CN1274320C - Notoginseng ginkgo health care food and its preparation method - Google Patents
Notoginseng ginkgo health care food and its preparation method Download PDFInfo
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- CN1274320C CN1274320C CNB200410021677XA CN200410021677A CN1274320C CN 1274320 C CN1274320 C CN 1274320C CN B200410021677X A CNB200410021677X A CN B200410021677XA CN 200410021677 A CN200410021677 A CN 200410021677A CN 1274320 C CN1274320 C CN 1274320C
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- radix notoginseng
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Abstract
The present invention relates to a health care food with notoginseng and ginkgo leaf and a preparation method thereof. The health care food with notoginseng and ginkgo leaf is composed of a conjunct extractive of notoginseng and chrysanthemum, an extractive of ginkgo leaf, and medicinal supplementary materials, the medicinal supplementary materials are dextrin and powdered sugar or starch. When prepared into granules, the components has the following weight percentages: 5 to 40% of thick paste of conjunct extractive of notoginseng and chrysanthemum, 0.1 to 10% of an extractive of ginkgo leaf, 4 to 6% of dextrin and 44 to 90% of powdered sugar. When prepared into capsules, the components has the following weight percentages: 40 to 80% of dry power of a conjunct extractive of notoginseng and chrysanthemum, 8 to 20% of an extractive of ginkgo leaf and 0.1 to 52% of starch. The health care food comprises effective components of 1 to 80% notoginseng saponin and 0.1 to 30% of ginkgetin. The health care food of the present invention is prepared by extracting and merging effective components in notoginseng, gingko and chrysanthemum, has the functions of resisting oxidation, raising immunizing power, improving microcirculation, and is favourable for the health of the angiocarpy and the cerebral blood vessel. The health care food can be prepared into tea with notoginseng and gingko, and line products, has scientific and reasonable preparation method, and effectively reserves effective active components in notoginseng, chrysanthemum and ginkgo leaf.
Description
Technical field
The invention belongs to the health food technology field, especially by natural plants Radix Notoginseng, Folium Ginkgo, Flos Chrysanthemi prescription, the health food that behind extraction separation, makes.
Background technology
Radix Notoginseng (having another name called Panax pseudoginseng, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae)) is a jewel in China's medicine treasure-house, is the treasure of generally acknowledging both at home and abroad, Yunnan, main product ground.The clinical for hundreds of years blood circulation promoting and blood stasis dispelling, tonifying blood and arresting bleeding, subduing swelling and relieving pain of being used for obtained special effect, and modern scientific research proves that its total saponin content is higher than Radix Ginseng, is described as " king in the ginseng ".Radix Notoginseng has human body immunity improving power, anoxia enduring, resisting fatigue, defying age, increase coronary flow, effects such as microcirculation improvement, anticoagulant, reduction blood viscosity, prevention of arterial is atherosis, its effect mainly gives the credit to the active effective ingredient Radix Notoginseng total arasaponins that is contained.Semen Ginkgo has survived more than 200,000,000 year on earth, have the title of " living fossil ", in recent years, a large amount of research has been carried out to Folium Ginkgo in countries in the world, the ginkgo agent developing focus is placed on the health food, and obtained a series of important achievement, experimental results show that: the ginkgetin that contains in the Folium Ginkgo extract has extremely strong antioxidation, can eliminate the interior superfluous harmful substance (various free radical) of organism, stops body lipid peroxidating, human body immunity improving power, improves the heart and brain blood circulation, promotes study, improving memory, slow down aging etc.Flos Chrysanthemi contains effective ingredient such as volatile oil and echinacoside, has the effect of liver heat removing and eyesight improving, resolving heat and reducing pathogenic fire.In the prior art, the health food that contains the part effective ingredient of above-mentioned three kind of plant, only generally being with a kind of plant wherein is that the major ingredient effective component extracting is made, its effect is more single, so far also do not have a kind of effective ingredient of above-mentioned three kind of plant can being combined together, have the food of composite health care function.
Summary of the invention
Purpose of the present invention provides in order to overcome above-mentioned the deficiencies in the prior art just a kind of extracts active ingredients with Chinese herbal medicines such as Radix Notoginseng, Semen Ginkgo, Flos Chrysanthemis to merge to make that function is remarkable, curative effect is high, quality controllable, take safely, have anti-hypoxia, improve immunity, microcirculation improvement, be of value to the notoginseng-gingko tea health food of cardiovascular and cerebrovascular vessel health.Another object of the present invention provides the preparation method of this class health food.
The objective of the invention is to be achieved through the following technical solutions.
Radix Notoginseng gingkgo health care food of the present invention, by Radix Notoginseng and Flos Chrysanthemi by weight percentage the common water extract, the ethanol extraction and the pharmaceutic adjuvant of Folium Ginkgo of Radix Notoginseng 80～90%, Flos Chrysanthemi 10～20% form, described pharmaceutic adjuvant is dextrin, Icing Sugar or starch; The percentage by weight of each component when granulating is: the common water extract thick paste 5～40% of Radix Notoginseng and Flos Chrysanthemi, Folium Ginkgo extract 0.1～10%, dextrin 4～6%, Icing Sugar 44～90%; When the glue capsule be: the common water extract dry powder 40～80% of Radix Notoginseng and Flos Chrysanthemi, the ethanol extraction 8～20% of Folium Ginkgo, starch 0.1～52%; This Radix Notoginseng gingkgo health care food contains effective composition Radix Notoginseng total arasaponins 1～80%, ginkgetin 0.1～30%.
Radix Notoginseng gingkgo health care food of the present invention, its process for producing granula is as follows:
(1) preparation extract:
1. the preparation of the common water extract thick paste of Radix Notoginseng and Flos Chrysanthemi: with the percentage by weight of pulverizing is after the Flos Chrysanthemi of 80～90% Radix Notoginseng and 10～20% is put into extraction pot and added water boil, to extract filtrate, and the filtrate of extracting is condensed into the thick paste shape;
2. the preparation of Folium Ginkgo ethanol extraction: will put into the extraction pot soak with ethanol after the Folium Ginkgo pulverizing, will soak filtrate extraction back to concentration tank and be condensed into no pure liquid, and carry out column purification then and handle;
(2) granulate: with the co-extracted thing thick paste 5～40% of Radix Notoginseng and Flos Chrysanthemi, Folium Ginkgo extract 0.1～10%, dextrin 4～6%, Icing Sugar 44～90% uniform mixing add an amount of ethanol, and wet granulation obtains fine grained after drying;
Capsular preparation method is as follows:
(1) preparation extract:
1. the preparation of the common water extract thick paste of Radix Notoginseng and Flos Chrysanthemi: with the percentage by weight of pulverizing is after the Flos Chrysanthemi of 80～90% Radix Notoginseng and 10～20% is put into extraction pot and added water boil, to extract filtrate, and the filtrate of extracting is condensed into the thick paste shape;
2. the preparation of the co-extracted thing dry powder of Radix Notoginseng and Flos Chrysanthemi: with the common water extract thick paste of the Radix Notoginseng that makes and Flos Chrysanthemi with boulton process crushed after being dried powdering;
3. the preparation of Folium Ginkgo ethanol extraction: will put into the extraction pot soak with ethanol after the Folium Ginkgo pulverizing, will soak filtrate extraction back to concentration tank and be condensed into no pure liquid, and carry out column purification then and handle;
(2) glue capsule: Radix Notoginseng is mixed filled capsules behind vacuum drying with common water extract dry powder 40～80%, the ethanol extraction 8～20% of Folium Ginkgo, the starch 0.1～52% of Flos Chrysanthemi.
