CN100560086C - Chinese medicine Radix Platycodonis is as the application of killing sperms in vitro medicine and prepare the method for medicine - Google Patents
Chinese medicine Radix Platycodonis is as the application of killing sperms in vitro medicine and prepare the method for medicine Download PDFInfo
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- CN100560086C CN100560086C CNB2006100695595A CN200610069559A CN100560086C CN 100560086 C CN100560086 C CN 100560086C CN B2006100695595 A CNB2006100695595 A CN B2006100695595A CN 200610069559 A CN200610069559 A CN 200610069559A CN 100560086 C CN100560086 C CN 100560086C
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Abstract
The invention discloses a kind of Chinese medicine Radix Platycodonis as the medicinal application of killing sperms in vitro and prepare the method for medicine, described Chinese medicine Radix Platycodonis is made Emulsion or suppository as the medicine material of killing sperms in vitro with its extracting solution, is used for the vaginal contraception medicine.The preparation method of its medicine is that raw material of Chinese medicine Radix Platycodonis is ground, be placed in 0.9% the normal saline and soak, the ratio of Radix Platycodonis raw material and normal saline is 100 grams: the 900-1200 milliliter, be placed in 100 ℃ the metal bath and heat, the taking-up after-filtration removes slag and obtains Radix Platycodonis extract liquid, Radix Platycodonis extract liquid is made Emulsion or suppository, be used for the killing in vitro sperm.The present invention's experiment shows: Radix Platycodonis extract liquid is non-stimulated to vaginal mucosa, the calcination phenomenon, and vaginal microbial flora there is not destruction, it is without any side effects to human internal organ to be absorbed by the body by vaginal mucosa, but life-time service, and have advantage easy to use, for family planning provides a kind of nontoxic, cheap, easy to use, contraceptive effect system of selection in the know reliably.
Description
Technical field
The present invention relates to Chinese medicine, be a kind of Chinese medicine Radix Platycodonis as the application of killing sperms in vitro medicine and prepare the method for medicine.
Background technology
In contraceptives, intrauterine device, Unterbindung des Eileiter and vasoligation, the capital damages human body, and for this reason, people adopt condom or oral contraceptive, it is minimum in the hope of injury is reduced to, but long-term oral contraceptive will produce bigger side effect to human body, and the use of condom is except that sense organ is relatively poor, still there is the probability of necessarily becoming pregnant, so this area is in recent years again at the medicine of making great efforts the research killing sperms in vitro.The medicine of killing sperms in vitro uses imported medicine the earliest, the back is domestic to have more kind to go on the market again, because the Main Ingredients and Appearance of medicine all is Western medicine, in use find, these medicines have irritation to vaginal mucosa, and after absorption of human body, easily liver are produced infringement, so for a long time, the medicine of these killing sperms in vitro is not the first-selected measure of contraception.At this situation, the spermicide thing of Chinese medicine composition has more report, still, because the uncertainty of its toxic and side effects, and kill the smart more reasons such as lower of rendeing a service, still can not be extensive use of so far.Some chemical compound spermicide report, but because multiple actions such as these contraceptive have sterilization, kill the virus, spermicide are applicable to sexually transmitted disease (STD), acquired immune deficiency syndrome (AIDS) prone areas, so still have toxic and side effects for the contraceptives of killing smart purposes merely.
Summary of the invention
The objective of the invention is, providing a kind of adopts single raw material of Chinese medicine Radix Platycodonis as the application of killing sperms in vitro medicine and prepare the method for medicine, make Radix Platycodonis that significantly effect be arranged in the application of killing sperms in vitro preferably, can be used as a kind of nontoxicly, non-stimulated to human vagina's mucosa, life-time service does not produce the medicine of any injury to human body.
The present invention is achieved through the following technical solutions for achieving the above object: draw on the basis of research and experiment: Chinese medicine Radix Platycodonis is as the medicinal application of killing sperms in vitro.
Described Chinese medicine Radix Platycodonis is as the application of killing sperms in vitro medicine, and its Chinese medicine Radix Platycodonis is made Emulsion or suppository as the medicine material of killing sperms in vitro with its extracting solution, is used for the vaginal contraception medicine.
Described Chinese medicine Radix Platycodonis as the preparation method of killing sperms in vitro medicine is: raw material of Chinese medicine Radix Platycodonis is ground, be placed in 0.9% the normal saline and soaked 1.5-2.5 hour, the ratio of Radix Platycodonis raw material and normal saline is 100 grams: the 900-1200 milliliter, be placed in 100 ℃ the metal bath heating 15-40 minute, the taking-up after-filtration removes slag and obtains Radix Platycodonis extract liquid, Radix Platycodonis extract liquid is made Emulsion or suppository, be used for the killing in vitro sperm.
Described Chinese medicine Radix Platycodonis is as the preparation method of killing sperms in vitro medicine, and the ratio of its Radix Platycodonis raw material and normal saline is 100 grams: 1000 milliliters.
Raw material of Chinese medicine Radix Platycodonis of the present invention is one of the most salable 40 kinds of Chinese medicine materials of China.The Shennong's Herbal record, Radix Platycodonis is flat, bitter in the mouth, suffering has the effect of preventing phlegm from forming and stopping coughing, relieving sore throat to recover voice, the smooth lung qi of a surname, removing pus and relieving carbuncle.In recent years, as the Chinese medicine of integration of edible and medicinal herbs, Radix Platycodonis at immunomodulating, antiinflammatory, eliminate the phlegm, protect the liver, the pharmacological action of aspect such as blood fat reducing caused extensive concern.At present, the more monomeric compound of research is Platycodin A C D, B, C, D, D
3, D
2With senega-saponin D, D
2
The tradition traditional Chinese medical science thinks that Radix Platycodonis has: immunoregulation effect, and antiinflammatory action, phlegm-dispelling functions, hepatoprotective effect improves the insulin resistant effect, blood fat reducing and fat-reducing, adjusting central nervous system and antioxidation and beautification function.Have not yet to see the experimentation report of relevant Radix Platycodonis killing sperms in vitro.
