CN210158974U - Support structure for central nerve repair - Google Patents

Abstract

The utility model discloses a supporting structure thing for central nervous system is restoreed, concretely relates to medical instrument technical field, including the cellosilk, the cellosilk is including last cellosilk and lower cellosilk, go up the inside bonding body that all is provided with of cellosilk and lower cellosilk, the cellosilk outside is provided with the pipe membrane, the pipe membrane outside is provided with the protective layer, and the bonding body sets up to paste viscous material, go up the cellosilk and utilize paste viscous material to bond into the halfcylinder with lower cellosilk and be tied in a bundle. The utility model discloses a be equipped with bonding body and tube membrane, the inside orientation structure that does benefit to nerve growth that has of halfcylinder is tied in a bundle, and paste viscous material bonds and makes there is the space between the cellosilk is inside for nerve cell grows into easily, has the porous tube membrane of nanometer, can prevent that the surrounding histiocyte from growing into, can remain nutrient substance's free business turn over in addition on the one hand, creates the microenvironment that is favorable to nerve regeneration.

Description

Support structure for central nerve repair

Technical Field

The utility model relates to the technical field of medical equipment, more specifically say, the utility model relates to a support structure thing for central nervous system is restoreed.

Background

Central nerve injuries such as severe spinal cord trauma are mainly manifested by paraplegia and quadriplegia, and no effective treatment is currently available. Traditionally, it has been thought that regeneration is difficult following central nerve injury. It is now believed that the major causes of central nerve regeneration difficulties are the presence of chemical factors in the microenvironment they reside in that inhibit nerve regeneration, and the lack of neurotrophic factors that promote nerve regeneration. At the present stage, the strategy for promoting the repair of spinal cord injury focuses on improving the regeneration microenvironment of nerve fibers emitted by neurons, so that the regenerated nerve fibers pass through the injury area by means of a bridge support and enter the spinal cord tissue on the other side, the nerve pathway connection is reconstructed, and the original functions are recovered.

The use of biomaterials in the medical field has been in history. In spinal cord injury, biological tissue engineering materials are attracting attention as transplantation cells or carriers of active factors having the effects of protecting neurons and promoting axon regeneration thereof, for treating spinal cord injury. This is also determined by the properties of the biological tissue engineering material itself. The tissue engineering material has natural biological material, non-degradable synthetic material and degradable polymer synthetic material. 1. Naturally derived biomaterials include gelatin, collagen and alginate, among others, which can promote, to some extent, the restoration of spinal cord structure and function. Due to the inherent structural disorder and poor mechanical properties of natural material scaffolds, although relatively ideal experimental results are observed in vitro, it is difficult to transplant the scaffolds into a body to play a role in guiding axon regeneration. 2. The main representative of the non-degradable material is silicone tube, the non-degradable synthetic material has high infection rate, is easy to cause chronic inflammatory reaction and fibrosis, and tends to generate blocking pressure on regenerated axon along with the prolonging of time, so that the catheter needs to be taken out again through operation. It is generally believed that an inactive targeting channel, which does not promote the passage of regenerating axons through the damaged area in the absence of exogenous growth factors, is not degradable. It is due to these disadvantages that non-degradable materials have not been extensively studied. 3. The degradable high molecular material has the greatest advantages of good biocompatibility, easy absorption of degradation products without inflammatory reaction, and is a main research object of the current biological tissue engineering material. The degradable high molecular material is represented by multi-channel biopolymer material-poly (D, L-lactic acid, PLLA) and poly (lactic-co-glycolic acid, PLGA). However, there are many problems to be solved in experiments for in vivo nerve damage repair. For example, acidic substances and collapse, etc. are generated after the stent material is degraded.

Gel, gelatin sponge and collagen sponge made of natural biological materials or catheters made of degradable high-molecular synthetic materials can be used for repairing the transectional spinal cord injury. The gel can fill in the cavity of spinal cord injury, promote axon regeneration, and reduce scar due to astrocytosis. However, it does not mediate well the passage of regenerating axons across the damaged area, especially in the absence of mechanical strength. Gelatin sponges and collagen sponges have the advantages of gels and can conveniently carry active substances, but their mechanical strength is not high. The catheter has the greatest advantage that the catheter has certain mechanical strength and can mediate regenerated axons to pass through the catheter to reach the other end of the transected spinal cord tissue, namely, the catheter plays a role in bridging, but acid substances generated by the degraded catheter have a damaging effect on adjacent cells.

