CN210964038U

CN210964038U - Device for replacing gun head in solid-phase extraction

Info

Publication number: CN210964038U
Application number: CN201921881887.4U
Authority: CN
Inventors: 周宏�; 简清云; 杨先龙; 陈欣伟; 佘振宇
Original assignee: Sichuan Alpha Energy Equipment Co Ltd
Current assignee: Sichuan Alpha Energy Equipment Co Ltd
Priority date: 2019-11-04
Filing date: 2019-11-04
Publication date: 2020-07-10
Anticipated expiration: 2029-11-04

Abstract

The utility model discloses a device for solid phase extraction changing gun head, which comprises a box body, a moving component and a liquid-transferring gun head changing box are arranged in the box body, a guide pipe is arranged on the moving component, a gun head is arranged on the guide pipe, a changing groove is arranged on the liquid-transferring gun head changing box, the changing groove is in a gourd shape composed of a big round hole and a small round hole, the inner diameter of the big round hole is larger than the outer diameter of the gun head, the inner diameter of the small round hole is larger than the outer diameter of the guide pipe and smaller than the outer diameter of the gun head, when in use, the guide pipe is firstly moved into the big round hole by the moving component, then the guide pipe is translated into the small round hole, and finally the guide pipe is lifted upwards, because the outer diameter of the gun head is larger than the inner diameter of the small round hole, the purpose of changing the gun head is realized, the guide pipe and the, the effect of extraction is affected, the waste of medicine is caused, and the extraction cost is increased.

Description

Device for replacing gun head in solid-phase extraction

Technical Field

The utility model relates to a solid phase extraction field specifically is a device that is used for solid phase extraction to trade rifle head.

Background

The solid phase extraction is a sample pretreatment technology developed in recent years, is developed by combining a liquid-solid extraction technology and a column liquid chromatography technology, is mainly used for separating, purifying and concentrating samples, can improve the recovery rate of analytes compared with the traditional liquid-liquid extraction method, more effectively separates the analytes from interfering components, reduces the sample pretreatment process, and is simple to operate, time-saving and labor-saving. The main purpose is to reduce the matrix interference of the sample and improve the detection sensitivity. The existing automatic solid phase extraction instrument mainly realizes positioning through the movement of a three-dimensional moving arm, the injection pump is matched with a sample needle to realize the absorption and injection of a reagent, the sample needle cannot be replaced in the extraction process, but the absorption and injection of various reagents are carried out, in order to avoid cross contamination, the sample needle needs to be cleaned for multiple times, the existing cleaning modes mainly comprise nitrogen purging, solvent cleaning, air blowing stirring and the like, but the modes spend a large amount of time and resources in the extraction process, and waste is caused.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to overcome prior art's is not enough, provides a device that is used for solid phase extraction to trade rifle head, can change automatically and install the rifle head, need not wash pipe and rifle head at the in-process of extraction, has shortened the extraction time, has improved efficiency, has avoided simultaneously to wash not thoroughly, causes the cross infection of medicine, influences the effect of extraction, has caused the waste of medicine, has increased the extraction cost.

The purpose of the utility model is realized through the following technical scheme: a device for replacing a gun head in solid-phase extraction comprises a box body, wherein a moving assembly and a pipette head replacing box are arranged in the box body, a jacket is arranged on the moving assembly, a plurality of guide pipes are arranged on the jacket, the guide pipes are arranged in a rectangular shape and are arranged at equal intervals, the gun head is arranged at the lower end of each guide pipe, and the moving assembly is used for moving the jacket to the pipette head replacing box to replace the gun head;

the liquid transferring gun head replacing box is divided into a replacing cavity and a liquid transferring cavity by a partition plate, a replacing gun head plate is arranged at the upper end of the replacing cavity, a plurality of replacing grooves are formed in the replacing gun head plate, the replacing grooves are arranged in a rectangular mode and are arranged at equal intervals, the replacing grooves are in a gourd shape formed by a large round hole and a small round hole, the inner diameter of the large round hole is larger than the outer diameter of the gun head, the inner diameter of the small round hole is larger than the outer diameter of the guide pipe and smaller than the outer diameter of the gun head, the replacing grooves are used for detaching the gun head on the guide pipe, a liquid transferring gun head seat is arranged at the upper end of the liquid transferring cavity, a plurality of gun heads are arranged on the liquid transferring gun head seat, the gun heads are arranged in a rectangular mode and are arranged at equal intervals, and the liquid;

the distance between every two adjacent guide pipes is equal to the distance between every two adjacent replacement grooves, and the distance between every two adjacent guide pipes is equal to the distance between every two adjacent liquid-transferring gun heads on the liquid-transferring gun head bases.

Furthermore, the moving assembly comprises an X-axis sliding rail and a Y-axis moving seat, the X-axis sliding rail is fixed on the inner wall of the box body, the Y-axis moving seat is movably arranged on the X-axis sliding rail, and the jacket is slidably arranged in the Y-axis moving seat.

Furthermore, the jacket comprises a fixed seat, a Z-axis moving device and a conduit seat, the bottom of the fixed seat is slidably arranged in the Y-axis moving seat, the fixed seat and the Y-axis moving seat are vertically arranged, the Z-axis moving device is arranged in the fixed seat, the conduit seat is fixed on the Z-axis moving device, a plurality of conduits are fixedly arranged on the conduit seat in a penetrating manner, the conduits are arranged in parallel with the conduit seat, a fixed plate is further fixed on the fixed seat and positioned below the conduit seat, and one end of the conduit, provided with the gun head, is arranged on the fixed plate in a penetrating manner.

Furthermore, the Z-axis moving device comprises a screw rod, a sliding block and a motor, a sliding groove is formed in the fixed seat, the screw rod is rotatably arranged in the sliding groove, the sliding block is slidably arranged in the sliding groove and is in threaded connection with the screw rod, the catheter seat is fixed on the sliding block, the motor is fixed at the top end of the fixed seat, and an output shaft of the motor is fixedly connected with the screw rod.

Further, the guide pipe and the gun head are in interference fit.

The utility model has the advantages that:

a device for replacing a gun head in solid-phase extraction comprises a box body, wherein a moving assembly and a liquid-transferring gun head replacing box are arranged in the box body, a guide pipe is arranged on the moving assembly, the gun head is arranged on the guide pipe, a replacing groove is formed in the liquid-transferring gun head replacing box, the replacing groove is in a gourd shape consisting of a large round hole and a small round hole, the inner diameter of the large round hole is larger than the outer diameter of the gun head, the inner diameter of the small round hole is larger than the outer diameter of the guide pipe and smaller than the outer diameter of the gun head, the guide pipe is firstly moved into the large round hole by the moving assembly during use, then the guide pipe is translated into the small round hole, and finally the guide pipe and the gun head are lifted upwards, because the outer diameter of the gun head is larger than the inner diameter of the small round hole, the purpose of replacing the gun head is realized, the guide pipe and the, causing waste of medicine and increasing the extraction cost.

Because the rifle head needs to be changed many times among the solid phase extraction process, adopt artifical change inefficiency, still cause the pollution to the medicine easily, this application uses the removal subassembly to replace the manual work to carry out solid phase extraction, and it is efficient to change the rifle head, has avoided the pollution of medicine simultaneously, has also improved the quality of solid phase extraction when having improved efficiency.

Drawings

FIG. 1 is a schematic view of the overall structure of a device for replacing the tips of the solid-phase extraction apparatus according to the present invention;

FIG. 2 is a schematic structural view of a pipette tip changing box part in the device for solid phase extraction of pipette tips according to the present invention;

FIG. 3 is a schematic view of the overall structure of a pipette tip changing box in the device for changing pipette tips in solid phase extraction according to the present invention;

FIG. 4 is a schematic structural view of a moving assembly in the apparatus for replacing the lance head in solid phase extraction according to the present invention;

FIG. 5 is a schematic view of a jacket structure in an apparatus for exchanging tips in solid phase extraction according to the present invention;

FIG. 6 is a schematic structural view of a Z-axis moving device in the apparatus for replacing the tips of the solid-phase extraction apparatus of the present invention;

fig. 7 is a schematic diagram of a replacement gun head of the device for replacing the gun head in solid phase extraction according to the present invention;

in the figure, 1-guide pipe rack, 2-pipetting gun head replacing box, 3-moving assembly, 4-guide pipe, 5-pipetting gun head seat, 6-replacing gun head plate, 7-clapboard, 8-replacing cavity, 9-pipetting cavity, 10-gun head, 11-replacing groove, 12-fixing seat, 13-Z-axis moving device, 14-guide pipe seat, 15-X-axis slide rail, 16-Y-axis moving seat, 17-fixing plate, 18-lead screw, 19-slide block, 20-motor and 21-chute.

Detailed Description

The technical solution of the present invention is described in further detail below with reference to the accompanying drawings, but the scope of the present invention is not limited to the following description.

As shown in fig. 1 to 7, a device for replacing a pipette head in solid phase extraction comprises a box body, wherein a moving assembly 3 and a pipette head replacement box 2 are arranged in the box body, a jacket 1 is arranged on the moving assembly 3, a plurality of guide tubes 4 are arranged on the jacket 1, the guide tubes 4 are arranged in a rectangular shape and are arranged at equal intervals, the pipette heads 10 are arranged at the lower ends of the guide tubes 4, and the moving assembly 3 is used for moving the jacket 1 to the pipette head replacement box 2 to replace the pipette heads 10;

as shown in fig. 2 and 3, the pipetting head replacing box 2 is divided into a replacing cavity 8 and a pipetting cavity 9 by a partition plate 7, a replacing head plate 6 is arranged at the upper end of the replacing cavity 8, a plurality of replacing grooves 11 are formed in the replacing head plate 6, the replacing grooves 11 are arranged in a rectangular shape and are arranged at equal intervals, the replacing grooves 11 are in a gourd shape formed by a large round hole and a small round hole, the inner diameter of the large round hole is larger than the outer diameter of the pipetting head 10, the inner diameter of the small round hole is larger than the outer diameter of the catheter 4 and is smaller than the outer diameter of the pipetting head 10, the replacing grooves 11 are used for dismounting the pipetting head 10 on the catheter 4, a pipetting head seat 5 is arranged at the upper end of the pipetting cavity 9, a plurality of pipetting heads 10 are arranged on the pipetting head seat 5, the plurality of pipetting heads 10 are arranged in a rectangular shape and;

the distance between two adjacent guide pipes 4 is equal to the distance between two adjacent replacing grooves 11, and the distance between two adjacent guide pipes 4 is equal to the distance between two adjacent gun heads 10 on the liquid-transferring gun head base 5.

The working process of automatically replacing the gun head is as follows: the jacket 1 is moved to the position above the liquid-transferring gun head replacement box 2 by the aid of the moving assembly 3, then the jacket 1 is moved downwards, the guide pipe 4 on the jacket 1 is moved into the large round hole, then the guide pipe is translated into the small round hole, and finally the gun head 10 is lifted upwards, because the outer diameter of the gun head 10 is larger than the inner diameter of the small round hole and the outer diameter of the guide pipe 4 is smaller than the inner diameter of the small round hole, the gun head 10 is clamped in the small round hole in the upward lifting process until the gun head 10 falls off from the guide pipe 4, the gun head 10 is dismounted, after the gun head 10 is dismounted, the jacket 1 is moved to the position above the liquid-transferring cavity 9 by the moving assembly 3 again, the guide pipe 4 on the jacket 1 corresponds to the gun head 10 on the liquid-transferring gun head base 5, and. Whole process has realized changing rifle head 10 automatically, need not wash pipe and rifle head at the in-process of extraction, has shortened the extraction time, has improved efficiency, has avoided simultaneously that the washing is not thorough, causes the cross infection of medicine, influences the effect of extraction, has caused the waste of medicine, has increased the extraction cost.

In order to avoid falling off of the gun head 10 from the guide pipe 4 and influence on the extraction effect, the guide pipe 4 and the gun head 10 are in interference fit. In specific implementation, the mounting hole on the lance head 10 is designed to be frustum-shaped, and the large-diameter hole is located on the outer side, so that the guide pipe 4 can be conveniently inserted into the mounting hole on the lance head 10, and the replacement of the lance head 10 is faster.

