CN201441839U - Multifunctional chromatographic fractionation device for simulation moving bed - Google Patents
Multifunctional chromatographic fractionation device for simulation moving bed Download PDFInfo
- Publication number
- CN201441839U CN201441839U CN2009200159953U CN200920015995U CN201441839U CN 201441839 U CN201441839 U CN 201441839U CN 2009200159953 U CN2009200159953 U CN 2009200159953U CN 200920015995 U CN200920015995 U CN 200920015995U CN 201441839 U CN201441839 U CN 201441839U
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- conduit
- fixing seal
- rolling disc
- seal dish
- moving bed
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Abstract
The utility model relates to a multifunctional chromatographic fractionation device for a simulation moving bed including a separation system and an auxiliary system. A motor shaft of a motor of the separation system is coupled with a gearbox; the lower part of the gearbox is fixedly coupled with a fixed seal disc; and a transmission shaft of the gearbox is fixedly coupled with a rotation plate. The fixed seal disc is coaxially embedded in the rotation plate and is tangent to a ring surface in the rotation plate along the ring circumference; conduits communicated with each other are arranged both in the fixed seal disc and in the rotation plate; an interface communicated with the conduits is arranged on the upper plane of the fixed seal disc, and a conduit at the outer ring circumference is communicated with the conduit in the rotation plate; and an interface of the conduit at the outer ring circumference of the rotation plate is connected with the interfaces at two ends of a chromatographic column through pipelines respectively. The utility model can change the connection among a feeding hole, a discharge hole and the pipelines on a rotary distributing valve according to the requirement of processing parameters, thereby achieving the multifunctional effect, and achieving the effects of chromatograph preparation, moving bed simulation and an ion-exchange bed; furthermore, the utility model realizes multi-material purification and fractionation in multiple methods, and realizes multipurpose, thereby saving experiment and production costs and improving the working efficiency.
Description
Technical field
The utility model belongs to separator, particularly relates to a kind of multi-functional moving bed imitation chromatogram separation facility.
Background technology
The separation purification technology of preparative chromatography, ion-exchange chromatography and SMBC is used more extensive at home at present, though it has all finished separating effect in various degree, reached and separated purpose preferably, but, limitation according to raw-material needs and experimental condition, a certain instrument and equipment can only be more single in the experimental study process finishes separation to a class material, this has just limited to the range of application of equipment, as: preparative chromatography can only be carried out the separation preparation of material on a small quantity, belong to step, do not reach the purpose of continuous separation; SMBC can reach the purpose of continuous separation, but it is suitable for the separation to two kinds of components, and this just makes the separation equipment separate mode more single; Ion-exchange chromatography can only separate the material with ion-exchange capacity, this also makes separation equipment separate a certain series products, has caused the unicity operation of equipment, can not adapt to the needs of multimode test, cause the waste of equipment, increased production and experimentation cost.
Summary of the invention
The utility model is intended to fill up above-mentioned shortcoming, a kind of multi-functional moving bed imitation chromatogram separation facility is provided, can on an instrument, reach the test of multiple function simultaneously, requirement according to technology, promptly can reach the function of preparative chromatography, SMBC, ion-exchange chromatography by the connected mode that changes pipeline and valve body, can finish various materials, multimode separation, realized " a tractor serves several purposes " purpose, save test and production cost, reached good separating effect simultaneously.
Multi-functional moving bed imitation chromatogram separation facility of the present utility model is to be made of piece-rate system and accessory system, piece-rate system places in the casing, piece-rate system is to be connected and composed by motor, gear-box, rotary distributor and chromatographic column and pipeline, the motor shaft and the gear-box of motor link, the bottom of gear-box fixes with the fixing seal dish of rotary distributor and connects, and the power transmission shaft of gear-box fixes with the rolling disc of rotary distributor and connects.The fixing seal dish is that radial section is trapezoidal disk, and rolling disc is a trapezoidal depressed disk in radial section is, in the coaxial embedding rolling disc of fixing seal dish, the ring of fixing seal dish week becomes anchor ring tangent with rolling disc is interior along ring week; The conduit that links is all arranged in fixing seal dish and rolling disc, the plane is provided with the material interface a, the conduit in outer shroud week and the conduit in the rolling disc that link with conduit and dynamically links on the fixing seal dish, is connected with the interface pipeline at chromatographic column two ends respectively at the interface that conduit is arranged in rolling disc outer shroud week.
As further improvement of the utility model, the fixing seal dish is that the centrum plunger type matches with rolling disc.
As further improvement of the utility model, the limit spring of fixing seal dish is arranged on the shell of power transmission shaft.
As further improvement of the utility model, be fixed with the conduit terminal pad in the outside of casing, be provided with paired material import and export pipe joint in the upper surface of conduit terminal pad, be provided with pipe joint corresponding with the material import and export pipe joint, that conduit is communicated with in the lower surface, the pipe joint of lower surface respectively with chromatographic separation device in the fixing seal dish on the interface pipeline be connected, in the connection that is provided with needle valve control upper surface pipe joint the outer shroud week of conduit terminal pad.
Multi-functional moving bed imitation chromatogram separation facility of the present utility model, requirement according to technological parameter, the feed inlet and outlet and being connected of pipeline that can change on the rotary distributor reach multi-functional effect, can make it reach the effect of preparative chromatography, simulation moving-bed effect and ion exchange bed, realization separates the purification of many materials, multi-method, it has realized the function of a tractor serves several purposes, has saved test and production cost, has improved the efficient of work.
Description of drawings
Fig. 1 is a structural representation of the present utility model;
Fig. 2 is the structural representation of the utility model piece-rate system;
Fig. 3 is the structural representation of the utility model external conduit terminal pad;
Fig. 4 is that Fig. 3 A-A is to profile.
The specific embodiment
Multi-functional moving bed imitation chromatogram separation facility of the present utility model is to be made of piece-rate system and accessory system two parts, sees that accompanying drawing 1, Fig. 2, Fig. 3, Fig. 4 have indicated apparatus of the present invention member composition and the effect of playing, and are described in detail as follows:
Piece-rate system is the key problem in technology of the multi-functional chromatogram separator of the present invention, by the close fit of sharing out the work and help one another of this component of a system key element, realizes the orderly operation of continous-stable long period of multi-functional chromatogram separator, reaches high accuracy and separates purpose.Native system reaches different separation purposes by the regulation and control of external rotary distributor conduit hookup.
Multi-functional moving bed imitation chromatogram separation facility piece-rate system of the present utility model places in the casing 13, piece-rate system is to be connected and composed by motor, gear-box, rotary distributor and chromatographic column and pipeline, the motor shaft 2 and the gear-box 3 of motor 1 link, the bottom of gear-box 3 fixes with the fixing seal dish 4 of rotary distributor and connects, and the power transmission shaft 5 of gear-box 3 fixes with the rolling disc 6 of rotary distributor and connects; Fixing seal dish 4 is that radial section is trapezoidal disk, and rolling disc 6 is trapezoidal depressed disks in radial section is, in the fixing seal dish 4 coaxial embedding rolling discs 6, the ring of fixing seal dish 4 week becomes anchor ring tangent with 6 interior edge ring weeks of rolling disc; The conduit 7,8 that links is all arranged in fixing seal dish 4 and rolling disc 6, the conduit 8 that the plane is provided with in material interface a, the conduit in outer shroud week 7 and the rolling disc 6 that links with conduit 7 on the fixing seal dish 4 dynamically links, and is connected with the interface pipeline at chromatographic column 11 two ends respectively at the interface 9,10 that conduit 8 is arranged in 6 outer shroud weeks of rolling disc.
Chromatographic column is the key problem in technology of multi-functional chromatogram separator, according to the needs that separate different material, choose and have the fixedly phase (or claiming adsorbent) of separating this material performance and mobile (or claiming strippant) mutually that certain desorption ability is arranged, under certain process conditions, just can finish the purpose of separating this material of purifying.
Fixing seal dish 4 matches with rolling disc 6 for the centrum plunger type.
The limit spring 12 that fixing seal dish 4 is arranged on the shell of power transmission shaft 5.
Be fixed with conduit terminal pad 14 in the outside of casing 13, be provided with paired material import and export pipe joint 15,16 in the upper surface of conduit terminal pad 14, be provided with pipe joint 17,18 15,16 corresponding with pipe joint, that conduit is communicated with in the lower surface, pipe joint 17,18 respectively with chromatographic separation device in fixing seal dish 4 on interface a pipeline be connected, in the connection that is provided with needle valve 19 control valve joints 15 and pipe joint 16 the outer shroud week of conduit terminal pad 14.
Multi-functional rotation distributing valve is combined by conduit terminal pad, fixing seal dish, rolling disc.By motor-driven gear, make turn disc by gear drive, the fixing seal dish is motionless, forms and relatively move between two dishes, the mobile effect of fixing simulation mutually of chromatographic column is caused in conversion material import and export position regularly, make different material after the chromatographic column of flowing through, reach to separate and purify.
Multi-functional rotation distributing valve conduit is external, be about to the conduit terminal pad and be connected on the fixed disk by pipeline, realize external function.Realize the multi-functional effect of this machine by changing external rotary distributor conduit again.
The preparative chromatography effect; Multi-functional chromatogram separator is made up of many root chromatogram columns, and it carries out the switching of post position at set intervals, thereby reach the purpose of separation by the control of the servicing unit time relay.When with time set during in fixed value, chromatographic column just can not rotated, and by the adjusting of external rotary distributor, makes material flow through single chromatographic column, has so just formed the effect of single-column separation, promptly reaches the effect of the chromatogram of preparation.
Simulation moving-bed effect: by the needle valve on the external rotary distributor is opened, block interface tube, make to form the loop between the chromatographic column, reach the purpose of series connection, make the chromatographic column group can be divided into 3～5 and have the difference in functionality zone of action with plug; Fixed disk and rotating disc that every post exports up and down all with multi-functional rotation distributing valve link, and feed inlet and outlet is set at the corresponding post item of fixed disk place, keep being back to back material, carry out uninterrupted component and separate, realize simulating the effect that moves with two phase countercurrent flow.
Ion exchange bed effect: by the needle valve on the external rotary distributor partially opens or cuts out, and according to the needs of experimental condition, make the relation that forms serial or parallel connection between the chromatographic column, reach the purpose of absorption, wash-out between the different chromatographic columns, finish ion-exchange, thereby reach the effect of ion exchange bed material and eluent.
Accessory system of the present utility model by instrument control section, column oven part, and mass transport partly form, each several part cooperatively interacts, and reaches the process conditions requirement of separation process, can continuously, efficiently finish the chromatographic isolation task.Specify as follows:
The instrument control section comprises battery main switch, the adjustable time relay, humidostat, pressure-regulating valve, Pressure gauge, flowmeter composition.
The column oven part: this part is made up of column oven and air-heater, and it mainly acts on is to keep the temperature inside the box to move under controlled condition.
Mass transport part: mainly constitute by 4～6 constant current measuring pumps and with multi-functional rotation distributing valve fixed disk connecting line, mainly be the effect of in chromatographic column, quantitatively carrying material circulation in separated raw material, strippant and the post, guarantee that multi-functional moving bed imitation chromatogram separation facility moves continuously.
Claims (4)
1. multi-functional moving bed imitation chromatogram separation facility, be to constitute by piece-rate system and accessory system, piece-rate system places in the casing (13), it is characterized in that piece-rate system is to be connected and composed by motor, gear-box, rotary distributor and chromatographic column and pipeline, the motor shaft (2) of motor (1) links with gear-box (3), the bottom of gear-box (3) fixes with the fixing seal dish (4) of rotary distributor and connects, and the power transmission shaft (5) of gear-box (3) fixes with the rolling disc (6) of rotary distributor and connects; Fixing seal dish (4) is that radial section is trapezoidal disk, rolling disc (6) is a trapezoidal depressed disk in radial section is, in the coaxial embedding rolling disc of fixing seal dish (4) (6), the ring of fixing seal dish (4) week becomes anchor ring tangent with rolling disc (6) is interior along ring week; The conduit (7,8) that links is all arranged in fixing seal dish (4) and rolling disc (6), the conduit (8) that fixing seal dish (4) is gone up in material interface a, the conduit in outer shroud week (7) and the rolling disc (6) that the plane is provided with and conduit (7) links dynamically links, and is connected with the interface pipeline at chromatographic column (11) two ends respectively at the interface (9,10) that conduit (8) are arranged in rolling disc (6) outer shroud week.
2. multi-functional moving bed imitation chromatogram separation facility as claimed in claim 1 is characterized in that fixing seal dish (4) matches with rolling disc (6) for the centrum plunger type.
3. multi-functional moving bed imitation chromatogram separation facility as claimed in claim 1 or 2 is characterized in that having the limit spring (12) of fixing seal dish (4) on the shell of power transmission shaft (5).
4. multi-functional moving bed imitation chromatogram separation facility as claimed in claim 1 or 2, it is characterized in that being fixed with conduit terminal pad (14) in the outside of casing (13), be provided with paired material import and export pipe joint (15 in the upper surface of conduit terminal pad (14), 16), be provided with and pipe joint (15 in the lower surface, 16) corresponding, the pipe joint (17 that conduit is communicated with, 18), pipe joint (17,18) respectively with chromatographic separation device in fixing seal dish (4) on interface a pipeline be connected, be provided with the connection of needle valve (19) control valve joint (15) and pipe joint (16) in the outer shroud week of conduit terminal pad (14).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200159953U CN201441839U (en) | 2009-07-30 | 2009-07-30 | Multifunctional chromatographic fractionation device for simulation moving bed |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200159953U CN201441839U (en) | 2009-07-30 | 2009-07-30 | Multifunctional chromatographic fractionation device for simulation moving bed |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201441839U true CN201441839U (en) | 2010-04-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009200159953U Expired - Fee Related CN201441839U (en) | 2009-07-30 | 2009-07-30 | Multifunctional chromatographic fractionation device for simulation moving bed |
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| CN (1) | CN201441839U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102221099A (en) * | 2011-05-25 | 2011-10-19 | 上海浦东汉威阀门有限公司 | Novel chromatographic separation rotating valve |
| CN102635725A (en) * | 2012-04-27 | 2012-08-15 | 工信华鑫科技有限公司 | Movable valve hydraulic action system used for continuous adsorption switching equipment |
-
2009
- 2009-07-30 CN CN2009200159953U patent/CN201441839U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102221099A (en) * | 2011-05-25 | 2011-10-19 | 上海浦东汉威阀门有限公司 | Novel chromatographic separation rotating valve |
| CN102221099B (en) * | 2011-05-25 | 2014-01-29 | 上海浦东汉威阀门有限公司 | Novel chromatographic separation rotating valve |
| CN102635725A (en) * | 2012-04-27 | 2012-08-15 | 工信华鑫科技有限公司 | Movable valve hydraulic action system used for continuous adsorption switching equipment |
| CN102635725B (en) * | 2012-04-27 | 2013-08-14 | 工信华鑫科技有限公司 | Movable valve hydraulic action system used for continuous adsorption switching equipment |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100428 Termination date: 20120730 |