CN201283233Y - Separation device of simulated moving bed chromatography - Google Patents
Separation device of simulated moving bed chromatography Download PDFInfo
- Publication number
- CN201283233Y CN201283233Y CNU2008202183083U CN200820218308U CN201283233Y CN 201283233 Y CN201283233 Y CN 201283233Y CN U2008202183083 U CNU2008202183083 U CN U2008202183083U CN 200820218308 U CN200820218308 U CN 200820218308U CN 201283233 Y CN201283233 Y CN 201283233Y
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- moving bed
- rotor disk
- conduit
- stator dish
- chromatographic column
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Abstract
The utility model relates to a simulated moving bed chromatographic separation device, which belongs to a separation device, and is formed by connecting a driving system, an actuating system, a rotary distribution valve, a chromatographic column and a pipe line, wherein the driving system is formed by an electromagnetic brake motor, the actuating system is that the electromagnetic brake motor shaft is connected with a gear box, a transmission shaft of the gear box is fixedly connected with a rotor disc of the rotary distribution valve, and the rotary distribution valve contacts and is moveably engaged with the surface of a stator disc by the rotor disc. Channel flows which are mutually communicated are arranged in the stator disc and the rotor disc, a material inlet and a material outlet which are communicated with the channel flows are arranged on the stator disc, and the periphery and the lower plane of the rotor disc are both provided with path pipes which are connected with the chromatographic column. The simulated moving bed chromatographic separation device has stable fluid flow during separating, high separation precision, fast extraction and low application cost. The simulated moving bed chromatographic separation device can continuously feed materials and continuously discharge materials in the aspect of materials. A simulated moving bed technique and a chromatographic separation principle are combined to lead chromatographic separation to be continuous from intermission, production capacity is greatly improved, and energy consumption and production cost are lowered.
Description
Technical field
The utility model belongs to separator, particularly relates to a kind of moving bed imitation chromatogram separation facility.
Background technology
Problems such as single-column separation at present and preparative chromatography purification are used more extensive at home, and both treating capacities are less, intermittently operated efficient is low, product quality is wayward, production cost is higher.For solving this situation, we have carried out the research and development of SMBC separation process technique, successful development moving bed imitation chromatogram separation facility, be applied in experimental study and the suitability for industrialized production.
Summary of the invention
The utility model is intended to overcome the deficiencies in the prior art, and a kind of moving bed imitation chromatogram separation facility that industry compounding substances such as petrochemical industry, fine chemistry industry, medicine, food extract high purity product that is applied to is provided.
Moving bed imitation chromatogram separation facility of the present utility model is to be connected and composed by drive system, transmission system, rotary distributor and chromatographic column and pipeline.Drive system is to be made of electromagnetic braking motor, transmission system is that electromagnetic braking motor axle and gear-box link, the bottom of gear-box fixes with the stator dish of rotary distributor and connects, the power transmission shaft of gear-box fixes with the rotor disk of rotary distributor and connects, and rotary distributor is contacted with the stator card mutually movingly by rotor disk.The conduit of linking up is mutually all arranged in stator dish and rotor disk, the stator dish is provided with material import and export a, the b that is connected with conduit, is provided with the tube connector of chromatographic column one end that is connected with conduit rotor disk ring week, the lower plane of rotor disk is provided with the chromatographic column other end tube connector that is connected with conduit.Power transmission shaft lower end and support shaft are connected and fixed, and settle down position top of support shaft lower end and support is upright.
As further improvement of the utility model, on support shaft, be symmetrically welded two groups of disks, the disk border position offers the breach of stationary chromatographic post.
As further improvement of the utility model, between rotor disk and stator dish, be fixed with pad and have and the corresponding passage of conduit.
As further improvement of the utility model, the spring that compresses the stator dish is arranged on the shell of power transmission shaft and adjust cover.
As further improvement of the utility model, there are some chromatographic columns to be connected with rotor disk ring Zhou Guanlu.
Moving bed imitation chromatogram separation facility of the present utility model has separation process liquid stream stable state, and the separation accuracy height extracts soon, and application cost is low.Can continuous feed and discharging continuously aspect material.Simulated moving bed technology combines with the chromatographic isolation principle and makes chromatographic isolation from intermittently becoming continuously, production capacity increases substantially, energy consumption and production cost reduce, product quality requires index to be easy to control, because device is operation at a lower temperature, process conditions provide guarantee for the separation of heat-sensitive substance.
Description of drawings
Figure of description is the structural representation of the utility model moving bed imitation chromatogram separation facility.
The specific embodiment
Embodiment 1
Moving bed imitation chromatogram separation facility of the present utility model, be by drive system, transmission system, it is to be made of electromagnetic braking motor 1 that rotary distributor and chromatographic column and pipeline connect and compose drive system, transmission system is that electromagnetic braking motor axle 2 links with gear-box 3, the bottom of gear-box 3 fixes with the stator dish 6 of rotary distributor and connects, the power transmission shaft 4 of gear-box 3 fixes with the rotor disk 5 of rotary distributor and connects, rotary distributor is contacted mutually movingly by 6 on rotor disk 5 and stator dish, the conduit 7 of linking up is mutually all arranged in stator dish 6 and rotor disk 5,8, stator dish 6 is provided with the material import and export a that is connected with conduit 7, b.5 ring weeks of rotor disk are provided with the tube connector 10 of chromatographic column 9 one ends that are connected with conduit 8, the lower plane of rotor disk is provided with chromatographic column 9 other end tube connectors 11 that are connected with conduit 8; Power transmission shaft 4 lower ends and support shaft 12 are connected and fixed, and support shaft 12 lower ends are sat 13 location with support and pushed up upright.
Moving bed imitation chromatogram separation facility of the present utility model, be by drive system, transmission system, it is to be made of electromagnetic braking motor 1 that rotary distributor and chromatographic column and pipeline connect and compose drive system, transmission system is that electromagnetic braking motor axle 2 links with gear-box 3, the bottom of gear-box 3 fixes with the stator dish 6 of rotary distributor and connects, the power transmission shaft 4 of gear-box 3 fixes with the rotor disk 5 of rotary distributor and connects, rotary distributor is contacted mutually movingly by 6 on rotor disk 5 and stator dish, the conduit 7 of linking up is mutually all arranged in stator dish 6 and rotor disk 5,8, be fixed with pad 15 at rotor disk 5 and 6 on stator dish, and have and conduit 7,8 corresponding passages.The spring 16 that compresses stator dish 6 is arranged on the shell of power transmission shaft 4 and adjust cover 17.Stator dish 6 is provided with material import and export a, the b that is connected with conduit 7.5 ring weeks of rotor disk are provided with the tube connector 10 of chromatographic column 9 one ends that are connected with conduit 8, the lower plane of rotor disk is provided with chromatographic column 9 other end tube connectors 11 that are connected with conduit 8; Power transmission shaft 4 lower ends and support shaft 12 are connected and fixed, and support shaft 12 lower ends are sat 13 location with support and pushed up upright.Be symmetrically welded two groups of disks 14 on support shaft 12, disk 14 edges offer the breach of stationary chromatographic post 9.
In conjunction with the accompanying drawings the member of moving bed imitation chromatogram separation facility of the present invention is formed and the effect of playing, is described in detail as follows:
Piece-rate system is the key problem in technology of moving bed imitation chromatogram separation facility of the present invention, by the close fit of sharing out the work and help one another of this component of a system key element, realizes the orderly operation of continous-stable long period of moving bed imitation chromatogram separation facility, reaches high accuracy and separates purpose.Native system has realized that through multiway rotary distributing valve stator dish and rotor disk simulation is moved and the effect of two phase countercurrent flow, and with the chromatographic column close fit, reach the purpose of separation.This system is made of electromagnetic braking motor, multiway rotary distributing valve and chromatographic column unit, sees accompanying drawing for details, and its structure is described below:
Each component function and effect are described below:
Electromagnetic braking motor: after time controller provides turn signal, electromagnetic braking motor 1 energising is rotated, by being installed in the internal gear 19 that pinion 18 on the motor shaft 2 is delivered to gear-box 3, reach deceleration by conversion between gear and transmit purpose with power, give power transmission shaft 4 with the displacement transmission of power, drive the rotor disk 5 and chromatographic column support shaft 12 synchronous purposes of rotating of multiway rotary distributing valve.The nut of power transmission shaft 4 bottoms plays 5 effects of fastening rotor disk, can closely contact at moving process between the stator dish 6 that keeps multiway rotary distributing valve and the rotor disk 5, keeps the excellent sealing state, and material is taken their own roads in valve body, and is mixed mutually mutually.Electromagnetic braking motor 1 is fixed on the loam cake of gear-box 3, and gear-box 3 can play protection internal gear 19 and pinion 18 effects; The middle part also can cooperatively interact with adjustment cover 17 and have the function of regulating spring 16 pressure sizes; The fixedly stator dish 6 of multiway rotary distributing valve is inlayed in the bottom, makes its position keep motionless.
