A kind of automatic liquor removing workstation
Technical field
The utility model relates to the automatic liquid shifting equipment that biology, chemical experiment are used, and more precisely, relates to a kind of automated fluid treatment system of simultaneously liquid reagent, fluid sample etc. accurately being distributed and carrying of being used for.
Background technology
Develop rapidly along with science and technology, research work biological, chemical laboratory no longer is around several equipment, operate the small scale experiments of some samples, but, carry out multipath, diversified large scale experiment with the kinds of experiments technology in the face of more complicated research object and the sample size of being on the increase.Research as library screening, gene order-checking and the genetic chip of genetics; proteomics the be wanting in searching, evaluation, the screening of albumen crystallization, the analysis of higher structure of M-band, the quantity of sample handling work that also has laboratory such as the extensive screening compound of new drug discovery aspect and evaluation to be born every day increases day by day.And in a lot of laboratories and the R﹠D institution, the extraction of a lot of samples is by manually-operated with application of sample entirely, and the hand-held pipettor generally has four elemental motions---set up suction nozzle, get liquid, liquid feeding, throw away suction nozzle, these are that armrest moves and finishes entirely.Manual operation exists problems: a large amount of sample treatment work not only need lot of manpower and material resources and time, and because manually-operated brings a lot of human errors, make sample treatment to move the liquid accuracy low, the probability height of makeing mistakes, the stability of sample treatment and repeatable poor.Manual mode of operation can not satisfy desired high efficiency, accuracy and security in the high flux sample treatment process.Part or overall process in the experimental implementation flow process are realized that automatic operating has become inevitable trend.
The at present existing liquid treating system that moves is used to reagent, sample etc. is transported in a plurality of holes on porous plate.The described liquid treating system that moves has a distributor gear and a travel mechanism, and described distributor gear is equipped with the tube of a nozzle, on described nozzle, dispensing head is installed, can suck and discharge liquid by it, in the described tube plunger is housed, be used for liquid is sucked the dispensing head that is installed on the nozzle, and liquid is discharged from described dispensing head is inner.Because porous plate commonly used now is 96 international hole on-gauge plates, so have four types the liquid treating system that moves now: 12 groups of types, 8 groups of types, 1 group of type and 96 groups of types.Move in the liquid treating system at 12 groups of types, the nozzle of 12 tubes vertically is arranged in a straight line along porous plate, and be operation synchronized with each other, can unify to be installed on the dispensing head on these 12 nozzles, finish suction or discharge such as liquid such as reagent, and the distance between these 12 nozzles is fixed the pitch of holes of corresponding porous plate.Same, move in the liquid treating system at 8 groups of types, 8 nozzle arrangement are in line, and operation simultaneously each other, 96 groups of types move liquid treating system and then 96 nozzle arrangement are become 12 * 8 matrix, and 1 group of type moves liquid treating system and then only operates a nozzle.When being emitted on above-mentioned these when moving liquid treating system and on porous plate, operating, its emission direction limits, moving at 12 groups of types such as standard 12 * 8 standard porous plates can only be with nozzle arrangement in 12 hole direction in the liquid treating system, can only be in the liquid treating system and move with nozzle arrangement in 8 hole directions at 8 groups of types, 96 groups move liquid treating system then can only operation such as unified implementation suction and discharge on all 96 holes.
These a plurality of nozzles that move liquid treating system all are unified to suck with discharging operation synchronously, thus just require in porous plate, must carry out the operation of a round simultaneously, and draw in can not some therein or a plurality of holes or add liquid.And these distances of moving between a plurality of nozzles of liquid treating system are all fixed, and corresponding to the pitch of holes of porous plate, thereby are not suitable for the bigger situation of spacing, such as test tube, reagent bottle, glass etc.And a lot of sample collecting and to deposit all be with test tube or plastic-like QC in the practice so just need be transferred to sample and just can carry out sample treatment in the porous plate, operate more loaded down with trivial detailsly, and make mistakes easily.
And, existing moving in the liquid treating system monopolized by import equipment substantially, the device rate of these imports is fast, precision is high, good operating stability, but these equipment prices are high, and the cost of annex and consumptive material is also all very high, are difficult to promote, homemade liquid shifting equipment is then because simple in structure, function singleness, precision and stability are not high, so occupation rate of market is low.
Based on the national conditions of present our country, and in order to satisfy the needs of laboratory and hospital, we will overcome a series of problems and the defective that exists in the home equipment, develop the full-automatic liquor-transferring system that applicability is stronger, precision is high and cheap.
Summary of the invention
The purpose of this utility model just is to overcome the existing existing problem of liquor-transferring system, provides a kind of compact conformation, modularization, precision height, cross pollution is few, applicability is strong, automaticity is high moves liquid treating system.This liquor-transferring system not only is fit to the scientific research and the application of laboratory and hospital, and can be used for large-scale sample treatment.
