CN106901868B - A kind of upper joint capsule rebuilds reparation sticking patch and preparation method thereof - Google Patents
A kind of upper joint capsule rebuilds reparation sticking patch and preparation method thereof Download PDFInfo
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- CN106901868B CN106901868B CN201710101636.9A CN201710101636A CN106901868B CN 106901868 B CN106901868 B CN 106901868B CN 201710101636 A CN201710101636 A CN 201710101636A CN 106901868 B CN106901868 B CN 106901868B
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- Prior art keywords
- layer
- sticking patch
- biological tissue
- upper joint
- joint capsule
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
Abstract
The present invention discloses a kind of upper joint capsule reconstruction reparation sticking patch, including two layers of biological tissue's layer and one layer of fibrous layer, biological tissue's layer is identical with fibrous layer geomery, two layers of biological tissue layer is formed by a piece of biomembrane doubling, the fibrous layer is clipped between two layers of biological tissue's layer, and sticking patch forms the sandwich composite construction of biological tissue's layer/fibrous layer.The present invention can ensure that sticking patch has enough mechanical property and biocompatibility as the sticking patch for rebuilding the operation of upper joint capsule under arthroscope, the sandwich composite construction of biological tissue's layer/fibrous layer.Invention also discloses the preparation method of the sticking patch, and this method is simple to operate, meets operation requirement.
Description
Technical field
The present invention relates to medical patch fields, and in particular to a kind of upper joint capsule rebuilds reparation sticking patch and its preparation side
Method.
Background technology
Rotator cuff tear is common Shoulder joint, and incidence gradually increases with advancing age.Rotator cuff tear is
Cause shoulder arthralgia, mobility to reduce, the common cause of miopragia, accounts for about the 60% of shoulder lesion.Chronic regression type is huge
Big unrepairable rotator cuff tear is difficult to usually because tendon tissue regression is followed the string the problems such as muscular atrophy and fatty infiltration
It repairs completely.To through the invalid Patients with Rotator Cuff Injury After of expectant treatment and shoulder sleeve mass lesions patient, surgical operation is usually taken
Treatment repairing tearing tendon, to mitigate pain, and rebuilds function of joint.Previous solution be usually Sub acromial decompression at
Type and cleaning, partial repair, tendon of subscapularis muscle indexing, great circle Muscle transplant, supraspinatus tendon lift art, and triangle musculocutaneous flap is rebuild, the back of the body
Platysma indexing, pectoralis major indexing, tear portion tendon grafting or anti-shoulder displacement technique.However these methods are in clinical effectiveness
Display has more or less otherness, and all there is various postoperative complications, may be with infection, failure, fracture, nerve
The multiple risks such as vascular complication.
It is exactly pain caused by subacromial impingement, the muscle of shoulder joint that the maximum of the huge rotator cuff tear of unrepairable, which refers to disease,
Powerless, hand arm held upward is limited.Cause the missing for being stability above Glenohumeral joint the main reason for these, shoulder sleeve muscle (hilllock
Upper flesh) function lose.It is a kind of relatively new surgical technic that upper joint capsule is rebuild under arthroscope, and technique passes through implantation
Graft connects Scapula glenoid and major tubercle restores upper joint capsule structure to have the function that push humerus head, can restore shoulder joint
Top stability.Technique can be completed under mirror, and compared to anti-shoulder displacement technique, whole process risk is very small.And tendon
It is the weak spot in shoulder sleeve repair process, pulls in art and attempt the shoulder tissue sleeve that bulk tear being fixed on former attached before injury
A little more difficult, humerus head covering deficiency when needing to solve the problems, such as huge rotator cuff tear with shoulder sleeve structure enhancing sticking patch at this time,
The mechanical property for ensureing neoplasty back porch tissue sleeve, maintains the stability and function of shoulder joint.Currently used for being rebuild under arthroscope
The patching material of upper joint capsule uses self fascia late, has good biological attribute, will not cause the inflammatory reaction of body.But
The fascia late thickness of each patient is different, and there are larger differences for manufactured sticking patch mechanical property, and fascia late sticking patch can be slowly
There is creep to stretch, it is thinning elongated, to reduce the strength for pushing humerus head, make the humerus head for having pushed reset, it may
Occur humerus head after surgery to move up on a small quantity, reset the phenomenon that loss.
In view of drawbacks described above, creator of the present invention obtains by prolonged research and practice in one kind of the invention finally
Capsular ligament rebuilds reparation sticking patch and preparation method thereof.
