CN1957960A - General flavone of Glabrous Herbcoral - Google Patents
General flavone of Glabrous Herbcoral Download PDFInfo
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- CN1957960A CN1957960A CN 200610051245 CN200610051245A CN1957960A CN 1957960 A CN1957960 A CN 1957960A CN 200610051245 CN200610051245 CN 200610051245 CN 200610051245 A CN200610051245 A CN 200610051245A CN 1957960 A CN1957960 A CN 1957960A
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- ethanol
- general flavone
- total flavones
- upper prop
- resin
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Abstract
A general flavone of sarcundra glabra can be used to prepare the medicines in the form of injection, oral liquid, tablet, capsule, or particle for relieving inflammation, removing heat and toxin, preventing and treating tumor and influenza, promoting blood circulation and healing of bone fracture, etc. Its preparing process includes extracting in alcohol step by step, separating and purifying by macroreticular resin, and microwave vacuum drying.
Description
The present invention relates to a kind of is the fully natural green medical material that raw material compatibility behind the effective component extracting total flavones is made with the plant plait Corallium Japonicum Kishinouye, belongs to the biological medical product field.
The objective of the invention is to: a kind of bioactive ingredients that derives from the natural plants Herba Pileae Scriptae is provided, through processes such as extraction separation purification drying refining form have anti-inflammation, suppress multiple pathogen, heat-clearing and toxic substances removing, anti-kinds of tumors, promote union of fracture, improve blood circulation, multiple bioactive medical material general flavone of Glabrous Herbcoral such as analgesia, resisting fatigue, antioxidation, inhibition influenza virus, be a kind of fully natural green medical product.It can be as the raw material of producing injection, oral liquid, tablet, capsule, granule.Do not produce any toxic side effects after its uses, noresidue, easy to use, evident in efficacy, steady quality, applied range, to overcome the deficiency of existing medicine.
The present invention be achieved in that it by Herba Pileae Scriptae through the ethanol step impregnation extract, vacuum concentration filters step by step, refining the forming of production technology of the remove impurity of cold and hot processing precipitation, hybrid combination, macroporous resin separation and purification, microwave vacuum drying.
1. get Herba Pileae Scriptae herb (digging up the roots) system coarse powder, with 65%, 75%, 85%, 95% ethanol 20 ℃ of-30 ℃ of each lixiviates once (the ethanol consumption be the medical material amount 3-5 doubly), 10-24 hour at every turn.Merge alcohol extract after the extraction, filter, decompression recycling ethanol is extremely most, filtered while hot, and filtrate 0.1%-0.3% adding activated carbon by volume is heated with stirring to and boils, and filters de-carbon.12-24 hour after-filtration left standstill at cold place, and filtration is left standstill in cold preservation after adding the equivalent distilled water and transferring pH6-8, and the percentage concentration requirement heating back distilled water standardize solution by certain gets the total flavones extracting solution, measures general flavone content, and cold preservation is standby.
2. it is an amount of to take by weighing respectively the AB-8 type macroporous absorbent resin of having handled well; Wet method is packed in the chromatographic column of 2-4cm * 300-600cm; (upper prop general flavone amount is 1 with the resin ratio: 12-15 with the Chloranthus glaber extract; Upper prop liquid general flavone concentration is 16-20mg/mL; Upper prop liquid pH value 4～5) with the flow velocity upper prop of 2mL-4mL-/min; Cross the complete rear distilled water with 2-4 times of resin volume of post and wash post to going out water colorless with the speed of 3mL-4mL-/mi n; Be eluted to water white transparency with the ethanol of 2-4 times of resin volume 60-90% with the elution speed of 2-4mL/min again
3. collection ethanol elution, concentrating under reduced pressure, microwave vacuum drying was pulverized the 80-120 mesh sieve, weighed, and measured general flavone content and should be not less than 95%.
4. the present invention compared with prior art has following advantage:
4.1 process innovation.Technological process science of the present invention is succinct, and whole production technology has been taked refining the forming of production technology that the ethanol step impregnation extracts, vacuum concentration filters step by step, cold and hot processing precipitates remove impurity, hybrid combination, macroporous resin separation and purification, microwave vacuum drying.Clarifier and activated carbon remove impurity in technology, have been used.Its finished product active constituent content height, steady quality, color and luster degree are good.Be suitable for suitability for industrialized production, packing of product transportation is easy to carry.
4.2 the present invention is the fully natural green medical product, use the secondary residual action of the no any poison in back, safe and reliable, easy to use, applied range, evident in efficacy, instant effect, promptly brought into play globality, pleiotropy, amphicheirality, synergitic traditional compatibility advantage that Chinese herbal medicine is cured the disease and regulated, embodied modern science and technology again, advantage such as easy to use, quick, portable the refining advantage of Chinese herbal medicine.Meet " green product " developing direction.
4.3 applied range.General flavone of Glabrous Herbcoral is a kind of anti-inflammation that has, and suppresses multiple pathogen, heat-clearing and toxic substances removing, anti-kinds of tumors, promote union of fracture, improve blood circulation, analgesia, resisting fatigue, antioxidation suppresses multiple bioactive medical materials such as influenza virus, is a kind of fully natural green medical product.It can be as the raw material of producing injection, oral liquid, tablet, capsule, granule.
Embodiments of the invention:
1. get Herba Pileae Scriptae herb (digging up the roots) system coarse powder 5000g, get 65%, 75%, 85%, 95% ethanol 20 ℃ of-30 ℃ of each lixiviates once (the ethanol consumption is 3 times of medical material amount), each 12 hours.Merge alcohol extract after the extraction, filter, decompression recycling ethanol is extremely most, filtered while hot, and filtrate 0.1% adding activated carbon by volume is heated with stirring to and boils, and filters de-carbon.12 hours after-filtration are left standstill at cold place, leave standstill 12 hours after-filtration in 2～4 ℃ of cold preservations after adding the equivalent distilled water and transferring pH6-7, the total flavones concentration requirement distilled water standardize solution of 1.6-2% is pressed in the heating back, and (general flavone content: 16-20mg/mL), cold preservation is standby to get the total flavones extracting solution.
2. take by weighing the AB-8 type adsorbent resin 500g that has handled well respectively, wet method is packed in the chromatographic column of 3cm * 500cm, (upper prop total flavones amount is 1: 13 with the resin ratio with the total flavones extracting solution, upper prop liquid total flavones concentration is 18mg/mL, upper prop liquid pH value 4～5) with the flow velocity upper prop of 2mL-3mL/min, cross the intact back of post and wash post to going out water colorless with the distilled water of 2-3 times of resin volume with the speed of 3mL-4mL/min, the ethanol of reuse 2-3 times of resin volume 70% is eluted to water white transparency with the elution speed of 2-3mL/min.
3. collect 70% ethanol elution, be evaporated to the extractum shape, microwave vacuum drying was pulverized 100 mesh sieves, weighed, and measured general flavone content, and finished product contains the active ingredient total flavones more than 95%, fill, sealing, quality inspection, packing.
Claims (2)
1. pure natural medical material, general flavone of Glabrous Herbcoral.It is a raw material with the plant plait Corallium Japonicum Kishinouye, refining forming after the production technology that the ethanol step impregnation extracts, vacuum concentration filters step by step, cold and hot processing precipitates remove impurity, hybrid combination, macroporous adsorbent resin separation and purification, microwave vacuum drying is extracted its effective ingredient total flavones is characterized in that:
1.1 get Herba Pileae Scriptae herb (digging up the roots) system coarse powder, with 65%, 75%, 85%, 95% ethanol 20 ℃ of-30 ℃ of each lixiviates once (the ethanol consumption be the medical material amount 3-5 doubly), 10-24 hour at every turn.Merge alcohol extract after the extraction and filter, decompression recycling ethanol is extremely most, filtered while hot, and filtrate 0.1%-0.3% adding activated carbon by volume is heated with stirring to and boils, and filters de-carbon.12-24 hour after-filtration left standstill at cold place, and filtration is left standstill in cold preservation after adding the equivalent distilled water and transferring pH6-8, and the percentage concentration requirement heating back distilled water standardize solution by certain gets the total flavones extracting solution, measures general flavone content, and cold preservation is standby.
1.2 it is an amount of to take by weighing the AB-8 type macroporous adsorbent resin of having handled well, wet method is packed in the chromatographic column of 2-4cm * 300-600cm, (upper prop liquid total flavones amount presses 1 with the resin ratio: 12-15 with the Herba Pileae Scriptae extracting solution, upper prop liquid total flavones concentration is 16-20mg/mL, upper prop liquid pH value 4～5) with the flow velocity upper prop of 2mL-4mL/min, cross the intact back of post and wash post to going out water colorless with the distilled water of 2-4 times of resin volume with the speed of 3mL-4mL/min, the ethanol of reuse 2-4 times of resin volume 60%-90% is eluted to water white transparency with the elution speed of 2-4mL/min.
1.3 the collection ethanol elution, concentrating under reduced pressure, microwave vacuum drying was pulverized the 80-120 mesh sieve, weighed, and measured general flavone content and should be not less than 95%.
2. general flavone of Glabrous Herbcoral can be as the raw material of producing injection, oral liquid, tablet, capsule, granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610051245 CN1957960A (en) | 2006-10-09 | 2006-10-09 | General flavone of Glabrous Herbcoral |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610051245 CN1957960A (en) | 2006-10-09 | 2006-10-09 | General flavone of Glabrous Herbcoral |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1957960A true CN1957960A (en) | 2007-05-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610051245 Pending CN1957960A (en) | 2006-10-09 | 2006-10-09 | General flavone of Glabrous Herbcoral |
Country Status (1)
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| CN (1) | CN1957960A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102793731A (en) * | 2012-07-06 | 2012-11-28 | 广州白云山敬修堂药业股份有限公司 | Application of glabrous sarcandra glabrous herb extract in reducing susceptibility of influenza virus |
-
2006
- 2006-10-09 CN CN 200610051245 patent/CN1957960A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102793731A (en) * | 2012-07-06 | 2012-11-28 | 广州白云山敬修堂药业股份有限公司 | Application of glabrous sarcandra glabrous herb extract in reducing susceptibility of influenza virus |
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Open date: 20070509 |