CN103196899A - Fully-automatic high-flux joint detection chemiluminescent analyzer - Google Patents
Fully-automatic high-flux joint detection chemiluminescent analyzer Download PDFInfo
- Publication number
- CN103196899A CN103196899A CN2013100869703A CN201310086970A CN103196899A CN 103196899 A CN103196899 A CN 103196899A CN 2013100869703 A CN2013100869703 A CN 2013100869703A CN 201310086970 A CN201310086970 A CN 201310086970A CN 103196899 A CN103196899 A CN 103196899A
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- mechanical arm
- automatic high
- sample
- application
- reaction device
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- 238000001514 detection method Methods 0.000 title claims abstract description 22
- 238000006243 chemical reaction Methods 0.000 claims abstract description 20
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 9
- 238000004043 dyeing Methods 0.000 claims abstract description 4
- 210000000078 claw Anatomy 0.000 claims description 13
- 230000004907 flux Effects 0.000 claims description 10
- 238000012546 transfer Methods 0.000 claims description 4
- 230000001360 synchronised effect Effects 0.000 claims description 3
- 238000004458 analytical method Methods 0.000 abstract description 9
- 210000002966 serum Anatomy 0.000 abstract description 2
- 238000005070 sampling Methods 0.000 abstract 1
- 238000003556 assay Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000004020 luminiscence type Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000000018 DNA microarray Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- RXNXLAHQOVLMIE-UHFFFAOYSA-N phenyl 10-methylacridin-10-ium-9-carboxylate Chemical class C12=CC=CC=C2[N+](C)=C2C=CC=CC2=C1C(=O)OC1=CC=CC=C1 RXNXLAHQOVLMIE-UHFFFAOYSA-N 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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Abstract
The invention relates to a fully-automatic chemiluminescent analysis instrument for serum detection, and in particular relates to a fully-automatic high-flux joint detection chemiluminescent analyzer. The fully-automatic high-flux joint detection chemiluminescent analyzer comprises a rack, wherein a chemiluminescent reaction device and a charge coupled device (CCD) detector are arranged on the rack; the chemiluminescent reaction device comprises a sample region, a reagent region, a dyeing region, and a sampling mechanical arm for absorbing a reagent; the rack is divided into three layers; the chemiluminescent reaction device is arranged on the upper layer of the rack, a storage region is arranged on the middle layer of the rack, and a constant-temperature vibration incubating device is arranged on the lower layer of the rack; the chemiluminescent reaction device is arranged on one side of a shifting mechanical arm; and the CCD detector is arranged on the other side of the shifting mechanical arm. By the combination of a reactor and an analyzer, for the fully-automatic high-flux joint detection chemiluminescent analyzer, the degree of automation is improved, and reaction and the analysis are simultaneously performed; and as the batch detection is adopted, the working efficiency is improved, and the total detection time is greatly saved.
Description
Technical field
The present invention relates to the full-automatic instrument of the chemiluminescence analysis of serum detection, specifically is a kind of full-automatic high flux joint-detection chemiluminescent analyzer.
Background technology
The chemiluminescent labeling immunoassay claims that again chemiluminescence immune assay is the immune analysis method with the direct labelled antigen of chemiluminescence agent or antibody.The chemiluminescent substance that is usually used in mark has the acridinium ester compounds, is effective luminous marker, and it is by starting luminescence reagent effect and luminous, and strong direct luminously finish in a second is luminous for glimmering fast.Chemiluminescence immune assay comprises two steps, i.e. immune response and chemiluminescence analysis, the system integration of existing full-automatic chemical luminescence immunoassay have immune response system and two subsystems of chemiluminescence analysis system to realize chemiluminescence immune assay.Its chemiluminescence analysis system carries out luminous measurement by adding luminous substrate in the chemiluminescence measuring chamber, then the detection of luminous intensity is carried out quantitatively or qualitative detection.Detection need manually be carried out part operation, do not have in the prior art can with reactions steps with detect the fully-automatic equipment that analytical procedure is combined, therefore greatly limited the time of detecting, influenced work efficiency.