The technical solution of the utility model is as follows:
A kind of automatic liquor removing workstation described in the utility model, mainly by workbench, support frame, the accurate electronic control translation stage of X-axis, X-axis drive motors, X-axis auxiliary guide rail, Y-axis overarm brace, Y-axis guide pillar, Y-axis screw mandrel, 1~12 separately the assemblies such as manipulator, electric cabinet, computer of independent control form, workbench is provided with the suction nozzle recovery area, can put other modules such as suction nozzle storage module, sample storage module as required on the workbench.
Wherein support frame is fixed on the workbench, supports automatically controlled platform of X-axis and X-axis auxiliary guide rail; Y-axis overarm brace one end is installed on the X-axis electronic control translation stage, and the other end rides on the X-axis auxiliary guide rail by draw-in groove, can move in the driving lower edge of X-axis drive motors X-axis; Y-axis guide pillar and Y-axis screw mandrel are fixed on the Y-axis overarm brace, play supported mechanical fingerprint piece; Manipulator is installed on Y-axis guide pillar and the Y-axis screw mandrel, can slide along Y-axis guide pillar and Y-axis screw mandrel.
Groove (or projection) interlock mutually on suction nozzle storage module and the sample storage module projection (or groove) by module bottom and the workbench is installed on the workbench in the mode that can dismantle flexibly.
Connect by data wire between X-axis drive motors, manipulator, electric cabinet and the computer, be subjected to computer software control.
Wherein manipulator comprises Y direction motion drive motors, be with synchronously, the Y direction drive nut, the guide pillar overcoat, the Z axis drive motor, the Z shaft movement mechanism, push rod Z axle motion drive motors, the push rod connector, push rod, remove suction nozzle Z axis drive motor, microsyringe, remove suction nozzle spare, the suction nozzle installed part, and be used to install Y direction motion drive motors, the Y direction drive nut, the guide pillar overcoat, the fixed support A of Z axis drive motor and Z shaft movement mechanism is used to install push rod Z axle motion drive motors, the push rod connector, microsyringe, remove suction nozzle Z axis drive motor, remove the fixed support B of suction nozzle spare and suction nozzle installed part.
This manipulator drives the Y direction drive nut by Y direction motion drive motors, and the Y direction drive nut rotates on the Y-axis screw mandrel and move on Y direction by the guiding of Y-axis guide pillar, each manipulator is coordinated each other distance and motion by computer and electric cabinet control.The Z axis drive motor by push rod Z axle motion drive motors, push rod connector, the microsyringe of Z shaft movement mechanism drive installation on fixed support B, remove suction nozzle Z axis drive motor, go suction nozzle spare and suction nozzle installed part to move up and down in Z-direction.Push rod Z axle motion drive motors makes the push rod of microsyringe move up and down in Z-direction by the push rod connector.Go suction nozzle Z axis drive motor to go suction nozzle spare to move up and down and suction nozzle is released from the suction nozzle installed part in Z-direction by driving, suction nozzle is owing to self gravitation falls down.
Be useful on equidistant groove (or projection) of each module positioning and fixing on the described workbench.In the modules such as described suction nozzle storage module, sample storage module separately base bottom all have with workbench on the match projection (or groove) of location of groove (or projection), the spacing of the groove (or projection) on its spacing and the workbench is corresponding.Can also put other functional module on the workbench, such as detection module, reaction module, wash module etc.
Described automatic liquor removing workstation has comprised 1~20 group of suction nozzle storage module, and wherein said each suction nozzle storage module comprises that suction nozzle, suction nozzle storage rack and suction nozzle deposit base.Wherein suction nozzle is international standard disposable tip.A plurality of pore space structures are arranged on the suction nozzle storage rack, a plurality of suction nozzles are arranged on the suction nozzle storage rack by its most advanced and sophisticated pore space structure that inserts correspondence, and the suction nozzle storage rack is placed in suction nozzle and deposits on the base, deposits projection below the base or the depressions or protrusions on depression and the workbench by suction nozzle and cooperates and be positioned on the workbench.
Described automatic liquor removing workstation has comprised 1~10 group of sample storage module, and described sample storage module comprises test tube, test tube storage rack.Described test tube is that external diameter general on the market is 8mm~12mm test tube.Described test tube storage rack is formed for the multilayer orifice plate, and has deformable the extruding to the center, hole to design around each hole, can deposit the stability that the different test tube of external diameter guarantees that simultaneously test tube is placed, and the quantity of the test tube that can put on the frame is 1~96.
Described computer software, by electric cabinet control be whole manipulator in the position of X-direction and each manipulator in the position of Y direction, the installation of suction nozzle and removal, suction nozzle be in the height of Z-direction, the actions such as push-and-pull of microsyringe push rod.
