CN104226386A - Universal micro fluidic chip interface - Google Patents
Universal micro fluidic chip interface Download PDFInfo
- Publication number
- CN104226386A CN104226386A CN201310236545.8A CN201310236545A CN104226386A CN 104226386 A CN104226386 A CN 104226386A CN 201310236545 A CN201310236545 A CN 201310236545A CN 104226386 A CN104226386 A CN 104226386A
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- chip
- sealed interface
- interface
- woven hose
- screwing screw
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Abstract
The invention relates to an universal micro fluidic chip interface, which comprises a chip support A, a chip, a fixed screw for the chip support A and a chip support B, the chip support B, a chip and interface sealing ring, a seal interface screw nut, a seal interface screw, a liquid transport tube compaction screw and a liquid transport tube. The universal micro fluidic chip interface is characterized in that a long aperture is opened on the chip support A, the seal interface screw enables free movement in the long aperture, the liquid transport tube is inserted in the chip liquid transport tube by aligning at a liquid transport port on the chip, the seal interface screw nut and the liquid transport tube compaction screw are screwed, the seal performance is good, and the operation is convenient; the liquid transport tube is tightly pressed by the liquid transport tube compaction screw, the compaction screw employs a screw thread with a standard that 3/16''N equals 32, usage of fittings is convenient, selection scope is wide, and the universal micro fluidic chip interface has the advantages of economic and reliable performance, the chip enables free movement at two sides of the support, so that alignment is conveniently carried out.
Description
Technical field:
The present invention relates to the application technology of micro-fluidic chip, specifically provide a kind of connecting interface being specifically designed to the external fluid of micro-fluidic chip.
Background technology:
Micro-total analysis system (Micro Total Analysis Systems, μ-TAS) be a frontier interdisciplinary, its final purpose is by the microminiaturization of chemical device and integrated, to greatest extent the function of assay laboratory is transferred to (as all kinds of chip) in portable analytical equipment, " microminiaturization " of Realization analysis equipment, therefore micro-total analysis system is also often colloquially referred to as " chip lab " (Lab-on-a-chip), two large classes can be divided into again: micro-array chip (Microarray chip) according to chip structure and working mechanism, be also called " biochip ", with micro-fluidic chip (Microfluidic chip), the former development is quite ripe, degree of depth industrialization abroad, the latter, mainly based on analytical chemistry and biochemistry, utilizes micro electronmechanical process technology (MEMS), at silicon, glass, quartz, frosting processes the microchannel network of 10-100 micron, using EOF and electrophoresis stream or directly with external pump as driving force, control the flow direction of fluid in microchannel network and speed, thus realize sampling to target analytes, dilution, reagent adding, enrichment, extraction, mixing, reaction, be separated, the steps such as detection.Realize the connection of external fluid and micro-fluidic chip, a very important ring, must there be an interface centre, bad (mainly sealing means and the material of interface withstand voltage properties of existing bibliographical information or company's publicity at present, normal pressure, rarely more than 20KG mostly), inconvenient operation.Hinder the application and development of micro-fluidic chip work.
Summary of the invention:
The object of the invention is to specifically provide a kind of connecting interface being specifically designed to the external fluid of micro-fluidic chip:
This interface comprises chip set A, chip, chip set A and B fixed screw, chip set B, chip and sealing joint circle, sealed interface tightening nut, sealed interface screwing screw, woven hose housing pin, woven hose;
Chip is rectangular flat plate chip, and its edge, left and right sides is respectively equipped with the infusion port of more than 1 or 2, is provided with the microchannel be connected with at least 1 right side infusion port with at least 1 left side infusion port respectively in the middle part of chip;
Chip set B is the grooved that falls that bottom is provided with rectangular recess, be provided with rectangular through holes in the middle part of groove, sealed interface screwing screw is placed through in through hole, sealed interface screwing screw can move freely in this through hole, is screwed with sealed interface tightening nut in being in down in groove, sealed interface screwing screw;
Chip set A is two flat boards, falls the both sides of groove respectively fix with chip set A and B fixed screw and chip set B bottom;
Chip is placed on two chip set A, and chip is in the groove at the chip set B bottom place of falling trench structure; The both sides of chip are amplexiformed with two chip set A phases respectively; Infusion port object chip support B side on chip;
Sealed interface tightening nut is positioned at chip set B bottom and falls groove, and after sealed interface screwing screw is aimed at the infusion port on chip, rotatory sealing interface tightening nut makes chip and ring-type sealing joint circle compress;
Axial through hole is provided with in sealed interface screwing screw; Woven hose housing pin is provided with axial through hole,
One end of woven hose housing pin is set in one end through hole of sealed interface screwing screw, and the end that wears that woven hose housing pin is set in sealed interface screwing screw is truncated cone;
Sealed interface screwing screw one end and chip abut against, and the shape and size of other end through hole and woven hose housing pin wear end and match, and wall is provided with the internal thread be screwed with woven hose housing pin in the inner;
Woven hose, through the infusion port inserted after woven hose housing pin, sealed interface screwing screw ring-type sealing joint circle on chip, closely cooperates with infusion port and is connected,
Woven hose housing pin is for compressing woven hose; Infusion tube via hole woven hose housing pin is pressed in sealed interface screwing screw.
