CN101303327A - Microflow control chip clamping device - Google Patents
Microflow control chip clamping device Download PDFInfo
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- CN101303327A CN101303327A CNA2008100636238A CN200810063623A CN101303327A CN 101303327 A CN101303327 A CN 101303327A CN A2008100636238 A CNA2008100636238 A CN A2008100636238A CN 200810063623 A CN200810063623 A CN 200810063623A CN 101303327 A CN101303327 A CN 101303327A
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Abstract
The invention discloses a microfluidic chip clamping device. Two lateral limit blocks are respectively arranged at the two side faces of a fixing chassis, while two T-shaped guide rails are respectively arranged at the other two side faces; the clamped microfluidic chips are positioned on the fixing chassis, two pressed blocks are connected between the two T-shaped guide rails in a bridging way, an elongated slot parallel to the lateral limit blocks is cut in the middle of the two pressed blocks, and connectors with a number equal to the number of the microfluidic chips are arranged in the elongated slots; the centers of the connectors are cut with axial through holes, rubber sealing rings are sheathed at one end of the connectors that contacts with the microfluidic chips, and the two pressed blocks can move on the two T-shaped guide rails and be locked, so as to regulate the pressing force between the connectors and the microfluidic chip holes. The clamping device of the invention adopts the structure of two-dimensional orthogonal guide rail and the pressed blocks, thus solving the adaptability problem of multi-position interfaces, utilizes the manner of the connectors and the sealing rings, thus settling the problem of the sealing of interfaces, and employs the structure of adjustable bolts and pressed blocks, thus guaranteeing the adaptability to chips with different thickness.
Description
Technical field
The present invention relates to clamping device, particularly relates to a kind of microflow control chip clamping device.
Background technology
The micro-fluidic chip technology grows up on the chip capillary cataphoresis basis, has realized by the leap of simple electrophoretic separation to extensive multi-functional integrated experimentation chamber.1992, Manz etc. adopted microelectron-mechanical process technology etching microchannel on sheet glass, develop Capillary Electrophoresis microchip analytical equipment, have successfully realized fluorescently-labeled amino acid whose separation, have started the beginning of micro-fluidic chip technology.Micro-fluidic chip with the microchannel is that network connects that Micropump, little valve, little reservoir, little electricity are pulled, little detecting element etc. has the components and parts of light, electricity and FLUID TRANSPORTATION function, to greatest extent specimen preparation, biological with chemical reaction, separate, basic operation unit such as detection is integrated or be integrated into substantially on more than one square centimeters the chip, in order to finishing different biological or chemical courses of reaction, and its product is analyzed.It not only makes the consumption of biological sample and reagent be reduced to and receives liter (n1) even skin liter (p1) level, and analysis speed is improved greatly, and analysis cost reduces greatly, thereby for analysis and testing technology spreads to the open air, family has opened up a new road.Up to now, the separation that is used for a series of chemical substances that the micro-fluidic chip technology is successful, especially in biochemical field, successful carrying out the separation detection of determined dna sequence, polypeptide and protein, amino acid, unicellular and unimolecule etc.
When using micro-fluidic chip to carry out various operation such as biochemical analysis, detection, sample and reagent are injected into the fluid channel from the corresponding liquid injection port of micro-fluidic chip, and when injecting for test sample, operate the generation waste liquid and can constantly get rid of from the liquid outlet of chip.Clamping device plays is exactly the effect that connects macro-scale devices such as the fluid channel of micro-fluidic chip inside and common syringe.Along with subject development such as biology, chemistry, the requirement integrated to the functional diversities of micro-fluidic chip and structure improves constantly.The complicacy of the flow passage structure of micro-fluidic chip is compared with traditional cross electrophoresis chip and is improved greatly at present.Same micro-fluidic chip comprises a plurality of liquid injection port and liquid outlet usually, is distributed in the diverse location of chip, and the phase mutual edge distance is very approaching.This just proposes following requirement to clamping device:
(1) clamping device will have suitable dirigibility, to adapt to the micro-fluidic chip that liquid injection port, liquid outlet are in diverse location.
(2) the clamping device structural design is small and exquisite, to adapt to the less micro-fluidic chip of interface spacing.
(3) to have good sealing property, in order to avoid reagent goes out to leak from interface.
Summary of the invention
In order to overcome the shortcoming and defect of existing micro-fluidic chip interface mode, the object of the present invention is to provide to be applicable to a kind of microflow control chip clamping device with a plurality of liquid injection port and liquid outlet.
The technical scheme that the present invention solves its technical matters employing is:
On two sides of fixed underpan, the side direction limited block is housed respectively, on another two sides of fixed underpan, "T"-shaped guide rail is housed respectively, two "T"-shaped guide rails are positioned between two side direction limited blocks, the micro-fluidic chip that is held is arranged on the fixed underpan, two briquettings are connected across between two "T"-shaped guide rails, have the elongated slot parallel in the middle of two briquettings with the side direction limited block, the hookup that equates with clamping micro-fluidic chip interface number is housed in the elongated slot, the hookup center has axially extending bore, rubber seal is enclosed within the end that hookup contacts with micro-fluidic chip, two block pressur plates can move on two "T"-shaped guide rails and lock, thereby regulate the snap-in force in hookup and micro-fluidic chip hole.
Described fixed underpan middle part has watch window.
The beneficial effect that the present invention has is: this device adopts the structural design of two-dimensional quadrature guide rail pressurizing block to solve the adaptability problem of multiposition interface; The mode that has adopted hookup to add O-ring seal has solved the sealing joint problem; Adopt adjustable bolt and briquette structure to guarantee adaptability to the different-thickness chip.
Description of drawings
Fig. 1 is a structure principle chart of the present invention;
Fig. 2 is the sectional view on Figure 1A-A plane.
Among the figure: 1, side direction limited block, 2, "T"-shaped guide rail, 3, briquetting, 4, micro-fluidic chip, 5, housing screw, 6, hookup, 7, fixed underpan, 8, housing screw, 9, hookup, 10, hookup, 11, housing screw, 12, "T"-shaped guide rail, 13, housing screw, 14, briquetting, 15, the side direction limited block, 16, O-ring seal, 17, O-ring seal, 18, slide block, 19, slide block.
Embodiment
The present invention is further illustrated below in conjunction with drawings and Examples.
As Fig. 1, shown in Figure 2, the present invention is on two sides of fixed underpan 7, side direction limited block 1 is housed respectively, 15, on another two sides of fixed underpan 7, "T"-shaped guide rail 2 is housed respectively, 12, two "T"- shaped guide rails 2,12 are positioned at two side direction limited blocks 1,15, the micro-fluidic chip 4 that is held is arranged on the fixed underpan 7, two block pressur plates 3,14 are connected across two "T"- shaped guide rails 2,12, "T"-shaped guide rail 2, slide block 19 is housed respectively in 12,18, two briquettings 3, in 14 liang of stomidiums housing screw 8 is housed respectively, 11,13,5 are used for locking two briquettings 3,14, two block pressur plates 3, have the elongated slot parallel in the middle of 14 with the side direction limited block, the hookup 6 that equates with clamping micro-fluidic chip interface number is housed in the elongated slot, 9,10, hookup 6,9,10 centers have axially extending bore, rubber seal 16,17 are enclosed within hookup 6 respectively, 9,10 ends that contact with micro-fluidic chip 4, two block pressur plates 3,14 can be at two "T"-shaped guide rails 2, move above 12 and locking, thereby regulate hookup 6,9,10 with the snap-in force in micro-fluidic chip 4 holes.Described fixed underpan middle part has watch window.
The connected mode of a, the two "T"-shaped guide rails of employing and slide block, the slide block center has tapped through hole so that connect briquetting by bolt; The slide block width is greater than "T"-shaped guide rail top width but smaller bottom width, so can in guide rail, be free to slide but can not shift out guide rail, purpose is that briquetting can be free to slide along guide rail, thereby can regulate hookup to adapt to the interface of "T"-shaped guide rail direction diverse location.B, briquetting adopt the design of center grooved, and bolt is connected with the threaded hole at slide block center by the perforate on both sides.Hookup adopts the notch cuttype structure Design, the hookup center is equipped with through hole and is used for injecting reagent to micro-fluidic chip, narrow diameter of hookup is slightly less than the width of briquetting fluting, wide diameter of hookup is greater than the briquetting groove width, thereby hookup can be moved adapting to the distinct interface position along the briquetting direction of slotting, thereby compress the purpose that briquetting and hookup are realized sealing joint by bolt.C, chassis are that the middle part has rectangular window, window so that detection is observed in micro-fluidic chip inside in the bottom.D, make the sound construction of whole clamping device, increase reliability by the side direction limited block.
As shown in Figure 1 and Figure 2, fixed underpan 7, "T"- shaped guide rail 2,12 side direction limited blocks 1,15 make up by screw.Micro-fluidic chip 4 is placed fixed underpan 7 centers, guarantee that simultaneously needing to observe the part that detects places in the view window.Regulate the relevant position of the slide block 18,19 in the "T"- shaped guide rail 2,12 then, make its position corresponding with the inlet of chip 4 and liquid outlet.Select and be held the hookup 6,9,10 that micro-fluidic chip interface number equates, rubber seal 16,17 is enclosed within the end that hookup 6 contacts with chip; The other end connects external device (ED).Hookup 6,9,10 is inserted chip advance, locate interface accordingly.The top of hookup 6,9,10 is by the fluting at briquetting 3,14 centers, housing screw 5,8,11,13 passes the through hole of briquetting 3,14 both sides and realizes cooperating with the threaded hole at slide block 18,19 centers, thus the degree that compresses of regulating hookup 6,9,10 and micro-fluidic chip 4 holes.Use a plurality of briquettings if desired, operating process is identical.So just solved the connectivity problem of various micro-fluidic chips and common macroscopical liquid delivery device, convenient and reliable, adaptability is strong.
Claims (2)
1, a kind of microflow control chip clamping device, it is characterized in that: on two sides of fixed underpan, the side direction limited block is housed respectively, on another two sides of fixed underpan, "T"-shaped guide rail is housed respectively, two "T"-shaped guide rails are positioned between two side direction limited blocks, the micro-fluidic chip that is held is arranged on the fixed underpan, two briquettings are connected across between two "T"-shaped guide rails, have the elongated slot parallel in the middle of two briquettings with the side direction limited block, the hookup that equates with clamping micro-fluidic chip interface number is housed in the elongated slot, the hookup center has axially extending bore, rubber seal is enclosed within the end that hookup contacts with micro-fluidic chip, and two block pressur plates can move on two "T"-shaped guide rails and lock, thereby regulates the snap-in force in hookup and micro-fluidic chip hole.
2, a kind of microflow control chip clamping device according to claim 1 is characterized in that: described fixed underpan middle part has watch window.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100636238A CN101303327B (en) | 2008-06-20 | 2008-06-20 | Microflow control chip clamping device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100636238A CN101303327B (en) | 2008-06-20 | 2008-06-20 | Microflow control chip clamping device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101303327A true CN101303327A (en) | 2008-11-12 |
| CN101303327B CN101303327B (en) | 2012-05-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008100636238A Expired - Fee Related CN101303327B (en) | 2008-06-20 | 2008-06-20 | Microflow control chip clamping device |
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| CN103386345A (en) * | 2013-08-07 | 2013-11-13 | 苏州扬清芯片科技有限公司 | Micro-fluidic chip clamp |
| CN103386339A (en) * | 2013-08-07 | 2013-11-13 | 苏州扬清芯片科技有限公司 | Micro-fluidic chip connector device |
| CN103394383A (en) * | 2013-08-07 | 2013-11-20 | 苏州扬清芯片科技有限公司 | Universal microfluidic chip fixing device |
| CN103398252A (en) * | 2013-08-07 | 2013-11-20 | 苏州扬清芯片科技有限公司 | Electromagnetic type chip connector |
| CN103769252A (en) * | 2012-10-18 | 2014-05-07 | 中国科学院深圳先进技术研究院 | Connector of micro fluidic chip |
| CN104174988A (en) * | 2014-08-23 | 2014-12-03 | 华东光电集成器件研究所 | Multi-chip eutectic-bonding pressure dividing device |
| CN104226386A (en) * | 2013-06-14 | 2014-12-24 | 中国科学院大连化学物理研究所 | Universal micro fluidic chip interface |
| CN104777274A (en) * | 2015-04-20 | 2015-07-15 | 浙江大学 | Fixing hold-down device for PDMS micro flow cell |
| CN104930189A (en) * | 2014-03-17 | 2015-09-23 | 岛津工程技术有限公司 | Automatic sealing device |
| CN105344404A (en) * | 2015-12-04 | 2016-02-24 | 苏州汶颢芯片科技有限公司 | Micro-fluidic chip fixture |
| CN105344392A (en) * | 2015-12-07 | 2016-02-24 | 苏州汶颢芯片科技有限公司 | Fixture for microfluidic chip of sandwich structure |
| CN105396633A (en) * | 2015-12-22 | 2016-03-16 | 苏州汶颢芯片科技有限公司 | Soft microfluidic chip reversible clamp |
| CN105424698A (en) * | 2015-11-25 | 2016-03-23 | 江苏三联生物工程有限公司 | Biochip reading instrument with gripper function |
| CN105457695A (en) * | 2016-01-12 | 2016-04-06 | 苏州汶颢芯片科技有限公司 | Reversible clamp for micro-fluidic chip |
| CN105536904A (en) * | 2015-12-15 | 2016-05-04 | 苏州汶颢芯片科技有限公司 | Reversible micro fluidic chip clamp |
| CN102989538B (en) * | 2012-12-17 | 2016-08-10 | 江西恒盛晶微技术有限公司 | The clamping device of micro-fluidic chip |
| CN107817318A (en) * | 2017-11-23 | 2018-03-20 | 昌微系统科技(上海)有限公司 | A kind of mounting box and its application method for sensor chip |
| CN109709199A (en) * | 2019-03-01 | 2019-05-03 | 黄河科技学院 | Serum lipoprotein agarose gel electrophoresis notcher and bracket |
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| CN110404603A (en) * | 2019-08-28 | 2019-11-05 | 清华大学 | A kind of stationary fixture of micro-fluidic chip |
| CN110587333A (en) * | 2019-09-05 | 2019-12-20 | 芜湖德锐电子技术有限公司 | Universal type chip fixing device |
| CN111111798A (en) * | 2019-06-04 | 2020-05-08 | 厦门大学 | Micro-fluidic detection chip |
| CN111633589A (en) * | 2020-06-16 | 2020-09-08 | 南京沃天科技有限公司 | Sensor chip centre gripping fixed knot constructs |
| CN112691711A (en) * | 2021-01-29 | 2021-04-23 | 绿叶诊断产品技术(广东)有限公司 | Liquid transfer driving device and method of micro-fluidic chip |
| CN113005036A (en) * | 2021-03-29 | 2021-06-22 | 厦门大学 | Detachable cell culture flow chamber capable of generating turbulent flow |
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| CN115970780A (en) * | 2023-03-21 | 2023-04-18 | 浙江扬清芯片技术有限公司 | General type switching device and multifunctional microfluidic research and development platform with selectable modules |
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| CN201222052Y (en) * | 2008-06-20 | 2009-04-15 | 浙江大学 | Device for clamping micro-fluidic chip |
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- 2008-06-20 CN CN2008100636238A patent/CN101303327B/en not_active Expired - Fee Related
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| CN103769252A (en) * | 2012-10-18 | 2014-05-07 | 中国科学院深圳先进技术研究院 | Connector of micro fluidic chip |
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| CN104226386B (en) * | 2013-06-14 | 2015-12-09 | 中国科学院大连化学物理研究所 | A kind of Universal microfluidic chip interface |
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| CN103394383A (en) * | 2013-08-07 | 2013-11-20 | 苏州扬清芯片科技有限公司 | Universal microfluidic chip fixing device |
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| CN104930189A (en) * | 2014-03-17 | 2015-09-23 | 岛津工程技术有限公司 | Automatic sealing device |
| CN104174988A (en) * | 2014-08-23 | 2014-12-03 | 华东光电集成器件研究所 | Multi-chip eutectic-bonding pressure dividing device |
| CN104777274A (en) * | 2015-04-20 | 2015-07-15 | 浙江大学 | Fixing hold-down device for PDMS micro flow cell |
| CN104777274B (en) * | 2015-04-20 | 2017-04-19 | 浙江大学 | Fixing hold-down device for PDMS micro flow cell |
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| CN105424698A (en) * | 2015-11-25 | 2016-03-23 | 江苏三联生物工程有限公司 | Biochip reading instrument with gripper function |
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| CN105344392A (en) * | 2015-12-07 | 2016-02-24 | 苏州汶颢芯片科技有限公司 | Fixture for microfluidic chip of sandwich structure |
| CN105536904B (en) * | 2015-12-15 | 2018-04-10 | 苏州汶颢芯片科技有限公司 | Reversible micro-fluidic chip clamp |
| CN105536904A (en) * | 2015-12-15 | 2016-05-04 | 苏州汶颢芯片科技有限公司 | Reversible micro fluidic chip clamp |
| CN105396633A (en) * | 2015-12-22 | 2016-03-16 | 苏州汶颢芯片科技有限公司 | Soft microfluidic chip reversible clamp |
| CN105457695A (en) * | 2016-01-12 | 2016-04-06 | 苏州汶颢芯片科技有限公司 | Reversible clamp for micro-fluidic chip |
| CN107817318A (en) * | 2017-11-23 | 2018-03-20 | 昌微系统科技(上海)有限公司 | A kind of mounting box and its application method for sensor chip |
| CN107817318B (en) * | 2017-11-23 | 2023-11-10 | 宁卡赛科技(上海)有限公司 | Mounting box for sensor chip and use method thereof |
| CN109709199A (en) * | 2019-03-01 | 2019-05-03 | 黄河科技学院 | Serum lipoprotein agarose gel electrophoresis notcher and bracket |
| CN109709199B (en) * | 2019-03-01 | 2024-04-12 | 黄河科技学院 | Serum lipoprotein agarose gel electrophoresis groover and support |
| CN109985679A (en) * | 2019-04-24 | 2019-07-09 | 浙江警察学院 | A kind of SPR detector multichannel micro-fluidic chip grasping system |
| CN109991195A (en) * | 2019-04-24 | 2019-07-09 | 浙江警察学院 | A kind of SPR detector single channel micro-fluidic chip clamping system |
| CN111111798A (en) * | 2019-06-04 | 2020-05-08 | 厦门大学 | Micro-fluidic detection chip |
| CN110404603A (en) * | 2019-08-28 | 2019-11-05 | 清华大学 | A kind of stationary fixture of micro-fluidic chip |
| US11857977B2 (en) | 2019-08-28 | 2024-01-02 | Tsinghua University | Fixing clamp for microfluidic chip |
| CN110587333A (en) * | 2019-09-05 | 2019-12-20 | 芜湖德锐电子技术有限公司 | Universal type chip fixing device |
| CN111633589A (en) * | 2020-06-16 | 2020-09-08 | 南京沃天科技有限公司 | Sensor chip centre gripping fixed knot constructs |
| CN112691711B (en) * | 2021-01-29 | 2022-04-22 | 绿叶诊断产品技术(广东)有限公司 | Liquid transfer driving device and method of micro-fluidic chip |
| CN112691711A (en) * | 2021-01-29 | 2021-04-23 | 绿叶诊断产品技术(广东)有限公司 | Liquid transfer driving device and method of micro-fluidic chip |
| CN113005036B (en) * | 2021-03-29 | 2023-06-30 | 厦门大学 | Detachable cell culture flow chamber capable of generating turbulence |
| CN113005036A (en) * | 2021-03-29 | 2021-06-22 | 厦门大学 | Detachable cell culture flow chamber capable of generating turbulent flow |
| CN113281499A (en) * | 2021-05-18 | 2021-08-20 | 厦门先明生物技术有限公司 | Microfluidic immunoassay joint detection device and using method thereof |
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