Summary of the invention
Purpose of the present invention is exactly not have the problem of full-automatic checkout equipment for solving in the prior art, and has designed the brand-new equipment that combines seroreaction instrument and CCD analyzing and testing instrument, i.e. a kind of full-automatic high flux joint-detection chemiluminescent analyzer.
Technical scheme of the present invention is: a kind of full-automatic high flux joint-detection chemiluminescent analyzer, comprise frame, chemiluminescence reaction device and CCD detector are installed on the frame, described chemiluminescence reaction device includes sample area, reagent area, dyeing district, and the application of sample mechanical arm that is used for drawing reagent, described frame is divided into three layers, and the upper strata is provided with the chemiluminescence reaction device, the middle level is reserve zone, and lower floor is provided with the constant temperature vibrations and hatches device; Top one side of described frame is provided with cross slide way, and cross slide way is provided with motor-driven application of sample mechanical arm; The application of sample mechanical arm is provided with the electronic application of sample suction pipe of vertical direction, and electronic application of sample suction pipe drives by electronic leading screw, the vertical slide rail that is provided with in the application of sample mechanical arm and electronic synchronous band, and electronic leading screw and application of sample suction pipe are fixed on vertically to be with synchronously; The below vertical direction of described cross slide way is provided with upright guide rail, and upright guide rail is provided with the handover mechanical arm, and described handover mechanical arm is provided with gripper, and gripper is fixed on the long rails of transferring mechanical arm, and can drive mobile by stepper motor; Described chemiluminescence reaction device is arranged on a side of transferring mechanical arm, and the CCD detector is arranged on the opposite side of transferring mechanical arm.
Described gripper includes fixed frame, and the inboard of framework is provided with a pair of movable claw, and movable claw is connected with fixed frame by jointed shaft, is provided with preloading spring between the described movable claw; The outside of described fixed frame is provided with magnechuck, and the movable telescopic bar of magnechuck is fixedlyed connected with movable claw.
Described cross slide way and long rails adopt two slide bar guiding, and stepper motor drives band synchronously, and transfer arm is fixed on synchronously and is with.
The vibrations of described constant temperature are hatched device and are comprised vibrating disc, and vibrating disc is provided with six of being mutually 60 degree at interval and hatches accumulator tank, but hatches the loam cake that accumulator tank is provided with folding; The hinged place of loam cake is provided with torsion spring, and another free end is provided with presses the open-close type buckle; The center of described vibrating disc is provided with rotating shaft, and rotating shaft is connected with motor, and motor and vibrating disc are fixed on the jolting plate simultaneously, and the bottom surface of jolting plate is provided with three parallel motion guide rails, and electromagnetic vibrator is installed on the middle guide rail, and two side rails are free slide rail.
Described constant temperature vibrations are hatched device and are provided with two, lay respectively at the both sides of transferring mechanical arm.
Beneficial effect of the present invention can draw by such scheme: because the present invention combines reaction instrument and analyser, not only improved automaticity, and made reaction and analysis carry out simultaneously, detected in batches, improve work efficiency, saved total detection time greatly.
This shows that the present invention compared with prior art has substantive distinguishing features and progress, the beneficial effect of its enforcement also is apparent.
Description of drawings:
Fig. 1 is structural representation of the present invention;
Fig. 2 is the structure for amplifying synoptic diagram of A place gripper among Fig. 1;
Fig. 3 is hatched the structural representation of device for the constant temperature vibrations.
Wherein, 1 is frame, and 2 is the CCD detector, and 3 is the application of sample mechanical arm, 4 hatch device for constant temperature vibrations, and 5 is cross slide way, and 6 is the application of sample suction pipe, 7 is upright guide rail, and 8 for transferring mechanical arm, and 9 is framework, 10 is movable claw, and 11 is magnechuck, and 12 is preloading spring, 13 is vibrating disc, and 14 for hatching accumulator tank, and 15 is loam cake, 16 is buckle, and 17 is electromagnetic vibrator, and 18 is free slide rail.
Embodiment:
In order to understand the present invention better, explain embodiments of the present invention in detail below in conjunction with accompanying drawing.