Compared with conventional microfluidic control chip interface, advantage of the present invention is:
1. on chip, infusion port coordinates closely with woven hose, makes fluid dead volume little.
2. structure is formed two dimension adjustable, be convenient to aim at the infusion port of position any on chip, easy to use.
3. design of Sealing Structure is reasonable, resistance to pressure, good seal performance (can reach 70KG).
4. fixture woven hose housing pin adopts standard 3/16 " N=32 screw thread, accessory is easy to use, and range of choice is wide, economical reliable.
Accompanying drawing illustrates:
A kind of assembled state schematic diagram of Fig. 1 Universal microfluidic chip chip interface.
The top view of Fig. 2 Universal microfluidic chip chip interface.
Detailed description of the invention:
As shown in Figure 1, a kind of assembled state schematic diagram of Universal microfluidic chip chip interface, the present invention's combination is combined form by being comprised chip set A, chip, chip set A and B fixed screw, chip set B, chip and sealing joint circle, sealed interface tightening nut, sealed interface screwing screw, woven hose housing pin, woven hose etc.;
The left and right sides of chip set B respectively one be provided with downward strip projection, make it to be formed and fall trench structure, the place of falling groove between the middle part of chip set B, two projections is provided with rectangular through holes along transverse direction from left to right, sealed interface screwing screw is placed through in through hole, its can in this through hole transversely left and right directions move freely;
Chip set A is two flat boards, fall the both sides of groove with chip set A and B fixed screw and chip set B bottom respectively to fix, form the untight groove of a rectangular base after fixing, length, slightly larger than chip, makes chip can move freely longitudinal front and back in groove.
Chip is placed on two chip set A, and chip is in the groove at the chip set B bottom place of falling trench structure; The both sides of chip are amplexiformed with two chip set A phases respectively; Infusion port object chip support B side on chip, the sealed interface screwing screw laterally on adjustment chip set B, the chip longitudinally on adjustment chip set A.After aiming at the infusion port on chip, woven hose is inserted in chip infusion hole, screwing hermetic interface tightening nut and woven hose housing pin.
Claims (8)
1. a Universal microfluidic chip interface, is characterized in that: this interface comprises chip set A(1), chip (2), chip set A and B fixed screw (3), chip set B(4), chip and sealing joint circle (5), sealed interface tightening nut (6), sealed interface screwing screw (7), woven hose housing pin (8), woven hose (9);
Chip (2) is rectangular flat plate chip, and its edge, left and right sides is respectively equipped with the infusion port of more than 1 or 2, is provided with the microchannel be connected with at least 1 right side infusion port with at least 1 left side infusion port respectively in the middle part of chip;
Chip set B(4) for bottom be provided with rectangular recess fall grooved, be provided with rectangular through holes in the middle part of groove, sealed interface screwing screw (7) is placed through in through hole, sealed interface screwing screw (7) can move freely in this through hole, is screwed with sealed interface tightening nut (6) in being in down in groove, sealed interface screwing screw (7);
Chip set A(1) be two flat boards, use chip set A and B fixed screw (3) and chip set B(4 respectively) bottom falls the both sides of groove and fixes;
Chip (2) is placed in two chip set A(1) on, chip (2) is in chip set B(4) in the groove at the bottom place of falling trench structure; The both sides of chip (2) respectively with two chip set A(1) amplexiform mutually; Infusion port object chip support B(4 on chip) side;
Sealed interface tightening nut (6) is positioned at chip set B(4) bottom falls groove, and after sealed interface screwing screw (7) is aimed at the infusion port on chip (2), rotatory sealing interface tightening nut (6) makes chip and ring-type sealing joint circle (5) compress;
Axial through hole is provided with in sealed interface screwing screw (7); Woven hose housing pin (8) is provided with axial through hole,
One end of woven hose housing pin (8) is set in one end through hole of sealed interface screwing screw (7), and the end that wears that woven hose housing pin (8) is set in sealed interface screwing screw (7) is truncated cone;
Sealed interface screwing screw (7) one end and chip (2) abut against, and the shape and size of other end through hole and woven hose housing pin (8) wear end and match, and wall is provided with the internal thread be screwed with woven hose housing pin (8) in the inner;
Woven hose (9) inserts the infusion port on chip (2) afterwards through woven hose housing pin (8), sealed interface screwing screw (7) ring-type sealing joint circle (5), closely cooperate be connected with infusion port,
Woven hose housing pin (8) is for compressing woven hose (9); Woven hose (9) through hole woven hose housing pin (8) is pressed in sealed interface screwing screw (7).