Invention content
To solve above-mentioned technological deficiency, the technical solution adopted by the present invention is, provides a kind of upper joint capsule reconstruction reparation
With sticking patch, including two layers of biological tissue's layer and one layer of fibrous layer, biological tissue's layer is identical with fibrous layer geomery, described
Two layers of biological tissue's layer is formed by a piece of biomembrane doubling, and the fibrous layer is clipped between two layers of biological tissue's layer, and sticking patch is formed
The sandwich composite construction of biological tissue's layer/fibrous layer.
Preferably, the biomembrane is self fascia late.
Preferably, the fibrous layer is woven by polyester fiber.
Preferably, the polyester fiber is pet fiber, PTT Fiber
Or poly fiber.
Preferably, the fibrous layer has porous structure, pore size 250-350um.
Preferably, the sticking patch is rectangular, biological tissue's layer and fibrous layer are stitched together by fixed suture,
Per 0.5cm, for tool there are one stitch points, the sticking patch middle part, which has, at least connects two stitch points on four sides of the sticking patch.
Preferably, four sides of the sticking patch have compensation section, for connection of performing the operation, long side both sides uncompensation distance is 1-
1.5cm, broadside both sides uncompensation distance are 0.5-1cm.
Preferably, biological tissue's layer and the fiber layer thickness relationship meet formula：
Wherein, X is biological tissue's layer thickness, and Y is the fiber layer thickness, and thickness unit is mm.
A kind of upper joint capsule rebuilds the preparation method of reparation sticking patch, which is characterized in that includes the following steps successively：
Stp1：Tearing port size is measured, sticking patch length and width dimensions are calculated according to the tearing port size；
Stp2：Self fascia late size is determined by the patch size, self fascia late is removed by size requirement, by its table
Face is scabbled, and the repairing of four sides is rectangular, measures self fascia late thickness；
Stp3：Polyester fiber piece is cut out by size requirement, the polyester fiber piece thickness is thick according to the self fascia late
Degree is calculated；
Stp4：The self fascia late is folded to form upper layer and lower layer biological tissue layer, the polyester fiber piece is clipped in
Two layers of biological tissue's layer is intermediate to be used as fibrous layer；
Stp5：Four side seams of sticking patch are closed, per 0.5cm, there are one stitch points, middle part to have at least two stitch points for tool.
Preferably, the patch size, which is length, is more than tearing port 2-3cm, width is more than tearing port 1-2cm, and thickness is more than
Equal to 1cm；The self fascia late length is twice of the sticking patch length, and width is identical as the patch width；It is described poly-
Ester fiber piece length and width is identical as the sticking patch.
Compared with the prior art the beneficial effects of the present invention are：
1, the present invention can be used as under arthroscope rebuild upper joint capsule perform the operation sticking patch, biological tissue's layer/fibrous layer
Sandwich composite construction can ensure that sticking patch has enough mechanical property and biocompatibility.
2, there is the fibrous layer among sticking patch sufficient intensity to maintain shoulder joint reset, and can play the role of holder, prevent from mending
Piece creep, upper and lower both sides biological tissue layer cell proliferation and Osteoblast Differentiation have facilitation, histocyte can be along polyester fibre
Dimension growth, finally grows up to the upper joint lens capsule tissue of one layer of fully integratedization, restores the function that muscular strength maintains shoulder joint.Fibrous layer is more
Pore structure can interfere the formation hyperplasia of non-tendon or ligament within the organization, reduce the formation of internal cicatricial tissue.
3, the preparation that upper joint capsule rebuilds reparation sticking patch determines patch size according to tearing port, meets individual patients need
It asks, biological tissue's layer/fibrous layer multiple spot suture can prevent the opposite sliding of interlayer to be detached from.
4, by controlling the thickness of biological tissue's layer/fibrous layer, makes sticking patch that there is certain intensity and flexibility, ensure to mend
The consistency of piece mechanical property maintains the stability and function of shoulder joint.
Description of the drawings
It is required in being described below to embodiment in order to illustrate more clearly of the technical solution in various embodiments of the present invention
The attached drawing used is briefly described.
