CN203829090U - Nanofiber neural graft - Google Patents
Nanofiber neural graft Download PDFInfo
- Publication number
- CN203829090U CN203829090U CN201420182251.1U CN201420182251U CN203829090U CN 203829090 U CN203829090 U CN 203829090U CN 201420182251 U CN201420182251 U CN 201420182251U CN 203829090 U CN203829090 U CN 203829090U
- Authority
- CN
- China
- Prior art keywords
- nanofiber
- wall
- fiber
- layer
- nerve graft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002121 nanofiber Substances 0.000 title claims abstract description 35
- 230000001537 neural effect Effects 0.000 title abstract description 8
- 210000005036 nerve Anatomy 0.000 claims abstract description 37
- 239000000463 material Substances 0.000 claims abstract description 8
- 239000011148 porous material Substances 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000000835 fiber Substances 0.000 abstract description 7
- 210000003050 axon Anatomy 0.000 abstract description 4
- 230000006835 compression Effects 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 210000000578 peripheral nerve Anatomy 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 108010022355 Fibroins Proteins 0.000 description 2
- 208000010886 Peripheral nerve injury Diseases 0.000 description 2
- 229920000954 Polyglycolide Polymers 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 229920001610 polycaprolactone Polymers 0.000 description 2
- 239000004632 polycaprolactone Substances 0.000 description 2
- 239000004633 polyglycolic acid Substances 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The utility model discloses a nanofiber neural graft. The nanofiber neural graft is characterized by being made from biodegradable materials in one step and being in the shape of a hollow tube; the wall of the hollow tube is of a double-layer or multilayer structure composed of nanofiber, the inner layer of the wall of the hollow tube is composed axially parallel nanofiber, the outer layer of the wall of the hollow tube is composed of nanofiber which is arranged randomly, and the wall of the hollow tube is provided with uniformly-distributed micron holes. The nanofiber neural fiber has the advantages of being capable of directionally guiding extension of an axon to achieve rapid restoration of defected nerve due to the facts that the tube wall is of the double-layer or multilayer structure and the inner layer of the tube wall is an axially parallel nanofiber layer, and providing sufficient mechanical support to avoid deformation caused by compression of surrounding tissues due to the fact that the outer layer of the tube wall is composed of the disorder nanofiber or is of a mixed fiber structure formed by crossing unordered fiber and parallel fiber.
Description
Technical field
This utility model relates to a kind of nano-fiber nerve graft, belongs to biomaterial for medical purpose and tissue engineering technique field.
Background technology
The peripheral nerve defection that cause because various vehicle accidents, industrial injury, sport injury, surgical operation, life style are unhealthy etc. every year in the whole world is countless.After peripheral nervous is damaged, if peripheral nerve lacks successfully regeneration, the sensation of corresponding site, motor function defect or forfeiture cause the muscle deterioration of corresponding site simultaneously.Every year, the U.S. has the 800000 routine patients of surpassing that peripheral nerve injury occurs, and the annual newly-increased case of China approaches 1,000,000 examples, wherein, needs about 450,000 examples of repairing of neural injury.Yet peripheral nerve injury is especially after peripheral nerve defection, the reparation to peripheral nerve defection is a difficult problem of neurosurgical treatment always.Effectively Therapeutic Method is nerve autograft clinically at present, but autologous nerve source is limited, and is accompanied by for district's function impaired.During the nearly last ten years, along with the development of organizational project and biomaterial, artificial nerve graft starts to be developed and is applied to clinically, and this class artificial nerve graft mostly is hollow tubular structure, for neuranagenesis provides suitable passage.Yet simple hollow zrve graft, lacks the specificity guiding that nerve is repaired, the repairing effect of therefore obtaining is very limited.
First the desirable artificial nerve graft of generally acknowledging will meet the needed basic demand of nerve growth, should possess following characteristics: the biocompatibility that (1) is good; (2) degradability, can synchronously degrade with nerve recovery; (3) good mechanical strength and pliability; (4) tube wall has selection permeability, can from external world's tissue, draw nutrient substance; (4) there is unique structural pipe wall, can guide neuranagenesis; (5) there is biological activity, can promote neuranagenesis.
