CN106860519A - Herbal mixture sweet osmanthus oral spray - Google Patents
Herbal mixture sweet osmanthus oral spray Download PDFInfo
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- CN106860519A CN106860519A CN201510905917.0A CN201510905917A CN106860519A CN 106860519 A CN106860519 A CN 106860519A CN 201510905917 A CN201510905917 A CN 201510905917A CN 106860519 A CN106860519 A CN 106860519A
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- sweet osmanthus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of herbal mixture oral spray, it is related to one kind to carry out oral health, the herbal mixture sweet osmanthus oral spray of anti-inflammation belongs to field of health care products.It is prepared from by following active constituent：Each component weight portion meter, sweet osmanthus 30-100, leaf of Moringa 25-50.Compared to formulations such as tablet, lozenge, granule, tea bag, cream relatively at present on the market with clearing as healthcare function, the present invention is oral spray, it is convenient with method of administration, drug absorption is rapid-action soon, the features such as drug bioavailability is high, can also reduce side effect of the medicine to intestines and stomach, it is easy to carry, use simple and fast.Can either be inhibited for bacterium common in oral cavity, protection throat, the effect of fresh breath, with multi-efficiencies such as health care, prophylactic treatment oral cavity FAQs can be played again.It is particularly well-suited to treatment abscess of throat and prevention upper respiratory tract infection.
Description
Technical field
Oral health, the herbal mixture sweet osmanthus oral cavity of anti-inflammation can be carried out the present invention relates to oral spray, more particularly to one kind
Spray, belongs to field of health care products.
Background technology
As the saying goes " illness finds its way in by the mouth ", human oral cavity chews the residual of food because of breathing and mouth, permitted as streptococcus, staphylococcus etc.
The hotbed of many bacterial reproductions, it is easy to cause such as canker sore, carious tooth, sphagitis and the various diseases of the infection of the upper respiratory tract, sternly
Ghost image rings the healthy of people.Particularly now, people live in for a long time fast pace, spiritual high-pressure, operating pressure compared with
Under big environment, it is easy to cause to worry beyond measure, heart is impatient, unbalance, taste are caused to lack of proper care, lung stomach heat symptom-complex occur.This person
Group is annual to have the long period in various degree with diseases such as halitosis, ulcer, dry throat, toothache.And halitosis not only brings the discomfort of itself
Also bring the inconvenient and pain of social activity, some occupations that young crowd, high-end commercial crowd, needs are linked up face-to-face such as in love
Colony etc..So as modern people's doings increase, more paying attention to oral cavity halitosis, oral hygiene turns into prevention and treatment
The important door of disease.The formulations such as current tablet, lozenge, granule, tea bag on the market with clearing as healthcare function are more
Common, oral spray formulation is more rare.Oral spray formulation can make medicine directly and efficiently contact the upper respiratory tract, medicine
It is good with effect, and with easy to carry, it is deep to receive patient and consumers welcomed the advantages of take simple and fast, in existing compound
Medicine spray is more for fresh breath, anti-halitosis health products, such as Chinese patent 2009101190830 reports a kind of " fresh
Jujube is removed smells oral spray and preparation method thereof ", 991044614 report " compound oral sacandra glabra spray agent ", composition list
One does not have antimicrobial therapy effect.And have the herbal mixture spray complicated component of bactericidal effect concurrently, it is more than mostly 4 kinds compositions, and
Preparation method is numerous and diverse, is unfavorable for industrialized production.Existing market be badly in need of exploitation have inhibiting bacteria and diminishing inflammation, have to oral cavity health-care effect and
Simple, the practical herbal mixture spray of prescription.
The content of the invention
For existing market situation, present invention aim at provide a kind of prescription it is simple, with anti-inflammation, and to oral cavity,
The illnesss such as throat have the herbal mixture sweet osmanthus oral spray of auxiliary therapeutic action.
To realize the object of the invention, technical scheme is as follows：
Herbal mixture sweet osmanthus oral spray of the present invention is prepared from by following composition with weight portion：
Sweet osmanthus 30-100, leaf of Moringa 25-50；It is preferred that：Sweet osmanthus 50-100, leaf of Moringa 30-50；More preferably：Sweet osmanthus 50-60,
Leaf of Moringa 40-50.
Its preparation technology：
Sweet osmanthus, leaf of Moringa are weighed, is added water, steam distillation collects aqua aromatica standby；By sweet osmanthus, the dregs of a decoction mistake of leaf of Moringa
Filtrate is filtered to obtain, filtrate is concentrated to give medicinal extract；Medicinal extract is diluted with the aqua aromatica of above-mentioned collection, liquid is obtained, tween is added, filtered,
The 0.5-1 times of distilled water diluting of liquid is added, sterilizing is distributed into bottle.