Fig. 1 is that the upper joint capsule of the present invention rebuilds the sectional view of reparation sticking patch；
Fig. 2 is that the upper joint capsule of the present invention rebuilds the front view of reparation sticking patch；
Fig. 3 is the structure chart of fibrous layer of the present invention；
Fig. 4 is the flow chart that upper joint capsule of the present invention rebuilds reparation sticking patch preparation method；
Fig. 5 is the datagram of self fascia late in experimental example of the present invention；
Fig. 6 is the datagram of sticking patch in experimental example of the present invention.
Specific implementation mode
Below in conjunction with attached drawing, the forgoing and additional technical features and advantages are described in more detail.
Embodiment 1
As shown in Figure 1, a kind of upper joint capsule rebuilds reparation sticking patch, including two layers of biological tissue's layer 1 and one layer of fibrous layer
2, two layers of biological tissue's layer 1 is formed by a piece of biomembrane doubling, and the fibrous layer 2 is clipped between two layers of biological tissue's layer 1, described
Biological tissue's layer 1 is identical with 2 geomery of fibrous layer, and sticking patch forms the sandwich composite construction of biological tissue's layer/fibrous layer.
In conjunction with shown in Fig. 2, the sticking patch is rectangular, and biological tissue's layer 1 and fibrous layer 2 are by fixing suture 3 by four
Side seam is combined, and per 0.5cm, tool is there are one stitch points, it is ensured that interlayer without departing from, and in the middle part of sticking patch tool there are two stitch points,
Prevent opposite slide.Patch size is more than tearing port, and there are compensation sections on four sides, for fixation of performing the operation.
The present invention can provide enough power as the sticking patch for rebuilding the operation of upper joint capsule under arthroscope, fibrous layer
Learn performance, prevent sticking patch creep stretch, it is thinning elongated, to avoid it is postoperative occur humerus head move up on a small quantity, resets loss show
As biological tissue's layer can provide biocompatibility, promote tissue cell growth, such biological tissue's layer/fibrous layer sandwich
Composite construction makes sticking patch while being provided with good biocompatibility and mechanical property.
Embodiment 2
A kind of upper joint capsule reconstruction reparation sticking patch, including two layers of biological tissue's 1 one layers of fibrous layer 2 of layer, two layers of biological group
Tissue layer 1 is formed by a piece of biomembrane doubling, and fibrous layer 2 is clipped between two layers of biological tissue's layer 1, the biological tissue 1 and fiber
2 geomery of layer are identical, are stitched together by fixed suture 3, and the sandwich that sticking patch forms biological tissue's layer/fibrous layer is multiple
Close structure.The biomembrane is self fascia late, autogenous cell can be promoted to grow.The fibrous layer 2 is by poly terephthalic acid
Glycol ester fibrage forms, which has good mechanical performance and biocompatibility.
In conjunction with shown in Fig. 3, there is the fibrous layer 2 porous structure, pore size 250um, porous structure can do
The formation hyperplasia of non-tendon or ligament within the organization is disturbed, the formation of internal cicatricial tissue is reduced, ensures that joint lens capsule tissue is normal
Growth.
The sticking patch is rectangular, four sides have compensation section, long side both sides uncompensation distance be 1cm, broadside both sides compensation away from
From for 0.5cm.Described repair is closed with four side seam of sticking patch, and per 0.5cm, there are one stitch points for tool, and there are two stitch points for middle part tool.Institute
It states sticking patch thickness and is more than or equal to 10cm, ensure that sticking patch has good mechanical property.
When upper joint capsule reconstruction operations by woven sticking patch by syringe be sent into shoulder joint chamber, by sticking patch inner end with
Mattress suture is fixed on Scapula glenoid upper limb, and sticking patch rear side end carries out side side seam conjunction with infraspinous muscle, and outboard end is quick with pre-knotted
Suture bridge technology is fixed on greater tubercles of humerus, completes sticking patch and fixes.Fibrous layer 2 among postoperative sticking patch plays the role of holder, tool
There is sufficient intensity to maintain shoulder joint reset, prevents sticking patch creep, upper and lower both sides biological tissue 1 cell proliferation of layer and Osteoblast Differentiation
There are facilitation, histocyte that can be grown along fibrous layer 2, finally grows up to the upper joint lens capsule tissue of one layer of fully integratedization, it is extensive
Multiple muscular strength maintains the function of shoulder joint.
