CN1965904A - Application of Chinese medicine lilac flower as in-vitro spermaticide and method for preparing the medicament thereof - Google Patents
Application of Chinese medicine lilac flower as in-vitro spermaticide and method for preparing the medicament thereof Download PDFInfo
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- CN1965904A CN1965904A CN 200610069561 CN200610069561A CN1965904A CN 1965904 A CN1965904 A CN 1965904A CN 200610069561 CN200610069561 CN 200610069561 CN 200610069561 A CN200610069561 A CN 200610069561A CN 1965904 A CN1965904 A CN 1965904A
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- flos caryophylli
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Abstract
The invention relates to a method for using cloves to kill sperm externally, wherein it uses cloves as the drug to kill sperm externally, makes extractive into emulsion or suppositorium, to be used in vagina contraceptive. And its production comprises that: breaking cloves, immerges in 0.9% normal saline, while their ration is 100g: 900-1200ml, to be heated in 100Deg. C metal bath; taking out, filtering out the slag. The inventive cloves extractive has non stimulation on vaginal mucosa, without damage on vaginal bacterial and side effect. And it has low cost.
Description
Technical field
The present invention relates to Chinese medicine, be a kind of Chinese medicine Flos Caryophylli as the application of killing sperms in vitro medicine and prepare the method for medicine.
Background technology
In contraceptives, intrauterine device, Unterbindung des Eileiter and vasoligation, the capital damages human body, and for this reason, people adopt condom or oral contraceptive, it is minimum in the hope of injury is reduced to, but long-term oral contraceptive will produce bigger side effect to human body, and the use of condom is except that sense organ is relatively poor, still there is the probability of necessarily becoming pregnant, so this area is in recent years again at the medicine of making great efforts the research killing sperms in vitro.The medicine of killing sperms in vitro uses imported medicine the earliest, the back is domestic to have more kind to go on the market again, because the Main Ingredients and Appearance of medicine all is Western medicine, in use find, these medicines have irritation to vaginal mucosa, and after absorption of human body, easily liver are produced infringement, so for a long time, the medicine of these killing sperms in vitro is not the first-selected measure of contraception.At this situation, the spermicide thing of Chinese medicine composition has more report, still, because the uncertainty of its toxic and side effects, and kill the smart more reasons such as lower of rendeing a service, still can not be extensive use of so far.Some chemical compound spermicide report, but because multiple actions such as these contraceptive have sterilization, kill the virus, spermicide are applicable to sexually transmitted disease (STD), acquired immune deficiency syndrome (AIDS) prone areas, so still have toxic and side effects for the contraceptives of killing smart purposes merely.
Summary of the invention
The objective of the invention is, providing a kind of adopts single raw material of Chinese medicine Flos Caryophylli as the application of killing sperms in vitro medicine and prepare the method for medicine, make Flos Caryophylli that significantly effect be arranged in the application of killing sperms in vitro preferably, can be used as a kind of nontoxicly, non-stimulated to human vagina's mucosa, life-time service does not produce the medicine of any injury to human body.
The present invention is achieved through the following technical solutions for achieving the above object: draw on the basis of research and experiment: the Chinese medicine Flos Caryophylli is as the medicinal application of killing sperms in vitro.
Described Chinese medicine Flos Caryophylli is as the application of killing sperms in vitro medicine, and its Chinese medicine Flos Caryophylli is made Emulsion or suppository as the medicine material of killing sperms in vitro with its extracting solution, is used for the vaginal contraception medicine.
Described Chinese medicine Flos Caryophylli as the preparation method of killing sperms in vitro medicine is: the raw material of Chinese medicine Flos Caryophylli is ground, be placed in 0.9% the normal saline and soaked 1.5-2.5 hour, the ratio of Flos Caryophylli raw material and normal saline is 100 grams: the 900-1200 milliliter, be placed in 100 ℃ the metal bath heating 15-40 minute, the taking-up after-filtration removes slag and obtains the Flos Caryophylli extracting solution, the Flos Caryophylli extracting solution is made Emulsion or suppository, be used for the killing in vitro sperm.
Described Chinese medicine Flos Caryophylli is as the preparation method of killing sperms in vitro medicine, and the ratio of its Flos Caryophylli raw material and normal saline is 100 grams: 1000 milliliters.
Raw material of Chinese medicine Flos Caryophylli of the present invention is the alabastrum of golden ma section aiphyllium plant, and its fruit is a Fructus Caryophylli, nature and flavor suffering, temperature.The traditional Chinese medical science thinks that it has warming middle-JIAO to send down the adverse QI, the effect of warming the kidney to activate YANG.Studies show that Flos Caryophylli contains volatile oil, main component of essential oil is eugenol, acetyleugenol etc.Flos Caryophylli is an aromatic stomachic, the tradition traditional Chinese medical science is used to alleviate abdominal bloating, increase gastric secretion, strengthen digestion power, alleviate nausea and vomiting, the water decoction of Flos Caryophylli has inhibitory action to multiple pathogenic fungus, bacillus, influenza virus, staphylococcus, streptococcus, escherichia coli, Bacillus typhi, bacillus pyocyaneus etc., and is used for anthelmintic with Chinese prescription, is good for the stomach, convulsion, brings high blood pressure down, suppresses diseases such as breathing.Modern Chinese medicine research is thought and singultus person occurred after the treatments such as being applicable to digestive tract tumor and various tumor operation, chemotherapy.Retrieval before the present invention's research is used for spermicide never is useful on the report of killing sperms in vitro.
The present invention's experiment shows: the Flos Caryophylli extracting solution is mixed by 1: 1 with seminal fluid, sperm is all killed in second at 8-12, make sperm lose mobility, with Flos Caryophylli extracting solution and seminal fluid by 1: 2-5 mixes, and can all kill the mobility of adult rats sperm in one minute.Further experiment shows: the Flos Caryophylli extracting solution is non-stimulated to vaginal mucosa, the calcination phenomenon, and vaginal microbial flora there is not destruction, it is without any side effects to human internal organ to be absorbed by the body by vaginal mucosa, but life-time service, and have advantage easy to use, for family planning provides a kind of nontoxic, cheap, easy to use, contraceptive effect system of selection in the know reliably.
The specific embodiment
Chinese medicine Flos Caryophylli of the present invention is as the medicinal application of killing sperms in vitro, and its Chinese medicine Flos Caryophylli is made Emulsion or suppository as the medicine material of killing sperms in vitro with its extracting solution, is used for the vaginal contraception medicine.Employed excipient and consumption all are conventional pharmaceutical excipient and consumptions in Emulsion and the suppository.
Described Chinese medicine Flos Caryophylli as the preparation method of the medicine of killing sperms in vitro is: the raw material of Chinese medicine Flos Caryophylli is ground, be placed in 0.9% the normal saline and soaked 1.5-2.5 hour, preferred 2 hours, the ratio of Flos Caryophylli raw material and normal saline is 100 grams: the 900-1200 milliliter, preferred 100 grams: 1000 milliliters, be placed in 100 ℃ the metal bath heating 15-40 minute, preferred 30 minutes, the taking-up after-filtration removes slag and obtains the Flos Caryophylli extracting solution, Flos Caryophylli extracting solution and conventional pharmaceutical excipient and conventional pharmaceutical excipient consumption are made Emulsion or suppository, be used for the killing in vitro sperm.
Claims (4)
1, the Chinese medicine Flos Caryophylli is as the medicinal application of killing sperms in vitro.
2, Chinese medicine Flos Caryophylli according to claim 1 is characterized in that as the application of killing sperms in vitro medicine: the Chinese medicine Flos Caryophylli is made Emulsion or suppository as the medicine material of killing sperms in vitro with its extracting solution, is used for the vaginal contraception medicine.
3, the Chinese medicine Flos Caryophylli is as the preparation method of killing sperms in vitro medicine, it is characterized in that: the raw material of Chinese medicine Flos Caryophylli is ground, be placed in 0.9% the normal saline and soaked 1.5-2.5 hour, the ratio of Flos Caryophylli raw material and normal saline is 100 grams: the 900-1200 milliliter, be placed in 100 ℃ the metal bath heating 15-40 minute, the taking-up after-filtration removes slag and obtains the Flos Caryophylli extracting solution, and the Flos Caryophylli extracting solution is made Emulsion or suppository, is used for the killing in vitro sperm.
4, Chinese medicine Flos Caryophylli according to claim 3 is characterized in that as the preparation method of killing sperms in vitro medicine: the ratio of Flos Caryophylli raw material and normal saline is 100 grams: 1000 milliliters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610069561 CN1965904A (en) | 2006-11-01 | 2006-11-01 | Application of Chinese medicine lilac flower as in-vitro spermaticide and method for preparing the medicament thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610069561 CN1965904A (en) | 2006-11-01 | 2006-11-01 | Application of Chinese medicine lilac flower as in-vitro spermaticide and method for preparing the medicament thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1965904A true CN1965904A (en) | 2007-05-23 |
Family
ID=38074997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610069561 Pending CN1965904A (en) | 2006-11-01 | 2006-11-01 | Application of Chinese medicine lilac flower as in-vitro spermaticide and method for preparing the medicament thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1965904A (en) |
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2006
- 2006-11-01 CN CN 200610069561 patent/CN1965904A/en active Pending
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| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |