B502 self-expanding stents, self-expanding stents C601, D602 self-expanding stent, the segmented modified nano-coating artificial rotator cuff patch may be folded state conversion between the expanded state. 请参见图4中朝向纸面右边的箭头,所述分段式纳米涂层修饰的人工肩袖补片从完全展开状态(即自然状态)被逐渐压缩高度,然后沿宽度方向对分段式纳米涂层修饰的人工肩袖补片进行卷曲,使得所述分段式纳米涂层修饰的人工肩袖补片能够被塞入导管,以沿导管送往病灶处,当到达病灶处后,通过由记忆合金制成的自展开支架A501、自展开支架B502、自展开支架C601、自展开支架D602从卷取状态自展开,然后由医者拉拽使所述分段式纳米涂层修饰的人工肩袖补片的高度变大直到完全展开状态。 See Figure 4 arrows toward the right in the drawing, the segmented modified nano-coating artificial patch rotator cuff height is gradually compressed from a fully expanded state (i.e., state of nature), then the width direction of the segmented nano coating the modified artificial rotator cuff patch crimped, such that the segmented modified nano-coating artificial rotator cuff patch can be inserted into the catheter, the catheter taken along lesions, lesions after reaching, by the self-expanding stents made of memory alloy A501, B502 self-expanding stents, self-expanding stents C601, D602 self-expanding stent from the winding state of the self-expanding, then the doctor pulls the segmented modified nano-coating artificial rotator cuff patch height is increased until fully deployed state.

[0080]如图3所示,优选地,所述分段式纳米涂层修饰的人工肩袖补片能够被塞入导管还包括:外保护层901、内保护层902; [0080] 3, preferably, the segmented modified nano-coating artificial rotator cuff patch can be inserted into the catheter further comprising: an outer protective layer 901, the protective layer 902;

[0081] 外保护层901、内保护层902均由一编织片1001和一自由纤维片1002构成; [0081] The outer protective layer 901, the protective layer 902 by a woven sheet consisting of a fibrous sheet 1001 and 1002 configured;

[0082]外保护层901的编织片1001覆盖住肱骨编织段I的外表面,且位于自展开支架A501、自展开支架B502的外侧; [0082] The outer protective layer 901 is woven around the outer surface of the cover sheet 1001 humeral braided section I, and self-expanding stent located A501, B502 of the self-expanding outer stent;

[0083]外保护层901的自由纤维片1002覆盖住肌腱自由纤维段2的外表面,且位于自展开支架C601、自展开支架D602的外侧; [0083] The outer protective layer 901 free fiber sheet 1002 covers the outer surface of the tendon segment 2 consisting of fibers, and the self-expanding stent located C601, D602 of self-expanding outer stent;

[0084]内保护层902的编织片1001覆盖住肱骨编织段I的内表面,其位于自展开支架A501、自展开支架B502的内侧; The protective layer 902 [0084] 1001 the woven sheet covering the inner surface of the humeral knitting section I, which is self-expanding stent located A501, B502 of the self-expanding inner stent;

[0085]内保护层902的自由纤维片1002覆盖住肌腱自由纤维段2的内表面,且位于自展开支架C601、自展开支架D602的内侧。 [0085] The inner protective layer 902 consisting of fibrous sheet 1002 covers an inner surface of the tendon segment 2 consisting of fibers, and the self-expanding stent located C601, D602 of self-expanding inner stent.

[0086]如图5所示,在图1所示实施例的变化例中所述肱骨编织段I的下端连接所述肌腱自由纤维段2的上端所形成的接合界线D呈锯齿状。 [0086] As shown in FIG 5, in a variation of the embodiment shown in FIG. 1 in the humerus braided section I is connected to the upper end of the tendon fiber section consisting of the two joining line D formed serrated. 肱骨编织段I的下端边缘呈锯齿状,肌腱自由纤维段2的上端边缘呈与肱骨编织段I的下端边缘相匹配的锯齿状。 Lower end edge of the humeral woven zigzag section I, the tendon fiber section consisting of the upper end edge 2 and the lower end edge of the humerus was woven segments I match the serrated.

