CN103323493A - Direct-compression type rapid assembling micro-circulation detection tank device - Google Patents
Direct-compression type rapid assembling micro-circulation detection tank device Download PDFInfo
- Publication number
- CN103323493A CN103323493A CN2013102174516A CN201310217451A CN103323493A CN 103323493 A CN103323493 A CN 103323493A CN 2013102174516 A CN2013102174516 A CN 2013102174516A CN 201310217451 A CN201310217451 A CN 201310217451A CN 103323493 A CN103323493 A CN 103323493A
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- Prior art keywords
- guide rail
- hole
- plate
- board
- lower platen
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
Abstract
The invention discloses a direct pressure type rapid assembling micro-circulation detection tank device. The device comprises a circulation tank and a compressing device. The circulation tank comprises a circulation board, a baseboard, a sealing element, a detection chip, an interface board, a first locating pin and a second locating pin. The compressing device comprises a supporting board, a lower compressing board, an upper compressing board, a pull rod, a pull rod cap, a first spring, and a second spring. The direct pressure type rapid assembling micro-circulation detection tank device has the characteristics of rapid assembling, few elements to wash, and balanced pressure, and is capable of applying widely to all kinds of fields of analysis and detection of biology, chemistry and life sciences.
Description
Technical field
The present invention relates to the analyzing and testing field, relate in particular to a kind of direct press type little circulation detecting pool device of assembling fast.
Background technology
The logical pick-up unit of miniflow is because to have a required sample volume of detection little, the detection sensitivity height, and advantage such as detection speed is fast is widely used in various analyses and detection range.The logical pick-up unit critical component of miniflow is little detection chip and flow cell.Common method is that microelectrode and flow cell are made inseparable integral body at present.This method is to the processing request height, if seal bad or dimensional discrepancy and cause chip rejection rate height, causes the expensive of chip.Another mode is dismantled and assembled mode, and as described in patent 200710070709.9, this design is made up of top board, elastic membrane, lower platen, micro-electrode chip etc.The assembling back is just tightened and can be used by set bolt, has repeated use and waits advantage often.But the degree of tightening that has set bolt varies with each individual and causes screwing force uncontrollable, and causes shortcomings such as the seal pressurized is inhomogeneous easily.In use also need circulation detecting pool is cleaned, because flow cell is formed by bolt by top board, lower platen, need the Bolt dismantling of whole flow cell be cleaned the back assembling and re-use, whole process is more loaded down with trivial details.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, a kind of direct press type little circulation detecting pool device of assembling fast is provided.
The technical solution used in the present invention is as follows: a kind of direct press type is the little circulation detecting pool device of assembling fast, it comprises flow cell and hold down gag, described flow cell comprises flow plate, base plate, seal, detection chip, interface board, first register pin, second register pin, and hold down gag comprises supporting plate, lower platen, top board, pull bar, pull bar cap, first spring, second spring; The flow plate end face has fluid intake and fluid egress point, respectively inlet and outlet piping is installed in fluid intake and fluid outlet with two interface tubes; The bottom surface of flow plate has seal groove that seal is installed, and seal groove is positioned at fluid intake and fluid egress point below.Seal is in the detection zone top of detection chip; The flow plate bottom surface has the interface board slot to be used for the mounting interface plate.The end face of base plate has chip groove setting-in detection chip.Interface board contacts with the contact conductor elastomeric electrical of detection chip.Interface board is used for first contact conductor, second contact conductor of switching detection chip.Interface board and flow plate pass through bolt.Flow plate is installed on the top of base plate.First fixed pin holes of base plate, the second fixed pin holes setting-in, first register pin, second register pin, flow plate is by first register pin, the assembling of second register pin location of first pilot hole, second pilot hole and the base plate of its bottom surface.First guide rail, second guide rail be in the left and right sides of supporting plate, is separately fixed in first guide rail hole on the supporting plate, second guide rail hole by pin.Lower platen is enclosed within first guide rail, the second guide rail bottom by the 3rd guide rail hole, the 4th guide rail hole.Top board is enclosed within first guide rail, the second guide rail top by the 5th guide rail hole, the 6th guide rail hole, and top board is fixed by pin and first guide rail, second guide rail.First spring, second spring are enclosed within respectively on first guide rail, second guide rail, and are limited between top board and the lower platen.The little head end of pull bar is fixed with the pull bar cap after passing the tie rod hole of lower platen and top board tie rod hole, and stub end is limited in the tie rod hole.The bottom surface of lower platen contacts with the end face of flow plate.Angle between described fluid intake and fluid egress point and the normal is 0 degree ~ 90 degree.
The beneficial effect that the present invention has is: direct press type of the present invention is the little circulation detecting pool device of assembling fast, have quick, the advantages such as cleaning part is few, equalization of pressure of installation and removal, can be extensive use of in fields such as analyzing and testing, can replace the complicated pick-up unit based on precision processing technology, but all widespread uses in life science, chemical analysis, food security, environmental monitoring and relevant scientific domain.
Description of drawings
Fig. 1 is system of the present invention front elevational schematic;
Fig. 2 is system of the present invention schematic side view;
Fig. 3 is flow plate backplan of the present invention;
Fig. 4 is base plate vertical view of the present invention;
Fig. 5 is supporting plate front elevation of the present invention;
Fig. 6 is lower platen vertical view of the present invention;
Fig. 7 is top board sectional view of the present invention;
Fig. 8 is typical detection chip synoptic diagram of the present invention.
Among the figure, flow plate 1, base plate 2, seal 3, detection chip 4, interface board 5, supporting plate 6, lower platen 7, top board 8, pull bar 9, pull bar cap 10, first spring 11, second spring 12, first register pin 13, second register pin 14, first guide rail 15, second guide rail 16, first pilot hole 101, second pilot hole 102, seal groove 103, fluid intake 104, fluid egress point 105, first fixed orifice 106, second fixed orifice 107, interface board slot 108, first fixed pin holes 201, second fixed pin holes 202, first threaded hole 203, second threaded hole 204, chip groove 205, first contact conductor 401, second contact conductor 402, detection zone 403, first guide rail hole 601, second guide rail hole 602, chute 603, the 3rd guide rail hole 701, the 4th guide rail hole 702, tie rod hole 703, the 5th guide rail hole 801, the 6th guide rail hole 802, tie rod hole 803.
Embodiment
The invention will be further described below in conjunction with drawings and Examples.
As Fig. 1～shown in Figure 8, the present invention includes flow cell and hold down gag, flow cell comprises flow plate 1, base plate 2, seal 3, detection chip 4, interface board 5, first register pin 13, second register pin 14, and hold down gag comprises supporting plate 6, lower platen 7, top board 8, pull bar 9, pull bar cap 10, first spring 11, second spring 12.
First fixed pin holes 201 of base plate 2, second fixed pin holes, 202 setting-ins, first register pin 13, second register pin 14, flow plate 1 assembles with first register pin 13, second register pin, 14 location of base plate 2 by first pilot hole 101, second pilot hole 102 of its bottom surface.
The little head end of pull bar 9 passes the tie rod hole 703 of lower platen 7 and top board 8 tie rod holes 803 backs and pull bar cap 10 and fixes by pin, and stub end is limited in the tie rod hole 703.
The bottom surface of lower platen 7 contacts with the end face of flow plate 1.
Angle between described fluid intake 104 and fluid egress point 105 and the normal is 0 degree ~ 90 degree.
Application process of the present invention is as follows:
1, assembles hold down gag as shown in Figure 1, and each parts of flow cell are cleaned up.
2, interface board 5 is placed in the interface board slot 108 of flow plate 1, and uses bolt.
3, detection chip 4 is put in the chip groove 205 of base plate 2.
4, seal 3 is put in the seal groove 103 of flow plate 1, flow plate 1 and base plate 2 are assembled by first register pin 13, second register pin, 14 location.Flow cell has just assembled like this.
5, two pipe joints are installed in pipeline fluid intake 104 and fluid egress point 105 places of flow plate 1 respectively.If manually injection connects syringe to inlet duct.If auto injection connects outlet conduit equipment such as peristaltic pump or syringe pump, inlet duct reception test sample product or detection reagent.