Further research to Radix Platycodonis is learnt, Radix Platycodonis of the present invention contains multiple kikyosaponin and polygalin, and contain derivant of Radix Platycodonis alkali, Radix Platycodonis sugar alcohol, N-acetyl-D-amino glucose, xanthone and cinnamic acid etc., further research experiment shows, kikyosaponin that contains in the Radix Platycodonis and polygalin have bigger effect for killing sperms in vitro.
The present invention's experiment shows: Radix Platycodonis extract liquid is mixed by 1: 1 with seminal fluid, sperm is all killed in second at 8-12, make sperm lose mobility, with Radix Platycodonis extract liquid and seminal fluid by 1: 2-5 mixes, and can all kill the mobility of adult rats sperm in one minute.Further experiment shows: Radix Platycodonis extract liquid is non-stimulated to vaginal mucosa, the calcination phenomenon, and vaginal microbial flora there is not destruction, it is without any side effects to human internal organ to be absorbed by the body by vaginal mucosa, but life-time service, and have advantage easy to use, for family planning provides a kind of nontoxic, cheap, easy to use, contraceptive effect system of selection in the know reliably.
The specific embodiment
Chinese medicine Radix Platycodonis of the present invention is as the medicinal application of killing sperms in vitro, and its Chinese medicine Radix Platycodonis is made Emulsion or suppository as the medicine material of killing sperms in vitro with its extracting solution, is used for the vaginal contraception medicine.Employed excipient and consumption all are conventional pharmaceutical excipient and consumptions in Emulsion and the suppository.
Described Chinese medicine Radix Platycodonis as the preparation method of the medicine of killing sperms in vitro is: raw material of Chinese medicine Radix Platycodonis is ground, be placed in 0.9% the normal saline and soaked 1.5-2.5 hour, preferred 2 hours, the ratio of Radix Platycodonis raw material and normal saline is 100 grams: the 900-1200 milliliter, preferred 100 grams: 1000 milliliters, be placed in 100 ℃ the metal bath heating 15-40 minute, preferred 30 minutes, the taking-up after-filtration removes slag and obtains Radix Platycodonis extract liquid, Radix Platycodonis extract liquid and conventional pharmaceutical excipient and conventional pharmaceutical excipient consumption are made Emulsion or suppository, be used for the killing in vitro sperm.
Claims (2)
1, Chinese medicine Radix Platycodonis is as the application of preparation killing sperms in vitro medicine.
2, Chinese medicine Radix Platycodonis according to claim 1 is as the application of preparation killing sperms in vitro medicine, it is characterized in that: Chinese medicine Radix Platycodonis is as the medicine material of killing sperms in vitro, its extracting solution is made Emulsion or suppository, be used for the vaginal contraception medicine, Radix Platycodonis extract liquid obtains as follows: raw material of Chinese medicine Radix Platycodonis is ground, be placed in 0.9% the normal saline and soaked 1.5-2.5 hour, the ratio of Radix Platycodonis raw material and normal saline is 100 grams: the 900-1200 milliliter, be placed in 100 ℃ the metal bath heating 15-40 minute, and took out after-filtration and remove slag and obtain Radix Platycodonis extract liquid.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100695595A CN100560086C (en) | 2006-11-01 | 2006-11-01 | Chinese medicine Radix Platycodonis is as the application of killing sperms in vitro medicine and prepare the method for medicine |
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|---|---|---|---|
| CNB2006100695595A CN100560086C (en) | 2006-11-01 | 2006-11-01 | Chinese medicine Radix Platycodonis is as the application of killing sperms in vitro medicine and prepare the method for medicine |
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| Publication Number | Publication Date |
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| CN1965881A CN1965881A (en) | 2007-05-23 |
| CN100560086C true CN100560086C (en) | 2009-11-18 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101319973B (en) * | 2008-05-28 | 2010-06-02 | 山东省计划生育科学技术研究所 | Sperm nucleoprotein lysate |
| CN101319251B (en) * | 2008-05-28 | 2010-09-01 | 山东省计划生育科学技术研究所 | Method for detecting spermatozoon DNA fragment with spermatozoon chromatin diffusion experiment |
| CN103006542A (en) * | 2011-09-28 | 2013-04-03 | 王磊光 | Platycodin D sperm-killing contraceptive suppository for external use and placing device thereof |
| CN103494664B (en) * | 2013-07-15 | 2015-01-28 | 山东省计划生育科学技术研究所 | Extracorporal spermicidal tool using platycodon grandiflorum gallnuts |
| CN105749149B (en) * | 2016-03-03 | 2019-08-16 | 黑龙江成功药业有限公司 | A kind of nonirritant conception control gel and preparation method thereof with bacteria resistance function |
| CN106265830A (en) * | 2016-08-31 | 2017-01-04 | 郭东军 | Conception control gel |
-
2006
- 2006-11-01 CN CNB2006100695595A patent/CN100560086C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 桔梗总皂苷的制备工艺研究. 杨献文等.沈阳药科大学学报，第19卷第6期. 2002 |
| 桔梗总皂苷的制备工艺研究. 杨献文等.沈阳药科大学学报，第19卷第6期. 2002 * |
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| CN1965881A (en) | 2007-05-23 |
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