CN1946384B - 治疗眼高压和青光眼的他汀类 - Google Patents

治疗眼高压和青光眼的他汀类 Download PDF

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Publication number
CN1946384B
CN1946384B CN2005800130061A CN200580013006A CN1946384B CN 1946384 B CN1946384 B CN 1946384B CN 2005800130061 A CN2005800130061 A CN 2005800130061A CN 200580013006 A CN200580013006 A CN 200580013006A CN 1946384 B CN1946384 B CN 1946384B
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China
Prior art keywords
composition
statin
pravastatin
use according
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN2005800130061A
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English (en)
Chinese (zh)
Other versions
CN1946384A (zh
Inventor
M·R·赫尔伯格
D·L·弗里诺尔
A·谢泼德
彭玉豪
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Alcon Inc
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Alcon Inc
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Filing date
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Publication of CN1946384A publication Critical patent/CN1946384A/zh
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Publication of CN1946384B publication Critical patent/CN1946384B/zh
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Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2005800130061A 2004-04-26 2005-04-25 治疗眼高压和青光眼的他汀类 Expired - Fee Related CN1946384B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56546904P 2004-04-26 2004-04-26
US60/565,469 2004-04-26
PCT/US2005/014255 WO2005105069A1 (en) 2004-04-26 2005-04-25 Statins for the treatment of ocular hypertension and glaucoma

Publications (2)

Publication Number Publication Date
CN1946384A CN1946384A (zh) 2007-04-11
CN1946384B true CN1946384B (zh) 2011-04-20

Family

ID=34966865

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800130061A Expired - Fee Related CN1946384B (zh) 2004-04-26 2005-04-25 治疗眼高压和青光眼的他汀类

Country Status (19)

Country Link
US (2) US20050239871A1 (enExample)
EP (1) EP1740164B1 (enExample)
JP (1) JP2007534699A (enExample)
KR (2) KR20110091600A (enExample)
CN (1) CN1946384B (enExample)
AT (1) ATE404189T1 (enExample)
AU (1) AU2005237543B2 (enExample)
BR (1) BRPI0510245A (enExample)
CA (1) CA2560167A1 (enExample)
CY (1) CY1108490T1 (enExample)
DE (1) DE602005008935D1 (enExample)
DK (1) DK1740164T3 (enExample)
ES (1) ES2311986T3 (enExample)
MX (1) MXPA06012225A (enExample)
PL (1) PL1740164T3 (enExample)
PT (1) PT1740164E (enExample)
SI (1) SI1740164T1 (enExample)
WO (1) WO2005105069A1 (enExample)
ZA (1) ZA200607988B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007512347A (ja) * 2003-11-26 2007-05-17 デューク・ユニバーシティー 緑内障を予防するかまたは治療する方法
CN101330914A (zh) * 2005-12-16 2008-12-24 爱尔康公司 使用alk5调节剂控制眼内压
PL2018153T3 (pl) 2006-04-26 2012-09-28 Rosemont Pharmaceuticals Ltd Ciekłe kompozycje doustne
US20090202524A1 (en) * 2007-10-31 2009-08-13 Alcon Research, Ltd. Pai-1 expression and activity inhibitors for the treatment of ocular disorders
ES2330184B1 (es) * 2008-06-03 2010-07-05 Neuron Biopharma, S.A. Uso de estatinas como anticonvulsivantes, antiepilepticos y neuroprotectores.
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
CN102093984B (zh) * 2010-11-23 2012-07-04 清华大学 一种杂合酶P450sca2-BMR及其编码基因与应用
WO2013113067A1 (en) 2012-02-02 2013-08-08 The University Of Sydney Improvements in tear film stability
GB201611782D0 (en) * 2016-07-06 2016-08-17 Optibiotix Ltd Composition
US10696638B2 (en) 2017-12-26 2020-06-30 Industrial Technology Research Institute Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same
WO2025147589A1 (en) * 2024-01-05 2025-07-10 Osanni Bio, Inc. Implants, compositions, and methods for treating retinal diseases and disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0473337A2 (en) * 1990-08-29 1992-03-04 Pfizer Inc. Nor-statine and nor-cyclostatine polypeptides in the treatment of ocular hypertension and glaucoma
US5134124A (en) * 1989-06-05 1992-07-28 Sanofi Use of a statin derivative in the treatment of eye complaints

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534580A1 (fr) * 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
FR2585708B1 (fr) * 1985-07-31 1989-07-07 Sanofi Sa Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
US5151444B1 (en) * 1987-09-18 1999-07-06 R Tech Ueno Ltd Ocular hypotensive agents
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
DE68929435T2 (de) * 1988-09-06 2003-07-17 Pharmacia Ab, Stockholm Prostaglandinderivate zur Behandlung des grünen Stars oder einer okularen Hypertension
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US5599535A (en) * 1995-06-07 1997-02-04 Regents Of The University Of California Methods for the cyto-protection of the trabecular meshwork
US6586425B2 (en) * 1996-02-21 2003-07-01 Wisconsin Alumni Research Foundation Cytoskeletal active agents for glaucoma therapy
US6569461B1 (en) * 1999-03-08 2003-05-27 Merck & Co., Inc. Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors
JP2004512278A (ja) * 2000-09-19 2004-04-22 ノビムーヌ　ソシエテ　アノニム 新規な免疫調節剤、免疫阻害剤、及び抗炎症剤としてのスタチン（ＨＭＧ−ＣｏＡリダクターゼ阻害剤）
US20030065020A1 (en) * 2001-07-13 2003-04-03 Catharine Gale Treatment of macular degeneration
US20030195167A1 (en) * 2002-04-15 2003-10-16 Kowa Co., Ltd. PTX3-gene expression inhibitor
JP2004149480A (ja) * 2002-10-31 2004-05-27 Saisentan Igaku Kenkyusho:Kk 経口又は経皮投与用の眼科疾患治療剤
US20040248957A1 (en) * 2003-05-16 2004-12-09 Ambit Biosciences Corporation Heterocyclic compounds and uses thereof
US20040248972A1 (en) * 2003-05-16 2004-12-09 Ambit Biosciences Corporation Compounds and uses thereof
EP1631279A4 (en) * 2003-05-30 2007-03-14 Combinatorx Inc COMBINED THERAPY FOR THE TREATMENT OF NEOPLASMS
JP2007512347A (ja) * 2003-11-26 2007-05-17 デューク・ユニバーシティー 緑内障を予防するかまたは治療する方法
US20090202524A1 (en) * 2007-10-31 2009-08-13 Alcon Research, Ltd. Pai-1 expression and activity inhibitors for the treatment of ocular disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5134124A (en) * 1989-06-05 1992-07-28 Sanofi Use of a statin derivative in the treatment of eye complaints
EP0473337A2 (en) * 1990-08-29 1992-03-04 Pfizer Inc. Nor-statine and nor-cyclostatine polypeptides in the treatment of ocular hypertension and glaucoma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
于海等.hmg-coa还原酶抑制剂及其生物转化.《食品与发酵工业》.2002,第28卷(第6期),66-69页. *

Also Published As

Publication number Publication date
PT1740164E (pt) 2008-10-21
KR20110091600A (ko) 2011-08-11
KR20070007932A (ko) 2007-01-16
ATE404189T1 (de) 2008-08-15
KR101071192B1 (ko) 2011-10-10
EP1740164A1 (en) 2007-01-10
PL1740164T3 (pl) 2009-01-30
ZA200607988B (en) 2007-12-27
AU2005237543B2 (en) 2011-02-10
US20110098314A1 (en) 2011-04-28
AU2005237543A1 (en) 2005-11-10
EP1740164B1 (en) 2008-08-13
BRPI0510245A (pt) 2007-10-23
SI1740164T1 (sl) 2009-02-28
HK1102913A1 (en) 2007-12-07
US20050239871A1 (en) 2005-10-27
JP2007534699A (ja) 2007-11-29
CN1946384A (zh) 2007-04-11
MXPA06012225A (es) 2007-01-31
DE602005008935D1 (de) 2008-09-25
ES2311986T3 (es) 2009-02-16
WO2005105069A1 (en) 2005-11-10
CY1108490T1 (el) 2014-04-09
DK1740164T3 (da) 2008-11-10
CA2560167A1 (en) 2005-11-10

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SE01 Entry into force of request for substantive examination
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C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20110420

Termination date: 20130425