As shown in fig. 4, the moving assembly 3 includes an X-axis slide rail 15 and a Y-axis moving base 16, the X-axis slide rail 15 is fixed on the inner wall of the box body, the Y-axis moving base 16 is movably disposed on the X-axis slide rail 15, and the jacket 1 is slidably disposed in the Y-axis moving base 16;

as shown in fig. 5, the jacket 1 includes a fixed seat 12, a Z-axis moving device 13 and a conduit seat 14, the bottom of the fixed seat 12 is slidably disposed in the Y-axis moving seat 16, the fixed seat 12 is perpendicular to the Y-axis moving seat 16, the fixed seat 12 is internally provided with the Z-axis moving device 13, the Z-axis moving device 13 is fixed with the conduit seat 14, the conduit seat 14 is fixedly provided with a plurality of conduits 4, the conduits 4 are parallel to the conduit seat 14, the fixed seat 12 is further fixed with a fixed plate 17, the fixed plate 17 is located below the conduit seat 14, and one ends of the conduits 4, which are provided with the gun tips 10, are arranged on the fixed plate 17;

as shown in fig. 6, the Z-axis moving device 13 includes a screw rod 18, a sliding block 19 and a motor 20, a sliding slot 21 is formed in the fixed base 12, the screw rod 18 is rotatably disposed in the sliding slot 21, the sliding block 19 is slidably disposed in the sliding slot 21 and is in threaded connection with the screw rod 18, the catheter seat 14 is fixed on the sliding block 19, the motor 20 is fixed at the top end of the fixed base 12, and an output shaft of the motor 20 is fixedly connected with the screw rod 18.

The working process of the Z-axis moving device 13 is as follows: the motor 20 is started, the motor 20 drives the screw rod 18 to rotate, and the slide block 19 is limited to rotate due to the fact that the slide block 19 is matched with the sliding groove 21, so that when the screw rod 18 rotates, the slide block 19 moves up and down along the screw rod 18, the catheter seat 14 on the slide block 19 is driven to move, and the catheter seat 14 is enabled to move up and down along the Z axis.

The Y-axis moving seat 16 is movably arranged on the X-axis sliding rail 15, the catheter seat 14 is moved left and right along the X axis, the catheter holder 1 can be slidably arranged in the Y-axis moving seat 16, the catheter seat 14 can move back and forth along the Y axis, the catheter seat 14 can move along the X axis, the Y axis and the Z axis, manual solid-phase extraction is replaced, the gun head replacement efficiency is high, meanwhile, pollution to medicines is avoided, and the quality of solid-phase extraction is improved while the efficiency is improved.

When the Y-axis moving seat 16 is implemented specifically, the movement on the X-axis slide rail can be realized by adopting an electric push rod, hydraulic driving and the like, the hydraulic driving cost is higher, therefore, the electric push rod and the screw rod transmission can be adopted, the specific structure is like the structure of the Z-axis moving device 13, the fixed seat 12 can be arranged in the Y-axis moving seat 16 in a sliding manner, and the electric push rod and the screw rod transmission can be adopted.

In order to enable the guide pipe 4 to replace the gun head 10 quickly and accurately, the guide pipe 4 needs to be accurately positioned in the replacing groove 11 to unload the gun head, and then the guide pipe is positioned and moved to the liquid-transferring gun head seat 5 to install the gun head 10, the application provides a positioning mode, and the positioning mode is specifically implemented as follows:

the controller is arranged in the box body, the moving distance of the Y-axis moving seat 16 on the X-axis sliding rail, the moving distance of the fixed seat 12 on the Y-axis moving seat 16 and the moving distance of the Z-axis moving device 13 on the fixed seat 12 are controlled by the controller, the position of the pipette tip replacing box 2 is fixed, the number of replacing grooves 11 on the replacing gun head plate 6 is larger than or equal to the number of guide tubes 4 on the guide tube seat 14, the distance between every two adjacent guide tubes 4 is equal to the distance between every two adjacent replacing grooves 11, the pipette tips 10 placed on the pipette tip seat 5 need to be guaranteed to be longitudinally and transversely integral multiples of a plurality of guide tubes 4 on the guide tube seat 14, the distance between every two adjacent guide tubes 4 is equal to the distance between every two adjacent pipette tips 10 on the pipette tip seat 5, and finally, the computer is used for programming the controller, so that the moving assembly can move. Notably, the automatic moving process is: when the gun head 10 is replaced for the first time, the guide pipe seat 14 moves to the replacement groove 11 to dismount the gun head 10, the gun head 10 is replaced on the liquid transferring gun head seat 5 after the gun head 10 is moved to the replacement groove 11, the position of the first replacement gun head 10 is taken as the original point, the subsequent replacement gun heads 10 advance horizontally in sequence, after the horizontal gun head 10 is replaced, the gun head 10 is longitudinally moved to the next horizontal row for replacement, the process is repeated, the process is stopped until the gun head 10 on the liquid transferring gun head seat 5 is replaced, at the moment, if the gun head 10 needs to be replaced, the gun head 10 needs to be installed on the liquid transferring gun head seat 5, then the process is set to zero, and the gun head 10 is

The foregoing is illustrative of the preferred embodiments of the present invention, and it is to be understood that the invention is not limited to the precise forms disclosed herein, and that various other combinations, modifications, and environments may be resorted to, falling within the scope of the invention as defined by the appended claims. But that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention, which is to be limited only by the claims appended hereto.

Claims

1. The device for replacing the gun heads in the solid-phase extraction comprises a box body and is characterized in that a moving assembly (3) and a pipetting gun head replacing box (2) are arranged in the box body, a jacket (1) is arranged on the moving assembly (3), a plurality of guide pipes (4) are arranged on the jacket (1), the guide pipes (4) are arranged in a rectangular shape and are arranged at equal intervals, gun heads (10) are arranged at the lower ends of the guide pipes (4), and the moving assembly (3) is used for moving the jacket (1) to the pipetting gun head replacing box (2) to replace the gun heads (10);

the pipette tip replacing box (2) is divided into a replacing cavity (8) and a pipette cavity (9) by a partition plate (7), a replacing head plate (6) is arranged at the upper end of the replacing cavity (8), a plurality of replacing grooves (11) are formed in the replacing head plate (6), the replacing grooves (11) are arranged in a rectangular shape and are arranged at equal intervals, each replacing groove (11) is in a gourd shape formed by a large round hole and a small round hole, the inner diameter of the large round hole is larger than the outer diameter of the pipette tip (10), the inner diameter of the small round hole is larger than the outer diameter of the guide tube (4) and smaller than the outer diameter of the pipette tip (10), the replacing grooves (11) are used for dismounting the pipette tips (10) on the guide tube (4), a pipette tip seat (5) is arranged at the upper end of the pipette cavity (9), a plurality of pipette tips (10) are arranged on the pipette tip seat (5), and the pipette tips (10) are arranged in a rectangular shape, the pipette tips are arranged at equal intervals, and the pipette tip seats (5) are used for mounting the pipette tips (10) on the guide pipe (4);

the distance between two adjacent guide pipes (4) is equal to the distance between two adjacent replacement grooves (11), and the distance between two adjacent guide pipes (4) is equal to the distance between two adjacent gun heads (10) on the liquid-transferring gun head seat (5).

2. The device for the solid phase extraction lance head of claim 1, wherein the moving assembly (3) comprises an X-axis slide rail (15) and a Y-axis moving seat (16), the X-axis slide rail (15) is fixed on the inner wall of the box body, the Y-axis moving seat (16) is slidably arranged on the X-axis slide rail (15), and the conduit frame (1) is slidably arranged in the Y-axis moving seat (16).

3. An apparatus for a solid phase extraction lance head according to claim 2, the jacket (1) comprises a fixed seat (12), a Z-axis moving device (13) and a jacket (14), the bottom of the fixed seat (12) is slidably arranged in the Y-axis moving seat (16), the fixed seat (12) is perpendicular to the Y-axis moving seat (16), the Z-axis moving device (13) is arranged in the fixed seat (12), a conduit seat (14) is fixed on the Z-axis moving device (13), a plurality of conduits (4) are fixedly arranged on the conduit seat (14) in a penetrating way, the catheter (4) is arranged in parallel with the catheter seat (14), a fixing plate (17) is fixed on the fixing seat (12), the fixing plate (17) is positioned below the guide pipe seat (14), and one end of the guide pipe (4) provided with the gun head (10) penetrates through the fixing plate (17).

4. The device for solid phase extraction and lance tip replacement according to claim 3, wherein the Z-axis moving device (13) comprises a screw rod (18), a sliding block (19) and a motor (20), a sliding groove (21) is formed in the fixed base (12), the screw rod (18) is rotatably arranged in the sliding groove (21), the sliding block (19) is slidably arranged in the sliding groove (21) and is in threaded connection with the screw rod (18), the conduit seat (14) is fixed on the sliding block (19), the motor (20) is fixed at the top end of the fixed base (12), and an output shaft of the motor (20) is fixedly connected with the screw rod (18).

5. An apparatus for a solid phase extraction lance tip according to claim 1, wherein the conduit (4) is in an interference fit with the lance tip (10).