Embodiment: a kind of full-automatic high flux joint-detection chemiluminescent analyzer, comprise frame 1, chemiluminescence reaction device and CCD detector 2 are installed on the frame 1, described chemiluminescence reaction device includes sample area, reagent area, dyeing district, and the application of sample mechanical arm 3 that is used for drawing reagent.Frame 1 is divided into three layers, and the upper strata is provided with the chemiluminescence reaction device, and the middle level is reserve zone, and reserve zone is biochip and disposable aspiration needle storage area.The lower floor of frame 1 is provided with the constant temperature vibrations and hatches device 4.Upper strata one side of described frame 1 is provided with cross slide way 5,, cross slide way 5 is provided with motor-driven application of sample mechanical arm 3; Application of sample mechanical arm 3 is provided with the electronic application of sample suction pipe 6 of vertical direction, and electronic application of sample suction pipe 6 drives by electronic leading screw, the vertical slide rail that is provided with in the application of sample mechanical arm 3 and electronic synchronous band, and electronic leading screw and application of sample suction pipe 6 are fixed on vertically to be with synchronously; The below vertical direction of described cross slide way 5 is provided with upright guide rail 7, and upright guide rail 7 is provided with transfers mechanical arm 8.
As described in Figure 2, transfer mechanical arm 8 and be provided with gripper, gripper is fixed on the long rails of transferring mechanical arm 8, and can drive mobile by stepper motor; Described gripper includes fixed frame 9, and the inboard of framework 9 is provided with a pair of movable claw 10, and movable claw 10 is connected with fixed frame 9 by jointed shaft, is provided with preloading spring 12 between the described movable claw 10; The outside of described fixed frame is provided with magnechuck 11, and the movable telescopic bar of magnechuck is fixedlyed connected with movable claw 10.The chemiluminescence reaction device is arranged on a side of transferring mechanical arm 8, and CCD detector 2 is arranged on the opposite side of transferring mechanical arm 8.
As shown in Figure 3, constant temperature vibrations are hatched device 4 and are comprised vibrating disc 13, and vibrating disc 13 is provided with six of being mutually 60 degree at interval and hatches accumulator tank 14, but hatches the loam cake 15 that accumulator tank 14 is provided with folding; The hinged place of loam cake 15 is provided with torsion spring, and another free end is provided with presses open-close type buckle 16; The center of described vibrating disc 13 is provided with rotating shaft, and rotating shaft is connected with motor, and motor and vibrating disc are fixed on the jolting plate simultaneously, and the bottom surface of jolting plate is provided with three parallel motion guide rails, and it is free slide rail 18 that electromagnetic vibrator 17, two side rails are installed on the middle guide rail.Described constant temperature vibrations are hatched device 4 and are provided with two, lay respectively at the both sides of transferring mechanical arm 8.
Above-mentioned explanation is not to be limitation of the present invention, and the present invention also is not limited in above-mentioned giving an example, and the variation that those skilled in the art make in essential scope of the present invention, remodeling, interpolation or replacement also should belong to protection scope of the present invention.
Claims (5)
1. full-automatic high flux joint-detection chemiluminescent analyzer, comprise frame, chemiluminescence reaction device and CCD detector are installed on the frame, described chemiluminescence reaction device includes sample area, reagent area, dyeing district, and the application of sample mechanical arm that is used for drawing reagent, it is characterized in that: described frame is divided into three layers, and the upper strata is provided with the chemiluminescence reaction device, the middle level is reserve zone, and lower floor is provided with the constant temperature vibrations and hatches device; Top one side of described frame is provided with cross slide way, and cross slide way is provided with motor-driven application of sample mechanical arm; The application of sample mechanical arm is provided with the electronic application of sample suction pipe of vertical direction, and electronic application of sample suction pipe drives by electronic leading screw, the vertical slide rail that is provided with in the application of sample mechanical arm and electronic synchronous band, and electronic leading screw and application of sample suction pipe are fixed on vertically to be with synchronously; The below vertical direction of described cross slide way is provided with upright guide rail, and upright guide rail is provided with the handover mechanical arm, and described handover mechanical arm is provided with gripper, and gripper is fixed on the long rails of transferring mechanical arm, and can drive mobile by stepper motor; Described chemiluminescence reaction device is arranged on a side of transferring mechanical arm, and the CCD detector is arranged on the opposite side of transferring mechanical arm.
