CN201634681U - Gravity hybrid biological reaction device slantwise rotating along central shaft of culture container - Google Patents
Gravity hybrid biological reaction device slantwise rotating along central shaft of culture container Download PDFInfo
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- CN201634681U CN201634681U CN2010201036493U CN201020103649U CN201634681U CN 201634681 U CN201634681 U CN 201634681U CN 2010201036493 U CN2010201036493 U CN 2010201036493U CN 201020103649 U CN201020103649 U CN 201020103649U CN 201634681 U CN201634681 U CN 201634681U
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- column
- biological reaction
- transmission shaft
- reaction apparatus
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Abstract
The utility model discloses a biological reaction device enabling a culture bottle with a cylindrical main body to carry out microcarrier cell culture. In a frame having functions of fixing and supporting, a plurality of parallel column-shaped transmission shafts which form an angle of 5-80 degrees with the horizontal surface are driven by a motor to rotate to drive the cylindrical culture bottle to rotate. The column-shaped transmission shafts consist of a drive rotating transmission shaft and a driven rotating transmission shaft adjacent to the drive rotating transmission shaft, and two adjacent transmission shafts and a support base at the bottom of the transmission shafts commonly support the column-shaped culture container to rotate. Each row or each column of the drive rotating column-shaped transmission shafts can be transmitted by a transmission belt or a gear, and each row or each column of the drive rotating column-shaped transmission shafts and the motor can be transmitted by the transmission belt or the gear. The utility model can include a circuit controlling part and can be placed in a temperature control container including a greenhouse and a temperature cabinet.
Description
Technical field
The microcarrier cell cultures is the main method that mass cell is cultivated, the conventional bio-reactor that is used for the microcarrier cell cultures costs an arm and a leg, complex structure, need the operator of specialty to use, the biological reaction apparatus that the present invention relates to is economical and practical, simple to operate, make the microcarrier cell cultures easy as common cell bottle cell cultures.
Background technology
Because there are many, the easy contaminating microorganisms of big, the required bottle of labor capacity quantity in traditional rolling bottle culturing cell, power consumption is big and produce shortcomings such as dirt is many, the microcarrier cell culture technology receives publicity day by day.And the bio-reactor of import costs an arm and a leg, and the home-made bio-reactor is cheap, the bad again assurance of culture effect and stability.
Summary of the invention
In order to address the above problem, the invention provides a kind of microcarrier biological reaction apparatus can be that column culture vessel (as 3L rolling bottle etc.) carries out the microcarrier cell cultures by main body, reaches high-cell density, economical and practical.
The technical solution adopted in the present invention is: a kind of main body that makes is the biological reaction apparatus that columned culturing bottle carries out the microcarrier cell cultures, in the framework that plays fixing and supporting role, rotate to drive cylindric culturing bottle rotation by motor drive multirow, multiple row column transmission shaft, carry out the microcarrier cell cultures, each column transmission shaft, cylindric culturing bottle is parallel to each other and all tilt to be fixed in the support frame.
The column transmission shaft of this biological reaction apparatus can one be divided into many groups, each group be 1 by electric motor driven active rotation axle and be adjacent about each driven rotating shaft free to rotate forms, 2 the adjacent rotation axiss and the base for supporting of its bottom are held the rotation of column culture vessel jointly.
Each column transmission shaft of this biological reaction apparatus, the column culture vessel is parallel to each other and and horizontal plane be 5～80 the degree angles.
Can use transmission belt transmission or geartransmission between each row of this biological reaction apparatus or each row between initiatively column is rotated, each row or each colonnade shape rotation axis and the electric motor.
This biological reaction apparatus can contain the pilot circuit part, and pilot circuit comprises power switch, electromotor velocity regulating circuit, corresponding button.
This biological reaction apparatus can be placed in the temperature control container, and temperature control container comprises the greenhouse, incubator.
Description of drawings
Fig. 1, Fig. 2 are the side-view of two kinds of types of realization the design thinking
2 groups of column transmission shafts that Fig. 3 links to each other and places for level
Fig. 4 is the schematic perspective view of spending the column transmission shaft group at angles with horizontal plane journey 5～80
(1) framework that play fixed supporting role; (2) electric motor; (3) column transmission shaft group; (4) crossbeam; (5) belt or the gear of connection cylindrical active rotation transmission shaft; (6) belt or the gear of connection cylindrical active rotation transmission shaft and electric motor; (7) position of the cylindric culturing bottle of placement; (8) cylindrical active rotation transmission shaft; (9) passive rotation column transmission shaft; (10) rubber jacket layer; (11) base for supporting of placement column culture vessel;
Embodiment
For the features and advantages of the present invention can be become apparent more, the present invention is further detailed explanation below in conjunction with the drawings and specific embodiments.
