CN103323493B - Direct-compression type rapid assembling micro-circulation detection tank device - Google Patents

Direct-compression type rapid assembling micro-circulation detection tank device Download PDF

Info

Publication number
CN103323493B
CN103323493B CN201310217451.6A CN201310217451A CN103323493B CN 103323493 B CN103323493 B CN 103323493B CN 201310217451 A CN201310217451 A CN 201310217451A CN 103323493 B CN103323493 B CN 103323493B
Authority
CN
China
Prior art keywords
guide rail
hole
plate
board
lower platen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201310217451.6A
Other languages
Chinese (zh)
Other versions
CN103323493A (en
Inventor
叶尊忠
应义斌
吴坚
李延斌
王剑平
徐文道
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang University ZJU
Original Assignee
Zhejiang University ZJU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang University ZJU filed Critical Zhejiang University ZJU
Priority to CN201310217451.6A priority Critical patent/CN103323493B/en
Priority to PCT/CN2013/080389 priority patent/WO2014194556A1/en
Publication of CN103323493A publication Critical patent/CN103323493A/en
Application granted granted Critical
Publication of CN103323493B publication Critical patent/CN103323493B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04Exchange or ejection of cartridges, containers or reservoirs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention discloses a direct pressure type rapid assembling micro-circulation detection tank device. The device comprises a circulation tank and a compressing device. The circulation tank comprises a circulation board, a baseboard, a sealing element, a detection chip, an interface board, a first locating pin and a second locating pin. The compressing device comprises a supporting board, a lower compressing board, an upper compressing board, a pull rod, a pull rod cap, a first spring, and a second spring. The direct pressure type rapid assembling micro-circulation detection tank device has the characteristics of rapid assembling, few elements to wash, and balanced pressure, and is capable of applying widely to all kinds of fields of analysis and detection of biology, chemistry and life sciences.