Compare with present existing products, major advantage of the present utility model is:
1) error is few, and sample treatment result is reliable and stable.Move all processes that liquid handles in the utility model and all finished automatically by system, the error of having avoided manual operation to bring has improved sample treatment result's stability and reliability greatly.
2) accuracy height.The utility model is because overall process machinery is finished automatically, and all processes can both be monitored, thus all relate to move step that liquid handles can optimising and adjustment, thereby reach higher accuracy.
3) speed is fast, the efficient height.Because integrated a plurality of manipulator have not only been optimized the cooperation time in the utility model, and a plurality of module can work simultaneously, improved detection speed greatly, optimized and moved liquid work of treatment efficient.
4) compact conformation.The utility model is not only with each functional module miniaturization, and each functional module is carried out central combination, and compact conformation has improved effective utilization in space greatly.
5) cross pollution is few.Adopt disposable suction nozzle to carry out imbibition and liquid feeding in the utility model, the suction nozzle of using during a kind of liquid handling before just abandoning in the different fluid operated processes has been avoided the cross pollution between the different liquids.
6) flexibility is good, and applicability is wide.The utility model has adopted modularized design, each functional module not only can be used separately, but also combination that can be random, forming different system's collocation uses, and can also be suitable for the container of various ways such as 96 hole on-gauge plates, test tube, reagent bottle, and can select 1~12 manipulator work as required, so not only be fit to the scientific research and the small-scale application of laboratory and hospital, and can be used for the large-scale application such as sample examination of large hospital and blood station.
7) easy and simple to handle.Because the utility model all adopts machinery to replace operating personnel to finish all complex operations processes automatically, only the reagent of required distribution or sample, porous plate to be placed or reagent bottle etc. need be placed into corresponding position, set the liquid process of moving again, just can be by the machinery remaining work of all doing, up to finishing all allocating tasks.
8) save human and material resources, reduced the sample treatment cost.Because the manufacturing cost of the utility model itself is lower, and overall process employing mechanical automation finishes, and reduced the loaded down with trivial details operation element of operating personnel greatly, and the treatment effeciency height, improved usage ratio of equipment greatly, reduced the sample treatment cost.
In a word, the utility model has overcome the defective of existing sample processing system, has reduced the error that manual operation brings, sample treatment result is reliable and stable, not only cross pollution is few, and processing speed is fast, the efficient height, flexibility is good, applicable to the liquid that moves under the container of various ways and specification and the multiple situation, and use cost is low, and this system is simple to operate, not only be fit to the scientific research and the application of laboratory and hospital, and can be used for large-scale sample treatment such as large hospital, drug research and blood station.
Description of drawings
Figure .1 is the schematic three dimensional views of a kind of embodiment of automatic liquor removing workstation described in the utility model;
Figure .2 is the last apparent direction schematic diagram of a kind of embodiment of automatic liquor removing workstation described in the utility model;
Figure .3 is the schematic three dimensional views of a manipulator among a kind of embodiment of automatic liquor removing workstation described in the utility model;
The specific embodiment
Below in conjunction with drawings and Examples the utility model is further specified:
As shown in the figure, (1) is workbench, (2) be the suction nozzle storage module, (3) be the suction nozzle recovery area, (4) be support frame, (5) be the X-axis auxiliary guide rail, (6) be the X-axis drive motors, (7) be the X-axis electronic control translation stage, (8) be the Y-axis overarm brace, (9) be a manipulator, (10) be link, (11) with used guide pillar and the screw mandrel of (12) Y direction motion, (13) be the sample storage module, (14) be computer, (15) be adjustable caster group, (16) be fixed support A, be used to install Y direction motion drive motors (17), Y direction drive nut (19), guide pillar overcoat (20), Z axis drive motor (21) and Z shaft movement mechanism (22) etc., (17) drive motors that moves for Y direction, (18) be to be with synchronously, (19) be the Y direction drive nut, (20) be the guide pillar overcoat, (21) be the Z axis drive motor, (22) are the Z shaft movement mechanism, and (23) are fixed support B, be used to install push rod Z axle motion drive motors (24), push rod connector (25), microsyringe (28), remove suction nozzle Z axis drive motor (27), remove suction nozzle spare (29) and suction nozzle installed part (30) etc., (24) be push rod Z axle motion drive motors, (25) are the push rod connector, and (26) are push rod, (27) for removing suction nozzle Z axle motion drive motors, (28) be microsyringe, (29) for removing suction nozzle spare, (30) are the suction nozzle installed part.