Fig. 1, Fig. 2 are the side-view of two kinds of types of realization the design thinking, connecting on the crossbeam (4) in framework (1) by 1 row or multirow, 1 row or multiple row is parallel to each other and with the column transmission shaft group (3) at horizontal plane journey 5～80 degree angles, the cylindrical active rotation transmission shaft of the cylindric culturing bottle stationary installation of every row or every row (3) is connected by belt or gear (5), and be connected to common electric motor (2) by belt or gear (6), rotate by pilot circuit control motor drive cylindrical active rotation transmission shaft.
Fig. 3 is the frontview of the column culture vessel stationary installation of horizontal positioned, 1 passive rotation column transmission shaft (9) is arranged in the adjacent both sides of its cylindrical active rotation transmission shaft (8), each is walked crosswise can a plurality of active rotation axles, the spacing of all adjacent rotated axles all equates, and and these two adjacent rotation axiss between base for supporting (10) form 1 position (7) of placing cylindric culturing bottle jointly.
Fig. 4 is the schematic perspective view of spending the cylindric culturing bottle stationary installation stationary installation at angles with horizontal plane journey 5～80, all is fixed with rubber jacket layer (11) on all rotation axiss.
Claims (6)
- One kind can to make main body be the biological reaction apparatus that columned culturing bottle carries out the microcarrier cell cultures, it is characterized in that in the framework that plays fixing and supporting role, rotate to drive cylindric culturing bottle rotation by motor drive multirow, multiple row column transmission shaft, carry out the microcarrier cell cultures, each column transmission shaft, cylindric culturing bottle is parallel to each other and all tilt to be fixed in the support frame.
- 2. biological reaction apparatus according to claim 1, the column transmission shaft that it is characterized in that its inclination can one be divided into many groups, each group be 1 by electric motor driven active rotation axle and be adjacent about each driven rotating shaft free to rotate forms, 2 the adjacent rotation axiss and the base for supporting of its bottom are held cylindric culturing bottle rotation jointly.
- 3. according to any described biological reaction apparatus in the claim 1～2, it is characterized in that its each column transmission shaft parallel to each other, column culturing bottle all and horizontal plane be 5～80 degree angles.
- 4. according to any described biological reaction apparatus in the claim 1～2, between it is characterized in that its each row of each row initiatively column being rotated, can use the transmission belt transmission between each each colonnade shape rotation axis of row and the electric motor.
- 5. according to any described biological reaction apparatus in the claim 1～2, it is characterized in that it contains the pilot circuit part, pilot circuit comprises power switch, electromotor velocity regulating circuit, corresponding button.
- 6. according to any described biological reaction apparatus in the claim 1～2, it is characterized in that it can be placed in the temperature control container, temperature control container comprises greenhouse, incubator.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010201036493U CN201634681U (en) | 2010-01-29 | 2010-01-29 | Gravity hybrid biological reaction device slantwise rotating along central shaft of culture container |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010201036493U CN201634681U (en) | 2010-01-29 | 2010-01-29 | Gravity hybrid biological reaction device slantwise rotating along central shaft of culture container |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201634681U true CN201634681U (en) | 2010-11-17 |
Family
ID=43079170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010201036493U Expired - Lifetime CN201634681U (en) | 2010-01-29 | 2010-01-29 | Gravity hybrid biological reaction device slantwise rotating along central shaft of culture container |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201634681U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101805694B (en) * | 2010-01-29 | 2012-07-04 | 福尔生物制药股份有限公司 | Gravity mixing bioreactor obliquely rotating along central shaft of culture vessel |
-
2010
- 2010-01-29 CN CN2010201036493U patent/CN201634681U/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101805694B (en) * | 2010-01-29 | 2012-07-04 | 福尔生物制药股份有限公司 | Gravity mixing bioreactor obliquely rotating along central shaft of culture vessel |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: ZHONGKE BIOLOGICAL PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: FORWELL BIOPHARMACEUTICALS CO., LTD. |
|
| CP03 | Change of name, title or address |
Address after: 065201 No. 1155 Development Zone, Sanhe, Hebei, Yanjiao Patentee after: Zhongke biopharmaceutical Limited by Share Ltd Address before: 065201 Yingbin Road 38-2, Yanjiao Development Zone, Hebei, Sanhe Patentee before: Forwell Biopharmaceuticals Co., Ltd. |
|
| CX01 | Expiry of patent term |
Granted publication date: 20101117 |
|
| CX01 | Expiry of patent term |