Description

The micro-circulation detecting pool device of direct press type quick assembling
Technical field
The present invention relates to analysis detection field, particularly relate to the micro-circulation detecting pool device of a kind of direct press type quick assembling.
Background technology
Micro-circulation detection apparatus is little owing to having the required sample volume of detection, and the advantages such as detection sensitivity is high, and detection speed is fast, are widely used in various analysis and detection field.Micro-circulation detection apparatus critical component is micro-detection chip and flow cell.Current common method is that microelectrode and flow cell are made inseparable entirety.This method is high to processing request, if seal bad or dimensional discrepancy and cause chip rejection rate high, causes the expensive of chip.Another mode is dismantled and assembled mode, and as described in patent 200710070709.9, this design is made up of top board, elastic membrane, lower platen, micro-electrode chip etc.Tightened by set bolt after assembling and just can use, have and reuse the advantage such as often.But the degree of tightening that there is set bolt varies with each individual and causes screwing force uncontrollable, and the shortcoming such as easily cause seal pressurized uneven.In use also need to clean circulation detecting pool, form, need the Bolt dismantling whole flow cell because flow cell is bolted by top board, lower platen, after cleaning, assembling re-uses, and whole process is more loaded down with trivial details.
Summary of the invention
The object of the invention is for the deficiencies in the prior art, provide a kind of direct press type quick assembling micro-circulation detecting pool device.
The technical solution used in the present invention is as follows: the micro-circulation detecting pool device of a kind of direct press type quick assembling, it comprises flow cell and hold down gag, described flow cell comprises flow plate, base plate, seal, detection chip, interface board, the first register pin, the second register pin, and hold down gag comprises supporting plate, lower platen, top board, pull bar, pull bar cap, the first spring, the second spring; Flow plate end face has fluid intake and fluid egress point, respectively inlet and outlet piping is arranged on fluid intake and fluid outlet with two interface tubes; The bottom surface of flow plate has seal groove to install seal, and seal groove is positioned at below fluid intake and fluid egress point.Seal is in above the detection zone of detection chip; There is interface board slot flow plate bottom surface for mounting interface plate.The end face of base plate has chip groove setting-in detection chip.Interface board contacts with the contact conductor elastomeric electrical of detection chip.Interface board is for the first contact conductor, second contact conductor of detection chip of transferring.Interface board and flow plate are bolted.Flow plate is installed on the top of base plate.First fixed pin holes of base plate, the second fixed pin holes setting-in first register pin, the second register pin, flow plate is by the first register pin, the second register pin orientation assemble of the first pilot hole of its bottom surface, the second pilot hole and base plate.First guide rail, the second guide rail, in the left and right sides of supporting plate, are separately fixed at by pin in the first guide rail hole on supporting plate, the second guide rail hole.Lower platen is enclosed within the first guide rail, the second guide rail bottom by the 3rd guide rail hole, the 4th guide rail hole.Top board is enclosed within the first guide rail, the second guide upper by the 5th guide rail hole, the 6th guide rail hole, and top board is fixed by pin and the first guide rail, the second guide rail.First spring, the second spring are enclosed within the first guide rail, the second guide rail respectively, and are limited between top board and lower platen.The little head end of pull bar is fixed with pull bar cap through after the tie rod hole of lower platen and top board tie rod hole, and stub end is limited in tie rod hole.The bottom surface of lower platen contacts with the end face of flow plate.Described fluid intake and the angle between fluid egress point and normal are 0 degree ~ 90 degree.
The beneficial effect that the present invention has is: the micro-circulation detecting pool device of direct press type quick assembling of the present invention, there is the advantages such as installation and removal are quick, cleaning part is few, equalization of pressure, can widely use in fields such as analysis detections, the complicated pick-up unit based on precision processing technology can be replaced, all can widespread use in life science, chemical analysis, food security, environmental monitoring and relevant scientific field.
Accompanying drawing explanation
Fig. 1 is system front elevational schematic of the present invention;
Fig. 2 is system schematic side view of the present invention;
Fig. 3 is flow plate backplan of the present invention;
Fig. 4 is base plate vertical view of the present invention;
Fig. 5 is supporting plate front elevation of the present invention;
Fig. 6 is lower platen vertical view of the present invention;
Fig. 7 is top board sectional view of the present invention;
Fig. 8 is typical detection chip schematic diagram of the present invention.
In figure, flow plate 1, base plate 2, seal 3, detection chip 4, interface board 5, supporting plate 6, lower platen 7, top board 8, pull bar 9, pull bar cap 10, first spring 11, second spring 12, first register pin 13, second register pin 14, first guide rail 15, second guide rail 16, first pilot hole 101, second pilot hole 102, seal groove 103, fluid intake 104, fluid egress point 105, first fixed orifice 106, second fixed orifice 107, interface board slot 108, first fixed pin holes 201, second fixed pin holes 202, first threaded hole 203, second threaded hole 204, chip groove 205, first contact conductor 401, second contact conductor 402, detection zone 403, first guide rail hole 601, second guide rail hole 602, chute 603, 3rd guide rail hole 701, 4th guide rail hole 702, tie rod hole 703, 5th guide rail hole 801, 6th guide rail hole 802, tie rod hole 803.
Embodiment
Below in conjunction with drawings and Examples, the invention will be further described.
As shown in Fig. 1 ~ Fig. 8, the present invention includes flow cell and hold down gag, flow cell comprises flow plate 1, base plate 2, seal 3, detection chip 4, interface board 5, first register pin 13, second register pin 14, and hold down gag comprises supporting plate 6, lower platen 7, top board 8, pull bar 9, pull bar cap 10, first spring 11, second spring 12.
Flow plate 1 end face has fluid intake 104 and fluid egress point 105, respectively inlet and outlet piping is arranged on fluid intake 104 and fluid egress point 105 place with two interface tubes; The bottom surface of flow plate 1 has seal groove 103 to install seal 3, and seal groove 103 is positioned at below fluid intake 105 and fluid egress point 106.Seal 3 is in above the detection zone 403 of detection chip 4.
There is interface board slot 108 flow plate 1 bottom surface for mounting interface plate 5.The end face of base plate 2 has chip groove 205 setting-in detection chip 4.Interface board 5 contacts with the contact conductor elastomeric electrical of detection chip 4.Interface board 5 is for the first contact conductor 401, second contact conductor 402 of detection chip 4 of transferring.Interface board 5 and flow plate 1 are bolted.Flow plate 1 is installed on the top of base plate 2.
First fixed pin holes 201, second fixed pin holes 202 setting-in first register pin 13, second register pin 14 of base plate 2, first pilot hole 101, second pilot hole 102 of flow plate 1 by its bottom surface and the first register pin 13, second register pin 14 orientation assemble of base plate 2.
First guide rail 15, second guide rail 16, in the left and right sides of supporting plate 6, is separately fixed at by pin in the first guide rail hole 601, second guide rail hole 602 on supporting plate 6.Lower platen 7 is enclosed within the first guide rail 15, second guide rail 16 bottom by the 3rd guide rail hole 701, the 4th guide rail hole 702.Top board 8 is enclosed within the first guide rail 15, second guide rail 16 top by the 5th guide rail hole 801, the 6th guide rail hole 802, and top board 8 is fixed by pin and the first guide rail 15, second guide rail 16.First spring 11, second spring 12 is enclosed within the first guide rail 15, second guide rail 16 respectively, and is limited between top board 8 and lower platen 7.
The little head end of pull bar 9 passes the tie rod hole 703 of lower platen 7 and top board 8 tie rod hole 803 is rear and pull bar cap 10 is fixed by pin, and stub end is limited in tie rod hole 703.
The bottom surface of lower platen 7 contacts with the end face of flow plate 1.
Described fluid intake 104 and the angle between fluid egress point 105 and normal are 0 degree ~ 90 degree.
Application process of the present invention is as follows:
1, assemble hold down gag as shown in Figure 1, and all parts of flow cell is cleaned up.
2, interface board 5 is placed in the interface board slot 108 of flow plate 1, and fixes with bolt.
3, detection chip 4 is put in the chip groove 205 of base plate 2.
4, seal 3 is put in the seal groove 103 of flow plate 1, flow plate 1 and base plate 2 are passed through the first register pin 13, second register pin 14 orientation assemble.Such flow cell has just assembled.
5, two pipe joints respectively Pipe installing at the fluid intake 104 of flow plate 1 and fluid egress point 105 place.If hand injection, inlet duct is connected syringe.If auto injection, outlet conduit is connected the equipment such as peristaltic pump or syringe pump, inlet duct connects testing sample or detects reagent.
6, pull-up pull bar cap 10 drives pull bar 9, makes lower platen 7 increase along the first guide rail 15, second guide rail 16, then the flow cell assembled is pushed the chute of supporting plate 6, is positioned in the middle of the first guide rail 15, second guide rail 16.
7, put down pull bar cap 10, due to the effect of the first spring 11, second spring 12, lower platen 7 declines along the first guide rail 15, second guide rail 16, and the lower plane of lower platen 7 contacts with the end face of the flow plate 1 of flow cell.The compression degree of snap-in force and the first spring 11, second spring 12 has relation.
8, test cable interface is connected with the interface board 5 of circulation detecting pool device with one end, the other end is connected with the signal input part of detecting instrument.
9, detected sample is expelled to inlet duct, and in the detection space that form of the detection zone 403 flowing to detection chip 6 and seal 5, laggard outlet conduit outflow.The measuring-signal reading detecting instrument just can know the characteristic of detected sample.
10, after having detected, pull-up pull bar cap 10 drives pull bar 9, makes lower platen 7 increase along the first guide rail 15, second guide rail 16, then takes out flow cell.
11, take out flow plate 1, seal 3, detection chip 4, after cleaning up, install and just can again detect.Owing to directly not contacting sample, base plate 2 does not need often dismounting and cleaning.

Claims (2)

1. the micro-circulation detecting pool device of direct press type quick assembling, it is characterized in that, it comprises flow cell and hold down gag, described flow cell comprises flow plate (1), base plate (2), seal (3), detection chip (4), interface board (5), the first register pin (13), the second register pin (14), and hold down gag comprises supporting plate (6), lower platen (7), top board (8), pull bar (9), pull bar cap (10), the first spring (11), the second spring (12); Flow plate (1) end face has fluid intake (104) and fluid egress point (105), respectively inlet and outlet piping is arranged on fluid intake (104) and fluid egress point (105) place with two interface tubes; The bottom surface of flow plate (1) has seal groove (103) to install seal (3), and seal groove (103) is positioned at fluid intake (105) and fluid egress point (106) below; Seal (3) is in the top, detection zone (403) of detection chip (4); There is interface board slot (108) flow plate (1) bottom surface for mounting interface plate (5); The end face of base plate (2) has chip groove (205) setting-in detection chip (4); Interface board (5) contacts with the contact conductor elastomeric electrical of detection chip (4); Interface board (5) is for the first contact conductor (401), second contact conductor (402) of detection chip of transferring (4); Interface board (5) and flow plate (1) are bolted; Flow plate (1) is installed on the top of base plate (2); First fixed pin holes (201) of base plate (2), the second fixed pin holes (202) setting-in first register pin (13), the second register pin (14), flow plate (1) is by the first register pin (13), the second register pin (14) orientation assemble of first pilot hole (101) of its bottom surface, the second pilot hole (102) and base plate (2); First guide rail (15), the second guide rail (16), in the left and right sides of supporting plate (6), are separately fixed in the first guide rail hole (601) on supporting plate (6), the second guide rail hole (602) by pin; Lower platen (7) is enclosed within the first guide rail (15), the second guide rail (16) bottom by the 3rd guide rail hole (701), the 4th guide rail hole (702); Top board (8) is enclosed within the first guide rail (15), the second guide rail (16) top by the 5th guide rail hole (801), the 6th guide rail hole (802), and top board (8) is fixed by pin and the first guide rail (15), the second guide rail (16); First spring (11), the second spring (12) are enclosed within the first guide rail (15), the second guide rail (16) respectively, and are limited between top board (8) and lower platen (7); The little head end of pull bar (9) through the tie rod hole (703) of lower platen (7) and top board (8) tie rod hole (803) fixing with pull bar cap (10) afterwards, stub end is limited in tie rod hole (703); The bottom surface of lower platen (7) contacts with the end face of flow plate (1).
2. the micro-circulation detecting pool device of direct press type quick assembling according to claim 1, it is characterized in that, described fluid intake (104) and the angle between fluid egress point (105) and normal are 0 degree ~ 90 degree.
CN201310217451.6A 2013-06-03 2013-06-03 Direct-compression type rapid assembling micro-circulation detection tank device Active CN103323493B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201310217451.6A CN103323493B (en) 2013-06-03 2013-06-03 Direct-compression type rapid assembling micro-circulation detection tank device
PCT/CN2013/080389 WO2014194556A1 (en) 2013-06-03 2013-07-30 Direct-pressing quick-assemble microcirculation detection tank device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310217451.6A CN103323493B (en) 2013-06-03 2013-06-03 Direct-compression type rapid assembling micro-circulation detection tank device

Publications (2)

Publication Number Publication Date
CN103323493A CN103323493A (en) 2013-09-25
CN103323493B true CN103323493B (en) 2015-05-06

Family

ID=49192375

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201310217451.6A Active CN103323493B (en) 2013-06-03 2013-06-03 Direct-compression type rapid assembling micro-circulation detection tank device

Country Status (2)

Country Link
CN (1) CN103323493B (en)
WO (1) WO2014194556A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11213818B2 (en) 2015-11-25 2022-01-04 Spectradyne Llc Systems and devices for microfluidic instrumentation
US11105451B2 (en) 2017-07-07 2021-08-31 Eaton Intelligent Power Limited Heat transfer interruption for improved fire resistance/proof performance
CN109331191B (en) * 2018-09-10 2020-06-16 浙江大学 High-voltage electric field coupling ultrasonic treatment liquid sterilization testing device and method
CN109991195A (en) * 2019-04-24 2019-07-09 浙江警察学院 A kind of SPR detector single channel micro-fluidic chip clamping system
CN115246104A (en) * 2022-07-15 2022-10-28 重庆钢铁股份有限公司 Sample blank rapid clamping device