In the preparation method of Radix Notoginseng gingkgo health care food of the present invention, when Radix Notoginseng and the common extract of Flos Chrysanthemi prepare, in extraction pot, add water and be Radix Notoginseng and Flos Chrysanthemi gross weight 4～8 times, boiling time is 1～2 hour, can extract filtrate continuously 2～3 times, the filtrate that merges 2～3 extractions concentrates together; Receive perfume when extracting filtrate for the first time; In the preparation of Folium Ginkgo ethanol extraction, in extraction pot, added 4～6 times of Folium Ginkgo total amounts, concentration and be 50～70% soak with ethanol 1～3 hour, adopt respectively continuously hot reflux to extract then 2～3 times, merges the filtrate of extracting for 2～3 times and put into vacuum concentration pot and after 50～70 ℃ of concentrating under reduced pressure become no pure liquid, carry out the column purification processing.
The present invention has extracted Radix Notoginseng total arasaponins from Radix Notoginseng (Panax notonginseng (Burk) F.H.Chen) plant, from the leaf of Semen Ginkgo (Ginkgo biloba L.), extract ginkgetin, from the spending of chrysanthemum (Chrysanthcmum morifolium Ra mat.), extracted Flos Chrysanthemi volatile oil and echinacoside.
Ergonomy research of the present invention and evaluation result are as follows:
1, notoginseng-gingko tea anti-hypoxia efficacy study
(1) get 60 of body weight 18-22g healthy mices, male and female half and half are divided into four groups at random, i.e. blank group, notoginseng-gingko tea 2.5g/kg, 5g/kg, three dosage groups of 7.5g/kg.What each dosage group per os every day was irritated the stomach respective concentration is subjected to the reagent thing, matched group is given the equivalent distilled water, continuous 30 days, last was irritated behind the stomach 1 hour, each group mice is put into the 250ml ground wide mouthed bottle (1 every bottle) that fills the 15g sodica calx respectively, with the tight bottleneck of bottle stopper that scribbles an amount of vaseline, timing immediately, with the respiratory arrest is index, observes mice because of the dead time of anoxia.
Result of the test: three dosage groups of notoginseng-gingko tea all significantly are longer than blank group (P＜0.01) to the normal pressure hypoxia endurance time of mice
(2) sodium nitrite poisoning survival test
Get 60 of mices by above-mentioned identical four groups, each dosage group per os every day is irritated the notoginseng-gingko tea of stomach respective concentration, and matched group is irritated the distilled water of stomach equivalent, continuous 30 days, last is irritated stomach and is finished back 1 hour, and each organizes the equal lumbar injection sodium nitrite of mice (200mg/kg, BW).Clock immediately, observe mouse diing time.
Result of the test: the sodium nitrite poisoning time-to-live of three dosage groups of notoginseng-gingko tea mice all significantly is longer than blank group (P＜0.01)
2, notoginseng-gingko tea human body immunity improving effect research
(1) delayed allergy (the sufficient sole of the foot thickens method)
Get 60 of body weight 18-22g healthy mices, be divided into four groups, i.e. blank group, notoginseng-gingko tea 1.5g/kg, 2.5g/kg, three dosage groups of 5g/kg, matched group is given distilled water, and gastric infusion is 30 days continuously.Mouse peritoneal injection 2% (v/v) SRBC measured left back sufficient sole of the foot portion thickness in 4 days after the sensitization, at measuring point subcutaneous injection 20% (v/v) SRBC, every Mus is injected 20 μ L then, injects and measures left back sufficient sole of the foot thickness in back 24 hours, and same position is measured three times, gets average.The degree of representing delayed allergy with sufficient sole of the foot thickness difference (swelling degree of the paw) before and after attacking.
Experimental result: the notoginseng-gingko tea high dose group can suppress the mice swelling degree of the paw by the utmost point significantly, compares P＜0.01 with the distilled water group.
(2) antibody-producting cell inspection (Verre improves slide method)
Get 60 of body weight 18-22g healthy mices, be divided into four groups, it is the blank group, notoginseng-gingko tea 1.5g/kg, 2.5g/kg, three dosage groups of 5g/kg, matched group is given distilled water, gastric infusion is 30 days continuously, 1 hour execution animal is got spleen and makes cell suspension after the last administration, packing small test tube, every pipe 0.5mL will be mixed with the double Hanks liquid of equivalent after the culture medium heating for dissolving of top layer, in pipe, add 50 μ L10%SRBC (v/v prepares with SA liquid) again, 20 μ L splenocyte suspensions behind the mixing, are poured on the slide of brushing the agarose thin layer rapidly, after treating that agar solidifies, the slide level buckled be placed on the slide frame, put into CO2 incubator incubation 1.5 hours, the complement (1: 10) with the dilution of SA liquid joins in the slide frame groove then, continue incubation after 1.5 hours, counting hemolysis plaque number.