2., according to micro-fluidic chip interface described in claim 1, it is characterized in that:
Chip set A(1) with chip set B(4) form the untight groove of a rectangular base afterwards with chip set A and B fixed screw (3) are fixing, groove length (be seen as from Fig. 1 and be parallel to chip (2) surface direction), slightly larger than chip (2) width (being seen as perpendicular to chip (2) surface direction from Fig. 1), makes chip (2) longitudinal (being seen as perpendicular to paper direction from Fig. 1) can move freely in groove, chip set B(4) on the width of rectangular through holes fore-and-aft direction slightly larger than the diameter of sealed interface screwing screw (7), be less than sealed interface tightening nut (6), left and right directions is greater than the diameter of sealed interface screwing screw (7), be less than the width of chip (2), make sealed interface screwing screw (7) can at chip set B(4) on rectangular through holes in laterally move freely, like this for the infusion port on chip (2) and sealed interface screwing screw (7) just define one can two-dimension adjustment aim at structure, after the infusion port on sealed interface screwing screw (7) and chip (2) is aimed at, woven hose (9) is inserted in infusion port through sealed interface screwing screw (7), tighten woven hose housing pin (8), make woven hose (9) and sealed interface screwing screw (7) sealing, screwing hermetic interface tightening nut (6) makes sealed interface screwing screw (7) and chip (2) by chip and sealing joint circle (5) press seal again.
3., according to micro-fluidic chip interface described in claim 1, it is characterized in that:
Sealing joint circle (5) is positioned between the infusion port of sealed interface screwing screw (7) and chip (2), and sealing joint circle (5) is positioned at sealed interface screwing screw (7) bottom and contacts with edge on the infusion port of chip (2).
4., according to micro-fluidic chip interface described in claim 1, it is characterized in that:
Sealed interface tightening nut (6) screw thread is spun on sealed interface screwing screw (7), be positioned at chip set B(4) on rectangular through holes below, chip set B(4) on the width (being seen as perpendicular to paper direction from Fig. 1) of rectangular through holes be slightly less than the diameter of sealed interface tightening nut (6).
5. according to micro-fluidic chip interface described in claim 1, it is characterized in that: woven hose housing pin (8) screw thread is spun in the middle of sealed interface screwing screw (7) top, their adopt 3/16 " standard thread of N=32; Have the hole that just in time can insert woven hose in the middle of sealed interface screwing screw (7), and the diameter of woven hose can just inject the infusion port on chip (2).
6. according to micro-fluidic chip interface described in claim 1, it is characterized in that: chip (2) is rectangular flat plate chip, its left and right sides is respectively equipped with the opening as infusion port near edge, and left side and right openings number are as many, and each side opening number is more than 1 or 1; The microchannel be connected with at least 1 right side infusion port with at least 1 left side infusion port is respectively provided with in the middle part of chip.
7., according to micro-fluidic chip interface described in claim 1, it is characterized in that:
Chip set B(4) the left and right sides be respectively equipped with a downward strip projection, make it to be formed and fall trench structure, in chip set B(4) middle part, the place of falling groove between two projections be provided with rectangular through holes along transverse direction from left to right, sealed interface screwing screw (7) is placed through in through hole, it can move freely in left-right direction in this through hole;
Chip set A(1) be two flat boards, be fixed on chip set B(4 respectively by chip set A and B fixed screw (3)) below of left and right sides strip projection.
