CN105561036A - 一种治疗急性放射性直肠炎疗的中药配方及灌肠方法 - Google Patents

一种治疗急性放射性直肠炎疗的中药配方及灌肠方法 Download PDF

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CN105561036A
CN105561036A CN201610035088.XA CN201610035088A CN105561036A CN 105561036 A CN105561036 A CN 105561036A CN 201610035088 A CN201610035088 A CN 201610035088A CN 105561036 A CN105561036 A CN 105561036A
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formula
chinese medicine
enema
oral
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柳燕
隋光丽
李娜
王芳
窦美芳
陈丽媛
张立
尹喜玲
韩景奇
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Abstract

本发明公开了一种治疗急性放射性直肠炎疗的中药配方及灌肠方法，包括口服配方和灌肠配方，其灌肠方法为，以灌肠配方的中药制剂250ml，保留灌肠，用250ml盐水瓶密闭盛装灌肠液，插入一次性输液管，末端再接一次性肛管，嘱患者先排空大便，取左侧卧位，先排出管内气体，将涂以液体石蜡油的肛管插入肛门12-15cm，胶布固定打开调节器滴速为75滴/min，药物灌入肠道后，膝胸卧位20-30min，左右侧卧位各30-40min，平卧位30-40min，1剂/d，1个疗程7d。

Description

一种治疗急性放射性直肠炎疗的中药配方及灌肠方法
技术领域
本发明涉及肛肠病治疗技术领域，具体涉及一种治疗急性放射性直肠炎疗的中药配方及灌肠方法。
背景技术
直肠炎在我国是一个发病率非常高的疾病，治疗方法有口服柳氮磺胺吡啶(SASP)、5-氨基水杨酸、强的松、免疫抑制剂及应用SASP栓剂等，药物不良反应较大，可引起恶心、呕吐、纳差、头痛、皮下出血、溶血，甚至皮疹、肝脏毒性、白细胞减少及支气管哮喘，且服药时间长，停药后易复发，给临床治疗带来不便。药物长期服用价格昂贵，许多患者难以承受。
急性放射性直肠炎是指直肠(主要是黏膜)受到电离辐射(X、γ射线及电子辐射等)超过该器官耐受剂量，在半年内引起的急性放射性直肠炎症，是盆腹部肿瘤放疗常见并发症之一，如处理不当，往往会影响到放疗的进行，甚至造成永久性迁延不愈的严重放射性损伤[。目前治疗放射性直肠炎多采用抗生素、肠道黏膜保护剂、止泻剂、普悬液灌肠等，但疗效不佳。
发明内容
为了解决上述的问题，本发明提供了一种治疗急性放射性直肠炎疗的中药配方及灌肠方法，采用口服加保留灌肠治疗急性放射性直肠炎疗效显著，且安全、易实施，使药物直接作用于病灶，避免口服药物胃肠吸收不良所致药效下降、药物对胃肠道刺激，药物吸收迅速，疗程短，见效快，方法简单，无不良反应等优点，是治疗急性放射性直肠炎有效的方法，操作简单，患者容易接受，可以有效解决背景技术中的问题。
为了实现上述目的，本发明采用的技术方案如下：
一种治疗急性放射性直肠炎疗的中药配方，包括口服配方和灌肠配方，所述配方分别由以下重量克数的原料组成：
(1)口服配方：太子参15-17g，炙黄芪30-34g，炒白术15-17g，茯苓15-17g，薏苡仁30-34g，山药15-17g，金银花20-24g，黄芩10-12g，黄连6-8g，败酱草30-34g，元参15-17g，葛根15-17g，生地榆30-34g，槐花15-17g，乌梅15-17g，生甘草10-12g。
(2)灌肠配方：白头翁30-34g，秦皮15-17g，黄柏10-12g，大黄10-12g，栀子15-17g，白花蛇舌草15-17g，鸡蛋花15-17g，甘草6-8g，五倍子10-12g。
进一步地，所述配方分别由以下重量克数的原料组成：
(1)口服配方：太子参15g，炙黄芪30g，炒白术15g，茯苓15g，薏苡仁30g，山药15g，金银花20g，黄芩10g，黄连6g，败酱草30g，元参15g，葛根15g，生地榆30g，槐花15g，乌梅15g，生甘草10g。
(2)灌肠配方：白头翁30g，秦皮15g，黄柏10g，大黄10g，栀子15g，白花蛇舌草15g，鸡蛋花15g，甘草6g，五倍子10g。
进一步地，所述口服配方对于腹痛明显者添加白芍15-17g，元胡10-12g。
进一步地，所述口服配方对于黏液便者添加白头翁15-17g，秦皮10-12g。
进一步地，所述口服配方对于便血者添加仙鹤草30-34g，三七10-12g。
进一步地，所述口服配方对于里急后重病症明显者添加木香10-12g，槟榔10-12g。
另外本发明还设计了一种治疗急性放射性直肠炎疗的中药灌肠方法，以灌肠配方的中药制剂250ml，保留灌肠，用250ml盐水瓶密闭盛装灌肠液，插入一次性输液管，末端再接一次性肛管，让患者先排空大便，取左侧卧位，先排出管内气体，将涂以液体石蜡油的肛管插入肛门12-15cm，胶布固定打开调节器滴速为75滴/min，，药物灌入肠道后，膝胸卧位20-30min，左右侧卧位各30-40min，平卧位30-40min，1剂/d，1个疗程7d。
本发明有益效果为：本发明采用口服加保留灌肠治疗急性放射性直肠炎疗效显著，且安全、易实施，使药物直接作用于病灶，避免口服药物胃肠吸收不良所致药效下降、药物对胃肠道刺激，药物吸收迅速，疗程短，见效快，方法简单，无不良反应等优点，是治疗急性放射性直肠炎有效的方法，操作简单，患者容易接受。
具体实施方式
根据下述实施例，可以更好的理解本发明。然而，本领域的技术人员容易理解，实施例所描述的内容仅用于说明本发明，而不应当也不会限制权利要求书中所详细描述的本发明。
实施例1：
一种治疗急性放射性直肠炎疗的中药配方，包括口服配方和灌肠配方，所述配方分别由以下重量克数的原料组成：
(1)口服配方：太子参15g，炙黄芪30g，炒白术15g，茯苓15g，薏苡仁30g，山药15g，金银花20g，黄芩10g，黄连6g，败酱草30g，元参15g，葛根15g，生地榆30g，槐花15g，乌梅15g，生甘草10g。
(2)灌肠配方：白头翁30g，秦皮15g，黄柏10g，大黄10g，栀子15g，白花蛇舌草15g，鸡蛋花15g，甘草6g，五倍子10g。
其中，所述口服配方对于腹痛明显者添加白芍15g，元胡10g。
其中，所述口服配方对于黏液便者添加白头翁15g，秦皮10g。
其中，所述口服配方对于便血者添加仙鹤草30g，三七10g。
其中，所述口服配方对于里急后重病症明显者添加木香10g，槟榔10g。
其中药灌肠方法为，以灌肠配方的中药制剂250ml，保留灌肠，用250ml盐水瓶密闭盛装灌肠液，插入一次性输液管，末端再接一次性肛管，让患者先排空大便，取左侧卧位，先排出管内气体，将涂以液体石蜡油的肛管插入肛门12cm，胶布固定打开调节器滴速为75滴/min，，药物灌入肠道后，膝胸卧位20min，左右侧卧位各30min，平卧位30min，1剂/d，1个疗程7d。
实施例2：
一种治疗急性放射性直肠炎疗的中药配方，包括口服配方和灌肠配方，所述配方分别由以下重量克数的原料组成：
(1)口服配方：太子参16g，炙黄芪32g，炒白术16g，茯苓16g，薏苡仁32g，山药16g，金银花22g，黄芩11g，黄连7g，败酱草32g，元参16g，葛根16g，生地榆32g，槐花16g，乌梅16g，生甘草11g。
(2)灌肠配方：白头翁32g，秦皮16g，黄柏11g，大黄11g，栀子16g，白花蛇舌草16g，鸡蛋花16g，甘草7g，五倍子11g。
其中，所述口服配方对于腹痛明显者添加白芍16g，元胡11g。
其中，所述口服配方对于黏液便者添加白头翁16g，秦皮11g。
其中，所述口服配方对于便血者添加仙鹤草32g，三七11g。
其中，所述口服配方对于里急后重病症明显者添加木香11g，槟榔11g。
其中药灌肠方法为，以灌肠配方的中药制剂250ml，保留灌肠，用250ml盐水瓶密闭盛装灌肠液，插入一次性输液管，末端再接一次性肛管，让患者先排空大便，取左侧卧位，先排出管内气体，将涂以液体石蜡油的肛管插入肛门13cm，胶布固定打开调节器滴速为75滴/min，，药物灌入肠道后，膝胸卧位25min，左右侧卧位各35min，平卧位35min，1剂/d，1个疗程7d。
实施例3：
一种治疗急性放射性直肠炎疗的中药配方，包括口服配方和灌肠配方，所述配方分别由以下重量克数的原料组成：
(1)口服配方：太子参17g，炙黄芪34g，炒白术17g，茯苓17g，薏苡仁34g，山药17g，金银花24g，黄芩12g，黄连8g，败酱草34g，元参17g，葛根17g，生地榆34g，槐花17g，乌梅17g，生甘草12g。
(2)灌肠配方：白头翁34g，秦皮17g，黄柏12g，大黄12g，栀子17g，白花蛇舌草17g，鸡蛋花17g，甘草8g，五倍子12g。
其中，所述口服配方对于腹痛明显者添加白芍17g，元胡12g。
其中，所述口服配方对于黏液便者添加白头翁17g，秦皮12g
其中，所述口服配方对于便血者添加仙鹤草34g，三七12g。
其中，所述口服配方对于里急后重病症明显者添加木香10-12g，槟榔10-12g。
其中药灌肠方法为，以灌肠配方的中药制剂250ml，保留灌肠，用250ml盐水瓶密闭盛装灌肠液，插入一次性输液管，末端再接一次性肛管，让患者先排空大便，取左侧卧位，先排出管内气体，将涂以液体石蜡油的肛管插入肛门12-15cm，胶布固定打开调节器滴速为75滴/min，，药物灌入肠道后，膝胸卧位20-30min，左右侧卧位各30-40min，平卧位30-40min，1剂/d，1个疗程7d。
本发明对于该配方的实验方法：
本发明选某远医院1999-2002年收治的66例直肠癌根治术后患者，均接受6～8MvX线50Gy/5W盆腔野放射治疗；其中27例为干组，23例为对照组，16例为中药治疗组。
治疗方法：干预组于放疗第3周开始中药灌肠至放疗结束；对照组为单纯放疗；中药治疗组于放疗结束后出现放射性直肠炎并经纤维结肠镜证实开始采用本发明口服配方和灌肠配方进行治疗。
疗效判定：治愈(I级)：腹痛、粘液血样便消失，腹泻停止，结肠镜检粘膜正常；好转(II级)：腹痛、粘液血样便消失，大便次数每日2～3次，镜检粘膜轻度充血；无效(III级)：病情无改善。
治疗结果：干预组放射性直肠炎总发生率为51.5％(14/27)，其中I级9例、II级4例、III级1例；
对照组放射性直肠炎总发生率为56.5％(13/23)，其中I级8例、II级3例、III级2例；
以上两组间放射性直肠炎总发生率无明显统计学差异(P＞0.05)。
中药治疗组中放射性直肠炎I级10例，II级4例，III级2例和IV级1例，总治愈率87.5％(14/16)。
基于上述，本发明采用口服加保留灌肠治疗急性放射性直肠炎疗效显著，且安全、易实施，使药物直接作用于病灶，避免口服药物胃肠吸收不良所致药效下降、药物对胃肠道刺激，药物吸收迅速，疗程短，见效快，方法简单，无不良反应等优点，是治疗急性放射性直肠炎有效的方法，操作简单，患者容易接受。
本文中所描述的具体实施例仅仅是对本发明精神作举例说明。本发明所属技术领域的技术人员可以对所描述的具体实施例做各种各样的修改或补充或采用类似的方式替代，但并不会偏离本发明的精神或者超越所附权利要求书所定义的范围。

Claims (7)

1.一种治疗急性放射性直肠炎疗的中药配方，其特征在于，包括口服配方和灌肠配方，所述配方分别由以下重量克数的原料组成：
(1)口服配方：太子参15-17g，炙黄芪30-34g，炒白术15-17g，茯苓15-17g，薏苡仁30-34g，山药15-17g，金银花20-24g，黄芩10-12g，黄连6-8g，败酱草30-34g，元参15-17g，葛根15-17g，生地榆30-34g，槐花15-17g，乌梅15-17g，生甘草10-12g。
(2)灌肠配方：白头翁30-34g，秦皮15-17g，黄柏10-12g，大黄10-12g，栀子15-17g，白花蛇舌草15-17g，鸡蛋花15-17g，甘草6-8g，五倍子10-12g。
2.如权利要求1所述的一种治疗急性放射性直肠炎疗的中药配方，其特征在于，所述配方分别由以下重量克数的原料组成：
(1)口服配方：太子参15g，炙黄芪30g，炒白术15g，茯苓15g，薏苡仁30g，山药15g，金银花20g，黄芩10g，黄连6g，败酱草30g，元参15g，葛根15g，生地榆30g，槐花15g，乌梅15g，生甘草10g。
(2)灌肠配方：白头翁30g，秦皮15g，黄柏10g，大黄10g，栀子15g，白花蛇舌草15g，鸡蛋花15g，甘草6g，五倍子10g。
3.如权利要求1所述的一种治疗急性放射性直肠炎疗的中药配方，其特征在于，所述口服配方对于腹痛明显者添加白芍15-17g，元胡10-12g。
4.如权利要求1所述的一种治疗急性放射性直肠炎疗的中药配方，其特征在于，所述口服配方对于黏液便者添加白头翁15-17g，秦皮40-12g。
5.如权利要求1所述的一种治疗急性放射性直肠炎疗的中药配方，其特征在于，所述口服配方对于便血者添加仙鹤草30-34g，三七10-12g。
6.如权利要求1所述的一种治疗急性放射性直肠炎疗的中药配方，其特征在于，所述口服配方对于里急后重病症明显者添加木香10-12g，槟榔10-12g。
7.一种治疗急性放射性直肠炎疗的中药灌肠方法，其特征在于，以灌肠配方的中药制剂250ml，保留灌肠，用250ml盐水瓶密闭盛装灌肠液，插入一次性输液管，末端再接一次性肛管，让患者先排空大便，取左侧卧位，先排出管内气体，将涂以液体石蜡油的肛管插入肛门12-15cm，胶布固定打开调节器滴速为75滴/min，，药物灌入肠道后，膝胸卧20-30min，左右侧卧位各30-40min，平卧位30-40min，1剂/d，1个疗程7d。
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