CN201222052Y - Device for clamping micro-fluidic chip - Google Patents
Device for clamping micro-fluidic chip Download PDFInfo
- Publication number
- CN201222052Y CN201222052Y CNU2008201202087U CN200820120208U CN201222052Y CN 201222052 Y CN201222052 Y CN 201222052Y CN U2008201202087 U CNU2008201202087 U CN U2008201202087U CN 200820120208 U CN200820120208 U CN 200820120208U CN 201222052 Y CN201222052 Y CN 201222052Y
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- Prior art keywords
- micro
- fluidic chip
- shaped guide
- hookup
- guide rails
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- Expired - Lifetime
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- 238000007789 sealing Methods 0.000 abstract description 6
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 230000003044 adaptive effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 11
- 238000005516 engineering process Methods 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000004484 Briquette Substances 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000005357 flat glass Substances 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The utility model discloses a micro-fluidic chip holding device. Two lateral sides of a fixing underbed are respectively equipped with a lateral limiting block while another two lateral sides are respectively equipped with a T-shaped guide rail, a held micro-fluidic chip is disposed on the fixing underbed, two press plates cross between the two T-shaped guide rails, elongated slots parallel to the lateral limiting blocks are arranged at the centers of the two press plates, the elongated slots are internally equipped with connectors having the same number as that of joints for holding the micro-fluidic chip, an axial through hole is arranged at the center of the connector, a rubber sealing ring is sleeved at one end of the connector contacting with the micro-fluidic chip, and the two press plates can move on the two T-shaped guide rails to be locked for regulating the pressing force between the connectors and micro-fluidic chip holes. A structure of two-dimensional orthogonal guide rails and press plates is adopted in the holding device, thereby resolving the adaptive problem of multi-position joint, the adopted way of connectors and sealing rings resolves the problem of joint sealing, and the adopted structure of adjustable bolts and press plates guarantees adaptability for chips of different thickness.
Description
Technical field
The utility model relates to clamping device, particularly relates to a kind of microflow control chip clamping device.
Background technology
The micro-fluidic chip technology grows up on the chip capillary cataphoresis basis, has realized by the leap of simple electrophoretic separation to extensive multi-functional integrated experimentation chamber.1992, Manz etc. adopted microelectron-mechanical process technology etching microchannel on sheet glass, develop Capillary Electrophoresis microchip analytical equipment, have successfully realized fluorescently-labeled amino acid whose separation, have started the beginning of micro-fluidic chip technology.Micro-fluidic chip with the microchannel is that network connects that Micropump, little valve, little reservoir, little electricity are pulled, little detecting element etc. has the components and parts of light, electricity and FLUID TRANSPORTATION function, to greatest extent specimen preparation, biological with chemical reaction, separate, basic operation unit such as detection is integrated or be integrated into substantially on more than one square centimeters the chip, in order to finishing different biological or chemical courses of reaction, and its product is analyzed.It not only makes the consumption of biological sample and reagent be reduced to and receives liter (n1) even skin liter (p1) level, and analysis speed is improved greatly, and analysis cost reduces greatly, thereby for analysis and testing technology spreads to the open air, family has opened up a new road.Up to now, the separation that is used for a series of chemical substances that the micro-fluidic chip technology is successful, especially in biochemical field, successful carrying out the separation detection of determined dna sequence, polypeptide and protein, amino acid, unicellular and unimolecule etc.
When using micro-fluidic chip to carry out various operation such as biochemical analysis, detection, sample and reagent are injected into the fluid channel from the corresponding liquid injection port of micro-fluidic chip, and when injecting for test sample, operate the generation waste liquid and can constantly get rid of from the liquid outlet of chip.Clamping device plays is exactly the effect that connects macro-scale devices such as the fluid channel of micro-fluidic chip inside and common syringe.Along with subject development such as biology, chemistry, the requirement integrated to the functional diversities of micro-fluidic chip and structure improves constantly.The complicacy of the flow passage structure of micro-fluidic chip is compared with traditional cross electrophoresis chip and is improved greatly at present.Same micro-fluidic chip comprises a plurality of liquid injection port and liquid outlet usually, is distributed in the diverse location of chip, and the phase mutual edge distance is very approaching.This just proposes following requirement to clamping device:
(1) clamping device will have suitable dirigibility, to adapt to the micro-fluidic chip that liquid injection port, liquid outlet are in diverse location.
(2) the clamping device structural design is small and exquisite, to adapt to the less micro-fluidic chip of interface spacing.
(3) to have good sealing property, in order to avoid reagent goes out to leak from interface.
Summary of the invention
In order to overcome the shortcoming and defect of existing micro-fluidic chip interface mode, the purpose of this utility model is to provide and is applicable to a kind of microflow control chip clamping device with a plurality of liquid injection port and liquid outlet.