The utility model patent of patent application publication No. CN204394742U discloses a solid core nerve scaffold with a built-in degradable metal wire, which comprises a scaffold membrane material and a degradable metal wire wrapped by the scaffold membrane material; the stent membrane material is a biodegradable material and has a three-dimensional pore structure; the degradable metal wires are distributed along the transverse direction and the longitudinal direction of the nerve scaffold. The nerve scaffold not only has a three-dimensional structure required by nerve regeneration, but also can promote and guide nerve growth, has good mechanical properties, is biodegradable, and has profound significance for nerve repair.

However, when the scaffold is actually used, the scaffold membrane material cannot prevent the growth of peripheral tissues, and on the other hand, the scaffold membrane material cannot keep the free in and out of nutrient substances and cannot create a microenvironment beneficial to nerve regeneration.

SUMMERY OF THE UTILITY MODEL

In order to overcome prior art's above-mentioned defect, the embodiment of the utility model provides a supporting structure thing for central nervous system is restoreed, the utility model discloses a be equipped with bonding body and tube membrane, the inside orientation structure that does benefit to nerve growth that has of halfcylinder is tied in a bundle, paste viscous material bonds and exists the space between making the cellosilk inside for nerve cell grows into easily, has the porous tube membrane of nanometer, can prevent that the histiocyte from growing into on every side, can remain nutrient substance's free business turn over on the one hand in addition, creates the microenvironment that is favorable to nerve regeneration.

In order to achieve the above object, the utility model provides a following technical scheme: a support structure for central nerve repair comprises a fiber yarn, wherein the fiber yarn comprises an upper fiber yarn and a lower fiber yarn, bonding bodies are arranged inside the upper fiber yarn and the lower fiber yarn, a tube membrane is arranged outside the fiber yarn, and a protective layer is arranged outside the tube membrane;

the bonding body is made of a paste-like viscous material, the upper fiber yarns and the lower fiber yarns are bonded into semi-cylindrical bundles by the paste-like viscous material, and the two semi-cylindrical bundles of the upper fiber yarns and the lower fiber yarns can be combined into a bundle structure with a circular cross section;

the tube membrane covers the outside of the fiber filament, the tube membrane can be a thin-wall tubular object with nano-scale porous or a thin film with nano-scale porous, and the length of the two ends of the fiber filament is slightly shorter than that of the two ends of the tube membrane;

the protective layer comprises a mechanical layer and a conductive layer, the mechanical layer is arranged on the surface of the tube membrane, the conductive layer is arranged on the surface of the mechanical layer, and the conductive layer and the surface of the mechanical layer are both provided with nano-scale holes.

In a preferred embodiment, the binder material is mainly a polyester obtained by condensation of malic acid, citric acid and 1, 4-butanediol.

In a preferred embodiment, the biomaterial from which the upper and lower filaments are made may be polylactic acid, polyglycolide, lactide or polycaprolactone.

In a preferred embodiment, the biomaterial of which the tube membrane is made is predominantly an amphiphilic polyester-based material, such as polyethylene glycol polylactic acid, polyethylene glycol or polycaprolactone.

In a preferred embodiment, the conductive layer is formed from silk fibroin fibers by ion exfoliation techniques or by in situ adsorption of pyrrole.

In a preferred embodiment, the mechanical layer is prepared by compounding silk fibroin and hyaluronic acid.

The utility model discloses a technological effect and advantage:

1. the utility model discloses a be equipped with bonding body and tube membrane, because the length at cellosilk both ends is slightly short than the length at tube membrane both ends, can let defective nerve insert, realize the butt joint with the nerve that awaits repairing, the secondary damage of bringing has been avoided sewing up, because bonding body is paste viscous material, go up cellosilk and lower cellosilk utilize paste viscous material to bond into the semi-cylinder and gather a bundle, the inside orientation structure who does benefit to nerve growth that has of semi-cylinder is gathered a bundle, paste viscous material bonds and has the space between the inside cellosilk, make nerve cell grow into easily, have the porous tube membrane of nanometer, can prevent that peripheral histiocyte from growing into, can keep the free business turn over of nutrient substance on the one hand in addition, create the microenvironment that is favorable to nerve regeneration, and the medicine that promotes nerve regeneration inside the paste bonding body can slowly release to the microenvironment in nerve damage district through the nanometer porous on the tube membrane, a chemotactic factor enrichment area is formed by taking a stent transplantation part as a center, and related endogenous cells are promoted to migrate to the area, so that the aims of attracting the endogenous cells to migrate to the interior of the stent to survive and repairing central nerve injury through differentiation are fulfilled. The utility model, the fiber silk is bonded by the paste material, which is simple and convenient, has definite orientation structure, is beneficial to nerve regeneration, has easily obtained source of the paste, is completely degraded, is convenient to use, and can embed active ingredients;

2. the utility model discloses a be equipped with mechanical layer and conducting layer, the mechanical layer is formed by silk fibroin and hyaluronic acid complex preparation, has better mechanical properties and water-retaining property, can strengthen the toughness and the anti tractive ability of support, and the conducting layer is formed by silk fibroin fibre through the ion stripping technique or through the normal position absorption agglomeration pyrrole, has good signal of telecommunication transmission ability, more is favorable to central nervous system's recovery.