In this embodiment, a kind of automatic liquor removing workstation described in the utility model, mainly by workbench (1), support frame (4), the accurate electronic control translation stage (7) of X-axis, X-axis drive motors (6), X-axis auxiliary guide rail (5), Y-axis overarm brace (8), Y-axis guide pillar (11), Y-axis screw mandrel (12), 8 independent separately manipulator of controlling (9), electric cabinet, computer assemblies such as (14) is formed, the accurate electronic control translation stage (7) of workbench (1) and X-axis, X-axis auxiliary guide rail (5) all is installed on the support frame (4), Y-axis overarm brace (8) is across on accurate electronic control translation stage (7) of X-axis and X-axis auxiliary guide rail (5), Y-axis guide pillar (11) and Y-axis screw mandrel (12) are installed on the Y-axis overarm brace (8) by link (10), and each manipulator (9) is enclosed within Y-axis guide pillar (11) and the motion of Y-axis screw mandrel (12) upper edge Y direction by Y direction drive nut (19) and guide pillar overcoat (20).Workbench (1) is provided with suction nozzle recovery area (3), can put suction nozzle storage module (2) as required on the workbench (1), and sample storage module (13) waits other module.
Wherein, described each manipulator (9) comprises Y direction motion drive motors (17), be with synchronously (18), Y direction drive nut (19), guide pillar overcoat (20), Z axis drive motor (21), Z shaft movement mechanism (22), push rod Z axle motion drive motors (24), push rod connector (25), push rod (26), remove suction nozzle Z axis drive motor (27), microsyringe (28), remove suction nozzle spare (29), suction nozzle installed part (30), and be used to install Y direction motion drive motors (17), Y direction drive nut (19), guide pillar overcoat (20), the fixed support A (16) of Z axis drive motor (21) and Z shaft movement mechanism (22) is used to install push rod Z axle motion drive motors (24), push rod connector (25), microsyringe (28), remove suction nozzle Z axis drive motor (27), remove the fixed support B of suction nozzle spare (29) and suction nozzle installed part (30).
This manipulator (9) drives Y direction drive nut (19) by Y direction motion drive motors (17), and Y direction drive nut (19) moves on Y direction in the last rotation of Y-axis screw mandrel (12) and by the guiding of Y-axis guide pillar (11), each manipulator (9) is coordinated each other distance and motion by computer (14) and electric cabinet control.Z axis drive motor (21) drives fixed support B (23) and push rod Z axle motion drive motors (24), push rod connector (25), microsyringe (28) mounted thereto, removes suction nozzle Z axis drive motor (27), goes suction nozzle spare (29) and suction nozzle installed part (30) etc. to move up and down in Z-direction by Z shaft movement mechanism (22), with moving up and down of the Z-direction of realization suction nozzle.Push rod Z axle motion drive motors (24) makes the push rod (26) of microsyringe move up and down in Z-direction by push rod connector (25), to realize absorption and the liquid feeding to liquid.And go suction nozzle Z axis drive motor (27) to go suction nozzle spare (29) to move up and down in Z-direction by driving, and suction nozzle is released downwards from suction nozzle installed part (30), suction nozzle is owing to self gravitation falls down.
Be useful on equidistant groove (or projection) of each module positioning and fixing on the described workbench (1).In described suction nozzle storage module (2), the sample storage module modules such as (13) separately base bottom all have and workbench (1) on the match projection (or groove) of location of groove (or projection), the spacing of the groove (or projection) on its spacing and the workbench (1) is corresponding.Workbench can also be put other functional module on (1), such as detection module, reaction module, wash module etc., to realize the combination of multifunction module, finishes more multitask.
In this embodiment, described automatic liquor removing workstation has comprised 8 groups of suction nozzle storage module (2), and wherein said each suction nozzle storage module (2) comprises that suction nozzle, suction nozzle storage rack and suction nozzle deposit base.Wherein suction nozzle is international standard disposable tip.
In this embodiment, described automatic liquor removing workstation has comprised 3 groups of sample storage module (13), and described sample storage module (13) comprises test tube, test tube storage rack.Described test tube is that external diameter general on the market is 8mm~12mm test tube.Described test tube storage rack is formed for the multilayer orifice plate, and has deformable the extruding to the center, hole to design around each hole, can deposit the stability that the different test tube of external diameter guarantees that simultaneously test tube is placed, and the quantity of the test tube that can put on the frame is 48.
Described computer software, by being Y direction motion drive motors (17), Z axis drive motor (21), the push rod Z axle motion drive motors (24) in X-axis drive motors (6) and each manipulator (9) and removing suction nozzle Z axis drive motor (27) of electric cabinet control, thus control whole manipulator in the position of X-direction and the distance of each manipulator in the position of Y direction, between the manipulator, suction nozzle in actions such as the installation of height, suction nozzle imbibition and the liquid feeding of Z-direction, suction nozzle and removals.
Should be understood that the module described in the utility model can arbitrary combination, compound mode all covers within the utility model content arbitrarily.After reading foregoing of the present utility model, those skilled in the art can do various increases and decreases or modification to the utility model, and these equivalent form of values fall within the application's appended claims institute restricted portion equally.