8., according to micro-fluidic chip interface described in claim 1, it is characterized in that:
Woven hose housing pin (8) adopts 3/16 " standard thread of N=32 coordinates with sealed interface screwing screw (7); and bottom is inverted cone-shaped; there is a through hole centre; woven hose (9) is through through hole; insert in infusion port through sealed interface screwing screw (7); tighten woven hose housing pin (8), by the inverted cone-shaped structure compression bottom sealed interface screwing screw (7) and woven hose housing pin (8), woven hose (9) and sealed interface screwing screw (7) is sealed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310236545.8A CN104226386B (en) | 2013-06-14 | 2013-06-14 | A kind of Universal microfluidic chip interface |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310236545.8A CN104226386B (en) | 2013-06-14 | 2013-06-14 | A kind of Universal microfluidic chip interface |
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| CN104226386A true CN104226386A (en) | 2014-12-24 |
| CN104226386B CN104226386B (en) | 2015-12-09 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104842535A (en) * | 2015-05-26 | 2015-08-19 | 大连理工大学 | Injection molding processing method for forming orthogonal through micro-hole |
| CN105618168A (en) * | 2016-03-09 | 2016-06-01 | 上海交通大学 | Plug-and-play low-cost micro-fluidic interface and manufacturing method |
| CN105665045A (en) * | 2016-02-05 | 2016-06-15 | 中国科学技术大学 | Micro-fluidic chip and preparation method thereof |
| CN110470856A (en) * | 2018-05-11 | 2019-11-19 | 中国石油化工股份有限公司 | The manual injector and sample injection method of controllable sampling volume and its application |
| CN115382595A (en) * | 2021-12-14 | 2022-11-25 | 中国石油大学(华东) | Chip clamp device suitable for high-pressure microfluid experiment |
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| US20030087454A1 (en) * | 2001-10-26 | 2003-05-08 | Schultz Gary A | Method and device for chemical analysis |
| WO2004065288A1 (en) * | 2003-01-24 | 2004-08-05 | Microtechnology Centre Management Limited | Microfluidic connectors |
| CN101303327A (en) * | 2008-06-20 | 2008-11-12 | 浙江大学 | Microflow control chip clamping device |
| CN201222052Y (en) * | 2008-06-20 | 2009-04-15 | 浙江大学 | Device for clamping micro-fluidic chip |
| CN101733174A (en) * | 2008-11-07 | 2010-06-16 | 中国科学院大连化学物理研究所 | Connecting interface and application thereof in mircofluidic chip system |
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2013
- 2013-06-14 CN CN201310236545.8A patent/CN104226386B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030087454A1 (en) * | 2001-10-26 | 2003-05-08 | Schultz Gary A | Method and device for chemical analysis |
| WO2004065288A1 (en) * | 2003-01-24 | 2004-08-05 | Microtechnology Centre Management Limited | Microfluidic connectors |
| CN101303327A (en) * | 2008-06-20 | 2008-11-12 | 浙江大学 | Microflow control chip clamping device |
| CN201222052Y (en) * | 2008-06-20 | 2009-04-15 | 浙江大学 | Device for clamping micro-fluidic chip |
| CN101733174A (en) * | 2008-11-07 | 2010-06-16 | 中国科学院大连化学物理研究所 | Connecting interface and application thereof in mircofluidic chip system |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104842535A (en) * | 2015-05-26 | 2015-08-19 | 大连理工大学 | Injection molding processing method for forming orthogonal through micro-hole |
| CN105665045A (en) * | 2016-02-05 | 2016-06-15 | 中国科学技术大学 | Micro-fluidic chip and preparation method thereof |
| CN105665045B (en) * | 2016-02-05 | 2018-01-30 | 中国科学技术大学 | A kind of micro-fluidic chip and preparation method thereof |
| CN105618168A (en) * | 2016-03-09 | 2016-06-01 | 上海交通大学 | Plug-and-play low-cost micro-fluidic interface and manufacturing method |
| CN110470856A (en) * | 2018-05-11 | 2019-11-19 | 中国石油化工股份有限公司 | The manual injector and sample injection method of controllable sampling volume and its application |
| CN115382595A (en) * | 2021-12-14 | 2022-11-25 | 中国石油大学(华东) | Chip clamp device suitable for high-pressure microfluid experiment |
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| CN104226386B (en) | 2015-12-09 |
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