CN105772125B - Micro-fluidic chip clamp experiment porch based on 3D printing - Google Patents
Micro-fluidic chip clamp experiment porch based on 3D printing Download PDFInfo
- Publication number
- CN105772125B CN105772125B CN201610258731.5A CN201610258731A CN105772125B CN 105772125 B CN105772125 B CN 105772125B CN 201610258731 A CN201610258731 A CN 201610258731A CN 105772125 B CN105772125 B CN 105772125B
- Authority
- CN
- China
- Prior art keywords
- substrate
- micro
- fluidic chip
- cover board
- insert port
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
Abstract
The invention discloses a kind of micro-fluidic chip clamp experiment porch based on 3D printing, substrate and cover board two parts are experiment porch agent structure, two parts are bolted, there are the rectangular window of same size and four bolt holes, four rectangular preiection positioning settings for substrate and cover plate central, substrate have ramp type micro-fluidic chip insert port, inside have left and right positioning chuck, cover board each side be distributed there are six connecting tube insert port and sealing ring installation site.There are the rectangular window of same size and four bolt holes, four rectangular preiection positioning settings for substrate cover plate central, substrate has ramp type micro-fluidic chip insert port, inside to have left and right positioning chuck, and each side there are six connecting tube insert port and sealing ring installation sites for distribution on cover board.Device is suitable for all kinds of micro-fluidic chips experiment detection and laboratory uses, and experiment porch rapid processing, cost of manufacture purpose that is cheap, easy to operate, improving experiment connecting tube effect may be implemented.
Description
Technical field
The present invention relates to a kind of micro-fluidic chip clamp experiment porch based on 3D printing, specifically, being 3D printing
Technology is applied in the making of micro-fluidic experiment porch, realizes the rapid processing of experiment porch, reduces cost of manufacture, is easy to operate
Purpose, which is suitable for various biomedical detections and chemical analysis application using micro-fluidic chip, belongs to
In microfluidic art.
Background technology
3D printing belongs to one kind of rapid shaping technique, and central principle is：" Layered manufacturing is successively superimposed ".3D printing
The printed material of machine is raw material of device, such as metal, ceramics, plastics, sand etc..Specific implementation process is to utilize computer aided manufacturing
It helps design or modeling software to commodity modeling, model division is then generated STL standard data files at section successively.3D
Printer successively prints and is bonded, produce entity by identifying file middle section information.At present its be widely used in automobile,
The fields such as aviation, medical treatment, building.Material is greatly saved in the principle of its increasing material manufacturing, reduces product cost, and product quality is steady
It is fixed.But for the very high product of required precision, need subsequently to polish and finish；Because in process, material is heated repeatedly,
Therefore interiors of products stress is complicated, product material performance is poor, such as intensity, rigidity etc..So 3D printing for required precision not
High, product strength requires also not high product highly advantageous.
Microfluidic chip technology is one of the hot spot of present analysis science research.Micro-fluidic chip is biology, chemistry, doctor
The basic operation units such as sample preparation, reaction, separation, the detection of analytic process are learned to be integrated on the chip of one piece of micro-meter scale,
It is automatically performed analysis overall process.Microfluidic chip analysis is using chip as operating platform, while based on analytical chemistry, with microcomputer
EDM Technology is to rely on, and is current main application with life science using microchannel network as structure feature, is current micro-
The emphasis of analysis system field development.And laboratory is needed through connecting tube when carrying out micro-fluidic chip experiment fluid
It imports in micro-fluidic chip, therefore experiment is required for connecting connecting tube in each interface every time, while being sealed.It is each micro-fluidic
Chip has several interfaces, and it is small to make an excuse size, so take over operation can consume the plenty of time in experiment, and quality of connection with
Manual operation stability is related, easily occurs leaking and blocking.The unreasonable arrangement of connecting tube can also influence Germicidal efficacy and result.
Invention content
Micro-fluidic chip connecting tube relies on experimenter's operating experience, time-consuming in order to overcome in existing laboratory work and
The cumbersome problem of connection procedure, the present invention provide a kind of micro-fluidic chip clamp experiment porch based on 3D printing, should be based on 3D
The micro-fluidic chip clamp experiment porch of printing not only assists in experimenter and quickly connects the company for completing disengaging micro-fluidic chip
It takes over, and can guarantee quality of connection, operation is simple.