[0087] 优选地,所述肱骨编织段I与肌腱自由纤维段2的连接处,是指:由肱骨编织段1、肌腱自由纤维段2所构成的整体在高度方向上包含有所述接合界线D的一段。 [0087] Preferably, said knitting section I humeral joint and the free tendon fiber section 2 refers to: woven segments humeral whole by 1, the tendon free fiber segment 2 is comprised in the height direction of the line joining paragraph D of.

[0088]以上对本发明的具体实施例进行了描述。 [0088] The foregoing specific embodiments of the invention have been described. 需要理解的是,本发明并不局限于上述特定实施方式,本领域技术人员可以在权利要求的范围内做出各种变化或修改,这并不影响本发明的实质内容。 Is to be understood that the present invention is not limited to the particular embodiments, those skilled in the art that various changes or modifications may be made within the scope of the appended claims, this does not affect the substance of the present invention. 在不冲突的情况下,本申请的实施例和实施例中的特征可以任意相互组合。 In case of no conflict, the embodiments of the present application features and embodiments may be arbitrarily combined with one another.

Claims (9)

1.一种分段式纳米涂层修饰的人工肩袖补片,其特征在于,包括:肱骨编织段(I)、肌腱自由纤维段(2); 肱骨编织段(I)的上部设置有骨端孔⑶,骨端孔(3)贯穿肱骨编织段(I)的内表面、夕卜表面; 肱骨编织段⑴的下端连接肌腱自由纤维段⑵的上端; 肌腱自由纤维段⑵的下部设置有腱端孔⑷,腱端孔⑷贯穿肌腱自由纤维段⑵的内表面、外表面; 肱骨编织段(I)的上端设置有牵引拉环(900);肌腱自由纤维段(2)的下端设置有牵引拉环(900); 肱骨编织段⑴与肌腱自由纤维段⑵所构成的整体为矩形或者圆角矩形形状; 还包括:自展开支架A (501)、自展开支架B (502)、自展开支架C (601)、自展开支架D(602); 肱骨编织段⑴设置有通孔A⑵; 自展开支架A (501)与自展开支架B (502)交叉设置,且均穿过通孔A⑵; 自展开支架A (501)、自展开支架B (502)的上端均紧固连接于肱骨编织段(I)的外 A segmented modified nano-coating artificial patch rotator cuff, characterized by, comprising: a woven segments humerus (I), consisting of the tendon fiber section (2); knit upper humeral segment (I) is provided with a bone end hole ⑶, bone end hole (3) penetrating the inner surface of the humeral knitting section (I), and Xi Bu surface; lower woven segments ⑴ humeral connecting the upper end section ⑵ tendon free fibers; lower section ⑵ tendon free fibers provided with a tendon end hole ⑷, tendon end hole ⑷ through the inner surface of the tendon section ⑵ free fiber, an outer surface; humerus knitting section (I) is provided with a pulling tab (900); the lower end of the tendon free fiber section (2) is provided with a traction tab (900); humeral integrally woven segments ⑴ ⑵ fiber section consisting of the tendon composed of a rectangular shape or a rounded rectangle; further comprising: a self-expanding stent a (501), a self-expanding stent B (502), a self-expanding stent C (601), a self-expanding stent D (602); ⑴ humeral woven segments is provided with a through hole A⑵; self-expanding stent A (501) and a self-expanding stent B (502) disposed intersecting, through the through holes and both A⑵; from the upper end of deployment of the stent a (501), a self-expanding stent B (502) are fastened to the humerus knitting section (I) of the outer 面;自展开支架A (501)、自展开支架B (502)的下端均紧固连接于肱骨编织段(I)的内表面;肌腱自由纤维段⑵设置有通孔B⑶; 自展开支架C (601)与自展开支架D (602)交叉设置,且均穿过通孔B⑶; 自展开支架C (601)、自展开支架D (602)的下端均紧固连接于肌腱自由纤维段(2)的外表面;自展开支架C (601)、自展开支架D (602)的上端均紧固连接于肌腱自由纤维段(2)的内表面。 Surface; self-expanding stent A (501), the lower end of a self-expanding stent B (502) are fastened to the inner surface of the humeral knitting section (I); a fiber section consisting of the tendon is provided with a through hole ⑵ B⑶; self-expanding stent C ( 601) and a self-expanding stent D (602) disposed intersecting, through the through holes and both B⑶; C self-expanding stent (601), the lower end of a self-expanding stent D (602) are fastened to a fiber section consisting of the tendon (2) an outer surface; self-expanding stent C (601), the upper end of a self-expanding stent D (602) are fastened to the inner surface of the fiber section consisting of the tendon (2).
2.根据权利要求1所述的分段式纳米涂层修饰的人工肩袖补片,其特征在于,骨端孔(3)系有牵引线A,腱端孔(4)系有牵引线B。 The segmented modified nano-coating of claim 1 artificial rotator cuff patch as claimed in claim, characterized in that the end of the bone hole (3) has a pull wire lines A, tendon end hole (4) tied with pull wire B .
3.根据权利要求1所述的分段式纳米涂层修饰的人工肩袖补片,其特征在于,肱骨编织段(I)采用纤维编织而成的网状结构。 The segmented according to a modified nano-coating artificial rotator cuff patch as claimed in claim, characterized in that the woven segments humerus (I) using woven fiber mesh structure.
4.根据权利要求1所述的分段式纳米涂层修饰的人工肩袖补片,其特征在于,骨端孔⑶和腱端孔⑷采用如下任一种方式: -骨端孔⑶为螺钉孔,腱端孔⑷为穿针孔; -骨端孔⑶为带线锚钉孔,腱端孔⑷为穿针孔; -骨端孔⑶为穿针孔,腱端孔⑷为穿针孔。 The segmented modified nano-coating of claim 1 artificial rotator cuff patch as claimed in claim, characterized in that the ends of the bones and tendons end bore hole ⑶ ⑷ using any of the following ways: - bone ends is a screw hole ⑶ hole through the tendon end of the pinhole aperture ⑷; - end of the bone hole as a strip line ⑶ anchor hole through the tendon end of the pinhole aperture ⑷; - end of the bone hole as a through-pinhole ⑶, tendon end is through a pinhole aperture ⑷ .
5.根据权利要求1所述的分段式纳米涂层修饰的人工肩袖补片,其特征在于,肱骨编织段(I)的上部表面或全部表面设置有涂层I,肌腱自由纤维段(2)的下部表面或全部表面设置有涂层II,在肱骨编织段(I)与肌腱自由纤维段(2)的连接处涂覆有涂层III; 进一步地,具体为: -所述涂层III是由涂层I的材料与涂层II的材料所构成的复合涂层; -与涂层I和/或涂层II相比,所述涂层III含有不同的成骨生长因子、成骨生长药物、成肌生长因子或者成肌生长药物; -所述涂层1、涂层I1、涂层III均为纳米涂层。 The segmented modified nano-coating of claim 1 artificial rotator cuff patch as claimed in claim, characterized in that the upper surface or the entire surface of the humeral knitting section (I) is provided with a coating I, free tendon fiber segments ( 2) the entire surface or a lower surface provided with a coating II, coated woven segments connecting the humerus (I) and the free fiber section (2) of the coated tendon III; further, in particular: - the coating III is a composite coating of a material coated with the coating material I, II, consisting of; - I as compared with coating and / or coatings II, III said coating containing different osteogenic growth factor, osteogenesis growth drugs, growth factors or myoblasts into muscle growth drugs; - the coating 1, coating I1, III are coated nano-coating.
6.根据权利要求1或5所述的分段式纳米涂层修饰的人工肩袖补片,其特征在于,所述肱骨编织段(I)的下端连接所述肌腱自由纤维段(2)的上端所形成的接合界线呈锯齿状。 The segmented nanocoating 1 or 5, wherein the modified artificial rotator cuff patch as claimed in claim, characterized in that the lower end of the humerus braided section (I) is connected to the fiber section consisting of the tendon (2) engaging an upper edge line is formed in a zigzag.
