CN201006014Y - 一种蒙脱石结肠定位释放胶囊 - Google Patents

一种蒙脱石结肠定位释放胶囊 Download PDF

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Publication number
CN201006014Y
CN201006014Y CNU2007200171903U CN200720017190U CN201006014Y CN 201006014 Y CN201006014 Y CN 201006014Y CN U2007200171903 U CNU2007200171903 U CN U2007200171903U CN 200720017190 U CN200720017190 U CN 200720017190U CN 201006014 Y CN201006014 Y CN 201006014Y
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montmorillonite
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张为胜
刘源水
张晶
梅笑玲
张昕
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SHANDONG HONGJITANG PHARMACEUTICAL GROUP CO., LTD.
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Jinan Kangzhong Pharmaceutical Research and Development Co Ltd
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Abstract

本实用新型提供一种蒙脱石结肠定位释放胶囊的技术方案，其特征在于蒙脱石胶囊1，外包一种在胃液、小肠液中均不溶的ph依赖型结肠溶树脂薄膜衣2。本实用新型口服后，在胃和小肠中不释放药物，从而保证把药物定量输送到结肠中。可提高发病部位在结肠及直肠的各种急、慢性腹泻尤其是结肠炎等的疗效。服用方便。

Description

一种蒙脱石结肠定位释放胶囊
技术领域
本实用新型涉及一种蒙脱石结肠定位释放胶囊，属医药技术领域。
技术背景
蒙脱石散作为一种高效的粘膜保护剂，病菌、病毒及其毒素的吸附剂，用于各种急、慢性腹泻病的治疗，高效无毒，现已在全世界100多个国家和地区上市。现已上市的蒙脱石制剂还有片剂、混悬剂、颗粒剂、分散片，它们均是普通制剂。当用于治疗发病部位在结肠及直肠的各种急、慢性腹泻病尤其是结肠炎时，采用口服或灌肠，灌肠疗效明显好于口服。
普通蒙脱石制剂口服后，药物在到达结肠前即被吸附于上消化道或吸附力已基本饱和，因而对结肠炎的治疗效果较差；保留灌肠给药，药效较口服好，但药物在结肠分布不均匀，个体差异大，且药物往往仅能到达直肠和乙状结肠，不易到达横结肠和升结肠，同时此种给药途径，使患者十分痛苦，医务人员负担也重。
发明内容
为了克服已有普通蒙脱石制剂治疗发病部位在结肠及直肠的各种急、慢性腹泻的不足，本实用新型提出一种蒙脱石结肠定位释放胶囊。
本实用新型解决其技术问题所采用的技术方案是：将蒙脱石胶囊1，外包一种在胃液、小肠液中均不溶的ph依赖型结肠溶树脂薄膜衣2。
本实用新型有益作用和效果是，药物口服后，在胃和小肠段，由于ph依赖型结肠溶树脂薄膜衣的保护，药物在胃和小肠中不释放，从而保证把药物定量输送到结肠中。当药物到达结肠时，树脂在1小时左右被溶解，开始释放药物。因而，在结肠部位局部药物有效浓度较普通制剂高出数倍。局部药物浓度高，有利于更多的病菌、病毒及其毒素被吸附固定并排出体外，更有利于增强局部黏膜的防御功能。故可提高发病部位在结肠及直肠的各种急、慢性腹泻尤其是结肠炎等的疗效。专一性更高，又服用方便，可提高广大患者的依从性。
附图说明
附图本实用新型的剖视示意图。
具体实施方式
配制在胃液、小肠液中均不溶的ph依赖型结肠溶树脂薄膜包衣液：称取聚丙烯酸树脂III45g，倒入1000ml 95％的乙醇中，搅拌均匀，加入邻苯二甲酸二丁脂3ml，搅拌均匀，使聚丙烯酸树脂III全部溶解，备用。
将蒙脱石胶囊1，置包衣机中，按常规薄膜包衣法，用在胃液、小肠液中均不溶的ph依赖型结肠溶树脂薄膜包衣液，包薄膜衣2。

Claims (2)

1.一种治疗急、慢性腹泻的蒙脱石结肠定位释放胶囊，其特征在于蒙脱石胶囊1，外包一种在胃液、小肠液中均不溶的ph依赖型结肠溶树脂薄膜衣2。
2.根据权利要求1所述一种治疗急、慢性腹泻的蒙脱石结肠定位释放胶囊，其特征在于：在胃液、小肠液中均不溶的ph依赖型结肠溶树脂薄膜包衣2主要材料是聚丙烯酸树脂III。
CNU2007200171903U 2007-01-11 2007-01-11 一种蒙脱石结肠定位释放胶囊 Expired - Lifetime CN201006014Y (zh)

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CNU2007200171903U CN201006014Y (zh) 2007-01-11 2007-01-11 一种蒙脱石结肠定位释放胶囊

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CNU2007200171903U CN201006014Y (zh) 2007-01-11 2007-01-11 一种蒙脱石结肠定位释放胶囊

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CN201006014Y true CN201006014Y (zh) 2008-01-16

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