CN105833340A - Nerve conduit with function of nerve regeneration promotion - Google Patents
Nerve conduit with function of nerve regeneration promotion Download PDFInfo
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- CN105833340A CN105833340A CN201610376427.0A CN201610376427A CN105833340A CN 105833340 A CN105833340 A CN 105833340A CN 201610376427 A CN201610376427 A CN 201610376427A CN 105833340 A CN105833340 A CN 105833340A
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- nerve
- sleeve pipe
- intercalation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/08—Carbon ; Graphite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
Abstract
The invention belongs to the technical field of medical instruments and discloses a nerve conduit with a function of nerve regeneration promotion. The nerve conduit is used for promoting regeneration of injured nerves. The technical scheme includes that a graphene insert rod is put in an inner cavity or inner wall of a cannula which is made of magnesium alloy; due to excellent electrical conductivity of the magnesium alloy and the graphene, a plurality of local microelectrodes can be generated at a neural stump to simulate a nerve conduction mode; in addition, since nerve growth factors can be added into a gap between the cannula and the insert rod, nerve regeneration can be further promoted. Owing to a self-degradation property of metal magnesium or the magnesium alloy in a human body, an transplantation nerve scaffold can be substituted, and the problem of insufficiency of transplantation materials is solved; due to excellent plastic deformation property of the magnesium alloy and the graphene, the nerve conduit is adaptive to different defect types and capable of well meeting operation requirements owing to trimming availability. The nerve conduit is initiative in the field of nerve injury repair and creates a new approach for nerve conduit repair.
Description
Technical field
The present invention relates to the nerve trachea that a kind of nerve promoting damaged carries out regenerating, belong to technical field of medical instruments.
Background technology
Nervous system is one of topmost tissue in human body, and it controls sensation and the motor function of human body.Various wounds such as compressing, drawing-off, tear, cut off and other factors such as ischemia, tumor etc. will cause neural part or all of damage, thus cause afunction and cause other nervous system disease.The reparation of defect nerve and one of difficult problem rebuilding always medical circle of function.
Current theory and medical practice prove, perineural neuron axon can extend under proper condition, grow damaged region, reach neuranagenesis purpose.By means of the development of neurosurgery particularly microneurosurgery, reparation and the regeneration of nerve injury are possibly realized.Research at present and the CO2 laser weld technology applied clinically mainly have three kinds: the most identical, neural transplantation (autologous or allosome) and nerve trachea reparation.
Directly coincide is directly near end neural for dialysis, remote body end to be carried out operation stitching, it is limited only to shorter neurotmesis (less than 8mm), this is not stretch function due to nerve, sew up the tension force produced and can affect the regeneration of nerve, therefore the most helpless to the neurologic defect of long pause, and its curative effect acceptance rate is only 50%.
Neural transplantation can cause losing for function of nervous system of district, to neurologic defect supply source deficiency thicker relatively greatly, and the problem having second operation.The solution immune-suppression problems and heteroplastic transplantation is still needed.Directly it coincide and neural transplantation there is also broken ends of fractured bone sensory nerve and Motor nerve fibre connects problem of misalignment.Due in the traumatology department field, repairing of neural injury is to sew up by nerve end end, but owing to peripheral nerve is mixed nerve, and also lack at present and can distinguish neural broken ends of fractured bone sensory nerve and the science discrimination method of Motor nerve fibre in operation quickly and accurately, even if applying fine microsurgical technique row perineurial suture, it is also difficult to avoid after nerve end end is sewed up, because of sensation, the misorientation docking of Motor nerve fibre, and affect the curative effect of nerve suture, affect the recovery of function of nervous system.
The nerve injury longer for defect or lack the patient of suitable nerve autograft condition, needs to use nerve autograft substitute artificial nerve catheter or Nerve Scaffold, promotes nerve fiber regeneration.It is the study hotspot that current neuranagenesis is repaired that nerve trachea repairs (bridge joint art), is the big focus jointly paid close attention to of tissue engineering, materialogy, biology, medical circle.Chinese scholars has been proven that nerve trachea substitutes autotransplantation to repair the feasibility of neurologic defect in recent ten years.Owing to nerve has certain Regeneration and Repair ability, induced by conduit, put up a bridge for the near end of defect nerve, remote body end, guide neural direction of regeneration, the neuranagenesis reparation that defect length is shorter can be made.Scholar is had to utilize the chitosan material of NT3 to make " spinal cord rebuilds pipe ", to promote spinal cord regeneration, injury repairing.
In sum, nerve trachea reparation is up-and-coming neuranagenesis recovery technique, is induced by conduit, puts up a bridge for the near end of defect nerve, remote body end, guides neural direction of regeneration, can make the neuranagenesis reparation that defect length is shorter.But, above-mentioned nerve trachea, timbering material meet far away clinical requirement and patient's expectation, become restriction nerve trachea recovery technique to implement and the bottleneck of development, how to improve the design of nerve trachea, timbering material, improve difficult point and the focus promoting that CO2 laser weld and regeneration are research at present, it would be highly desirable to scientific research personnel and medical worker solve.
Owing to the critical function of nerve fiber is transmission impulsion, the conductive process of neural impulse is the process of electrochemistry, is the electrochemical change that order occurs in nerve fiber.If implanting the material that electroneurographic signal can be promoted to conduct between the nerve fiber or spinal cord of defect, thus promote the regeneration of nerve fiber.Promoting peripheral nerve injury and the ability of repair of spinal cord injury to further enhance Nerve Scaffold, we have developed Nerve Scaffold that include Graphene or magnesium metal and alloy thereof, that promote CO2 laser weld to regenerate by advantageously promoting neuroelectricity conduction of impulse and catheter design.
Summary of the invention
The technical problem to be solved is to provide a kind of nerve trachea promoting neuranagenesis, this nerve trachea uses degradable artificial material as nerve conduit stent, add Graphene or magnesium metal or its alloy strengthens the effect that its afferent nerve electricity is got excited, can significantly repair long section neurologic defect, there is good clinical benefit.
The technical scheme solving above-mentioned technical problem is:
A kind of nerve trachea promoting neuranagenesis, it is by sleeve pipe, intercalation rod, implant forms, sleeve pipe is magnesium metal or the hollow sleeve of magnesium alloy making, or by NTx, poly-d, l-lactic acid, polyglycolic acid, extracellular matrix (ECM), chitosan, PLGA, hyaluronic acid, laminin，LN, the hollow sleeve that the degradation materials such as polyglycolic acid make, intercalation rod is Graphene stock, or be magnesium metal or magnesium alloy stock, implant is neurotrophy material and somatomedin, intercalation rod is placed in the hollow cavity of sleeve pipe, or be inlaid in internal surface of sleeve pipe, intercalation rod is a plurality of, parallel uniform along casing length direction, implant is filled in the hollow cavity of sleeve pipe.
The above-mentioned nerve trachea promoting neuranagenesis, on the inwall of described sleeve pipe fluted, groove is parallel uniform along casing length direction, and channel section is shaped as rectangle, or oval, or it is semicircle, or circular, or semilune, or the various shape such as trapezoidal, intercalation rod cross sectional shape is suitable with channel section shape, and intercalation rod is inlaid in groove.
The above-mentioned nerve trachea promoting neuranagenesis, described intercalation rod is woven into columnar slab organization or network structure, the cancellated external diameter of cylinder matches with casing inner diameter, cylinder cancellated intercalation rod is inlaid in the inner chamber of sleeve pipe, cancellated grid is hexagon, or triangle, or tetragon, or pentagon, or the geometry of the rule such as circle.
The above-mentioned nerve trachea promoting neuranagenesis, described intercalation rod is woven into slab organization or the network structure of the arc of 1/20 ~ 1/2d circumference, the cancellated external diameter of cylinder matches with casing inner diameter, slab organization or the network structure intercalation rod of arc are inlaid in the inner chamber of sleeve pipe, cancellated grid is hexagon, or triangle, or tetragon, or pentagon, or the geometry of the rule such as circle.
The above-mentioned nerve trachea promoting neuranagenesis, described intercalation rod is woven into slab organization or the network structure of the arc of 1/20 ~ 1/2d circumference, and slab organization or the cancellated intercalation rod of arc are inlaid in the middle of internal surface of sleeve pipe
The invention has the beneficial effects as follows:
Neural biological theoretical and medical practice shows, the important physiological function of nerve fiber is transmission impulsion, and the conductive process of neural impulse is the process of electrochemistry, is the electrochemical change that order occurs in nerve fiber.If implanting the material that electroneurographic signal can be promoted to conduct between the nerve fiber or spinal cord of defect, it will promote peripheral nerve injury and the ability of repair of spinal cord injury.According to above-mentioned theory, the present invention uses magnesium alloy as sleeve pipe, Graphene intercalation rod is placed in the cavity of sleeve pipe, the excellent electric conductivity that magnesium alloy and Graphene have, several local microelectrode can be produced at the neural broken ends of fractured bone, analog neuron conduction mode, can add nerve growth factor in the gap of sleeve pipe and intercalation rod in addition, and multitube can promote neuranagenesis under it further.Owing to magnesium metal or its alloy have the characteristic can degraded voluntarily in human body, therefore can substitute for the Nerve Scaffold transplanted, solve the problem that graft materials is not enough.Magnesium alloy and Graphene have good plastic deformation simultaneously, are suitable for different Defect types, and it can prune performance also can be well adapted for the needs of operation.
The present invention is initiating in repairing of neural injury field, solve the difficult problem that during nerve trachea is repaired, Nerve Scaffold material is not enough, can significantly repair long section neurologic defect, there is good clinical benefit, open up a new way for nerve trachea reparation, to promoting that the enforcement of nerve trachea recovery technique and development are made that contribution, in industry there is great application value.
Accompanying drawing explanation
Fig. 1 is the result schematic diagram of the present invention；
Fig. 2 is the A-A sectional view of Fig. 1；
Fig. 3 is the another kind of structural representation of the present invention；
Fig. 4 is the another kind of structural representation of the present invention；
Fig. 5 is the intercalation rod network structure schematic diagram of the present invention.
In figure, labelling is as follows: sleeve pipe 1, intercalation rod 2, implant 3, groove 4.
Detailed description of the invention
The present invention is made up of sleeve pipe 1, intercalation rod 2, implant 3.
Figure shows, sleeve pipe 1 is magnesium metal or the hollow sleeve of magnesium alloy making, or by NTx, poly-d, the hollow sleeve that the degradation material such as l-lactic acid, polyglycolic acid, extracellular matrix (ECM), chitosan, PLGA, hyaluronic acid, laminin，LN, polyglycolic acid makes.Intercalation rod 2 is Graphene stock, or is magnesium metal or magnesium alloy stock.Implant 3 is neurotrophy material and somatomedin, and implant 3 can fill the part or all of of sleeve pipe hollow cavity.The excellent electric conductivity that magnesium alloy and Graphene have, can produce several local microelectrode, analog neuron conduction mode at the neural broken ends of fractured bone, can add nerve growth factor in addition in the gap of sleeve pipe 1 and intercalation rod 2, and multitube can promote neuranagenesis under it further.Owing to magnesium metal or its alloy have the characteristic can degraded voluntarily in human body, therefore can substitute for the Nerve Scaffold transplanted, solve the problem that graft materials is not enough.Magnesium alloy and Graphene have good plastic deformation simultaneously, are suitable for different Defect types, and it can prune performance also can be well adapted for the needs of operation.
Showing in figure, a kind of structure of the present invention is on the inwall of sleeve pipe 1 fluted 4, and groove 4 is parallel uniform along sleeve pipe 1 length direction.Groove 4 cross sectional shape is rectangle, or oval, or semicircle, or circular, or semilune, or trapezoidal waits various shape, and excellent 2 cross sectional shapes of intercalation are suitable with groove 4 cross sectional shape, and intercalation rod 2 is inlaid in groove 4.
The a length of 5-100mm of the sleeve pipe 1 of one embodiment of the present of invention, diameter, between 1-10mm, sleeve pipe 1 inwall is uniformly distributed 2-20 groove 4.
Showing in figure, in the another kind of structure of the present invention is the hollow cavity that intercalation rod 2 is placed on sleeve pipe 1, intercalation rod 2 is a plurality of, parallel uniform along sleeve pipe 1 length direction.
Showing in figure, the another kind of structure of the present invention is that intercalation rod 2 is inlaid in the middle of sleeve pipe 1 inwall, and such as, the pipe thickness of sleeve pipe 1 is 2mm, and intercalation rod 2 is inlaid at middle 1mm or at 1.5mm.
Figure shows, the intercalation rod 2 of the present invention can be woven into columnar network structure, the cancellated external diameter of cylinder matches with sleeve pipe 1 internal diameter, cylinder cancellated intercalation rod 2 is inlaid in the inner chamber of sleeve pipe 1, cancellated grid is hexagon, or triangle, or tetragon, or pentagon, or the geometry of the rule such as circle.
The intercalation rod 2 of the present invention can also be woven into slab organization or the network structure of the arc of 1/20 ~ 1/2d circumference, and the cancellated external diameter of cylinder matches with sleeve pipe 1 internal diameter, and slab organization or the network structure intercalation rod of arc are inlaid in the inner chamber of sleeve pipe.Cancellated grid is hexagon, or triangle, or tetragon, or pentagon, or the geometry of the rule such as circle.
The intercalation rod 2 of the present invention can also be woven into slab organization or the network structure of the arc of 1/20 ~ 1/2d circumference, the slab organization of arc or cancellated intercalation rod 2 are inlaid in the middle of internal surface of sleeve pipe 1, as, the pipe thickness of sleeve pipe 1 is 2mm, and the slab organization of arc or cancellated intercalation rod 2 are inlaid at middle 1mm or at 1.5mm.
Claims (5)
- null1. the nerve trachea that can promote neuranagenesis，It is characterized in that: it is by sleeve pipe (1)、Intercalation rod (2)、Implant (3) forms，Sleeve pipe (1) is magnesium metal or the hollow sleeve of magnesium alloy making,Or by NTx、Poly-d,L-lactic acid、Polyglycolic acid、Extracellular matrix (ECM)、Chitosan、PLGA、Hyaluronic acid、Laminin，LN、The hollow sleeve that the degradation materials such as polyglycolic acid make，Intercalation rod (2) is Graphene stock，Or be magnesium metal or magnesium alloy stock，Implant (3) is neurotrophy material and somatomedin，Intercalation rod (2) is placed in the hollow cavity of sleeve pipe (1)，Or be inlaid in sleeve pipe (1) inwall，Intercalation rod (2) is a plurality of，Parallel uniform along sleeve pipe (1) length direction，Implant (3) is filled in the hollow cavity of sleeve pipe (1).
- The nerve trachea promoting neuranagenesis the most according to claim 1, it is characterized in that: fluted (4) on the inwall of described sleeve pipe (1), groove (4) is parallel uniform along sleeve pipe (1) length direction, groove (4) cross sectional shape is rectangle, or it is oval, or it is semicircle, or it is circular, or semilune, or the various shape such as trapezoidal, the degree of depth of groove (4) is less than 1/2nd of sleeve pipe (1) pipe thickness, and intercalation rod (2) cross sectional shape is suitable with groove (4) cross sectional shape, and intercalation rod (2) is inlaid in groove (4).
- The nerve trachea promoting neuranagenesis the most according to claim 1, it is characterized in that: described intercalation rod (2) is woven into columnar slab organization or network structure, columnar slab organization or cancellated external diameter match with sleeve pipe (1) internal diameter, columnar slab organization or cancellated intercalation rod (2) are inlaid in the inner chamber of sleeve pipe (1), cancellated grid is hexagon, or triangle, or tetragon, or pentagon, or the geometry of the rule such as circle.
- The nerve trachea promoting neuranagenesis the most according to claim 1, it is characterized in that: described intercalation rod (2) is woven into slab organization or the network structure of the arc of 1/20 ~ 1/2d circumference, the cancellated external diameter of cylinder matches with sleeve pipe (1) internal diameter, the slab organization of arc or network structure intercalation rod (2) are inlaid in the inner chamber of sleeve pipe (1), cancellated grid is hexagon, or triangle, or tetragon, or pentagon, or the geometry of the rule such as circle.
- The nerve trachea promoting neuranagenesis the most according to claim 1, it is characterized in that: described intercalation rod (2) is woven into slab organization or the network structure of the arc of 1/20 ~ 1/2d circumference, the slab organization of arc or cancellated intercalation rod (2) and is inlaid in the middle of internal surface of sleeve pipe (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610376427.0A CN105833340A (en) | 2016-05-31 | 2016-05-31 | Nerve conduit with function of nerve regeneration promotion |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610376427.0A CN105833340A (en) | 2016-05-31 | 2016-05-31 | Nerve conduit with function of nerve regeneration promotion |
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| CN105833340A true CN105833340A (en) | 2016-08-10 |
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| CN201610376427.0A Pending CN105833340A (en) | 2016-05-31 | 2016-05-31 | Nerve conduit with function of nerve regeneration promotion |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793594A (en) * | 2019-02-18 | 2019-05-24 | 北京科技大学 | Can spontaneous electro photoluminescence block structure conduction nerve trachea and preparation method thereof |
| CN109833516A (en) * | 2017-11-27 | 2019-06-04 | 上海交通大学 | A kind of graphene catheter combination object, conduit preparation method and application |
| CN111643727A (en) * | 2020-06-02 | 2020-09-11 | 中国人民解放军总医院 | Nerve conduit with electromagnetic induction function and using method and preparation method thereof |
| CN113180885A (en) * | 2021-04-01 | 2021-07-30 | 重庆市畜牧科学院 | Optic nerve interface and its preparing method |
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| US20020137706A1 (en) * | 2000-07-21 | 2002-09-26 | Evans Gregory R.D. | Regulated growth factor delivery for engineered peripheral nerve |
| CN103405289A (en) * | 2013-07-26 | 2013-11-27 | 清华大学 | Device based on liquid metal and used for repairing defective peripheral nerve function |
| CN105288744A (en) * | 2015-10-29 | 2016-02-03 | 温州医科大学 | Neural unit spherical support and preparation thereof |
| CN105457103A (en) * | 2015-12-31 | 2016-04-06 | 复旦大学附属华山医院 | 3D-printed peripheral nerve conduit and preparing method thereof |
-
2016
- 2016-05-31 CN CN201610376427.0A patent/CN105833340A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020137706A1 (en) * | 2000-07-21 | 2002-09-26 | Evans Gregory R.D. | Regulated growth factor delivery for engineered peripheral nerve |
| CN103405289A (en) * | 2013-07-26 | 2013-11-27 | 清华大学 | Device based on liquid metal and used for repairing defective peripheral nerve function |
| CN105288744A (en) * | 2015-10-29 | 2016-02-03 | 温州医科大学 | Neural unit spherical support and preparation thereof |
| CN105457103A (en) * | 2015-12-31 | 2016-04-06 | 复旦大学附属华山医院 | 3D-printed peripheral nerve conduit and preparing method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109833516A (en) * | 2017-11-27 | 2019-06-04 | 上海交通大学 | A kind of graphene catheter combination object, conduit preparation method and application |
| CN109793594A (en) * | 2019-02-18 | 2019-05-24 | 北京科技大学 | Can spontaneous electro photoluminescence block structure conduction nerve trachea and preparation method thereof |
| CN109793594B (en) * | 2019-02-18 | 2021-04-09 | 北京科技大学 | Block structure conductive nerve conduit capable of spontaneous electrical stimulation and preparation method thereof |
| CN111643727A (en) * | 2020-06-02 | 2020-09-11 | 中国人民解放军总医院 | Nerve conduit with electromagnetic induction function and using method and preparation method thereof |
| CN111643727B (en) * | 2020-06-02 | 2021-02-09 | 中国人民解放军总医院 | Nerve conduit with electromagnetic induction function and using method and preparation method thereof |
| CN113180885A (en) * | 2021-04-01 | 2021-07-30 | 重庆市畜牧科学院 | Optic nerve interface and its preparing method |
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Application publication date: 20160810 |