Embodiment 3
A kind of upper joint capsule reconstruction reparation sticking patch, including two layers of biological tissue's layer and one layer of fibrous layer, two layers of biological group
Tissue layer is formed by a piece of self fascia late doubling, and fibrous layer is clipped between two layers of biological tissue's layer, the biological tissue and fiber
Layer geomery is identical, is stitched together by fixed suture, the sandwich that sticking patch forms biological tissue's layer/fibrous layer is compound
Structure.The sticking patch is rectangular, and it is 1.5cm, broadside both sides uncompensation distance that four sides, which have compensation section, long side both sides uncompensation distance,
For 1cm.Described repair is closed with four side seam of sticking patch, and per 0.5cm, there are one stitch points for tool, and there are four stitch points for middle part tool.The fibre
Dimension layer is woven by PTT Fiber, has porous structure, pore size 350um.
Biological tissue's layer and fiber layer thickness relationship meets formula：
Wherein, X is biological tissue's layer thickness, and Y is the fiber layer thickness, and thickness unit is mm.It is given birth to by controlling
The thickness of object organized layer/fibrous layer ensures the consistency of sticking patch mechanical property, maintains the stability and function of shoulder joint.
Embodiment 4
A kind of upper joint capsule reconstruction reparation sticking patch, including two layers of biological tissue's layer and one layer of fibrous layer, two layers of biological group
Tissue layer is formed by a piece of self fascia late doubling, and fibrous layer is clipped between two layers of biological tissue's layer, the biological tissue and fiber
Layer geomery is identical, is stitched together by fixed suture, the sandwich that sticking patch forms biological tissue's layer/fibrous layer is compound
Structure.The sticking patch is rectangular, and it is 1.2cm, broadside both sides uncompensation distance that four sides, which have compensation section, long side both sides uncompensation distance,
For 0.8cm.Described repair is closed with four side seam of sticking patch, and per 0.5cm, there are one stitch points for tool, and there are three stitch points for middle part tool.It is described
Fibrous layer is woven by poly fiber, has porous structure, pore size 300um.The life
The thickness of object organized layer is 4mm, and the thickness of the fibrous layer is 2mm.
Embodiment 5
As shown in figure 4, a kind of upper joint capsule rebuilds reparation sticking patch preparation method, include the following steps：
Stp1：Patch size confirms, measures tearing port size, and sticking patch length and width dimensions are calculated according to the tearing port size,
Patch size is that length is more than tearing port 2-3cm, and width is more than tearing port 1-2cm；
Stp2：Fascia late takes out processing, determines that self fascia late size, the self fascia late are long by the patch size
Degree is twice of sticking patch length, and width is identical as patch width, removes self fascia late by size requirement, its surface is scabbled,
The repairing of four sides is rectangular, measures self fascia late thickness；
Stp3：Polyester fiber piece being carried out by size requirement to cut out, the polyester fiber piece length and width is identical as the sticking patch,
Confirm polyester fiber piece thickness according to self fascia late thickness；
Stp4：Sandwich structure stacks, and the self fascia late is folded to form upper layer and lower layer biological tissue layer, will be described
Polyester fiber piece, which is clipped among two layers, is used as fibrous layer；
Stp5：Sticking patch suture is fixed, and four side seams of sticking patch are closed, and per 0.5cm, there are one stitch points, middle part to have at least for tool
Even two stitch points.
This sandwich composite construction sticking patch production method is simple, meets operation requirement, and the size of sticking patch is according to tearing
Breach determines, is suitble to individual needs of patients, biological tissue's layer/fibrous layer multiple spot suture that the opposite sliding of interlayer can be prevented de-
From.
Embodiment 6
This implementation place unlike the embodiments above is that biological tissue's layer and fiber layer thickness relationship meets formula：
Wherein, X is biological tissue's layer thickness, and Y is the fiber layer thickness, and thickness unit is mm.Polyester in Stp3
Fibre plate thickness can be calculated according to self fascia late thickness and formula, by the thickness for controlling biological tissue's layer/fibrous layer
Degree ensures the consistency of sticking patch mechanical property.
Experimental example
The self fascia late and sticking patch of same thickness are done into tension test respectively, measure its mechanical property.
As shown in Figure 5, Figure 6, it is respectively power-time, the force-displacement relationship figure of self fascia late and sticking patch.
Wherein L1 is the force-time curve of self fascia late, and L2 is the force-displacement curve of self fascia late, and L3 is sticking patch
Force-time curve, L4 be sticking patch force-displacement curve.