Drawings

Fig. 1 is a front view of the overall structure of the present invention.

Fig. 2 is a side view of the upper filament structure of the present invention.

Fig. 3 is a front view of the upper filament structure of the present invention.

Fig. 4 is a side view of the lower filament structure of the present invention.

Fig. 5 is a front view of the lower filament structure of the present invention.

Fig. 6 is a schematic view of the tube membrane structure of the present invention.

Fig. 7 is a side view of the overall structure of the present invention.

The reference signs are: 1 fiber yarn, 11 upper fiber yarn, 12 lower fiber yarn, 2 bonding body, 3 tube film, 4 protective layer, 41 mechanical layer and 42 conductive layer.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

The utility model provides a support structure for central nerve repair, which comprises a fiber filament 1, wherein the fiber filament 1 comprises an upper fiber filament 11 and a lower fiber filament 12, bonding bodies 2 are arranged inside the upper fiber filament 11 and the lower fiber filament 12, a tube membrane 3 is arranged outside the fiber filament 1, and a protective layer 4 is arranged outside the tube membrane 3; the bonding body 2 is made of a paste-like viscous material, the upper fiber yarns 11 and the lower fiber yarns 12 are bonded into semi-cylindrical bundles by the paste-like viscous material, and the two semi-cylindrical bundles of the upper fiber yarns 11 and the lower fiber yarns 12 can be combined into a bundle structure with a circular cross section; the tube membrane 3 covers the exterior of the fiber filament 1, the tube membrane 3 can be a thin-wall tube with nanometer-scale porous or a thin film with nanometer-scale porous, and the length of the two ends of the fiber filament 1 is slightly shorter than that of the two ends of the tube membrane 3; the protective layer 4 comprises a mechanical layer 41 and a conductive layer 42, the mechanical layer 41 is arranged on the surface of the tube membrane 3, the conductive layer 42 is arranged on the surface of the mechanical layer 41, and the surfaces of the conductive layer 42 and the mechanical layer 41 are both provided with nano-scale pores.

As shown in fig. 1 to 7, the embodiment specifically is: when the multifunctional nerve repairing bracket works, a medical worker can implant the central nerve repairing bracket to a nerve to be repaired, because the length of two ends of the fiber filament 1 is slightly shorter than that of two ends of the tube membrane 3, the defective nerve can be inserted to realize butt joint with the nerve to be repaired, and secondary damage caused by sewing is avoided, because the bonding body 2 is a paste viscous material, the upper fiber filament 11 and the lower fiber filament 12 are bonded into a semi-cylinder cluster by the paste viscous material, the inside of the semi-cylinder cluster has an oriented structure beneficial to nerve growth, the diameter of the fiber filament 1 can be conveniently adjusted by the paste viscous material, gaps exist among the fiber filament 1 due to bonding of the paste viscous material, nerve cells can easily grow in, the tube membrane 3 with nano-scale porous holes can prevent the growth of peripheral tissue cells, and in addition, on one hand, the free access of nutrient substances can be reserved, and a microenvironment beneficial to nerve regeneration is created, the paste adhesive body 2 can conveniently contain various medicines for nerve regeneration, water-soluble or oil-soluble medicines, and the medicines for promoting nerve regeneration in the paste adhesive body 2 can be slowly released into a microenvironment of a nerve injury area through the nano-scale porous on the tube membrane 3, and a chemokine enrichment area is formed by taking a stent transplantation part as a center, so that related endogenous cells are promoted to migrate to the area, and the purposes of attracting the endogenous cells to migrate to the interior of the stent to survive and differentiating and repairing central nerve injury are achieved.

The bonding body 2 is mainly made of polyester obtained by condensing malic acid, citric acid and 1, 4-butanediol, the biological materials of the upper fiber 11 and the lower fiber 12 can be polylactic acid, polyglycolide lactide and polycaprolactone, the biological materials of the tube membrane 3 are mainly made of amphiphilic polyester materials such as polyethylene glycol polylactic acid and polyethylene glycol polycaprolactone, the conducting layer 42 is formed by silk fibroin fibers through an ion stripping technology or through in-situ adsorption pyrrole, and the mechanical layer 41 is prepared by compounding silk fibroin and hyaluronic acid.