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101118226A (en) * 2007-08-06 2008-02-06 浙江大学 Multifunctional micro-electrode chip circulation detecting pool device
CN201143629Y (en) * 2007-12-29 2008-11-05 比亚迪股份有限公司 Clamping apparatus
CN203310792U (en) * 2013-06-03 2013-11-27 浙江大学 Direct-pressing quickly-assembled microcirculation detection tank device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7497994B2 (en) * 1998-02-24 2009-03-03 Khushroo Gandhi Microfluidic devices and systems incorporating cover layers
KR100425536B1 (en) * 2001-07-16 2004-03-30 학교법인 포항공과대학교 Bread board for microfluidic chip
CN201130165Y (en) * 2007-12-26 2008-10-08 上海神开石油化工装备股份有限公司 Apparatus for measuring sulfureted hydrogen gas
EP2366993A1 (en) * 2010-03-08 2011-09-21 Nxp B.V. A sensor and a method of assembling a sensor
CN101957322B (en) * 2010-08-17 2012-01-11 中国科学院苏州纳米技术与纳米仿生研究所 Flow cell for electrochemiluminescence detection and system thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101118226A (en) * 2007-08-06 2008-02-06 浙江大学 Multifunctional micro-electrode chip circulation detecting pool device
CN201143629Y (en) * 2007-12-29 2008-11-05 比亚迪股份有限公司 Clamping apparatus
CN203310792U (en) * 2013-06-03 2013-11-27 浙江大学 Direct-pressing quickly-assembled microcirculation detection tank device

Also Published As

Publication number Publication date
WO2014194556A1 (en) 2014-12-11
CN103323493A (en) 2013-09-25

Similar Documents

Publication Publication Date Title
CN103323493B (en) Direct-compression type rapid assembling micro-circulation detection tank device
CN100549683C (en) Multifunctional micro-electrode chip circulation detecting pool device
CN101059465A (en) Ammonia test method and device
CN205228731U (en) Bellows quality detection device
CN203310792U (en) Direct-pressing quickly-assembled microcirculation detection tank device
CN103592346B (en) Integrated gas path structure for trace gas analyzer
CN103323492B (en) Rapid assembly micro-flow detection cell device with magnetic separation
CN103308559B (en) The micro-circulation detecting pool device of rotary quick assembling
CN104698131A (en) Hydrate gas logging while drilling electronic nose with fish-nasal-cavity-shaped nasal cavity
CN201897546U (en) Mechanical load testing device for photovoltaic cell component
CN203310790U (en) Rotary rapid assembling micro-circulation detection tank device
CN203310791U (en) Rapid-assembly micro-circulation detection pool device with magnetic separation
CN201072428Y (en) Circulation detecting pool device for multifunctional microelectrode chip
CN114910418A (en) Food sugar and salt concentration detection device
CN208060297U (en) Hydraulic pressure is bent deflection angle experimental rig
CN104237427A (en) Liquid chromatography mobile phase early warning device
CN208780602U (en) A kind of vehicle reinforcing corrosion test standard film hanging plate
CN208654143U (en) A kind of Monitoring And Analysis of The Quality unit
CN220119171U (en) Easy dismounting's pipeline vibration detector
CN107192663B (en) Test system for evaluating electrified service performance of disconnecting switch contact material
CN214787953U (en) Plunger assembly of high-pressure constant-flow pump of liquid chromatograph
CN205027380U (en) Connector detects connector fixing device of installation
CN2906577Y (en) Micro gas/liquid element leakage detector
CN211877316U (en) Device for detecting sealing performance of sealing element
CN221055970U (en) Fuel filter vibration test device

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant