CN104237427A - Liquid chromatography mobile phase early warning device - Google Patents
Liquid chromatography mobile phase early warning device Download PDFInfo
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- CN104237427A CN104237427A CN201410464890.1A CN201410464890A CN104237427A CN 104237427 A CN104237427 A CN 104237427A CN 201410464890 A CN201410464890 A CN 201410464890A CN 104237427 A CN104237427 A CN 104237427A
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Abstract
The invention discloses a liquid chromatography mobile phase early warning device. The liquid chromatography mobile phase early warning device mainly comprises a liquid chromatograph and an intelligent control system, wherein the liquid chromatograph comprises a pump, and a sample injector, a chromatographic column, a detector and a waste liquid bottle which are sequentially connected with one another through pipelines; the input end of the pump is connected with a mobile phase containing bottle; the output end of the pump is connected with the input end of the chromatographic column through a pipeline by virtue of the sample injector; the intelligent control system comprises a temperature sensor, a pressure sensor, a PLC host, a PLC module and a touch display screen; the PLC module is in plug-in connection with the PLC host; the temperature sensor and the pressure sensor are respectively arranged in the mobile phase containing bottle; an analog signal acquired by the temperature sensor and the pressure sensor is received through the PLC module, converted into a digital signal and fed into the touch display screen through the PLC host. According to the device, the operating temperature and the operating pressure of the mobile phase are monitored in real time, so that a phenomenon that air bubbles in the mobile phase escape due to temperature rise or pressure drop is avoided.
Description
Technical field
The present invention relates to technical field of analytical chemistry, be specifically related to a kind of liquid chromatogram mobile phase prior-warning device.
Background technology
Liquid chromatogram mobile phase typically refers to various low boiling point solvent and aqueous solution.Compare with gas chromatography, liquid chromatogram mobile phase not only selectable range is larger, and it is the very important adjustable factor that impact is separated.At present, the mobile phase of conventional liquid chromatograph is divided into polarity class, nonpolar class, volatile class, not volatile class etc., and the solvent bottle holding mobile phase is mostly the unenclosed construction communicated with air, unenclosed construction for conventional non-volatile class neutral mobile phase be not much affected, but for easily to absorb Carbon Dioxide in Air and affect the mobile phase of the aobvious alkalescence of its PH value, volatile mobile phase that organic phase proportion is larger, containing volatile pungency component mobile phase have larger limitation.
For solving the problem, publication number is that the Chinese patent of CN203635201U discloses a kind of phase chromatography-use mobile phase apparatus for placing, this device comprises the wide-necked bottle holding mobile phase, there is the feed tube of detachable connector, the valvular bend pipe of tool, there is the polybag of air intake opening and gas outlet, the bottle stopper that described wide-necked bottle comprises vial body and matches with vial body, bottle stopper have two through holes matched with feed tube and bend pipe respectively, one end that feed tube extend in wide-necked bottle is fixedly connected with sintered glass filter, the valve place of bend pipe is fixedly connected with the air intake opening of polybag, the volume of described polybag is the half of wide-necked bottle volume.This technical scheme has good sealing effectiveness, be applicable to volatile class mobile phase, but because the flat gas being employing polybag is to judge whether mobile phase is finished, judgment accuracy is poor, especially be difficult to judge whether mobile phase is finished when polybag exists leakage or mobile phase produces bubble, also can not produce early warning simultaneously, therefore can not make Real-Time Monitoring to mobile phase.
In order to realize supervision to liquid chromatogram mobile phase and prompting, publication number is that the Chinese patent of CN 202734898 U discloses a kind of supervision alarm set for liquid chromatogram mobile phase, this device arranges Weighing module in the bottom of flowing bottle, flowing bottle is provided with exterior display device, by exterior display device highlight indication contain residual volume and the replacing construction of mobile phase; But when causing mobile phase to produce bubble when temperature or pressure change, display device can not make prompting or early warning, therefore causes system jam, causes unnecessary economic loss.
Summary of the invention
The object of the invention is to the deficiency overcome existing for prior art, provide a kind of liquid chromatogram mobile phase prior-warning device.
The present invention is achieved by following technical solution:
A kind of liquid chromatogram mobile phase prior-warning device, primarily of liquid chromatograph and intelligent control system composition, injector, chromatographic column, detecting device and waste liquid bottle that described liquid chromatograph is comprised pump and connected successively by pipeline, the input end of described pump connects mobile phase and holds bottle, and delivery side of pump is connected with the input end of chromatographic column through injector by pipeline; Described intelligent control system comprises temperature sensor, pressure transducer, PLC main frame, PLC module and touch display screen, described PLC module and the grafting of PLC main frame, described temperature sensor and pressure transducer are arranged at mobile phase respectively and hold bottle, the analog signals of temperature sensor and pressure transducer collection is accepted by PLC module, convert digital signal to, send into touch display screen by PLC main frame.
Further, described mobile phase holds the filtrator being provided with bottom bottle and being connected with pipeline.
Further, described intelligent control system also comprises radiator fan, power light, abnormal pilot lamp and hummer.Indicating fault or warning is carried out by pilot lamp and hummer.
Further, described filtrator adopts sintered glass filter.
Further, described detecting device adopts conductometric detector.
The invention has the beneficial effects as follows:
Compared with prior art, working temperature and the working pressure of the present invention by adopting PLC intelligent control system to monitor mobile phase in real time, mobile phase Yin Wendu rising or pressure is avoided to reduce and cause bubble to be overflowed, prevent chance failure from occurring, improve the security of the work of liquid chromatograph, avoid causing unnecessary economic loss.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Wherein in Fig. 1, each several part is:
1-mobile phase holds bottle; 2-pump; 3-injector; 4-chromatographic column; 5-detecting device; 6-computing machine; 7-waste liquid bottle; 8-temperature sensor; 9-pressure transducer; 10-PLC main frame; 11-PLC module; 12-touch display screen; 13-filtrator.
Embodiment
Technical scheme of the present invention is further described below in conjunction with accompanying drawing, but described in claimed scope is not limited to.
As shown in Figure 1, a kind of liquid chromatogram mobile phase prior-warning device of the present invention, primarily of liquid chromatograph and intelligent control system composition, injector 3, chromatographic column 4, detecting device 5 and waste liquid bottle 7 that described liquid chromatograph is comprised pump 2 and connected successively by pipeline, the input end of described pump 2 connects mobile phase and holds bottle 1, and the output terminal of pump 2 is connected through the input end of injector 3 with chromatographic column 4 by pipeline; Described intelligent control system comprises temperature sensor 8, pressure transducer 9, PLC main frame 10, PLC module 11 and touch display screen 12, described PLC module 11 and PLC main frame 10 grafting, described temperature sensor 8 and pressure transducer 9 are arranged at mobile phase respectively and hold bottle 1, the analog signals of temperature sensor 8 and pressure transducer 9 collection is accepted by PLC module 11, convert digital signal to, touch display screen 12 is sent into by PLC main frame 10, show various running parameter, thus the real-time monitoring realized mobile phase and early warning.
Described detecting device 5 is also connected with computing machine 6.
Adopt technique scheme, when applying, liquid chromatogram mobile phase carries tested sample by chromatographic column 4, and mobile phase is delivered to analysis system with stable flow velocity (or pressure) by pump 2; Testing sample passed through injector 3 by Sample introduction before chromatographic column 4, and mobile phase brings sample into chromatographic column 4; In chromatographic column 4, each component is separated because of the difference of the partition factor in Stationary liquid or absorption affinity size, and flow to detecting device 5 with mobile phase successively; The signal detected is delivered to computing machine 6 and is recorded, processes or preserve by detecting device 5, can calculate the concentration of various component to be measured sample from the data of computing machine 6 record, and by discharging of waste liquid in waste liquid bottle 7.
In actual applications, in solvent, the amount of energy dissolved gas raises with temperature and reduces, and thus when solvent moves to the condition of high temperature from low-temperature condition, then the gas of Excessive lysis can be overflowed in the form of bubbles; Meanwhile, when the dividing potential drop of gas increases, gas meltage in a solvent increases, and the solution reached capacity at elevated pressures is once pressure drop will produce bubble.The technical program is monitored in real time by increasing the temperature and pressure of intelligent control system to mobile phase, to avoid the generation of bubble, its principle of work is: measured temperature and pressure analog signals is delivered to PLC module 11 by temperature sensor 8 and pressure transducer 9 respectively, corresponding digital quantity signal is converted to through PLC module 11, digital quantity signal after PLC main frame 10 reads PLC module 11 conversion is also shown by touch display screen 12, so that user observes the running parameter of mobile phase.Simultaneously user is by having carried out the supervision of the selection of the duty to mobile phase, the setting of running parameter and duty to the operation of touch display screen 12; When the temperature of mobile phase or pressure do not meet setting require time; shut down by PLC control system; fault-signal is also exported to PLC output control circuit and is made indication warning loop works by PLC main frame 10, sends sound and light alarm, the method showing phenomenon of the failure by touch display screen 12 simultaneously and fix a breakdown.
Described mobile phase holds the filtrator 13 being provided with bottom bottle 1 and being connected with pipeline.
Described intelligent control system also comprises radiator fan, power light, abnormal pilot lamp and hummer.Indicating fault or warning is carried out by pilot lamp and hummer.
Described filtrator 13 adopts sintered glass filter.
Described detecting device 5 adopts conductometric detector.
The above embodiment of the present invention is only for example of the present invention is clearly described, and is not the restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.All any amendments done within the spirit and principles in the present invention, equivalent to replace and improvement etc., within the protection domain that all should be included in the claims in the present invention.
Claims (5)
1. a liquid chromatogram mobile phase prior-warning device, primarily of liquid chromatograph and intelligent control system composition, the injector (3) that described liquid chromatograph is comprised pump (2) and connected successively by pipeline, chromatographic column (4), detecting device (5) and waste liquid bottle (7), the input end of described pump (2) connects mobile phase and holds bottle (1), the output terminal of pump (2) is connected through the input end of injector (2) with chromatographic column (4) by pipeline, it is characterized in that: described intelligent control system comprises temperature sensor (8), pressure transducer (9), PLC main frame (10), PLC module (11) and touch display screen (12), described PLC module (11) and PLC main frame (10) grafting, described temperature sensor (8) and pressure transducer (9) are arranged at mobile phase respectively and hold bottle (1), the analog signals that temperature sensor (8) and pressure transducer (9) gather is accepted by PLC module (11), convert digital signal to, touch display screen (12) is sent into by PLC main frame (10).
2. a kind of liquid chromatogram mobile phase prior-warning device according to claim 1, is characterized in that: described mobile phase holds bottle (1) bottom and is provided with the filtrator (13) be connected with pipeline.
3. a kind of liquid chromatogram mobile phase prior-warning device according to claim 1, it is characterized in that: described intelligent control system also comprises radiator fan, power light, abnormal pilot lamp and hummer, carry out indicating fault or warning by pilot lamp and hummer.
4. a kind of liquid chromatogram mobile phase prior-warning device according to claim 2, is characterized in that: described filtrator (13) adopts sintered glass filter.
5. a kind of liquid chromatogram mobile phase prior-warning device according to claim 1, is characterized in that: described detecting device (5) adopts conductometric detector.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410464890.1A CN104237427B (en) | 2014-09-12 | 2014-09-12 | A kind of liquid chromatogram mobile phase prior-warning device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410464890.1A CN104237427B (en) | 2014-09-12 | 2014-09-12 | A kind of liquid chromatogram mobile phase prior-warning device |
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| CN104237427A true CN104237427A (en) | 2014-12-24 |
| CN104237427B CN104237427B (en) | 2016-04-13 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108020606A (en) * | 2016-11-04 | 2018-05-11 | 罗斯蒙特分析公司 | The monitoring of analyzer component |
| CN114651175A (en) * | 2019-11-20 | 2022-06-21 | 思拓凡瑞典有限公司 | Method for determining operating flow rate for a chromatography column in an HPLC system |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62167472A (en) * | 1985-11-29 | 1987-07-23 | Shimadzu Corp | Solvent supply apparatus |
| JPS63165720A (en) * | 1986-12-26 | 1988-07-09 | Fujitsu Ltd | Liquid storage tank equipped with liquid level alarm |
| JP2008215978A (en) * | 2007-03-02 | 2008-09-18 | Shimadzu Corp | Liquid feed pump and liquid chromatograph using it |
| CN102171561A (en) * | 2008-10-06 | 2011-08-31 | 爱科来株式会社 | Analyzing device |
| CN102641711A (en) * | 2012-04-12 | 2012-08-22 | 山东创新药物研发有限公司 | Flowing phase containing device used for sealed liquid phase color spectrum |
| JP2013002815A (en) * | 2011-06-10 | 2013-01-07 | Ulvac Japan Ltd | Flow-through measuring device |
| CN202734898U (en) * | 2012-07-26 | 2013-02-13 | 尹磊 | Monitoring and reminding device used for flowing phase of liquid chromatogram |
| CN203397202U (en) * | 2013-08-30 | 2014-01-15 | 无锡衡联科技有限公司 | Real-time monitoring system used for enterprise production line |
| CN203705405U (en) * | 2014-02-26 | 2014-07-09 | 苏州环球色谱有限责任公司 | Liquid chromatographsystem |
| CN204065040U (en) * | 2014-09-12 | 2014-12-31 | 华南理工大学 | A kind of liquid chromatogram mobile phase prior-warning device |
-
2014
- 2014-09-12 CN CN201410464890.1A patent/CN104237427B/en not_active Expired - Fee Related
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62167472A (en) * | 1985-11-29 | 1987-07-23 | Shimadzu Corp | Solvent supply apparatus |
| JPS63165720A (en) * | 1986-12-26 | 1988-07-09 | Fujitsu Ltd | Liquid storage tank equipped with liquid level alarm |
| JP2008215978A (en) * | 2007-03-02 | 2008-09-18 | Shimadzu Corp | Liquid feed pump and liquid chromatograph using it |
| CN102171561A (en) * | 2008-10-06 | 2011-08-31 | 爱科来株式会社 | Analyzing device |
| JP2013002815A (en) * | 2011-06-10 | 2013-01-07 | Ulvac Japan Ltd | Flow-through measuring device |
| CN102641711A (en) * | 2012-04-12 | 2012-08-22 | 山东创新药物研发有限公司 | Flowing phase containing device used for sealed liquid phase color spectrum |
| CN202734898U (en) * | 2012-07-26 | 2013-02-13 | 尹磊 | Monitoring and reminding device used for flowing phase of liquid chromatogram |
| CN203397202U (en) * | 2013-08-30 | 2014-01-15 | 无锡衡联科技有限公司 | Real-time monitoring system used for enterprise production line |
| CN203705405U (en) * | 2014-02-26 | 2014-07-09 | 苏州环球色谱有限责任公司 | Liquid chromatographsystem |
| CN204065040U (en) * | 2014-09-12 | 2014-12-31 | 华南理工大学 | A kind of liquid chromatogram mobile phase prior-warning device |
Non-Patent Citations (2)
| Title |
|---|
| 张凯峰: "PLC在肉类行业腊肠生产工艺中的应用", 《包装与机械》, vol. 26, no. 6, 25 June 2005 (2005-06-25), pages 145 - 147 * |
| 王浩 等: "基于PID调节的浴池恒温恒压供水系统", 《软件》, vol. 32, no. 3, 16 June 2011 (2011-06-16) * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108020606A (en) * | 2016-11-04 | 2018-05-11 | 罗斯蒙特分析公司 | The monitoring of analyzer component |
| EP3535578A4 (en) * | 2016-11-04 | 2020-06-17 | Rosemount Inc. | A method of monitoring the components of gas analyser |
| CN108020606B (en) * | 2016-11-04 | 2024-03-26 | 罗斯蒙特公司 | Monitoring of analyzer components |
| CN114651175A (en) * | 2019-11-20 | 2022-06-21 | 思拓凡瑞典有限公司 | Method for determining operating flow rate for a chromatography column in an HPLC system |
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| CN104237427B (en) | 2016-04-13 |
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