CN210019796U

CN210019796U - A supporting structure thing for neural restoration

Info

Publication number: CN210019796U
Application number: CN201920616705.4U
Authority: CN
Inventors: 万玉青
Original assignee: Nanjing Bod Biotechnology Co Ltd
Current assignee: Nanjing Bod Biotechnology Co Ltd
Priority date: 2019-04-30
Filing date: 2019-04-30
Publication date: 2020-02-07
Anticipated expiration: 2029-04-30

Abstract

The utility model discloses a supporting structure thing for neural restoration, concretely relates to medical equipment field, including the outer cover pipe, the inside degradable tow that is equipped with of outer cover pipe, be equipped with the adhesion agent post between degradable tow and the outer cover pipe, evenly be equipped with a plurality of material exchange micropores on the outer cover pipe, the inside recovered medicament that is equipped with of adhesion agent post. The utility model discloses a be equipped with outer cover tube, degradable tow and adhesion agent post, degradable tow carries out the orientation guide that grows to nerve growth, the outer cover tube that has the material exchange micropore can prevent that the surrounding tissue from growing into, can remain nutrient substance again and guarantee free business turn over through the material exchange micropore, create the microenvironment that is favorable to nerve regeneration, degradable tow length is slightly short than outer cover tube length, can let defective nerve insert, the secondary damage who has avoided sewing up and has brought, recovered medicament and blood dissolve, directly carry out the medicine adjunctie therapy to the affected part.

Description

A supporting structure thing for neural restoration

Technical Field

The utility model relates to the technical field of medical equipment, more specifically say, the utility model relates to a supporting structure thing for neural restoration.

Background

Nerve damage is also increasingly common, especially peripheral nerve damage. Currently, autologous nerve transplantation or adventitia and perineurium suture is generally adopted for repair in clinic, but the source of donor nerves is limited, and the problems that the misconnection of sensory nerve fibers and motor nerve fibers, the invasion of scar tissues at the broken ends and the like are easy to occur when the suture is needed are solved. According to the nerve selective regeneration theory which has been proved by numerous scholars in recent years, the repair of peripheral nerves by using an artificial nerve sheath becomes an ideal alternative method, and the method mainly utilizes the space reserved by the broken end to provide a selective regeneration space to induce the regeneration of damaged nerves. Regeneration or repair of nerve damage has been a medical problem, particularly in the central nervous system. There have been many attempts to use structures constructed of degradable biomaterials for nerve regeneration. Most of them are natural biological materials, and there are inconsistency in material source and performance stability. Synthetic materials have great advantages in terms of uniformity of material properties.

The utility model patent of patent application publication No. CN205007321U discloses a nerve repair catheter, which comprises an inner layer and an outer layer arranged on the outer wall of the inner layer; the inner layer is made of one or more composite materials of collagen, chitosan and derivatives thereof, and the outer layer is made of one or more composite materials of collagen chitosan, silk fibroin and derivatives thereof.

The above patents have disadvantages in that therapeutic drugs cannot be carried and the stent material is not oriented to an adequate degree, thereby not utilizing nerve growth.

SUMMERY OF THE UTILITY MODEL

In order to overcome prior art's above-mentioned defect, the embodiment of the utility model provides a supporting structure thing for neural restoration, orientation guide through degradable tow to nerve growth goes on growing, have the micropore that covers the pipe setting outward of material exchange, on the one hand, in order to prevent that tissues from growing into on every side, keep nutrient substance to pass through the micropore that material exchange guarantees free business turn over on the one hand in addition, create the microenvironment that is favorable to neural regeneration, degradable tow length ratio covers pipe length slightly short outward, can let defective nerve insert, the secondary damage who has avoided sewing up and has brought, the porous characteristic of aquogel makes things convenient for recovered medicament and blood to dissolve, directly carry out medicine adjunctie therapy to the affected part, the growth of useful nerve.

In order to achieve the above object, the utility model provides a following technical scheme: a scaffold structure for nerve repair comprises an outer covering tube, wherein a degradable fiber bundle is arranged in the outer covering tube, and an adhesive column is arranged between the degradable fiber bundle and the outer covering tube;

a plurality of material exchange micropores are uniformly formed in the outer covering pipe, and penetrate through the outer covering pipe and are connected with the inner cavity;

the inside of the adhesive column is provided with a rehabilitation medicament which is set as a water-soluble or oil-soluble medicament for nerve regeneration.

In a preferred embodiment, the outer covering tube is made of an amphiphilic polyester-based biomaterial configured as one of polyethylene glycol polylactic acid or polyethylene glycol polycaprolactone.

In a preferred embodiment, the degradable fiber bundle comprises a plurality of degradable biomaterial fibers, and the degradable biomaterial fibers are made of one of polylactic acid, polyglycolide-lactide or polycaprolactone.

In a preferred embodiment, the adhesive column is made of a hydrogel material, and the degradable fiber bundle and the adhesive column are each shorter than the outer covering tube.

In a preferred embodiment, the pore size of the material exchange micropores is set to a nano-scale size.

The utility model discloses a technological effect and advantage:

the utility model discloses a be equipped with outer cover pipe, degradable tow and adhesion agent post, degradable tow carries out the orientation guide that grows to nerve growth, the outer cover pipe that has the material exchange micropore sets up, on the one hand, in order to prevent that tissues around grow into, keep nutrient substance to pass through the material exchange micropore on the one hand and guarantee free business turn over in addition, create the microenvironment that is favorable to nerve regeneration, degradable tow length is slightly shorter than outer cover pipe length, can let defective nerve insert, the secondary damage who has avoided sewing up and has brought, the convenient recovered medicament of porous characteristic of aquogel and blood dissolve, directly carry out medicine adjunctie therapy to the affected part, the growth of useful nerve.

Drawings

Fig. 1 is a schematic view of the overall structure of the present invention.

Fig. 2 is a schematic sectional view of the present invention.

Fig. 3 is a schematic view of the structure of the outer covering tube according to the present invention.

Fig. 4 is a schematic view of the structure of the adhesion agent column of the present invention.

The reference signs are: 1 outer covering tube, 11 material exchange micropores, 2 degradable fiber bundles, 3 adhesive column and 31 rehabilitation medicament.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

The utility model provides a supporting structure thing for neural restoration, including outer cover pipe 1, outer cover pipe 1 is inside to be equipped with degradable tow 2, be equipped with adhesion agent post 3 between degradable tow 2 and the outer cover pipe 1, evenly be equipped with a plurality of material exchange micropore 11 on the outer cover pipe 1, it is a plurality of material exchange micropore 11 all runs through outer cover pipe 1 and links to each other with the inner chamber, and adhesion agent post 3 is inside to be equipped with rehabilitation medicament 31, rehabilitation medicament 31 sets up to be used for neural regeneration's water-soluble or oil-soluble medicine, outer cover pipe 1 is made by amphiphilic polyester class biomaterial, amphiphilic polyester class biomaterial sets up to one kind in polyethylene glycol polylactic acid or polyethylene glycol polycaprolactone, degradable tow 2 includes many degradable biomaterial fibre, degradable biomaterial fibre is by polylactic acid, degradable biomaterial fibre, One material in polyglycolide lactide or polycaprolactone is made, adhesion agent post 3 is made by hydrogel material, degradable tow 2 and adhesion agent post 3 length all are less than 1 length of outer cover pipe, the aperture of material exchange micropore 11 sets up nanometer size.