The technical scheme that its technical matters that solves the utility model adopts is:
On two sides of fixed underpan, the side direction limited block is housed respectively, on another two sides of fixed underpan, "T"-shaped guide rail is housed respectively, two "T"-shaped guide rails are positioned between two side direction limited blocks, the micro-fluidic chip that is held is arranged on the fixed underpan, two briquettings are connected across between two "T"-shaped guide rails, have the elongated slot parallel in the middle of two briquettings with the side direction limited block, the hookup that equates with clamping micro-fluidic chip interface number is housed in the elongated slot, the hookup center has axially extending bore, rubber seal is enclosed within the end that hookup contacts with micro-fluidic chip, two block pressur plates can move on two "T"-shaped guide rails and lock, thereby regulate the snap-in force in hookup and micro-fluidic chip hole.
Described fixed underpan middle part has watch window.
The beneficial effect that the utlity model has is: this device adopts the structural design of two-dimensional quadrature guide rail pressurizing block to solve the adaptability problem of multiposition interface; The mode that has adopted hookup to add O-ring seal has solved the sealing joint problem; Adopt adjustable bolt and briquette structure to guarantee adaptability to the different-thickness chip.
Description of drawings
Fig. 1 is a structure principle chart of the present utility model;
Fig. 2 is the sectional view on Figure 1A-A plane.
Among the figure: 1, side direction limited block, 2, "T"-shaped guide rail, 3, briquetting, 4, micro-fluidic chip, 5, housing screw, 6, hookup, 7, fixed underpan, 8, housing screw, 9, hookup, 10, hookup, 11, housing screw, 12, "T"-shaped guide rail, 13, housing screw, 14, briquetting, 15, the side direction limited block, 16, O-ring seal, 17, O-ring seal, 18, slide block, 19, slide block.
Embodiment
Below in conjunction with drawings and Examples the utility model is further described.
As Fig. 1, shown in Figure 2, the utility model is on two sides of fixed underpan 7, side direction limited block 1 is housed respectively, 15, on another two sides of fixed underpan 7, "T"-shaped guide rail 2 is housed respectively, 12, two "T"-shaped guide rails 2,12 are positioned at two side direction limited blocks 1,15, the micro-fluidic chip 4 that is held is arranged on the fixed underpan 7, two block pressur plates 3,14 are connected across two "T"-shaped guide rails 2,12, "T"-shaped guide rail 2, slide block 19 is housed respectively in 12,18, two briquettings 3, in 14 liang of stomidiums housing screw 8 is housed respectively, 11,13,5 are used for locking two briquettings 3,14, two block pressur plates 3, have the elongated slot parallel in the middle of 14 with the side direction limited block, the hookup 6 that equates with clamping micro-fluidic chip interface number is housed in the elongated slot, 9,10, hookup 6,9,10 centers have axially extending bore, rubber seal 16,17 are enclosed within hookup 6 respectively, 9,10 ends that contact with micro-fluidic chip 4, two block pressur plates 3,14 can be at two "T"-shaped guide rails 2, move above 12 and locking, thereby regulate hookup 6,9,10 with the snap-in force in micro-fluidic chip 4 holes.Described fixed underpan middle part has watch window.
The connected mode of a, the two "T"-shaped guide rails of employing and slide block, the slide block center has tapped through hole so that connect briquetting by bolt; The slide block width is greater than "T"-shaped guide rail top width but smaller bottom width, so can in guide rail, be free to slide but can not shift out guide rail, purpose is that briquetting can be free to slide along guide rail, thereby can regulate hookup to adapt to the interface of "T"-shaped guide rail direction diverse location.B, briquetting adopt the design of center grooved, and bolt is connected with the threaded hole at slide block center by the perforate on both sides.Hookup adopts the notch cuttype structure Design, the hookup center is equipped with through hole and is used for injecting reagent to micro-fluidic chip, narrow diameter of hookup is slightly less than the width of briquetting fluting, wide diameter of hookup is greater than the briquetting groove width, thereby hookup can be moved adapting to the distinct interface position along the briquetting direction of slotting, thereby compress the purpose that briquetting and hookup are realized sealing joint by bolt.C, chassis are that the middle part has rectangular window, window so that detection is observed in micro-fluidic chip inside in the bottom.D, make the sound construction of whole clamping device, increase reliability by the side direction limited block.
As shown in Figure 1 and Figure 2, fixed underpan 7, "T"-shaped guide rail 2,12 side direction limited blocks 1,15 make up by screw.Micro-fluidic chip 4 is placed fixed underpan 7 centers, guarantee that simultaneously needing to observe the part that detects places in the view window.Regulate the relevant position of the slide block 18,19 in the "T"-shaped guide rail 2,12 then, make its position corresponding with the inlet of chip 4 and liquid outlet.Select and be held the hookup 6,9,10 that micro-fluidic chip interface number equates, rubber seal 16,17 is enclosed within the end that hookup 6 contacts with chip; The other end connects external device (ED).Hookup 6,9,10 is inserted chip advance, locate interface accordingly.The top of hookup 6,9,10 is by the fluting at briquetting 3,14 centers, housing screw 5,8,11,13 passes the through hole of briquetting 3,14 both sides and realizes cooperating with the threaded hole at slide block 18,19 centers, thus the degree that compresses of regulating hookup 6,9,10 and micro-fluidic chip 4 holes.Use a plurality of briquettings if desired, operating process is identical.So just solved the connectivity problem of various micro-fluidic chips and common macroscopical liquid delivery device, convenient and reliable, adaptability is strong.
Claims (2)
1, a kind of microflow control chip clamping device, it is characterized in that: on two sides of fixed underpan, the side direction limited block is housed respectively, on another two sides of fixed underpan, "T"-shaped guide rail is housed respectively, two "T"-shaped guide rails are positioned between two side direction limited blocks, the micro-fluidic chip that is held is arranged on the fixed underpan, two briquettings are connected across between two "T"-shaped guide rails, have the elongated slot parallel in the middle of two briquettings with the side direction limited block, the hookup that equates with clamping micro-fluidic chip interface number is housed in the elongated slot, the hookup center has axially extending bore, rubber seal is enclosed within the end that hookup contacts with micro-fluidic chip, and two block pressur plates can move on two "T"-shaped guide rails and lock, thereby regulates the snap-in force in hookup and micro-fluidic chip hole.
2, a kind of microflow control chip clamping device according to claim 1 is characterized in that: described fixed underpan middle part has watch window.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008201202087U CN201222052Y (en) | 2008-06-20 | 2008-06-20 | Device for clamping micro-fluidic chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008201202087U CN201222052Y (en) | 2008-06-20 | 2008-06-20 | Device for clamping micro-fluidic chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201222052Y true CN201222052Y (en) | 2009-04-15 |
Family
ID=40575558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2008201202087U Expired - Lifetime CN201222052Y (en) | 2008-06-20 | 2008-06-20 | Device for clamping micro-fluidic chip |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201222052Y (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101303327B (en) * | 2008-06-20 | 2012-05-23 | 浙江大学 | Microflow control chip clamping device |
| EP2587257A1 (en) * | 2011-10-31 | 2013-05-01 | Cellomics, Inc. | Slide holder assembly for comet assay |
| CN103769252A (en) * | 2012-10-18 | 2014-05-07 | 中国科学院深圳先进技术研究院 | Connector of micro fluidic chip |
| CN104226386A (en) * | 2013-06-14 | 2014-12-24 | 中国科学院大连化学物理研究所 | Universal micro fluidic chip interface |
| CN105772125A (en) * | 2016-04-23 | 2016-07-20 | 北京化工大学 | 3D printing-based microfluidic chip fixture experiment platform |
| CN107723227A (en) * | 2016-08-12 | 2018-02-23 | 广州康昕瑞基因健康科技有限公司 | Gene sequencing reaction cell and gene sequencing reaction device |
| CN109085229A (en) * | 2015-05-13 | 2018-12-25 | 爱科来株式会社 | Analysis tool and analysis system |
| CN113009140A (en) * | 2019-12-18 | 2021-06-22 | 洛阳中科生物芯片技术有限公司 | Joint inspection chip kit |
-
2008
- 2008-06-20 CN CNU2008201202087U patent/CN201222052Y/en not_active Expired - Lifetime
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101303327B (en) * | 2008-06-20 | 2012-05-23 | 浙江大学 | Microflow control chip clamping device |
| EP2587257A1 (en) * | 2011-10-31 | 2013-05-01 | Cellomics, Inc. | Slide holder assembly for comet assay |
| CN103769252A (en) * | 2012-10-18 | 2014-05-07 | 中国科学院深圳先进技术研究院 | Connector of micro fluidic chip |
| CN104226386A (en) * | 2013-06-14 | 2014-12-24 | 中国科学院大连化学物理研究所 | Universal micro fluidic chip interface |
| CN104226386B (en) * | 2013-06-14 | 2015-12-09 | 中国科学院大连化学物理研究所 | A kind of Universal microfluidic chip interface |
| CN109085229A (en) * | 2015-05-13 | 2018-12-25 | 爱科来株式会社 | Analysis tool and analysis system |
| CN105772125A (en) * | 2016-04-23 | 2016-07-20 | 北京化工大学 | 3D printing-based microfluidic chip fixture experiment platform |
| CN105772125B (en) * | 2016-04-23 | 2018-09-21 | 北京化工大学 | Micro-fluidic chip clamp experiment porch based on 3D printing |
| CN107723227A (en) * | 2016-08-12 | 2018-02-23 | 广州康昕瑞基因健康科技有限公司 | Gene sequencing reaction cell and gene sequencing reaction device |
| CN113009140A (en) * | 2019-12-18 | 2021-06-22 | 洛阳中科生物芯片技术有限公司 | Joint inspection chip kit |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20090415 Effective date of abandoning: 20080620 |