2. full-automatic high flux joint-detection chemiluminescent analyzer as claimed in claim 1, it is characterized in that: described gripper includes fixed frame, the inboard of framework is provided with a pair of movable claw, and movable claw is connected with fixed frame by jointed shaft, is provided with preloading spring between the described movable claw; The outside of described fixed frame is provided with magnechuck, and the movable telescopic bar of magnechuck is fixedlyed connected with movable claw.
3. full-automatic high flux joint-detection chemiluminescent analyzer as claimed in claim 2 is characterized in that: described cross slide way and long rails adopt two slide bars guiding, and stepper motor drives band synchronously, and transfer arm is fixed on synchronously and is with.
4. full-automatic high flux joint-detection chemiluminescent analyzer as claimed in claim 1, it is characterized in that: described constant temperature vibrations are hatched device and are comprised vibrating disc, vibrating disc is provided with six of being mutually at interval 60 degree and hatches accumulator tank, but hatches the loam cake that accumulator tank is provided with folding; The hinged place of loam cake is provided with torsion spring, and another free end is provided with presses the open-close type buckle; The center of described vibrating disc is provided with rotating shaft, and rotating shaft is connected with motor, and motor and vibrating disc are fixed on the jolting plate simultaneously, and the bottom surface of jolting plate is provided with three parallel motion guide rails, and electromagnetic vibrator is installed on the middle guide rail, and two side rails are free slide rail.
5. full-automatic high flux joint-detection chemiluminescent analyzer as claimed in claim 4 is characterized in that: described constant temperature vibrations are hatched device and are provided with two, lay respectively at the both sides of transferring mechanical arm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310086970.3A CN103196899B (en) | 2013-03-19 | 2013-03-19 | Fully-automatic high-flux joint detection chemiluminescent analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310086970.3A CN103196899B (en) | 2013-03-19 | 2013-03-19 | Fully-automatic high-flux joint detection chemiluminescent analyzer |
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| CN103196899A true CN103196899A (en) | 2013-07-10 |
| CN103196899B CN103196899B (en) | 2015-06-17 |
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| CN201310086970.3A Active CN103196899B (en) | 2013-03-19 | 2013-03-19 | Fully-automatic high-flux joint detection chemiluminescent analyzer |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104730268A (en) * | 2013-12-24 | 2015-06-24 | 广州万孚生物技术股份有限公司 | Method and device for detecting liquid samples |
| CN104730262A (en) * | 2013-12-24 | 2015-06-24 | 广州万孚生物技术股份有限公司 | Liquid detection device |
| CN104724454A (en) * | 2013-12-24 | 2015-06-24 | 广州万孚生物技术股份有限公司 | Reagent card settling transmission device |
| CN107831322A (en) * | 2017-12-08 | 2018-03-23 | 郑州科蒂亚生物技术有限公司 | A kind of Full-automatic chemiluminescence immunoassay analysis meter device |
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| CN2716842Y (en) * | 2004-06-14 | 2005-08-10 | 桂林市医疗电子仪器厂 | Transversal and horizontal automatic sample introduction mechanism for dry chemical urinalysis instrument |
| KR20060066178A (en) * | 2004-11-26 | 2006-06-16 | (주)인터페이스 엔지니어링 | Handling apparatus having gripper of oblong frame and sample test apparatus using same |
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| CN104724454A (en) * | 2013-12-24 | 2015-06-24 | 广州万孚生物技术股份有限公司 | Reagent card settling transmission device |
| CN107831322A (en) * | 2017-12-08 | 2018-03-23 | 郑州科蒂亚生物技术有限公司 | A kind of Full-automatic chemiluminescence immunoassay analysis meter device |
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| Publication number | Publication date |
|---|---|
| CN103196899B (en) | 2015-06-17 |
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Application publication date: 20130710 Assignee: SHANGHAI YULONG SHENGUANG MEDICAL LABORATORY Co.,Ltd. Assignor: Shanghai Yulong Biotech Co.,Ltd. Contract record no.: X2023980045714 Denomination of invention: Fully automatic high-throughput combined detection chemiluminescence analyzer Granted publication date: 20150617 License type: Common License Record date: 20231102 |