As shown in fig. 1 to 4, the embodiment specifically is as follows: a plurality of degradable biomaterial fibers are placed in the inner cavity of an outer covering tube 1, the degradable biomaterial fibers are bonded into a bundle by hydrogel to form a degradable fiber bundle 2, after the degradable biomaterial fiber bundle is installed at a nerve position to be repaired, the degradable biomaterial fibers can guide the growth of nerves in an oriented way, the diameter of the degradable biomaterial fibers can be automatically adjusted according to requirements, and gaps exist among the degradable biomaterial fibers by hydrogel bonding, so that nerve cells can grow easily, the outer covering tube 1 with material exchange micropores 11 is arranged, on one hand, the growth of surrounding tissues is prevented, on the other hand, nutrient substances are reserved to ensure free access through the material exchange micropores 11, a microenvironment beneficial to nerve regeneration is created, the length of the degradable fiber bundle 2 is slightly shorter than that of the outer covering tube 1, so that defective nerves can be inserted, and secondary damage caused by sewing is avoided, and degradable fiber bundle 2 can independently degrade in vivo after nerve repair, the adhesion agent column 3 of aquogel material is the adhesive that current medical science can implant the human body, can agree with the health environment completely, need not to perform the operation once more and dismantle, reduces the logical sense of touch of disease, and the porous characteristic of aquogel makes things convenient for recovered medicament 31 and blood to dissolve, directly carries out medicine adjunctie therapy to the affected part.

The utility model discloses the theory of operation:

referring to the attached drawings 1-4 of the specification, the degradable biomaterial fiber is used for oriented guidance of nerve growth, an outer covering tube 1 with substance exchange micropores 11 is arranged, on one hand, the purpose is to prevent peripheral tissues from growing in, on the other hand, nutrient substances are kept to ensure free access through the substance exchange micropores 11, the porous characteristic of hydrogel is convenient for dissolving the rehabilitation medicament 31 and blood, and the affected part is directly treated with medicine in an auxiliary way.

The points to be finally explained are: first, in the description of the present application, it should be noted that, unless otherwise specified and limited, the terms "mounted," "connected," and "connected" should be understood broadly, and may be a mechanical connection or an electrical connection, or a communication between two elements, and may be a direct connection, and "upper," "lower," "left," and "right" are only used to indicate a relative positional relationship, and when the absolute position of the object to be described is changed, the relative positional relationship may be changed;

secondly, the method comprises the following steps: in the drawings of the disclosed embodiments of the present invention, only the structures related to the disclosed embodiments are referred to, and other structures can refer to the common design, and under the condition of no conflict, the same embodiment and different embodiments of the present invention can be combined with each other;

and finally: the above description is only for the preferred embodiment of the present invention and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A scaffold structure for nerve repair, comprising: the degradable fiber bundle-based medical tube comprises an outer covering tube (1), wherein a degradable fiber bundle (2) is arranged inside the outer covering tube (1), and an adhesive column (3) is arranged between the degradable fiber bundle (2) and the outer covering tube (1);

a plurality of material exchange micropores (11) are uniformly arranged on the outer covering pipe (1), and the material exchange micropores (11) penetrate through the outer covering pipe (1) and are connected with the inner cavity;

a rehabilitation medicament (31) is arranged in the adhesion agent column (3), and the rehabilitation medicament (31) is a water-soluble or oil-soluble medicament for nerve regeneration.

2. A scaffold structure for nerve repair according to claim 1, wherein: the outer covering pipe (1) is made of an amphiphilic polyester biological material, and the amphiphilic polyester biological material is one of polyethylene glycol polylactic acid or polyethylene glycol polycaprolactone.

3. A scaffold structure for nerve repair according to claim 1, wherein: the degradable fiber bundle (2) comprises a plurality of degradable biological material fibers, and the degradable biological material fibers are made of one material of polylactic acid, polyglycolide lactide or polycaprolactone.

4. A scaffold structure for nerve repair according to claim 1, wherein: the adhesive column (3) is made of hydrogel materials, and the lengths of the degradable fiber bundle (2) and the adhesive column (3) are both smaller than that of the outer covering pipe (1).

5. A scaffold structure for nerve repair according to claim 1, wherein: the pore diameter of the material exchange micropores (11) is set to be nano-scale.