Summary of the invention
For solving the deficiencies in the prior art, the purpose of this utility model is to provide a kind of and has good biocompatibility and degradability, enough mechanical strength and pliability, tube walls have good selection permeability, can induce the nerve graft of aixs cylinder the direction detection extends.
In order to realize above-mentioned target, this utility model adopts following technical scheme:
A kind of nano-fiber nerve graft, it is characterized in that, nerve graft is made by Biodegradable material time processing, is hollow tubular, and tube wall is bilayer or the multiple structure consisting of nanofiber, internal layer consists of the nanofiber of axially parallel, the outer nanofiber by random alignment, or the nanofiber of random alignment and the nanofiber of the axially parallel formation that interweaves, have the micropore being evenly distributed on the tube wall of described nerve graft, micro-pore diameter 0.1～5 μ m, porosity 30%～70%.
Aforesaid nano-fiber nerve graft, is characterized in that, the internal diameter of aforementioned nerve graft is 1mm～10mm, and pipe thickness is 0.2mm～1mm, and length is 10mm～100mm.
Aforesaid nano-fiber nerve graft, is characterized in that, the thickness of the internal layer of aforementioned tube wall is 0.1mm～0.5mm, and outer field thickness is 0.1mm～0.9mm.
Aforesaid nano-fiber nerve graft, it is characterized in that, aforementioned nerve graft adopts the material with good biocompatibility and degradability to make, and previous materials comprises: one or more in polyglycolic acid, polycaprolactone, polylactide, chitosan, collagen and fibroin albumen.
Usefulness of the present utility model is: the tube wall of nerve graft has bilayer or multiple structure, and internal layer is the nanofiber layer that axially parallel is arranged, can directional guide axon elongation, realize the quick reparation of damaged nerve; Skin is unordered nanofiber, or unordered fiber and the parallel fiber composite fibre structure that interweaves and form, is used to provide sufficient mechanics and supports, and prevents that surrounding tissue compressing from causing neural transplantation composition deformation.
Accompanying drawing explanation
Fig. 1 is the structural representation of a specific embodiment of nerve graft of the present utility model;
Fig. 2 is the fine structure schematic diagram of the outer wall of the nerve graft in Fig. 1;
Fig. 3 is the fine structure schematic diagram of the inwall of the nerve graft in Fig. 1;
The implication of Reference numeral in figure: 1-internal layer, 2-is outer.
The specific embodiment
Below in conjunction with the drawings and specific embodiments, this utility model is done to concrete introduction.
Referring to figs. 1 through Fig. 3, nerve graft of the present utility model, by Biodegradable material time processing, made, its integral body is hollow tubular, tube wall is by the bilayer micro-, nanofibers forms or multiple structure, on tube wall, there is the micron hole being evenly distributed, micro-pore diameter 0.1～5 μ m, porosity 30%～70%.
Form the nanofiber of internal layer 1 and the axis of nerve graft parallel; The nanofiber that forms skin 2 is disordered structure, or unordered nanofiber and parallel nanofiber pilotaxitic texture.
As a kind of preferred scheme, the internal diameter of nerve graft of the present utility model is 1mm, 3mm, 5mm, and internal diameter maximum can reach 10mm; Pipe thickness is the preferred 0.5mm of 0.2mm～1mm(); Length is 10mm～100mm (preferably 50mm).
More preferably, the thickness of the internal layer 1 of tube wall is 0.1mm～0.5mm (preferably 0.2mm), and outer 2 thickness is 0.1mm～0.9mm (preferably 0.3mm), can guarantee that nerve graft of the present utility model has good degradation time.
In this utility model, nerve graft adopts the material with good biocompatibility and degradability to make, and this material comprises: one or more in polyglycolic acid, polycaprolactone, polylactide, chitosan, collagen and fibroin albumen.
The special construction energy specificity of product of the present utility model is induced the reparation of damaged nerve, be that tube wall internal layer is the nanofibrous structures that axially parallel is arranged, the function with specificity guiding axon elongation, its skin is the nanofibrous structures of lack of alignment, be used to provide sufficient mechanics and support, prevent that surrounding tissue compressing from causing neural transplantation composition deformation; On tube wall, equally distributed micron hole, can provide passage for the required nutrient substance of neuranagenesis, promotes neural axon regeneration.