Experimental result: gave the mouse stomach notoginseng-gingko tea 30 days, basic, normal, high dosage group all can the utmost point significantly improves the antibody-producting cell number of mice, with the distilled water matched group utmost point significant difference P＜0.01 is arranged relatively.
Experiment showed, that health food of the present invention has effect such as various free radicals, prevention body lipid peroxidization in anti-hypoxia, raising immunologic function, microcirculation improvement, the elimination body, is a kind of health food that is of value to cardiovascular and cerebrovascular vessel health.Be applicable to the health therapy of body anoxia, immunity degradation, cardiovascular and cerebrovascular disease, hypertension, hyperlipidemia, coronary heart disease and apoplexy etc.
Preparation method of the present invention is scientific and reasonable, can keep the effective active composition in Radix Notoginseng, Flos Chrysanthemi and the Folium Ginkgo effectively.
The specific embodiment:
At first, the co-extracted thing thick paste of preparation Radix Notoginseng and Flos Chrysanthemi: Radix Notoginseng and the Flos Chrysanthemi pulverized are dropped into extraction pot, and both weight percentage ranges are: Radix Notoginseng 80～90%, Flos Chrysanthemi 10～20%.For example select Radix Notoginseng 80%, Flos Chrysanthemi 20%; Perhaps Radix Notoginseng 90%, Flos Chrysanthemi 10%; Again or Radix Notoginseng 85%, Flos Chrysanthemi 15%.The water boil 2 hours that adds 6 times extracts 3 times continuously.Need receive perfume when extracting for the first time, use during in order to granulation.Merging the filtrate of extracting for three times, to be condensed into thick paste with the triple effect concentration tank stand-by.The thick paste that makes is put into vacuum dryer crushed after being dried powdering promptly make dry powder.
Refabrication Folium Ginkgo extract: get selected Folium Ginkgo dry product, pulverize earlier and be placed in the extraction pot, with 60% soak with ethanol of 6 times of amounts 2 hours, hot reflux is extracted 3 times then, each 2 hours, merge in 3 extraction filtrates adding vacuum concentration pots and after 60 ℃ of following concentrating under reduced pressure become no pure liquid, carry out the column purification processing.The process that column purification is handled is as follows: concentrated solution adds the water of about 3 times of amounts, staticly settles more than 8 hours, filters, and get filtrate and go up the DA-201 macroporous adsorptive resins, the control flow velocity, effluent is discarded.At any time carrying out saturated check (gets two of test liquids and puts on the white plaque, add 1 of glacial acetic acid, add 1 of 1% copperas solution, as solution is navy blue or black, represents that then post is saturated, as invariant color, then represent the post unsaturation), then stop to go up sample if any saturated reaction.Wash post then with water; to effluent limpid till; wash post with 80% ethanol then; collect the effluent of color than deep part; add protective agent (aqueous solution of 1% oxalic acid, 0.1% vitamin C, 0.1% tea catechin, 10% glacial acetic acid) reuse vacuum concentration pot decompression recycling ethanol; and use vacuum drying, vacuum be-0.06～-0.08MPa.Temperature is 60 ℃, can get flavone gruff bring up substance 3.5～4.5%, and yield is 3.0～3.6% after taking off ginkgoic acid.
The active constituent content of gained Folium Ginkgo extract is: ginkgetin 〉=24%, Ginkgo biloba terpenes lactone 〉=6%; Ginkgoic acid＜5PPm.
Co-extracted thing, Folium Ginkgo extract and pharmaceutic adjuvant with Radix Notoginseng that makes and Flos Chrysanthemi prepare health food, and first kind of mode is to granulate, and method is as follows:
Component one: by weight percentage with the co-extracted thing thick paste of 5% Radix Notoginseng and Flos Chrysanthemi, 1% Folium Ginkgo extract, 4% dextrin, 90% Icing Sugar uniform mixing, add an amount of 90% ethanol, wet granulation, 55～65 ℃ of dryings are about 3 hours, cross 12 orders and 40 mesh sieve granulate, collected the granule between 12 mesh sieves and 40 mesh sieves, color and luster is a yellow particle, and moisture content must not surpass 8%.Pack with the plastic-aluminum Small bag packaging machine behind the corning, carry out sterilization treatment again.
Component two: by weight percentage with the co-extracted thing thick paste of 40% Radix Notoginseng and Flos Chrysanthemi, 10% Folium Ginkgo extract, 6% dextrin, 44% Icing Sugar uniform mixing, add an amount of 90% ethanol, wet granulation, 55～65 ℃ of dryings are about 3 hours, and moisture content is controlled in 8%.Pack behind the corning, carry out sterilization treatment again.
Component three: the co-extracted thing thick paste 10kg that takes by weighing Radix Notoginseng and Flos Chrysanthemi, Folium Ginkgo extract 0.4kg, dextrin 4.6kg, Icing Sugar 85kg uniform mixing, add an amount of 90% ethanol then, wet granulation, 55～65 ℃ of dryings are about 3 hours, cross 12 orders and 40 mesh sieve granulate, collected the granule between 12 mesh sieves and 40 mesh sieves, moisture content must not surpass 8%.Pack behind the corning, carry out sterilization treatment again, this product is a notoginseng-gingko tea.
The second way is the preparation capsule, and manufacture method is as follows:
Component one: the co-extracted thing dry powder 40%, Folium Ginkgo extract 8%, starch 52% of getting Radix Notoginseng and Flos Chrysanthemi by weight percentage mixes the back in 75～80 ℃ of vacuum dryings about 2 hours, use automatic capsule filling machine filled capsules then, behind polishing, bubble-cap, adorn box.
Component two: the co-extracted thing dry powder 80%, Folium Ginkgo extract 19.9%, starch 0.1% of getting Radix Notoginseng and Flos Chrysanthemi by weight percentage mixes the back in 75～80 ℃ of vacuum dryings about 2 hours, use automatic capsule filling machine filled capsules then, behind polishing, bubble-cap, adorn box.
Component three: the co-extracted thing dry powder 200kg, Folium Ginkgo extract 40kg, starch 60kg that gets Radix Notoginseng and Flos Chrysanthemi mixes the back in 75～80 ℃ of vacuum dryings 2 hours, uses automatic capsule filling machine filled capsules then, adorns box behind polishing, bubble-cap.
Health food of the present invention can be made quick-dissolving agent (tea), hard capsule, soft capsule, tablet, oral liquid etc. by modern formulation method, no matter be made into which kind of dosage form, the content of its effective active composition Radix Notoginseng total arasaponins is all 1～80%, the content of ginkgetin is all 0.1～30%, and having Flos Chrysanthemi fragrance, mouthfeel is good.
Claims (6)
1, Radix Notoginseng gingkgo health care food, it is characterized in that, it by Radix Notoginseng and Flos Chrysanthemi by weight percentage the common water extract, the ethanol extraction and the pharmaceutic adjuvant of Folium Ginkgo of Radix Notoginseng 80～90%, Flos Chrysanthemi 10～20% form, described pharmaceutic adjuvant is dextrin, Icing Sugar or starch; The percentage by weight of each component when granulating is: the co-extracted thing thick paste 5～40% of Radix Notoginseng and Flos Chrysanthemi, Folium Ginkgo extract 0.1～10%, dextrin, Icing Sugar or starch proportion are, dextrin 4～6%, Icing Sugar 44～90% or starch 44～90%, and that satisfies each component is combined into 100%, when the glue capsule is: the co-extracted thing dry powder 40～80% of Radix Notoginseng and Flos Chrysanthemi, Folium Ginkgo extract 8～20%, starch 0.1～52%; This Radix Notoginseng gingkgo health care food contains effective composition Radix Notoginseng total arasaponins 1～80%, ginkgetin 0.1～30%.