7.根据权利要求6所述的分段式纳米涂层修饰的人工肩袖补片,其特征在于,所述肱骨编织段⑴与肌腱自由纤维段⑵的连接处,是指:由肱骨编织段⑴、肌腱自由纤维段⑵所构成的整体在高度方向上包含有所述接合界线的一段。 The segmented modified nano-coating 6 according to the rotator cuff artificial patch as claimed in claim wherein said braided section ⑴ humeral joint and tendon fiber segments consisting ⑵ refers to: a woven segments humeral overall ⑴, ⑵ tendon free fiber segment composed of the engagement with the boundary section in the height direction.
8.根据权利要求1所述的分段式纳米涂层修饰的人工肩袖补片,其特征在于,自展开支架A (501)、自展开支架B (502)、自展开支架C (601)、自展开支架D (602)均为采用记忆合金制成的长条形片状结构或者杆状结构; 自展开支架A (501)、自展开支架B (502)的具体结构均为:除了上端与下端之外,其余部分与肱骨编织段⑴的表面相分离; 自展开支架C (601)、自展开支架D (602)的具体结构均为:除了上端与下端之外,其余部分与肌腱自由纤维段⑵的表面相分离。 According to claim 1 nanocoating segmented modified artificial rotator cuff patch as claimed in claim wherein the self-expanding stent A (501), a self-expanding stent B (502), a self-expanding stent C (601) , self-expanding stents D (602) are employed elongated rod-like structure or a sheet-like structure made of memory alloy; specific configuration of the self-expanding stent a (501), a self-expanding stent B (502) are: in addition to the upper end and lower than, the rest of the surface of the humeral woven segments ⑴ phase; self-expanding stent C (601), a self-expanding stent D (602) are specific structures: in addition to upper and lower ends, with the rest consisting of tendon ⑵ surface section of the fiber phase separation.
9.根据权利要求8所述的分段式纳米涂层修饰的人工肩袖补片,其特征在于,还包括:外保护层(901)、内保护层(902);外保护层(901)、内保护层(902)均由一编织片(1001)和一自由纤维片(1002)构成; 外保护层(901)的编织片(1001)覆盖住肱骨编织段(I)的外表面,且位于自展开支架A(501)、自展开支架B (502)的外侧; 外保护层(901)的自由纤维片(1002)覆盖住肌腱自由纤维段(2)的外表面,且位于自展开支架C (601)、自展开支架D (602)的外侧; 内保护层(902)的编织片(1001)覆盖住肱骨编织段⑴的内表面,其位于自展开支架A(501)、自展开支架B (502)的内侧; 内保护层(902)的自由纤维片(1002)覆盖住肌腱自由纤维段(2)的内表面,且位于自展开支架C (601)、自展开支架D (602)的内侧。 The segmented modified nano-coating artificial rotator cuff patch according to claim 8, characterized in that, further comprising: an outer protective layer (901), the inner protective layer (902); an outer protective layer (901) , the inner protective layer (902) by a woven sheet (1001) and consisting of a fibrous sheet (1002) configured; outer protective layer (901) is woven sheet (1001) covers the outer surface of the humeral live braided section (I), and located self-expanding stent a (501), a self-expanding outer stent B (502); and an outer protective layer (901) consisting of fiber sheets (1002) cover (2) of the outer surface of live tendon free fiber section and located self-expanding stent the outer C (601), a self-expanding stent D (602); a inner protective layer (902) is woven sheet (1001) to cover the inner surface ⑴ humerus braided section, which is located self-expanding stent a (501), a self-expanding stent the inner side B (502); a inner protective layer (902) consisting of fiber sheets (1002) covers the inner surface of the living tendon free fiber section (2) and is located a self-expanding stent C (601), a self-expanding stent D (602) inside.
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