As shown in fig. 7, the embodiment specifically includes: the mechanical layer 41 is prepared by compounding silk fibroin and hyaluronic acid, has better mechanical property and water retention property, can enhance the toughness and the anti-pulling capacity of the stent, and the conducting layer 42 is formed by silk fibroin fibers through an ion stripping technology or in-situ adsorption pyrrole, has good electric signal transmission capacity, and is more beneficial to the recovery of a central nervous system.

The utility model discloses the theory of operation:

referring to the attached figures 1-7 of the specification, medical staff can implant the central nerve repair bracket to the nerve to be repaired, can insert the defective nerve and realize butt joint with the nerve to be repaired, because the bonding body 2 is a paste-like viscous material, the upper fiber yarns 11 and the lower fiber yarns 12 are bonded into a semi-cylindrical cluster by the paste-like viscous material, the interior of the semi-cylindrical cluster is provided with an oriented structure which is beneficial to nerve growth, the diameter of the fiber yarn 1 can be conveniently adjusted through the paste-like viscous material, the paste-like viscous material is bonded to ensure that gaps exist among the fiber yarn 1, the nerve cells are easy to grow in, the tube membrane 3 with the nanometer grade holes can prevent the cells of the surrounding tissues from growing in, on the other hand, the free entering and exiting of nutrient substances can be kept, and various medicines for nerve regeneration, water solubility or oil solubility can be conveniently contained in the paste bonding body 2;

referring to the attached figure 7 of the specification, the mechanical layer 41 is prepared by compounding silk fibroin and hyaluronic acid, has better mechanical property and water retention property, and the conductive layer 42 is formed by silk fibroin fibers through an ion stripping technology or in-situ adsorption pyrrole, and has good electric signal transmission capacity.

The points to be finally explained are: first, in the description of the present application, it should be noted that, unless otherwise specified and limited, the terms "mounted," "connected," and "connected" should be understood broadly, and may be a mechanical connection or an electrical connection, or a communication between two elements, and may be a direct connection, and "upper," "lower," "left," and "right" are only used to indicate a relative positional relationship, and when the absolute position of the object to be described is changed, the relative positional relationship may be changed;

secondly, the method comprises the following steps: in the drawings of the disclosed embodiments of the present invention, only the structures related to the disclosed embodiments are referred to, and other structures can refer to the common design, and under the condition of no conflict, the same embodiment and different embodiments of the present invention can be combined with each other;

and finally: the above description is only for the preferred embodiment of the present invention and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (4)

1. A scaffold structure for central nervous repair comprising a fiber filament (1), characterized in that: the fiber yarn (1) comprises an upper fiber yarn (11) and a lower fiber yarn (12), bonding bodies (2) are arranged inside the upper fiber yarn (11) and the lower fiber yarn (12), a tube membrane (3) is arranged outside the fiber yarn (1), and a protective layer (4) is arranged outside the tube membrane (3);

the bonding body (2) is made of a paste-like viscous material, the upper fiber yarns (11) and the lower fiber yarns (12) are bonded into a semi-cylindrical cluster by the paste-like viscous material, and the two semi-cylindrical clusters of the upper fiber yarns (11) and the lower fiber yarns (12) can be combined into a cluster structure with a circular cross section;

the tube membrane (3) covers the outside of the fiber filament (1), the tube membrane (3) can be a thin-wall tubular object with nano-scale holes or a thin film with nano-scale holes, and the length of two ends of the fiber filament (1) is slightly shorter than that of two ends of the tube membrane (3);

the protective layer (4) comprises a mechanical layer (41) and a conductive layer (42), the mechanical layer (41) is arranged on the surface of the tube membrane (3), the conductive layer (42) is arranged on the surface of the mechanical layer (41), and the surfaces of the conductive layer (42) and the mechanical layer (41) are both provided with nano-scale holes.

2. A scaffold structure for central nervous repair according to claim 1, wherein: the biological material for preparing the upper fiber thread (11) and the lower fiber thread (12) can be polylactic acid, polyglycolide, lactide or polycaprolactone.

3. A scaffold structure for central nervous repair according to claim 1, wherein: the biological material for preparing the tube membrane (3) is mainly amphiphilic polyester material, such as polyethylene glycol polylactic acid, polyethylene glycol or polycaprolactone.

4. A scaffold structure for central nervous repair according to claim 1, wherein: the conductive layer (42) is formed from silk fibroin fibers by ion exfoliation techniques or by in situ adsorption of pyrrole.

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