Described herbal mixture sweet osmanthus spray cures mainly the diseases such as canker sore, halitosis, dryness of the mouth and throat, toothache caused by lung, stomach energy
Disease.
The principle of the invention is：Sweet osmanthus fragrance is soft, enters lung channel, taste warp, with resolving sputum, dissipates the stasis of blood.Control phlegm and retained fluid and ridicule and cough, intestines
Wind bloody flux, hernia lump in the abdomen, toothache, halitosis effect.Leaf of Moringa is natural green food, containing several mineral materials, vitamin, 20 kinds
Amino acid, 46 kinds of antioxygen elements and 36 kinds of naturally anti-scorching bodies and mineral matter, it may replace B B-complex, calcium tablet, cod-liver oil etc..
For canker sore, it is a kind of common disease in oral keritonocytes, the incidence of disease in crowd can more than 20%, and
Recurrent oral ulceration is the disease of most commonly seen in oral keritonocytes and refractory reason.Current study show that, canker sore is main
Pathogenesis is relevant with bacterium infection, microelement deficiencies and immune factor etc..The abundant nutriment of leaf of Moringa can be well
Supplement human nutrition is not enough, is conducive to the treatment of canker sore.More importantly leaf of Moringa contains alkaloid, saponin and Moringa tree element,
Moringa tree element has antibacterial action to various pathogens.Leaf of Moringa also has various anti-inflammatory compounds, to dry, without saliva, throat
Pain has special efficacy, with the effect of promoting the production of body fluid.
Advantage of the present invention：1st, this prescription is simple, is acted on by sweet osmanthus, enters lung stomach, old complaint of going directly, and is conducive to halitosis symptom
Treatment；Along with the nutriment that Moringa enriches, collaboration supplement causes the nutriment that human body lacks outstanding because long-term taste are become estranged
Its B B-complex, iron, amino acid, mineral matter etc., so that oral cavity, throat disorders are not only had therapeutic action by inhibiting bacteria and diminishing inflammation,
Also have health-care effect concurrently.
2nd, prescription safety of the present invention, without antibiotic and ethanol, will not cause the generation of the bacterial drug resistance that antibiotic causes, and
And be equally applicable for alcohol or alcohol sensible crowd.And sweet osmanthus, leaf of Moringa are integration of drinking and medicinal herbs books on Chinese herbal medicine, thus as health care
Prevention routine use, without worrying its toxic side effect.
3rd, using traditional handicraft, the optimal property of medicine of Chinese medicine is retained to the full extent.Verified through clinical application for many years, it is evident in efficacy,
Mild in medicine property is closed, and is had no toxic side effect, and is the effective Chinese medicine for treating oral inflammation, efficient 100%, cure rate 98%.
4th, leaf of Moringa is rich in antioxidant, is both the effect that main composition also acts as natural antiseptic agent, without adding anti-corrosion again
Agent, favourable health, is longer than common oral spray at present at 24 months shelf-lifves.
5th, the formulations such as current tablet, lozenge, granule, tea bag, cream on the market with clearing as healthcare function are compared to,
The present invention is oral spray, convenient with method of administration, and drug absorption is rapid-action soon, the features such as drug bioavailability is high,
Can also reduce side effect of the medicine to intestines and stomach, it is easy to carry, use simple and fast.Can either be for bacterium common in oral cavity
It is inhibited, protection throat, the effect of fresh breath, with health care, prophylactic treatment oral cavity FAQs can be played again
Deng multi-efficiency.Treatment canker sore, abscess of throat and prevention upper respiratory tract infection are particularly well-suited to, with very good
Practical reference value.
Every bottle of 30-40ml, is sprayed directly on to oral cavity and throat affected part when using, three times a day, each 1-2 times.
Brief description of the drawings
Fig. 1 compound sweet osmanthus sprays of the present invention are to hay bacillus antibacterial ring size photo；
Fig. 2 compound sweet osmanthus sprays of the present invention are to staphylococcus aureus antibacterial ring size photo.
Fig. 3 compound sweet osmanthus sprays of the present invention are to Escherichia coli antibacterial ring size photo；
Fig. 4 compound sweet osmanthus sprays of the present invention are to Candida albicans antibacterial ring size photo；
Fig. 5 compound sweet osmanthus sprays of the present invention are to Pseudomonas aeruginosa antibacterial ring size photo.
Specific embodiment
It is that the present invention is better described, it is as follows for embodiment：
Embodiment 1
Weigh 30 grams of sweet osmanthus, 50 grams of leaf of Moringa；Add water 1000ml, steam distillation, collects aqua aromatica standby；By sweet osmanthus,
The dregs of a decoction of leaf of Moringa filter to get filtrate, and filtrate is concentrated to give medicinal extract；Medicinal extract is diluted with the aqua aromatica of above-mentioned collection, liquid is obtained, then add
Enter tween, filter, add the 0.5-1 times of distilled water diluting of liquid, sterilizing is distributed into every bottle of 30-40ml/.
Embodiment 2
Weigh 60 grams of sweet osmanthus, 50 grams of leaf of Moringa；Add water 1000ml, steam distillation, collects aqua aromatica standby；By sweet osmanthus,
The dregs of a decoction of leaf of Moringa filter to get filtrate, and filtrate is concentrated to give medicinal extract；Medicinal extract is diluted with the aqua aromatica of above-mentioned collection, liquid is obtained, then add
Enter tween, filter, add the 0.5-1 times of distilled water diluting of liquid, sterilizing is distributed into every bottle of 30-40ml/.
Embodiment 3
Weigh 100 grams of sweet osmanthus, 30 grams of leaf of Moringa；Add water 1000ml, steam distillation, collects aqua aromatica standby；By sweet osmanthus,
The dregs of a decoction of leaf of Moringa filter to get filtrate, and filtrate is concentrated to give medicinal extract；Medicinal extract is diluted with the aqua aromatica of above-mentioned collection, liquid is obtained, then add
Enter tween, filter, add the 0.5-1 times of distilled water diluting of liquid, sterilizing is distributed into every bottle of 30-40ml/.
Embodiment 4
Weigh 50 grams of sweet osmanthus, 25 grams of leaf of Moringa；Add water 1000ml, steam distillation, collects aqua aromatica standby；By sweet osmanthus,
The dregs of a decoction of leaf of Moringa filter to get filtrate, and filtrate is concentrated to give medicinal extract；Medicinal extract is diluted with the aqua aromatica of above-mentioned collection, liquid is obtained, then add
Enter tween, filter, add the 0.5-1 times of distilled water diluting of liquid, sterilizing is distributed into every bottle of 30-40ml/.
Above-mentioned compound oral spray is put into glassware, is sealed, after placing 24 months, do not see precipitation, uniformity, surely
It is qualitative good, do not occur going mouldy, peculiar smell phenomenon.
The fungistatic effect of embodiment 5 is tested
Compound oral spray obtained in the embodiment of the present invention is carried out into fungistatic effect experiment, following strain is purchased from Henan Province's medicine
Inspection institute, hay bacillus (CMCC (B) 44102, date 2013-05-15), Candida albicans (CMCC (F) 9800, date
2013-05-03), pseudomonas aeruginosa (CMCC (B) 44102, date 2013-05-15), staphylococcus aureus
(CMCC (B) 26003, date 2013-5-2), Escherichia coli (bacterium CMCC (B) 44102, date：2014-6-2).Adopt
Tested with agar diffusion method, AGP test experimental result is：The antibacterial ring size average value of hay bacillus：9.82mm, it is golden yellow
Staphylococcic antibacterial ring size average value：9.10mm, Escherichia coli antibacterial ring size average value 8.10mm, Pseudomonas aeruginosa antibacterial ring size average value
7.80mm, Candida albicans antibacterial ring size 8.05mm, specify, antibacterial circle diameter according in the sterile products technical manual of Department of Public Health
>=7mm, you can be considered as with fungistatic effect.Its bacteriostatic experiment effect photo is shown in accompanying drawing 1-5：Four filled circles around in accompanying drawing 1
Ring is four batches of filter paper containing medicament of the present invention, it can be seen that grown without hay bacillus in antibacterial ring size around it, and central circular is sky
White control；Four solid circles are four batches of filter paper containing medicament of the present invention around in accompanying drawing 2, it can be seen that antibacterial ring size around it
It is interior without staphylococcus aureus growth, central circular is blank.Accompanying drawing 3-5 is same.
Conclusion：Experiment shows that the invention has good antibacterial effect to gram-positive bacteria staphylococcus aureus and hay bacillus
Really, it is also effective to Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa and fungi Candida albicans.It is main for oral cavity position
If based on gram-positive bacteria, Gram-negative bacteria is predominantly located at internal viscera, and the formulation meets treatment oral condition effect
Position requires.
The clinical applicability of embodiment 6 is tested
Wang, 38 years old, female, abscess of throat tried out spray of the present invention, and three times per day, pharynx once, after spray is felt in spray every time
Throat position is refrigerant pleasant, and throat discomfort sense mitigates, and abscess of throat symptom disappears after four days, does not recur.
Marquis, 50 years old, female, taste moisture is deep on ordinary days, halitosis, and oral cavity outlet is not good, is talked with other people less, tries out this spray
After mist agent two days, oral cavity refreshing, halitosis symptom disappears, and does not recur.
Lee, 35 years old, man, the infection of the upper respiratory tract tried out spray of the present invention, three times per day, sprays secondary every time, feels after spray
Refrigerant pleasant to throat, throat discomfort sense mitigates, and symptom is gradually delayed after three days, and symptom disappears after five days, does not recur.
Chen, 65 years old, man, canker sore, the area soya bean of ulcer was differed in size, and ulcer surface is depression, and pain is obvious,
Loss of appetite, tries out spray of the present invention, three times per day, sprays secondary every time, sense is ached after spray and is mitigated, and appetite increases after one day,
Ulcer surface healing, does not recur after six days.
Zhang, 40 years old, female, toothache, halitosis, oral cavity outlet was not good, tried out this spray after two days, and toothache symptom disappears,
Oral cavity refreshing, halitosis symptom disappears, and does not recur.
Compound spray of the present invention is administered with spray form, allows medicament to directly and efficiently contact the upper respiratory tract, oral cavity, medicinal
Effect is good, rapid healing illness, does not recur, and patient and consumer demand are met well.
Claims (4)
1. a kind of herbal mixture sweet osmanthus spray, it is characterised in that be prepared from weight portion by the following raw material medicine：
Sweet osmanthus 30-100, leaf of Moringa 25-50；Preparation method：Sweet osmanthus, leaf of Moringa are weighed, is added water, steam distillation is received
Collection aqua aromatica is standby；The dregs of a decoction of sweet osmanthus, leaf of Moringa are filtered to get filtrate, filtrate is concentrated to give medicinal extract；With the aqua aromatica of above-mentioned collection
Dilution medicinal extract, obtains liquid, adds tween, filters, and adds the 0.5-1 times of distilled water diluting of liquid, and sterilizing is distributed into
Bottle.
2. herbal mixture sweet osmanthus spray as claimed in claim 1, it is characterised in that be prepared from weight portion by the following raw material medicine：
Sweet osmanthus 50-100, leaf of Moringa 30-50.
3. herbal mixture sweet osmanthus spray as claimed in claim 1, it is characterised in that be prepared from weight portion by the following raw material medicine：
Sweet osmanthus 50-60, leaf of Moringa 40-50.
4. herbal mixture sweet osmanthus spray as claimed in claim 1, it is characterised in that be prepared from weight portion by the following raw material medicine：
60 grams of sweet osmanthus, 50 grams of leaf of Moringa.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510905917.0A CN106860519A (en) | 2015-12-11 | 2015-12-11 | Herbal mixture sweet osmanthus oral spray |
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| CN201510905917.0A CN106860519A (en) | 2015-12-11 | 2015-12-11 | Herbal mixture sweet osmanthus oral spray |
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| CN201510905917.0A Pending CN106860519A (en) | 2015-12-11 | 2015-12-11 | Herbal mixture sweet osmanthus oral spray |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329945A (en) * | 2020-04-30 | 2020-06-26 | 云南风联科技有限公司 | Plant osmanthus fragrans fragrant oral cavity atomized liquid and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102440929A (en) * | 2011-12-27 | 2012-05-09 | 郑州大学 | Compound wild chrysanthemum spraying agent |
-
2015
- 2015-12-11 CN CN201510905917.0A patent/CN106860519A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102440929A (en) * | 2011-12-27 | 2012-05-09 | 郑州大学 | Compound wild chrysanthemum spraying agent |
Non-Patent Citations (2)
| Title |
|---|
| 盛军: "《现代辣木生物学》", 31 January 2015, 云南科技出版社 * |
| 褚洪标等: "《井冈山区域实用中草药图谱》", 31 July 2015, 第四军医大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111329945A (en) * | 2020-04-30 | 2020-06-26 | 云南风联科技有限公司 | Plant osmanthus fragrans fragrant oral cavity atomized liquid and preparation method thereof |
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Application publication date: 20170620 |