CN1965912B - Application of Chinese medicine polygala root as in-vitro spermaticide and method for preparing the medicament thereof - Google Patents
Application of Chinese medicine polygala root as in-vitro spermaticide and method for preparing the medicament thereof Download PDFInfo
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- CN1965912B CN1965912B CN2006100695608A CN200610069560A CN1965912B CN 1965912 B CN1965912 B CN 1965912B CN 2006100695608 A CN2006100695608 A CN 2006100695608A CN 200610069560 A CN200610069560 A CN 200610069560A CN 1965912 B CN1965912 B CN 1965912B
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Abstract
The invention relates to a method for using polygala root to kill sperm externally, wherein it uses polygala root as the drug to kill sperm externally, makes extractive into emulsion or suppositorium, to be used in vagina contraceptive. And its production comprises that: breaking polygala root, immerges in 0.9% normal saline, while their ration is 100g:900-1200ml, to be heated in 100Deg. C metal bath; taking out, filtering out the slag. The inventive polygala root extractive has non stimulation on vaginal mucosa, without damage on vaginal bacterial and side effect. And it has low cost.
Description
Technical field
The present invention relates to Chinese medicine, be a kind of Chinese medicine Radix Polygalae as the application of killing sperms in vitro medicine and prepare the method for medicine.
Background technology
In contraceptives, intrauterine device, Unterbindung des Eileiter and vasoligation, the capital damages human body, and for this reason, people adopt condom or oral contraceptive, it is minimum in the hope of injury is reduced to, but long-term oral contraceptive will produce bigger side effect to human body, and the use of condom is except that sense organ is relatively poor, still there is the probability of necessarily becoming pregnant, so this area is in recent years again at the medicine of making great efforts the research killing sperms in vitro.The medicine of killing sperms in vitro uses imported medicine the earliest, the back is domestic to have more kind to go on the market again, because the Main Ingredients and Appearance of medicine all is Western medicine, in use find, these medicines have irritation to vaginal mucosa, and after absorption of human body, easily liver are produced infringement, so for a long time, the medicine of these killing sperms in vitro is not the first-selected measure of contraception.At this situation, the spermicide thing of Chinese medicine composition has more report, still, because the uncertainty of its toxic and side effects, and kill the smart more reasons such as lower of rendeing a service, still can not be extensive use of so far.Some chemical compound spermicide report, but because multiple actions such as these contraceptive have sterilization, kill the virus, spermicide are applicable to sexually transmitted disease (STD), acquired immune deficiency syndrome (AIDS) prone areas, so still have toxic and side effects for the contraceptives of killing smart purposes merely.
Summary of the invention
The objective of the invention is, providing a kind of adopts single raw material of Chinese medicine Radix Polygalae as the application of killing sperms in vitro medicine and prepare the method for medicine, make Radix Polygalae that significantly effect be arranged in the application of killing sperms in vitro preferably, can be used as a kind of nontoxicly, non-stimulated to human vagina's mucosa, life-time service does not produce the medicine of any injury to human body.
The present invention is achieved through the following technical solutions for achieving the above object: draw on the basis of research and experiment: the Chinese medicine Radix Polygalae is as the medicinal application of killing sperms in vitro.
Described Chinese medicine Radix Polygalae is as the application of killing sperms in vitro medicine, and its Chinese medicine Radix Polygalae is made Emulsion or suppository as the medicine material of killing sperms in vitro with its extracting solution, is used for the vaginal contraception medicine.
Described Chinese medicine Radix Polygalae as the preparation method of killing sperms in vitro medicine is: the raw material of Chinese medicine Radix Polygalae is ground, be placed in 0.9% the normal saline and soaked 1.5-2.5 hour, the ratio of Radix Polygalae raw material and normal saline is 100 grams: the 900-1200 milliliter, be placed in 100 ℃ the metal bath heating 15-40 minute, the taking-up after-filtration removes slag and obtains Radix Polygalae extracting solution, Radix Polygalae extracting solution is made Emulsion or suppository, be used for the killing in vitro sperm.
Described Chinese medicine Radix Polygalae is as the preparation method of killing sperms in vitro medicine, and the ratio of its Radix Polygalae raw material and normal saline is 100 grams: 1000 milliliters.
Raw material of Chinese medicine Radix Polygalae of the present invention is the dry root of section's plant Radix Polygalae, and it is warm in nature, bitter in the mouth, suffering, puckery, has the reinforcing the heart of calming the nerves, Fructus Alpiniae Oxyphyllae, eliminates the phlegm, the effect of detumescence, the kidney invigorating, relaxing muscles and tendons to promote blood circulation.Diseases such as the tradition traditional Chinese medical science and various Chinese prescription are used for the treatment of physical weakness, suffer from a deficiency of the kidney, disarmony between the heart and kidney, insomnia and dreamful sleep, forgetful palpitation with fear, expectoration are not well, sore swollen toxin, breast swell and pain, traumatic injury.Retrieval before the present invention's research is used for spermicide never is useful on the report of killing sperms in vitro.
Further research to Radix Polygalae is learnt, Radix Polygalae of the present invention contains three kinds of terpenoid Saponins, and contain derivant of Radix Polygalae alkali, polygalite, N-acetyl-D-amino glucose, xanthone and cinnamic acid etc., further research experiment shows, the terpenoid Saponin that contains in the Radix Polygalae has bigger effect for killing sperms in vitro.