2, the preparation method of Radix Notoginseng gingkgo health care food as claimed in claim 1 is characterized in that process for producing granula is as follows:
(1) preparation extract:
1. the preparation of the common water extract thick paste of Radix Notoginseng and Flos Chrysanthemi: with the percentage by weight of pulverizing is after the Flos Chrysanthemi of 80～90% Radix Notoginseng and 10～20% is put into extraction pot and added water boil, to extract filtrate, and the filtrate of extracting is condensed into the thick paste shape;
2. the ethanol extraction of Folium Ginkgo preparation: will put into the extraction pot soak with ethanol after the Folium Ginkgo pulverizing, will soak filtrate extraction back to concentration tank and be condensed into no pure liquid, and carry out column purification then and handle;
(2) granulate: Radix Notoginseng and the common water extract thick paste 5～40% of Flos Chrysanthemi, Folium Ginkgo extract 0.1～10%, dextrin 4～6%, Icing Sugar 44～90% or starch 44～90% uniform mixing, and that satisfies each component is combined into 100%, add an amount of ethanol, wet granulation obtains fine grained after drying.
3, the preparation method of Radix Notoginseng gingkgo health care food according to claim 1 is characterized in that, capsular preparation method is as follows:
(1) preparation extract:
1. the preparation of the common water extract thick paste of Radix Notoginseng and Flos Chrysanthemi: with the percentage by weight of pulverizing is after the Flos Chrysanthemi of 80～90% Radix Notoginseng and 10～20% is put into extraction pot and added water boil, to extract filtrate, and the filtrate of extracting is condensed into the thick paste shape;
2. the preparation of the common water extract dry powder of Radix Notoginseng and Flos Chrysanthemi: with the co-extracted thing thick paste of the Radix Notoginseng that makes and Flos Chrysanthemi with boulton process crushed after being dried powdering;
3. the ethanol extraction of Folium Ginkgo preparation: will put into the extraction pot soak with ethanol after the Folium Ginkgo pulverizing, will soak filtrate extraction back to concentration tank and be condensed into no pure liquid, and carry out column purification then and handle;
(2) glue capsule: Radix Notoginseng is mixed filled capsules behind vacuum drying with common water extract dry powder 40～80%, the ethanol extraction 8～20% of Folium Ginkgo, the starch 0.1～52% of Flos Chrysanthemi.
4, the preparation method of Radix Notoginseng gingkgo health care food according to claim 2, it is characterized in that, in Radix Notoginseng and the common extract preparation of Flos Chrysanthemi, in extraction pot, add water and be Radix Notoginseng and Flos Chrysanthemi gross weight 4～8 times, boiling time is 1～2 hour, can extract filtrate continuously 2～3 times, the filtrate that merges 2～3 extractions concentrates together.
5, according to the preparation method of claim 2 or 3 described Radix Notoginseng gingkgo health care food, it is characterized in that, receive perfume when extracting filtrate for the first time.
6, the preparation method of Radix Notoginseng gingkgo health care food according to claim 2, it is characterized in that, in the Folium Ginkgo extract preparation, in extraction pot, put into 4～6 times, concentration and be 50～70% soak with ethanol 1～3 hour, adopt respectively continuously hot reflux to extract then 2～3 times, merges the filtrate of extracting for 2～3 times and put into vacuum concentration pot and after 50～70 ℃ of concentrating under reduced pressure become no pure liquid, carry out the column purification processing.
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| CN102397310B (en) * | 2011-09-29 | 2015-08-19 | 玉溪市维和维生堂保健食品有限公司 | Notoginseng triol group and ginkgo leaf extract composition and preparation and purposes |
| CN102488769B (en) * | 2011-12-16 | 2013-08-07 | 王立财 | Diet pill |
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