The technical solution adopted by the present invention to solve the technical problems is：It is of the present invention based on the micro-fluidic of 3D printing
Chip fixture experiment porch, including substrate, cover board, bolt connecting hole, substrate and cover board two parts are experiment porch agent structure,
Two parts are bolted, substrate and cover plate central there are the rectangular window of same size and four bolt holes, four
Rectangular preiection positioning setting, substrate have ramp type micro-fluidic chip insert port, inside to have left and right positioning chuck, the cover board left and right sides
There are six connecting tube insert port and sealing ring installation sites for each distribution.
The substrate and cover board is made of 3D printing.
Described connecting tube insert port or so is all provided with six, is arranged according to rectangular mode.
There is ramp type micro-fluidic chip insert port on the substrate.
There are many positioning methods, including rectangular preiection, left and right to position chuck, be bolted for substrate and cover board.
Apparatus of the present invention design is succinct, using 3D printing, realizes that inexpensive rapid processing, ramp type micro-fluidic chip are inserted
Entrance allows micro-fluidic chip to be smoothly inserted into, and will not damage, and rectangular preiection, is bolted so that base left and right positioning chuck
Plate and cover board are accurately positioned, and multiple connecting tube insert ports can meet the design requirement of different micro-fluidic chips in subsequent experimental.
The invention has the advantages that the process that cumbersome connecting fluid flows into pipe can be saved, it is only necessary to micro-fluidic
Chip is inserted into substrate cover upper cover plate and tightens fixing bolt, convenient succinct, ensures the quality of connection of connecting tube.
Description of the drawings
Fig. 1 is the substrate covering plate structure figure of the present invention.
In figure：1, bolt connecting hole, 2, connecting tube insert port, 3, sealing ring, 4, cover board, 5, substrate, 6, rectangular window, 7,
Rectangular preiection, 8, left and right positioning chuck, 9, ramp type micro-fluidic chip insert port, 10, rectangular recess.
Specific implementation mode
Present invention will be further explained below with reference to the attached drawings and examples.
In Fig. 1, designed structure is made using 3D printing, cover board (4) is equipped with sealing ring (3), installation site installation
Be not easy to be tested the sealing ring of flow-induced corrosion material used, connecting tube be installed in connecting tube insert port (2) position, substrate (5) with
Cover board (4) is aligned, and rectangular preiection (7) is aligned with rectangular recess (10)；After bolt is connect with bolt connecting hole (1), substrate (5) and
Cover board (4) is mutually fixed；When experiment, micro-fluidic chip is entered from ramp type micro-fluidic chip insert port (9), is positioned using left and right
Chuck (8) positions, and rectangular window (6) can observe fluid state in micro-fluidic chip, can also be placed directly within microscopically observation, ties
Beam can pop up micro-fluidic chip when testing from bottom rectangle window (6).
Claims (2)
1. the micro-fluidic chip clamp experiment porch based on 3D printing, it is characterised in that：The platform includes substrate, cover board, bolt
Connecting hole, substrate and cover board two parts are experiment porch agent structure, and two parts are bolted, and substrate and cover plate central stay
The rectangular window and four bolt holes, four rectangular preiection positioning settings, substrate for having same size have ramp type micro-fluidic
Chip insert port, inside have left and right positioning chuck, cover board each side be distributed there are six connecting tube insert port and sealing ring peace
Holding position；
The substrate and cover board is made of 3D printing；
Described connecting tube insert port or so is all provided with six, is arranged according to rectangular mode；
There is ramp type micro-fluidic chip insert port on the substrate；
Cover board (4) is equipped with sealing ring (3), and installation site installation is not easy to be tested the sealing ring of flow-induced corrosion material used,
Connecting tube is installed in connecting tube insert port (2) position, and substrate (5) is aligned with cover board (4), rectangular preiection (7) and rectangular recess (10)
Alignment；After bolt is connect with bolt connecting hole (1), substrate (5) is mutually fixed with cover board (4)；When experiment, micro-fluidic chip from oblique
Shelving micro-fluidic chip insert port (9) enters, and is positioned using left and right positioning chuck (8), and rectangular window (6) can observe micro-fluidic core
Fluid state in piece can also be placed directly within microscopically observation, can be popped up from bottom rectangle window (6) when terminating experiment micro-fluidic
Chip.
2. the micro-fluidic chip clamp experiment porch according to claim 1 based on 3D printing, it is characterised in that：Substrate and
There are many positioning methods, including rectangular preiection, left and right to position chuck, be bolted for cover board.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610258731.5A CN105772125B (en) | 2016-04-23 | 2016-04-23 | Micro-fluidic chip clamp experiment porch based on 3D printing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610258731.5A CN105772125B (en) | 2016-04-23 | 2016-04-23 | Micro-fluidic chip clamp experiment porch based on 3D printing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105772125A CN105772125A (en) | 2016-07-20 |
| CN105772125B true CN105772125B (en) | 2018-09-21 |
Family
ID=56399384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610258731.5A Active CN105772125B (en) | 2016-04-23 | 2016-04-23 | Micro-fluidic chip clamp experiment porch based on 3D printing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105772125B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109328229B (en) * | 2016-11-01 | 2021-07-27 | 深圳华大智造科技股份有限公司 | Gene sequencing chip and mounting frame thereof |
| EP3658284A4 (en) * | 2017-11-22 | 2020-11-11 | Hewlett-Packard Development Company, L.P. | Multizonal microfluidic devices |
| CN108311177B (en) * | 2018-01-15 | 2020-07-31 | 中国科学院上海微系统与信息技术研究所 | Manufacturing method of 3D PDMS micro-fluidic chip alignment assembly structure |
| CN110387321B (en) * | 2018-04-23 | 2023-03-17 | 深圳华大智造科技股份有限公司 | Gene sequencing chip and gene sequencing device |
| EP3875575B1 (en) * | 2018-10-29 | 2024-04-17 | NOK Corporation | Micro-fluid chip and micro-fluid device |
| CN110252436A (en) * | 2019-07-03 | 2019-09-20 | 水利部中国科学院水工程生态研究所 | A kind of detachable planktonic organism micro-fluidic chip for high power micro image collection |
| CN110564610A (en) * | 2019-10-15 | 2019-12-13 | 杭州比芯诊断技术有限公司 | Double-temperature-zone PCR amplification device |
| CN112113901A (en) * | 2020-09-18 | 2020-12-22 | 深圳先进技术研究院 | Chip fixing device |
| CN113059511A (en) * | 2021-03-19 | 2021-07-02 | 杭州比芯诊断技术有限公司 | Microfluidic PCR plate fixing device |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008039875A1 (en) * | 2006-09-28 | 2008-04-03 | California Institute Of Technology | System and method for interfacing with a microfluidic chip |
| CN201222052Y (en) * | 2008-06-20 | 2009-04-15 | 浙江大学 | Device for clamping micro-fluidic chip |
| CN102943665A (en) * | 2012-11-08 | 2013-02-27 | 西安信唯信息科技有限公司 | Real-time observation mechanism of flowing of fluid in porous medium |
| CN103058131A (en) * | 2012-12-19 | 2013-04-24 | 中国科学院上海微系统与信息技术研究所 | Manufacture method of reversible bonding micro-fluidic chip with high strength |
| CN103386345A (en) * | 2013-08-07 | 2013-11-13 | 苏州扬清芯片科技有限公司 | Micro-fluidic chip clamp |
| CN105344392A (en) * | 2015-12-07 | 2016-02-24 | 苏州汶颢芯片科技有限公司 | Fixture for microfluidic chip of sandwich structure |
| CN105396633A (en) * | 2015-12-22 | 2016-03-16 | 苏州汶颢芯片科技有限公司 | Soft microfluidic chip reversible clamp |
| CN105457695A (en) * | 2016-01-12 | 2016-04-06 | 苏州汶颢芯片科技有限公司 | Reversible clamp for micro-fluidic chip |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8522413B2 (en) * | 2007-06-26 | 2013-09-03 | Micronit Microfluids B.V. | Device and method for fluidic coupling of fluidic conduits to a microfluidic chip, and uncoupling thereof |
| FR2951153A1 (en) * | 2009-10-09 | 2011-04-15 | Corning Inc | MICROFLUIDIC DEVICE |
| DE102010037532A1 (en) * | 2010-09-14 | 2012-03-15 | Andreas Hettich Gmbh & Co. Kg | Connecting device for fluidic contacting of microfluidic chips |
| KR101737121B1 (en) * | 2010-12-21 | 2017-05-17 | 엘지전자 주식회사 | Microfluidic system |
-
2016
- 2016-04-23 CN CN201610258731.5A patent/CN105772125B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008039875A1 (en) * | 2006-09-28 | 2008-04-03 | California Institute Of Technology | System and method for interfacing with a microfluidic chip |
| CN201222052Y (en) * | 2008-06-20 | 2009-04-15 | 浙江大学 | Device for clamping micro-fluidic chip |
| CN102943665A (en) * | 2012-11-08 | 2013-02-27 | 西安信唯信息科技有限公司 | Real-time observation mechanism of flowing of fluid in porous medium |
| CN103058131A (en) * | 2012-12-19 | 2013-04-24 | 中国科学院上海微系统与信息技术研究所 | Manufacture method of reversible bonding micro-fluidic chip with high strength |
| CN103386345A (en) * | 2013-08-07 | 2013-11-13 | 苏州扬清芯片科技有限公司 | Micro-fluidic chip clamp |
| CN105344392A (en) * | 2015-12-07 | 2016-02-24 | 苏州汶颢芯片科技有限公司 | Fixture for microfluidic chip of sandwich structure |
| CN105396633A (en) * | 2015-12-22 | 2016-03-16 | 苏州汶颢芯片科技有限公司 | Soft microfluidic chip reversible clamp |
| CN105457695A (en) * | 2016-01-12 | 2016-04-06 | 苏州汶颢芯片科技有限公司 | Reversible clamp for micro-fluidic chip |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105772125A (en) | 2016-07-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105772125B (en) | Micro-fluidic chip clamp experiment porch based on 3D printing | |
| JP6654681B2 (en) | Single-structure biochip and process for providing process from sample introduction to result output | |
| US8617489B2 (en) | Microfluidic interface | |
| Karabacak et al. | Microfluidic, marker-free isolation of circulating tumor cells from blood samples | |
| CN107904156A (en) | A kind of one full-automation digital pcr detecting system and implementation | |
| CN104941703B (en) | Micro-fluidic chip method is prepared using 3D printing template and modularization assembling | |
| CN207933420U (en) | A kind of micro-fluidic chip of genetic test | |
| CN105349401A (en) | Multifunctional integrated microfluidic nucleic acid analysis chip and preparation and analysis method thereof | |
| CN104549591B (en) | A kind of general device fixed and connect belt electrode micro-fluidic chip | |
| Zhuang et al. | A fully integrated and automated microsystem for rapid pharmacogenetic typing of multiple warfarin-related single-nucleotide polymorphisms | |
| CN108593950A (en) | A kind of liquid automatic sample feeding device | |
| CN102784672A (en) | Centrifugal micro-fluidic chip for detecting nitrate and nitrite and preparation method of centrifugal micro-fluidic chip | |
| CN102660458A (en) | Nucleic acid extraction device capable of preventing cross-contamination | |
| Giannitsis et al. | Usage of microfluidic lab-on-chips in biomedicine | |
| Nouwairi et al. | Microchip electrophoresis for fluorescence-based measurement of polynucleic acids: recent developments | |
| Hou et al. | Experimental and numerical investigation into micro‐flow cytometer with 3‐D hydrodynamic focusing effect and micro‐weir structure | |
| AU2020202163A1 (en) | Unitary biochip providing sample-in to results-out processing and methods of manufacture | |
| CN103252262A (en) | Polymethylmethacrylate material micro-fluidic chip processing technology | |
| AU2013204387B2 (en) | Unitary biochip providing sample-in to results-out processing and methods of manufacture | |
| Schneider et al. | Integrated magneto–electrophoresis microfluidic chip purification on library preparation device for preimplantation genetic testing for aneuploidy detection | |
| CN106824316B (en) | A kind of microchannel forming method | |
| CN209024559U (en) | A kind of 48 hole deep-well plates extracted for full-automatic DNA | |
| Zhao et al. | Microfluidic gasketless interconnects sealed by superhydrophobic surfaces | |
| CN206298576U (en) | A kind of reagent disc that pre-treatment is automated for detection of nucleic acids | |
| CN101063674A (en) | Micro-domain heating apparatus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |