CN104524531A - 用于治疗放射性直肠炎的中药组合物及制备方法 - Google Patents

用于治疗放射性直肠炎的中药组合物及制备方法 Download PDF

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CN104524531A
CN104524531A CN201510015614.1A CN201510015614A CN104524531A CN 104524531 A CN104524531 A CN 104524531A CN 201510015614 A CN201510015614 A CN 201510015614A CN 104524531 A CN104524531 A CN 104524531A
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蒋方国
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Abstract

本发明提供一种见效快、效果好、无毒副作用的用于治疗放射性直肠炎的中药组合物及制备方法。其包括口服药和灌肠药，口服药由以下重量原料药物配比的组分组成：红升麻，当归，肉蔻，党参，白扁豆，白术，槟郎，金银花，枸杞，鳢肠，甘草，白芍，仙鹤草、盘龙七、生姜、阿胶、三七、肉桂、延胡索，黄柏，葛根，黄连，黄芩；灌肠药由以下重量原料药物配比的组分组成：马齿笕、白头翁、五倍子、秦皮、石榴皮、败酱草、生地榆、木通、藏茴香、鸢尾。

Description

用于治疗放射性直肠炎的中药组合物及制备方法
技术领域
    本发明涉及中药技术领域，具体涉及一种用于治疗放射性直肠炎的中药组合物及制备方法。
背景技术
放射性直肠炎是妇科恶性肿瘤男性前l列腺i恶性肿瘤放射治疗的主要并发症。文献报道宫颈癌体外照射结合腔内高剂量率放射治疗时，中、重度放射性直肠炎的发生率约为5.3～15.6%〔1-3〕。放射性直肠炎也是盆腔放射治疗的常见并发症。它是一种自愈性疾病。如治疗和护理及时、得当，可缩短其病程，减轻患者的痛苦和经济负担，提高其生存质量。 发病原因：妇女宫颈癌、外阴与阴道癌及肛管直肠癌，应用放射性镭、钴、铯等进行照射治疗，这些放射性原素对癌有抑制作用，对正常组织也有损害，损害直肠粘膜时，可造成放射性直肠炎。所以因放射治疗造成的放射性直肠炎，是临床上较多见的。目前国内主要采用激素和对症疗法，来缓解症状，效果不好。
发明内容
    本发明目的是提供一种见效快、效果好、无毒副作用的用于治疗放射性直肠炎的中药组合物及制备方法。
为了实现上述目的，本发明采用以下技术方案：
一种用于治疗放射性直肠炎的中药组合物，包括口服药和灌肠药，口服药由以下重量原料药物配比的组分组成：红升麻10～15g，当归6～8g，肉蔻5～6g，党参6～8g，白扁豆10～15g，白术6～8g，槟郎3～6g，金银花20～30g，枸杞12～15g，鳢肠10～12g，甘草4～6g，白芍10～15g，仙鹤草15～30g，盘龙七15～20g，生姜5～10g，阿胶5～10g，三七6～8g，肉桂5-8g，延胡索9～12 g，黄柏15～20g，葛根10～15g，黄连8～10克，黄芩8～10克；灌肠药由以下重量原料药物配比的组分组成：马齿笕15～20g、白头翁20～30g、五倍子15～20g、秦皮15～18g、石榴皮10～15g、败酱草10～15g、生地榆18～25g、木通3～6g，藏茴香5～15g、鸢尾1.5～3g。
一种用于治疗放射性直肠炎的中药组合物的制备方法，包括以下步骤1）口服药制备：按照口服药的原料药物配比称取除了三七及阿胶的原料药，置于砂锅内，加入水800ml浸过原料药，浸泡60分钟，小火煎熬30分钟，过滤取药汁；再加入水600ml，小火煎熬20分钟，过滤取药汁；三七及阿胶研磨成细末，然后和两次药汁混合即可；2）灌肠药制备：按照灌肠药的原料药物配比称取原料药，每剂药加水后煎2次，共浓缩至药液200毫升。
口服药服用方法：早晚两次温服；灌肠药用法：药液温度掌握在36～40℃，将其置于输液瓶中，连接输液管，末端接无菌导尿管并涂液体石蜡，导尿管插入肛门内30厘米左右，灌肠时间控制在30分钟为宜，灌肠后卧床休息2～3小时，每晚保留灌肠1次。
本发明口服药，各个中药的功效如下：
红升麻，味辛、苦，性温。活血止痛、祛风除湿、强筋健骨，解毒。
当归，味温甘辛。补血活血，调经止痛，润肠通便。
肉蔻，温中涩肠；行气消食。用于虚泻；冷痢；脘腹胀痛；食少呕吐；宿食不消。
党参，有补中益气、止渴、健脾益肺，养血生津。
白扁豆，归脾经、胃经。健脾，化湿，消暑。
白术，味苦、甘，性温。归脾，胃经。健脾益气，健胃，燥湿利尿，化痰，止汗，安胎，增食欲。
槟榔，有祛痰止咳、消食醒酒、宽胸止吐、驱虫等作用。
金银花，清热解毒，疏散风热。主治痈肿疔毒初起，红肿热痛，外感风热，温病初起，热毒血痢，暑热烦渴，咽喉肿痛。
枸杞，治肝肾阴亏，益精明目。用于虚劳精亏，腰膝酸痛，眩晕耳鸣，阳痿遗精，内热消渴，血虚萎黄，目昏不明。
鳢肠，滋养收敛之药，有收敛止血排脓之功，可治各种吐血、肠出血等症。
甘草，性平、味甘，归十二经。补脾益气，清热解毒，缓急止痛，调和诸药。
白芍，性凉，味苦酸，具有补血柔肝、缓中止痛、敛阴收汗等功效，适用于阴虚发热、月经不调、胸腹胁肋疼痛、泻痢腹痛、自汗盗汗、崩漏、带下等症。
仙鹤草，收敛止血，止痢，杀虫。广泛用于各种出血之证，例如：吐血、尿血、便血、崩漏、咯血、衄血，赤白痢疾，劳伤脱力，痈肿，跌打，创伤出血等证。
盘龙七，味涩微苦，性平。入肺、脾、肝、膀胱经，补脾健胃，收涩固肠，除湿利水，活血。
生姜，味辛、性微温，归肺、脾、胃经。 发汗解表，温中止呕，温肺止咳，解鱼蟹毒，解药毒。
三七，味甘、微苦，性温。归肝经、胃经、心经、肺经、大肠经。止血、散血，定痛。
阿胶，补血止血、滋润燥之良药，应用于血虚萎黄、眩晕心悸、肌痿无力、心烦失眠、虚风内动、肺燥咳嗽、劳咳咯血、 吐血、便血崩漏等。
肉桂，补火助阳，引火归源，散寒止疼，活血通经。
黄柏，清热燥湿，泻火除蒸，解毒疗疮。用于：湿热泻痢，黄疸，带下，热淋，脚气，骨蒸劳热，盗汗，遗精，疮疡肿毒，湿疹瘙痒。
葛根，有解肌退热，透疹，生津止渴，升阳止泻之功。
延胡索，味苦、辛，性温；归肝、心、胃经；善行走散，可升可降，具有活血散瘀，行气止痛的功效。主治胸痹心痛，胁肋、脘腹诸痛，头痛、腰痛、疝气痛、筋骨痛、痛经、经闭，产后瘀腹痛，跌打损伤。
黄连，有清热燥湿，泻火解毒之功效。
黄芩，有清热燥湿、泻火解毒、止血、安胎等功效。主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、高血压、痈肿疖疮等症。
本发明灌肠药，各个中药的功效如下：
马齿苋，有清热利湿、解毒消肿、消炎、止渴、利尿作用。
白头翁，具有清热解毒，凉血止痢，燥湿杀虫的功效。
五倍子，具有敛肺降火，涩肠止泻，敛汗，止血，收湿敛疮之功效。常用于肺虚久咳，肺热痰嗽，久泻久痢，自汗盗汗，消渴，便血痔血，外伤出血，痈肿疮毒，皮肤湿烂。
石榴皮，具有涩肠止泻，止血，驱虫之功效。常用于久泻，久痢，便血，脱肛，崩漏，带下，虫积腹痛。
生地榆，凉血止血，主治脾经湿热，痢疾下血。
木通，泻火行水。通利血脉。主治小便赤涩，淋浊，水肿，胸中烦热，喉痹咽痛，遍身拘痛，妇女经闭，乳汁不通。
藏茴香，芳香涩胃，驱风理气。治胃痛，腹痛，小肠疝气。
鸢尾，活血祛瘀，祛风利湿，解毒，消积。
临床疗效总结
一、一般资料：选择放疗放射性直肠炎患者112例，男62例，占55.36%，女性50例，占44.64%。
二、诊断标准：有腹部放射治疗史；临床表现为：便血、粘液和脱落坏死组织；直肠镜检测：肠壁充血、肿胀呈褐色，溃疡、穿孔。
三、服药方法，口服药：将两次药汁混合后分早晚两次冲三七及阿胶粉末温服；灌肠药：药液温度掌握在36～40℃，将其置于输液瓶中，连接输液管，末端接无菌导尿管并涂液体石蜡，导尿管插入肛门内30厘米左右，灌肠时间控制在30分钟为宜，灌肠后卧床休息2～3小时，每晚保留灌肠1次。
四、疗效判定标准：治愈：临床症状消失；好转：临床症状改善，患者腹痛、便血、腹泻好转；未愈：临床症状无改善。
五、治疗效果：
六、典型病例：
1、孙**,女，72，宫颈癌术后1个月，放射治疗25天，便血带着粘液一个星期，直肠镜检测：肠壁充血、肿胀呈褐色。患者服用本发明口服药并配合灌肠药7付后无便血，继续服用口服药10付并配合灌肠药10付，临床症状完全消失。