6, pull-up pull bar cap 10 drives pull bar 9, makes lower platen 7 rise along first guide rail 15, second guide rail 16, then the flow cell that assembles is pushed the chute of supporting plate 6, is positioned in the middle of first guide rail 15, second guide rail 16.
7, put down pull bar cap 10, because the effect of first spring 11, second spring 12, lower platen 7 descends along first guide rail 15, second guide rail 16, and the lower plane of lower platen 7 contacts with the end face of the flow plate of flow cell 1.The compression degree of snap-in force and first spring 11, second spring 12 has relation.
8, the test cable interface is linked to each other with the interface board 5 of circulation detecting pool device with an end, the other end is connected with the signal input part of detecting instrument.
9, detected sample is expelled to inlet duct, and in the detection space formed of the detection zone 403 that flows to detection chip 6 and seal 5, laggard outlet conduit flows out.The measuring-signal of reading detecting instrument just can be known the characteristic of detected sample.
10, after detection was finished, pull-up pull bar cap 10 drove pull bars 9, made lower platen 7 rise along first guide rail 15, second guide rail 16, took out flow cell then.
11, take out flow plate 1, seal 3, detection chip 4, after cleaning up, just install and to detect again.Because directly do not contact sample, base plate 2 does not need often dismounting and cleans.
Claims (2)
1. a direct press type assembles little circulation detecting pool device fast, it is characterized in that, it comprises flow cell and hold down gag, described flow cell comprises flow plate (1), base plate (2), seal (3), detection chip (4), interface board (5), first register pin (13), second register pin (14), and hold down gag comprises supporting plate (6), lower platen (7), top board (8), pull bar (9), pull bar cap (10), first spring (11), second spring (12); Flow plate (1) end face has fluid intake (104) and fluid egress point (105), respectively inlet and outlet piping is installed in fluid intake (104) and fluid egress point (105) is located with two interface tubes; The bottom surface of flow plate (1) has seal groove (103) that seal (3) is installed, and seal groove (103) is positioned at fluid intake (105) and fluid egress point (106) below; Seal (3) is in detection zone (403) top of detection chip (4); Flow plate (1) bottom surface has interface board slot (108) to be used for mounting interface plate (5); The end face of base plate (2) has chip groove (205) setting-in detection chip (4); Interface board (5) contacts with the contact conductor elastomeric electrical of detection chip (4); Interface board (5) is used for first contact conductor (401), second contact conductor (402) of switching detection chip (4); Interface board (5) passes through bolt with flow plate (1); Flow plate (1) is installed on the top of base plate (2); First fixed pin holes (201) of base plate (2), second fixed pin holes (202) setting-in first register pin (13), second register pin (14), flow plate (1) assembles with first register pin (13), second register pin (14) location of base plate (2) by first pilot hole (101), second pilot hole (102) of its bottom surface; First guide rail (15), second guide rail (16) be in the left and right sides of supporting plate (6), is separately fixed in first guide rail hole (601) on the supporting plate (6), second guide rail hole (602) by pin; Lower platen (7) is enclosed within first guide rail (15), second guide rail (16) bottom by the 3rd guide rail hole (701), the 4th guide rail hole (702); Top board 8 is enclosed within first guide rail (15), second guide rail (16) top by the 5th guide rail hole (801), the 6th guide rail hole (802), and top board (8) is fixed by pin and first guide rail (15), second guide rail (16); First spring (11), second spring (12) are enclosed within respectively on first guide rail (15), second guide rail (16), and are limited between top board (8) and the lower platen (7); It is fixing with pull bar cap (10) that the little head end of pull bar (9) passes tie rod hole (703) and top board (8) tie rod hole (803) back of lower platen (7), and stub end is limited in the tie rod hole (703); The bottom surface of lower platen (7) contacts with the end face of flow plate (1).
2. assemble little circulation detecting pool device fast according to the described direct press type of claim 1, it is characterized in that, the angle between described fluid intake (104) and fluid egress point (105) and the normal is 0 degree ~ 90 degree.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310217451.6A CN103323493B (en) | 2013-06-03 | 2013-06-03 | Direct-compression type rapid assembling micro-circulation detection tank device |
| PCT/CN2013/080389 WO2014194556A1 (en) | 2013-06-03 | 2013-07-30 | Direct-pressing quick-assemble microcirculation detection tank device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310217451.6A CN103323493B (en) | 2013-06-03 | 2013-06-03 | Direct-compression type rapid assembling micro-circulation detection tank device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103323493A true CN103323493A (en) | 2013-09-25 |
| CN103323493B CN103323493B (en) | 2015-05-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310217451.6A Active CN103323493B (en) | 2013-06-03 | 2013-06-03 | Direct-compression type rapid assembling micro-circulation detection tank device |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN103323493B (en) |
| WO (1) | WO2014194556A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109331191A (en) * | 2018-09-10 | 2019-02-15 | 浙江大学 | A kind of high voltage electric field coupling ultrasonic wave treatment liquid sterilizing test device and method |
| CN109991195A (en) * | 2019-04-24 | 2019-07-09 | 浙江警察学院 | A kind of SPR detector single channel micro-fluidic chip clamping system |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3380239B1 (en) * | 2015-11-25 | 2023-08-23 | Spectradyne, LLC | Systems and devices for microfluidic instrumentation |
| US11105451B2 (en) | 2017-07-07 | 2021-08-31 | Eaton Intelligent Power Limited | Heat transfer interruption for improved fire resistance/proof performance |
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| US20030012697A1 (en) * | 2001-07-16 | 2003-01-16 | Jong Hoon Hahn | Assembly microchip using microfluidic breadboard |
| US20040228770A1 (en) * | 1998-02-24 | 2004-11-18 | Caliper Life Sciences, Inc. | Microfluidic devices and systems incorporating cover layers |
| CN101118226A (en) * | 2007-08-06 | 2008-02-06 | 浙江大学 | Multifunctional micro-electrode chip circulation detecting pool device |
| CN201143629Y (en) * | 2007-12-29 | 2008-11-05 | 比亚迪股份有限公司 | Clamping apparatus |
| CN203310792U (en) * | 2013-06-03 | 2013-11-27 | 浙江大学 | Direct-pressing quickly-assembled microcirculation detection tank device |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201130165Y (en) * | 2007-12-26 | 2008-10-08 | 上海神开石油化工装备股份有限公司 | Apparatus for measuring sulfureted hydrogen gas |
| EP2366993A1 (en) * | 2010-03-08 | 2011-09-21 | Nxp B.V. | A sensor and a method of assembling a sensor |
| CN101957322B (en) * | 2010-08-17 | 2012-01-11 | 中国科学院苏州纳米技术与纳米仿生研究所 | Flow cell for electrochemiluminescence detection and system thereof |
-
2013
- 2013-06-03 CN CN201310217451.6A patent/CN103323493B/en active Active
- 2013-07-30 WO PCT/CN2013/080389 patent/WO2014194556A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040228770A1 (en) * | 1998-02-24 | 2004-11-18 | Caliper Life Sciences, Inc. | Microfluidic devices and systems incorporating cover layers |
| US20030012697A1 (en) * | 2001-07-16 | 2003-01-16 | Jong Hoon Hahn | Assembly microchip using microfluidic breadboard |
| CN101118226A (en) * | 2007-08-06 | 2008-02-06 | 浙江大学 | Multifunctional micro-electrode chip circulation detecting pool device |
| CN201143629Y (en) * | 2007-12-29 | 2008-11-05 | 比亚迪股份有限公司 | Clamping apparatus |
| CN203310792U (en) * | 2013-06-03 | 2013-11-27 | 浙江大学 | Direct-pressing quickly-assembled microcirculation detection tank device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109331191A (en) * | 2018-09-10 | 2019-02-15 | 浙江大学 | A kind of high voltage electric field coupling ultrasonic wave treatment liquid sterilizing test device and method |
| CN109991195A (en) * | 2019-04-24 | 2019-07-09 | 浙江警察学院 | A kind of SPR detector single channel micro-fluidic chip clamping system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103323493B (en) | 2015-05-06 |
| WO2014194556A1 (en) | 2014-12-11 |
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