Following table is the parameter measured from Fig. 5, Fig. 6：
| Extrusion | Maximum weighted (kN) | It can restore deformational displacement (mm) | It can restore deformation time (s) |
| Fascia late | 0.87 | 7.4 | 88 |
| Sticking patch | 3.59 | 19.2 | 208 |
The maximum weighted of self fascia late is less than the maximum weighted of sticking patch known to chart；Sticking patch in the case of identical power
Displacement be less than self fascia late, and the maximum displacement of sticking patch is more than self fascia late, the i.e. tensile strength of sticking patch and can
Retractility is superior to self fascia late.
The foregoing is merely presently preferred embodiments of the present invention, is merely illustrative for the purpose of the present invention, and not restrictive
's.Those skilled in the art understand that in the spirit and scope defined by the claims in the present invention many changes can be carried out to it,
It changes or even equivalent, but falls in protection scope of the present invention.
Claims (7)
1. a kind of upper joint capsule rebuilds reparation sticking patch, which is characterized in that including two layers of biological tissue's layer and one layer of fibrous layer, institute
It is identical with fibrous layer geomery to state biological tissue's layer, two layers of biological tissue layer is formed by a piece of biomembrane doubling, described
Fibrous layer is clipped between two layers of biological tissue's layer, and sticking patch forms the sandwich composite construction of biological tissue's layer/fibrous layer, the life
Object organized layer and the fiber layer thickness relationship meet formula：
Wherein, X is biological tissue's layer thickness, and Y is the fiber layer thickness, and thickness unit is mm.
2. upper joint capsule as described in claim 1 rebuilds reparation sticking patch, which is characterized in that the biomembrane is self wealthy muscle
Film.
3. upper joint capsule as described in claim 1 rebuilds reparation sticking patch, which is characterized in that the fibrous layer is by polyester fiber
It weaves.
4. upper joint capsule as claimed in claim 3 rebuilds reparation sticking patch, which is characterized in that the polyester fiber is poly- to benzene
Naphthalate fiber, PTT Fiber or poly fiber.
5. upper joint capsule as claimed in claim 4 rebuilds reparation sticking patch, which is characterized in that the fibrous layer has porous knot
Structure, pore size 250-350um.
6. upper joint capsule according to any one of claims 1 to 5 rebuilds reparation sticking patch, which is characterized in that the sticking patch is at square
Shape, biological tissue's layer and fibrous layer are stitched together by fixed suture, and four sides of the sticking patch have one per 0.5cm
A stitch points, the sticking patch middle part, which has, at least connects two stitch points.
7. upper joint capsule as claimed in claim 6 rebuilds reparation sticking patch, which is characterized in that four sides of the sticking patch, which have, mends
Portion is repaid, for connection of performing the operation, long side both sides uncompensation distance is 1-1.5cm, and broadside both sides uncompensation distance is 0.5-1cm.
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| CN107789092B (en) * | 2017-10-23 | 2023-07-18 | 上海利格泰生物科技股份有限公司 | Partially absorbable composite patch for rotator cuff repair and method of manufacture |
| CN107837129A (en) * | 2017-12-16 | 2018-03-27 | 诺迈尔（苏州）医学科技有限公司 | Non-degradable class hernia paster biocompatibility improved method |
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| CN105125317A (en) * | 2015-09-17 | 2015-12-09 | 复旦大学附属华山医院 | Segmented nano coating modified artificial rotator cuff patch |
| CN105708581A (en) * | 2016-01-21 | 2016-06-29 | 东华大学 | Electrostatic-spun coated composite pelvic mesh and manufacturing method thereof |
| CN105769378A (en) * | 2010-10-06 | 2016-07-20 | Ams研究公司 | Implants with absorbable and non-absorbable features for the treatment of female pelvic conditions |
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| EP1511442B1 (en) * | 2002-06-12 | 2010-01-06 | Boston Scientific Limited | Medical slings |
| US10265156B2 (en) * | 2015-06-15 | 2019-04-23 | Rotation Medical, Inc | Tendon repair implant and method of implantation |
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|---|---|---|---|---|
| CN105769378A (en) * | 2010-10-06 | 2016-07-20 | Ams研究公司 | Implants with absorbable and non-absorbable features for the treatment of female pelvic conditions |
| CN105125317A (en) * | 2015-09-17 | 2015-12-09 | 复旦大学附属华山医院 | Segmented nano coating modified artificial rotator cuff patch |
| CN105708581A (en) * | 2016-01-21 | 2016-06-29 | 东华大学 | Electrostatic-spun coated composite pelvic mesh and manufacturing method thereof |
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