Multiway rotary distributing valve: combine by stator dish 6, pad 15, rotor disk 5.By motor-driven gear, by gear drive rotor disk 5 is rotated, stator dish 6 is motionless, forms and relatively move between two dishes, the mobile effect of fixing simulation mutually of chromatographic column 9 is caused in conversion material import and export position regularly, make different material after the chromatographic column of flowing through, reach to separate and purify.Stator dish 6 tops are provided with circulation fluid material interface a, and first root chromatogram column discharging is injected end entrance on the last root post through delivery pump; Its side is provided with many group material import and exports duct b interface, material all injects or flows out through the set duct of stator dish, extend on two different circumference to core in every group of duct, evenly offer downward duct 7 respectively, can be communicated with the rotor disk 5 corresponding inner ducts 8 of offering, material is distributed to chromatographic column through the duct.Rotor disk 5 is embedded in power transmission shaft 4 belows by retainingf key, and is equipped with tightly by clamp nut, reaches between 5 of stator dish 6 and the rotor disks and closely contact, leakage and leaking in material does not allow; Rotor disk 5 sides and bottom are evenly offered respectively towards chromatographic column 9 pipelines, and material is through each pipeline input and output chromatographic column; The dish upper surface is offered and the corresponding the same duct of stator dish 6 lower surfaces equally, respectively with chromatographic column 9 on input be communicated with bottom outflow interface.Hold fixedly antifriction pad 15 at the rotor disk upper surface, and offer successively and the corresponding duct of stator dish.This pad 15 had both kept the material stream passed ability, possessed sealing effectiveness again, the holdout device long-term operation.
The chromatographic column unit, multiway rotary distributing valve props up the piece-rate system that chromatographic column 9 is connected with 6-30, it is the key problem in technology of moving bed imitation chromatogram separation facility, according to the needs that separate different material, choose and have fixedly phase or the title adsorbent that separates this material performance and the mutually mobile of certain desorption ability arranged or the title strippant, under certain process conditions, just can finish the purpose of separating this material of purifying.Be symmetrically welded two groups of disks 14 on the support shaft 12, but the breach of stationary chromatographic post 9 is offered in the edge; This top is embedded in the bottom of power transmission shaft 4, and with power transmission shaft 4 same moved further, the support shaft bottom is upright by support sitting top, 13 location, and is that rotate at the center according to the summit.Chromatographic column 9 is determined radical according to the needs of separating technology process, and filling is relevant in the post fixes phase or claim adsorbent.
This device also is provided with accessory system, comprise instrument control section, column oven part, and mass transport partly form, each several part cooperatively interacts, and reaches the process conditions requirement of separation process, can continuously, efficiently finish the chromatographic isolation task.
Claims (5)
1, moving bed imitation chromatogram separation facility, be by drive system, transmission system, rotary distributor and chromatographic column and pipeline connect and compose, it is characterized in that drive system is to be made of electromagnetic braking motor (1), transmission system is that electromagnetic braking motor axle (2) links with gear-box (3), the bottom of gear-box (3) fixes with the stator dish (6) of rotary distributor and connects, the power transmission shaft (4) of gear-box (3) fixes with the rotor disk (5) of rotary distributor and connects, rotary distributor is contacted with stator dish (6) face mutually movingly by rotor disk (5), the conduit (7 of linking up is mutually all arranged in stator dish (6) and rotor disk (5), 8), stator dish (6) is provided with the material import and export a that is connected with conduit (7), b, rotor disk (5) ring is provided with the tube connector (10) of chromatographic column (9) one ends that are connected with conduit (8) week, the lower plane of rotor disk is provided with chromatographic column (9) other end tube connector (11) that is connected with conduit (8); Power transmission shaft (4) lower end and support shaft (12) are connected and fixed, and support shaft (12) lower end is sat (13) location with support and pushed up upright.
2, moving bed imitation chromatogram separation facility as claimed in claim 1 is characterized in that being symmetrically welded two groups of disks (14) on support shaft (12), disk (14) edge offers the breach of stationary chromatographic post (9).
3, moving bed imitation chromatogram separation facility as claimed in claim 1 is characterized in that being fixed with pad (15) and has and the corresponding passage of conduit (7,8) between rotor disk (5) and stator dish (6).
4, moving bed imitation chromatogram separation facility as claimed in claim 1 is characterized in that having the spring (16) that compresses stator dish (6) and adjusts cover (17) on the shell of power transmission shaft (4).
5, moving bed imitation chromatogram separation facility as claimed in claim 1 is characterized in that having some chromatographic columns (9) to be connected with rotor disk (5) ring Zhou Guanlu.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008202183083U CN201283233Y (en) | 2008-09-28 | 2008-09-28 | Separation device of simulated moving bed chromatography |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008202183083U CN201283233Y (en) | 2008-09-28 | 2008-09-28 | Separation device of simulated moving bed chromatography |
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| Publication Number | Publication Date |
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| CN201283233Y true CN201283233Y (en) | 2009-08-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNU2008202183083U Expired - Fee Related CN201283233Y (en) | 2008-09-28 | 2008-09-28 | Separation device of simulated moving bed chromatography |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101899486A (en) * | 2010-07-20 | 2010-12-01 | 天津科技大学 | Method for separating and purifying oligo-xylose by using simulated moving bed |
| US8608830B2 (en) | 2010-02-12 | 2013-12-17 | Uop Llc | Valve, separation system, and method for minimizing wear |
| CN103562145A (en) * | 2010-12-06 | 2014-02-05 | 塔邦生物系统公司 | Continuous processing methods for biological products |
| CN105333190A (en) * | 2015-11-04 | 2016-02-17 | 三达膜科技（厦门）有限公司 | Fluid processing device |
| CN108704335A (en) * | 2018-07-03 | 2018-10-26 | 中国科学院青岛生物能源与过程研究所 | A kind of ion chromatographic separation device of pseudo moving bed type |
-
2008
- 2008-09-28 CN CNU2008202183083U patent/CN201283233Y/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8608830B2 (en) | 2010-02-12 | 2013-12-17 | Uop Llc | Valve, separation system, and method for minimizing wear |
| CN101899486A (en) * | 2010-07-20 | 2010-12-01 | 天津科技大学 | Method for separating and purifying oligo-xylose by using simulated moving bed |
| CN101899486B (en) * | 2010-07-20 | 2012-10-03 | 天津科技大学 | Method for separating and purifying oligo-xylose by using simulated moving bed |
| CN103562145A (en) * | 2010-12-06 | 2014-02-05 | 塔邦生物系统公司 | Continuous processing methods for biological products |
| CN103562145B (en) * | 2010-12-06 | 2016-09-21 | 颇尔公司 | The continuous process of biological product |
| CN105333190A (en) * | 2015-11-04 | 2016-02-17 | 三达膜科技（厦门）有限公司 | Fluid processing device |
| CN105333190B (en) * | 2015-11-04 | 2018-06-22 | 三达膜科技（厦门）有限公司 | Fluid processing equipment |
| CN108704335A (en) * | 2018-07-03 | 2018-10-26 | 中国科学院青岛生物能源与过程研究所 | A kind of ion chromatographic separation device of pseudo moving bed type |
| CN108704335B (en) * | 2018-07-03 | 2021-02-26 | 中国科学院青岛生物能源与过程研究所 | Simulated moving bed type ion chromatographic separation device |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090805 Termination date: 20110928 |