In addition, the product being prepared by method of the present utility model, it is time processing formed product, for seamless tubular shaped structure, avoided in former studies, be rolled into the process complexity of tubular structure after first doing in flakes, and avoided the adverse effect of seamed pipe to neuranagenesis.
It should be noted that, above-described embodiment does not limit this utility model in any form, and all employings are equal to replaces or technical scheme that the mode of equivalent transformation obtains, all drops in protection domain of the present utility model.
Claims (3)
1. a nano-fiber nerve graft, it is characterized in that, nerve graft is made by Biodegradable material time processing, be hollow tubular, tube wall is bilayer or the multiple structure consisting of nanofiber, internal layer consists of the nanofiber of axially parallel, the outer nanofiber by random alignment, or the nanofiber of random alignment and the nanofiber of the axially parallel formation that interweaves; On the tube wall of described nerve graft, there is the micropore being evenly distributed, micro-pore diameter 0.1～5 μ m, porosity 30%～70%.
2. nano-fiber nerve graft according to claim 1, is characterized in that, the internal diameter of described nerve graft is 1mm～10mm, and pipe thickness is 0.2mm～1mm, and length is 10mm～100mm.
3. nano-fiber nerve graft according to claim 2, is characterized in that, the thickness of described tube wall internal layer is 0.1mm～0.5mm, and outer layer thickness is 0.1mm～0.9mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420182251.1U CN203829090U (en) | 2014-04-16 | 2014-04-16 | Nanofiber neural graft |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420182251.1U CN203829090U (en) | 2014-04-16 | 2014-04-16 | Nanofiber neural graft |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203829090U true CN203829090U (en) | 2014-09-17 |
Family
ID=51506990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420182251.1U Expired - Lifetime CN203829090U (en) | 2014-04-16 | 2014-04-16 | Nanofiber neural graft |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203829090U (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105310794A (en) * | 2015-02-14 | 2016-02-10 | 李贵才 | Method for preparing porous artificial nerve conduit with orientation structures on inner walls |
| CN106236323A (en) * | 2016-08-05 | 2016-12-21 | 浙江大学 | A kind of nerve trachea with contact guiding function and preparation method thereof and device |
| WO2017052054A1 (en) * | 2015-09-25 | 2017-03-30 | 전북대학교산학협력단 | Aligned nanofiber manufacturing device, membrane for eardrum or cornea regeneration, and nerve conduit made of nanofibers and manufacturing method therefor |
| KR101764858B1 (en) * | 2015-09-25 | 2017-08-14 | 전북대학교산학협력단 | Nanofiber nerve conduit and preparation method thereof |
| CN110975016A (en) * | 2019-12-25 | 2020-04-10 | 武汉理工大学 | Nerve repair catheter and preparation method thereof |
| CN111035810A (en) * | 2019-12-05 | 2020-04-21 | 深圳先进技术研究院 | Multichannel nerve conduit and preparation method thereof |
| CN111097069A (en) * | 2019-07-04 | 2020-05-05 | 南开大学 | Bionic degradable artificial nerve conduit for regulating immune microenvironment and guiding regeneration by using topological structure and preparation method thereof |
-
2014
- 2014-04-16 CN CN201420182251.1U patent/CN203829090U/en not_active Expired - Lifetime
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105310794A (en) * | 2015-02-14 | 2016-02-10 | 李贵才 | Method for preparing porous artificial nerve conduit with orientation structures on inner walls |
| WO2017052054A1 (en) * | 2015-09-25 | 2017-03-30 | 전북대학교산학협력단 | Aligned nanofiber manufacturing device, membrane for eardrum or cornea regeneration, and nerve conduit made of nanofibers and manufacturing method therefor |
| KR101764858B1 (en) * | 2015-09-25 | 2017-08-14 | 전북대학교산학협력단 | Nanofiber nerve conduit and preparation method thereof |
| CN106236323A (en) * | 2016-08-05 | 2016-12-21 | 浙江大学 | A kind of nerve trachea with contact guiding function and preparation method thereof and device |
| CN106236323B (en) * | 2016-08-05 | 2017-11-17 | 浙江大学 | A kind of nerve trachea with contact guiding function and preparation method thereof and device |
| CN111097069A (en) * | 2019-07-04 | 2020-05-05 | 南开大学 | Bionic degradable artificial nerve conduit for regulating immune microenvironment and guiding regeneration by using topological structure and preparation method thereof |
| CN111035810A (en) * | 2019-12-05 | 2020-04-21 | 深圳先进技术研究院 | Multichannel nerve conduit and preparation method thereof |
| CN110975016A (en) * | 2019-12-25 | 2020-04-10 | 武汉理工大学 | Nerve repair catheter and preparation method thereof |
| CN110975016B (en) * | 2019-12-25 | 2021-07-20 | 武汉理工大学 | Nerve repair catheter and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN203829090U (en) | Nanofiber neural graft | |
| Pu et al. | Electrospun bilayer fibrous scaffolds for enhanced cell infiltration and vascularization in vivo | |
| Wang et al. | Effects of Schwann cell alignment along the oriented electrospun chitosan nanofibers on nerve regeneration | |
| DE102006047248B4 (en) | Three-dimensional artificial callus distraction | |
| Bian et al. | The construction and performance of multi-level hierarchical hydroxyapatite (HA)/collagen composite implant based on biomimetic bone Haversian motif | |
| EP2921136A1 (en) | Fiber membranes for repairing tissue and products and preparation method thereof | |
| JP2008504921A5 (en) | ||
| CN109701080A (en) | 4 axis 3D printing tubular medical brackets of one kind and preparation method thereof | |
| CN104645412A (en) | Preparation method of bionic artificial nerve scaffold established by collagen | |
| Saiding et al. | Heat‐shrinkable electrospun fibrous tape for restoring structure and function of loose soft tissue | |
| Zamani et al. | Enhanced osteogenic activity by MC3T3-E1 pre-osteoblasts on chemically surface-modified poly (ε-caprolactone) 3D-printed scaffolds compared to RGD immobilized scaffolds | |
| Mansouri | The influence of topography on tissue engineering perspective | |
| Jing et al. | Repair of dural defects with electrospun bacterial cellulose membranes in a rabbit experimental model | |
| WO2016192733A1 (en) | Conduit for regeneration of biological material | |
| CN104739473A (en) | Nanofiber yarn nerve conduit and preparing method thereof | |
| Dai et al. | Material advancement in tissue-engineered nerve conduit | |
| CN107206121B (en) | Tissue scaffold devices and methods for making the same | |
| CN100358589C (en) | Tubular type material for rehabilitating human peripheral nerve defection and its preparation method | |
| KR100926678B1 (en) | Biodegradable plastic / nano fiber composite support neural conduit manufacturing method. | |
| CN105833340A (en) | Nerve conduit with function of nerve regeneration promotion | |
| DE102009024133A1 (en) | Bacterial nanocellulose, useful e.g. for cartilage regeneration, comprises a structure consisting of a wide-meshed phase of bacterial nanocellulose and a close-meshed phase of bacterial nanocellulose firmly connected with wide-meshed phase | |
| CN104548203A (en) | Collagen-rich artificial nerve scaffold and preparation method thereof | |
| JP6469500B2 (en) | Nerve regeneration tube and method for manufacturing nerve regeneration tube | |
| CN105748171A (en) | Biological type nerve conduit | |
| EP2252238A1 (en) | Device comprising a swelling agent and sheathing for artificial callus distraction |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 264006, E District, No. 3, Pioneer Park, Zhujianglu Road 32, Yantai Development Zone, Shandong, China Patentee after: SHANDONG JUNXIU BIOTECHNOLOGY CO.,LTD. Address before: 264006, E District, No. 3, Pioneer Park, Zhujianglu Road 32, Yantai Development Zone, Shandong, China Patentee before: YANTAI JUANXIU BIOLOGICAL SCIENCE & TECHNOLOGY CO.,LTD. |
|
| C56 | Change in the name or address of the patentee | ||
| CP02 | Change in the address of a patent holder |
Address after: 264006 Shandong District, Yantai Development Zone, Zhujianglu Road, 32 studying abroad Pioneer Park No. 3 workshop E zone 539, Shandong Jun Xiu biological Polytron Technologies Inc Patentee after: SHANDONG JUNXIU BIOTECHNOLOGY CO.,LTD. Address before: 264006, E District, No. 3, Pioneer Park, Zhujianglu Road 32, Yantai Development Zone, Shandong, China Patentee before: SHANDONG JUNXIU BIOTECHNOLOGY CO.,LTD. |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140917 |