2、李**,男，68，直肠癌术后放射治1个半月，经结肠镜检测，诊断为放射性直肠炎，输液治疗半个月，临床症状改善，但是腹痛，大便带着粘液，滞下不畅，患者服用本发明口服药并配合灌肠药15付后无便血后、临床症状完全消失。随访3个月，无复发。
3、姜**,女，55，宫颈癌术后放射治2个周，出现便血、腹痛、腹泻、全身乏力症状，服用止血药及消炎药，病情反复，患者服用本发明口服药并配合灌肠药12付、临床症状完全消失。随访6个月，无复发。
本发明的有益效果：本发明的口服药符合中医药理论，诸药合用形成了解毒清热，去腐生肌，凉血止血的功效，用于治疗放射性直肠炎所致的腹痛、腹泻、血便等症，又能调节人体生理机能，达到标本兼治的目的。药物无副作用小，疗效好；本发明灌肠药，以清热解毒及凉血止血药为主；口服药及灌肠药配合扶正祛邪，口服药主要是健脾益肾、涩肠止泻，主要扶正之用。灌肠药主要是清热解毒、清利湿热、活血祛瘀、行气活血，主要祛邪之用。
具体实施方式
 下面结合具体实施例对本发明做进一步详细说明，下述说明仅是示例性的，不限定本发明的保护范围。
实施例1
一种用于治疗放射性直肠炎的中药组合物，包括口服药和灌肠药，口服药由以下重量原料药物配比的组分组成：红升麻10g，当归7g，肉蔻5g，党参7.5g，白扁豆15g，白术7.5g，槟郎5g，金银花20g，枸杞13g，鳢肠10g，甘草6g，白芍12g，仙鹤草15g、盘龙七15g、生姜10g、阿胶10g、三七6g、肉桂8g、延胡索9g，黄柏18g，葛根10g，黄连9克，黄芩9克；灌肠药由以下重量原料药物配比的组分组成：马齿笕18g、白头翁20g、五倍子18g、秦皮18g、石榴皮15g、败酱草15g、生地榆18g、木通5g，藏茴香5g，鸢尾2g。
配制及服用方法：
上述的用于治疗放射性直肠炎的中药组合物的制备方法，包括以下步骤1）口服药制备：按照口服药的原料药物配比称取除了三七及阿胶的原料药，置于砂锅内，加入水800ml浸过原料药，浸泡60分钟，小火煎熬30分钟，过滤取药汁；再加入水600ml，小火煎熬20分钟，过滤取药汁；三七及阿胶研磨成细末，然后和两次药汁混合即可；2）灌肠药制备：按照灌肠药的原料药物配比称取原料药，每剂药加水后煎2次，共浓缩至药液200毫升。
服用方法：口服药：将两次药汁混合后分早晚两次冲三七及阿胶粉末温服；灌肠药：药液温度掌握在36～40℃，将其置于输液瓶中，连接输液管，末端接无菌导尿管并涂液体石蜡，导尿管插入肛门内30厘米左右，灌肠时间控制在30分钟为宜，灌肠后卧床休息2～3小时，每晚保留灌肠1次。
实施例2
一种用于治疗放射性直肠炎的中药组合物，包括口服药和灌肠药，口服药由以下重量原料药物配比的组分组成：红升麻15g，当归6g，肉蔻5.5g，党参8g，白扁豆12g，白术6g，槟郎6g，金银花30g，枸杞15g，鳢肠12g，甘草5g，白芍10g，仙鹤草30g、盘龙七20g、生姜8g、阿胶8g、三七8g、肉桂5g、延胡索12 g，黄柏20g，葛根12g，黄连10克，黄芩10克；灌肠药由以下重量原料药物配比的组分组成：马齿笕15、白头翁30g、五倍子20g、秦皮15g、石榴皮10g、败酱草10g、生地榆25g、木通6g，藏茴香15g，鸢尾3g。
配制及服用方法同实施例1。
实施例3
一种用于治疗放射性直肠炎的中药组合物，包括口服药和灌肠药，口服药由以下重量原料药物配比的组分组成：红升麻12g，当归8g，肉蔻6g，党参6g，白扁豆10g，白术8g，槟郎3g，金银花25g，枸杞12g，鳢肠11g，甘草4g，白芍15g，仙鹤草25g、盘龙七18g、生姜5g、阿胶5g、三七7g、肉桂7g、延胡索10g，黄柏15g，葛根15g，黄连8克，黄芩8克；灌肠药由以下重量原料药物配比的组分组成：马齿笕20g、白头翁25g、五倍子15g、秦皮16g、石榴皮12g、败酱草12g、生地榆20g、木通3g，藏茴香10g，鸢尾1.5g。
配制及服用方法同实施例1。
虽然本发明已作出了详细说明并引证了一些具体实施例，但是对本领域人员来说，只要不离开本发明的精神和范围可以做各种改进是显而易见的。

Claims (2)

1.一种用于治疗放射性直肠炎的中药组合物，其特征在于：包括口服药和灌肠药，口服药由以下重量原料药物配比的组分组成：红升麻10～15g，当归6～8g，肉蔻5～6g，党参6～8g，白扁豆10～15g，白术6～8g，槟郎3～6g，金银花20～30g，枸杞12～15g，鳢肠10～12g，甘草4～6g，白芍10～15g，仙鹤草15～30g、盘龙七15～20g、生姜5～10g、阿胶5～10g、三七6～8g、肉桂5-8g、延胡索9～12 g，黄柏15～20g，葛根10～15g，黄连8～10克，黄芩8～10克；灌肠药由以下重量原料药物配比的组分组成：马齿笕15～20g、白头翁20～30g、五倍子15～20g、秦皮15～18g、石榴皮10～15g、败酱草10～15g、生地榆18～25g、木通3～6g，藏茴香5～15g，鸢尾1.5～3g。
2.一种权利要求1所述的用于治疗放射性直肠炎的中药组合物的制备方法，其特征在于包括以下步骤1）口服药制备：按照口服药的原料药物配比称取除了三七及阿胶的原料药，置于砂锅内，加入水800ml浸过原料药，浸泡60分钟，小火煎熬30分钟，过滤取药汁；再加入水600ml，小火煎熬20分钟，过滤取药汁；三七及阿胶研磨成细末，然后和两次药汁混合即可；2）灌肠药制备：按照灌肠药的原料药物配比称取原料药，每剂药加水后煎2次，共浓缩至药液200毫升。
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CN105561036A (zh) * 2016-01-19 2016-05-11 柳燕 一种治疗急性放射性直肠炎疗的中药配方及灌肠方法

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Application publication date: 20150422