The present invention's experiment shows: Radix Polygalae extracting solution is mixed by 1: 1 with seminal fluid, sperm is all killed in second at 8-12, make sperm lose mobility, with Radix Polygalae extracting solution and seminal fluid by 1: 2-5 mixes, and can all kill the mobility of adult rats sperm in one minute.Further experiment shows: Radix Polygalae extracting solution is non-stimulated to vaginal mucosa, the calcination phenomenon, and vaginal microbial flora there is not destruction, it is without any side effects to human internal organ to be absorbed by the body by vaginal mucosa, but life-time service, and have advantage easy to use, for family planning provides a kind of nontoxic, cheap, easy to use, contraceptive effect system of selection in the know reliably.
The specific embodiment
Chinese medicine Radix Polygalae of the present invention is as the medicinal application of killing sperms in vitro, and its Chinese medicine Radix Polygalae is made Emulsion or suppository as the medicine material of killing sperms in vitro with its extracting solution, is used for the vaginal contraception medicine.Employed excipient and consumption all are conventional pharmaceutical excipient and consumptions in Emulsion and the suppository.
Described Chinese medicine Radix Polygalae as the preparation method of the medicine of killing sperms in vitro is: the raw material of Chinese medicine Radix Polygalae is ground, be placed in 0.9% the normal saline and soaked 1.5-2.5 hour, preferred 2 hours, the ratio of Radix Polygalae raw material and normal saline is 100 grams: the 900-1200 milliliter, preferred 100 grams: 1000 milliliters, be placed in 100 ℃ the metal bath heating 15-40 minute, preferred 30 minutes, the taking-up after-filtration removes slag and obtains Radix Polygalae extracting solution, Radix Polygalae extracting solution and conventional pharmaceutical excipient and conventional pharmaceutical excipient consumption are made Emulsion or suppository, be used for the killing in vitro sperm.
Claims (2)
1. the Chinese medicine Radix Polygalae is as the application of unique active component in preparation killing sperms in vitro medicine, it is characterized in that: the Chinese medicine Radix Polygalae is as the medicine material of killing sperms in vitro, its extracting solution is made Emulsion or suppository, be used for the vaginal contraception medicine, the preparation method of this medicine is that the raw material of Chinese medicine Radix Polygalae is ground, be placed in 0.9% the normal saline and soaked 1.5-2.5 hour, the ratio of Radix Polygalae raw material and normal saline is 100 grams: the 900-1200 milliliter, be placed in 100 ℃ the metal bath heating 15-40 minute, the taking-up after-filtration removes slag and obtains Radix Polygalae extracting solution, Radix Polygalae extracting solution is made Emulsion or suppository, be used for the killing in vitro sperm.
2. Chinese medicine Radix Polygalae according to claim 1 is characterized in that as the preparation method of unique active component at preparation killing sperms in vitro medicine: the ratio of Radix Polygalae raw material and normal saline is 100 grams: 1000 milliliters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100695608A CN1965912B (en) | 2006-11-01 | 2006-11-01 | Application of Chinese medicine polygala root as in-vitro spermaticide and method for preparing the medicament thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100695608A CN1965912B (en) | 2006-11-01 | 2006-11-01 | Application of Chinese medicine polygala root as in-vitro spermaticide and method for preparing the medicament thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1965912A CN1965912A (en) | 2007-05-23 |
| CN1965912B true CN1965912B (en) | 2010-09-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006100695608A Expired - Fee Related CN1965912B (en) | 2006-11-01 | 2006-11-01 | Application of Chinese medicine polygala root as in-vitro spermaticide and method for preparing the medicament thereof |
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| CN (1) | CN1965912B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101319251B (en) * | 2008-05-28 | 2010-09-01 | 山东省计划生育科学技术研究所 | Method for detecting spermatozoon DNA fragment with spermatozoon chromatin diffusion experiment |
| CN101804109B (en) * | 2010-03-19 | 2011-11-16 | 山东省计划生育科学技术研究所 | Compound senegenin in vitro spermicidal drug |
| CN103006541A (en) * | 2011-09-28 | 2013-04-03 | 邱毅 | Polygalacic acid sperm-killing contraceptive suppository for external use and placing device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1253808A (en) * | 1999-09-29 | 2000-05-24 | 周文志 | Chinese medicine abortifacient |
| CN1491676A (en) * | 2002-10-22 | 2004-04-28 | 刘小兵 | Percutaneous or oral contraceptive, abortion and sterilizing composition |
-
2006
- 2006-11-01 CN CN2006100695608A patent/CN1965912B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1253808A (en) * | 1999-09-29 | 2000-05-24 | 周文志 | Chinese medicine abortifacient |
| CN1491676A (en) * | 2002-10-22 | 2004-04-28 | 刘小兵 | Percutaneous or oral contraceptive, abortion and sterilizing composition |
Non-Patent Citations (1)
| Title |
|---|
| 郭娟等.生远志及炮制品对小鼠止咳化痰作用.中药药理与临床19 4.2003,19(4),第29页. * |
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| CN1965912A (en) | 2007-05-23 |
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