CN1943654B - A Chinese traditional medicinal composition and its preparation method - Google Patents
A Chinese traditional medicinal composition and its preparation method Download PDFInfo
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- CN1943654B CN1943654B CN2005101059639A CN200510105963A CN1943654B CN 1943654 B CN1943654 B CN 1943654B CN 2005101059639 A CN2005101059639 A CN 2005101059639A CN 200510105963 A CN200510105963 A CN 200510105963A CN 1943654 B CN1943654 B CN 1943654B
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Abstract
This invention provides a Chinese traditional medicinal composition used for treating the weakening of digestive function. The composition is prepared by using certain ratio of crataegolic, kudzu roots, rose according to a certain processing technology. It has obvious performance in treating the child anorexia shown anorexia and les eating.
Description
Technical field
The present invention relates to a kind of treatment and receive the Chinese medicine composition of the slow-witted few apositia of food, belong to technical field of Chinese medicines.
Background technology
Functional dyspepsia has been meant the dyspepsia performance, but does not have one group of clinical symptom grouping that organic gastropathy is found, is one of digestive system common disease.According to statistics, the dyspepsia incidence rate is 20%～40%.Its pathogeny is not clear fully as yet, and treatment at present is based on medicine for stomach dynamic+antacid, is associated with spiritual psychological factor person and adds and use antidepressants, and its effective percentage is about 70%.
The traditional Chinese medical science is generally with functional dyspepsia (Functionaldyspepsia, FD) distension and fullness in the abdomen that causes is classified as " painful abdominal mass " and distinguishes and control, main pathogenesis is the taste functional activity of QI being not smooth, modern medicine thinks that then this sick pathogeny do not illustrate as yet fully, gastric motility disorder may be one of pathologic basis, the regulatory mechanism of gastrointestinal motility is very complicated, and research is at present thought and mainly had cholinergic m receptor, epinephrine α and beta receptor, histamine receptor, 5-HT receptor and multiple gut hormone receptor on the gastrointestinal wall.
Infantile anorexia is present usual diseases of childhood card.Infantile anorexia gets to the bottom of sb.'s illness how full disloyal with famine.Theory of Chinese medical science thinks that deficiency of spleen-QI and stomach-QI is dyspepsia then, and gastral cavilty feeling of fullness, feeling of distension and oppression do not relax, the softness of pressing, and food back or fatigue then increase the weight of, and anorexia is weak, singultus belch, tastelessness and no thirst, shallow complexion, pale tongue, white and thin fur, thready and weak pulse or empty slow.With the stomach function regulating QI invigorating, the invigorating middle warmer spleen invigorating is for instructing during treatment.
The pathogeny of children's's functional dyspepsia is still clear at present, may be relevant with following factor: the effect of (1) gastric acid; (2) the gastroduodenal motor function is unusual; (3) gastroduodenitis and helicobacter pylori infections; (4) spiritual psychological factor; (5) neuro hormone factor; (6) dietary factor.Treatment is based on power medicine+antacid, and be associated with spiritual psychological factor person and add and use antidepressants, but often ignore some important informations in the clinical treatment, as: equally with abdominal distention, early full patient for performance, having of having is weak, yellowish complexion, tastelessness, pale tongue with white fur, thready and weak pulse; What have then shows as nose heave heavy sensation of the body, and limb is soft weak, and it is not well to defecate, yellowish or reddish urine, red tongue with yellow fur, soft and rapid pulse; Have then with dry mouth and tougue, feverish sensation in the palms and soles, emaciated physique, stool is measured less and dry, body of the tongue is thin red, symptoms such as yellow and thin fur or no fur.Prompting is that the main functional dyspepsia that shows is simultaneously with different " card " with the epigastric discomfort, thereby except that the anti symptom treatment of medicine for stomach dynamic+antacid, regulate the state of body, promptly " card " treated, cooperate the adjusting of suitable rest, food and drink, the change of living habit, the dredging of emotion, suitable strengthens the spleen and stomach, and can reach the purpose for the treatment of both the principal and secondary aspects of a disease.Functional dyspepsia can be divided into several different types according to Traditional Chinese medical theory and interrelated data, more intactly summarize its all pattern of syndrome, in all types, the curative effect of due to weakness of spleen and stomach is best.Different pattern of syndrome may be relevant with the functional dyspepsia cause of disease, and may contain the etiological analysis that present modern medicine is not familiar with as yet, as: body constitution is relatively poor, the patient of weakness of the spleen and stomach is because overfatigue or eating and drinking without temperance and the epigastrium that arrives is vexed expands pantothenic acid belch, fatigue and weak, traditional medicine is distinguished and is weakness of the spleen and stomach, be common dyspepsia type, the no abnormal discovery of most gastroscopes or ultrasonic examination meets the diagnostic criteria of functional dyspepsia.
Though traditional Chinese medical science typing is simple, can combine with the disease of part with the card of integral body, the inspection through clinical practice in 1,100 has significant values.
Fructus Crataegi of the present invention is the product of promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis; Radix Puerariae is an expelling pathogenic factors from muscles for reducing heat, the product of the antidiarrheal of promoting the production of body fluid; The stasis of blood is separated in the Flos Rosae Rugosae circulation of qi promoting, is used for liver temper pain.The present invention has appetite promoting and the spleen strengthening, the expelling pathogenic factors from muscles effect of promoting the production of body fluid.Clinical observation shows that the present invention is appetite stimulator effectively, improves the infantile anorexia symptom rapidly, promotes the absorption of various nutrients, accelerates the recovery of anorexia children's body weight, promotes its growth promoter, when the good medicine for the treatment infantile anorexia.
Summary of the invention
The present invention seeks to be achieved through the following technical solutions
Medicine of the present invention is made by following component:
Fructus Crataegi 200-300 weight portion Radix Puerariae 200-300 weight portion Flos Rosae Rugosae 200-300 weight portion
Medicine optimum weight part proportioning of the present invention is:
Fructus Crataegi 250 weight portion Radix Puerariaes 250 weight portion Flos Rosae Rugosaes 150 weight portions
Above crude drug can be made multiple dosage form as required, comprises clinical common formulations such as oral liquid, tablet, capsule, granule.These dosage forms are all refining through the extraction in early stage, and this process is as follows:
Get the rose wate steam distillation, leave and take distillate just; Medicinal residues and Fructus Crataegi, Radix Puerariae decoct with water 1-3 time, and decocting liquid is concentrated into relative density 1.05-1.25, leaves standstill, and get supernatant and add above-mentioned distillate just, concentrate extractum, add suitable adjuvant, make required dosage form.
Technology after preferred is:
Get the rose wate steam distillation, leave and take distillate 50ml just; Medicinal residues and Fructus Crataegi, Radix Puerariae decoct with water 2 times, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1 hour, filtrate is concentrated into relative density 1.15, leave standstill more than 24 hours, get supernatant and add Mel 80g and above-mentioned distillate just, regulate pH value to 3.6～6.0, add water move to 1000ml, left standstill 24 hours, and filtered embedding, sterilization, promptly.
This product can be used for treating digestive function weakness card, for determining drug effect, this product has been carried out pharmacodynamics test research, and particles used dose is optimal proportion and optimised process preparation and get according to the present invention in the test.Concrete test is as follows:
Test the influence of a pair of laboratory animal gastrointestinal function
1.1 influence: get 40 of rats, body weight 100 ± 15g, male and female half and half to normal rat small intestine absorption function, evenly be divided into 3 groups at random, gavage the mountain Pueraria lobota appetizing extracting solution (relative density 1.15) and the normal saline of big low dose respectively, irritate stomach every day 1 time, irritate the stomach amount and be 1ml/100g, continuous irrigation stomach 15 days, 1h behind last 1 filling stomach, every Mus gavages 3% D-xylose solution 1ml/100g, the rat eye socket is got blood behind the 1h, and is centrifugal, preparation serum, get rat blood serum 0.05ml, add test tube to be measured.Other gets 2 test tubes, and 1 pipe adds D-xylose titer 0.05ml, 1 pipe adding distil water 0.05ml.Each pipe adds developer (with phloroglucinol 0.5g, add the 100ml glacial acetic acid, 10ml hydrochloric acid is formulated) 5ml, mixing.In 100 ℃ of heating in water bath 4 minutes, take out to put in the psychrolusia and cool off, with 72-1 spectrophotometer 554nm wavelength 1cm optical path colorimetric,, read and respectively manage trap with distillation water pipe zeroising, converse serum D-xylose amount according to following formula, the results are shown in Table 1.Serum D-xylose amount (mmol/L)=OD value molecular weight
1.2 influence to model of spleen deficiency rat small intestine absorption function: get 50 of rats, male and female half and half, body weight 100 ± 15g evenly is divided into 4 groups at random, wherein makes model of spleen deficiency for 3 groups, and 1 group is the blank group.3 groups on modeling type, every morning is irritated 100% Radix Et Rhizoma Rhei decocting liquid, and 2ml/100g divide to irritate big low dose of mountain Pueraria lobota appetizing extracting solution (relative density 1.15) afternoon and with the volume normal saline.Successive administration 15 days, 1h behind last 1 filling stomach, every Mus gavages 3% D-xylose liquid 1ml/100g, and behind the 1h, the rat eye socket is got blood, and is centrifugal, preparation serum, the same method is surveyed serum D-xylose content, the results are shown in Table 1.
The table 1 pair excretory influence of rat gastric juice (n=10) (X ± SD)
Can find out that from table 1 heavy dose of mountain Pueraria lobota appetizing extracting solution group can obviously promote the absorption (P＜0.01) of normal rat D-xylose, small dose group can significantly promote to absorb (P＜0.05), and its D-xylose absorbs the raising percentage rate and is respectively 41.0%, 25.0%.Its D-xylose absorption has decline slightly after making the Radix Et Rhizoma Rhei model of spleen deficiency, and strengthening the spleen to promote digestion looses and can improve the absorption function of Rats with Spleen-deficiency, and its raising rate (with the model group ratio) is respectively 27.3%, 23.8%.
2.2 the influence (charcoal end method) to the mouse small intestine motor function: get 50 of healthy mices, be divided into 5 groups at random, except that blank is organized to waiting the appearance normal saline, all the other each group gave for 100% one week of Radix Et Rhizoma Rhei decocting liquid (once/day, 0.3ml/10g body weight), caused model of spleen deficiency, first and second group is given the cold boiled water that contains 10% charcoal end behind the 24h that stops eating, be the 0.2ml/10g body weight for mountain Pueraria lobota appetizing extracting solution (11.7%, 35.1%, the 105.3%) volume that contains 10% charcoal end for the 3rd to five group.Take off cervical vertebra behind the administration 30min and put to death mice, open the abdominal cavity, separate mesentery, clip upper end intestinal tube to pylorus, lower end to ileocecus, place on the platform, gently small intestinal is pulled into straight line, measure the small intestinal total length, the length in forward position, end, is calculated the charcoal end with following formula and is advanced percentage rate in the propulsive distance of enteral as the charcoal end from pylorus to charcoal.
Charcoal end advances white branch rate=charcoal end pair respectively to organize data at the propulsive distance of enteral (cm) small intestinal total length (cm) * 100% to carry out t check in groups and handle, the results are shown in Table 2.
Pueraria lobota appetizing extracting solution in table 2 mountain is to the influence (X ± s of mouse small intestine motion; N=10)
Experiment shows that model group compares with blank group, has the difference of highly significant; High dose and model group relatively had significant difference during mountain Pueraria lobota appetizing extracting solution was low, and prompting this product has the effect that promotes the mouse small intestine motor function.
Below further specify technical scheme of the present invention with the specific embodiment, but the claimed scope of the application is not limited in dosage form described in the embodiment.
The specific embodiment:
Embodiment 1
[prescription] Fructus Crataegi 250g Radix Puerariae 250g Flos Rosae Rugosae 150g
[method for making] gets the rose wate steam distillation, leaves and takes distillate 50ml just, and be standby.Medicinal residues and all the other two flavor medical materials decoct with water secondary, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1 hour, decocting liquid and residue pressed liquor merge, filter, filtrate is concentrated into relative density 1.15, leaves standstill more than 24 hours, get supernatant, add Mel 80g and above-mentioned distillate just, regulate pH value to 3.6～6.0, add water move to 1000ml, left standstill 24 hours, filter, embedding, sterilization, i.e. De Shange appetizing oral liquid.
Embodiment 2
[prescription] Fructus Crataegi 250g Radix Puerariae 250g Flos Rosae Rugosae 150g
[method for making] gets the rose wate steam distillation, leaves and takes distillate 50ml just, and be standby.Medicinal residues and all the other two flavor medical materials decoct with water secondary, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1 hour, decocting liquid and residue pressed liquor merge, filter, filtrate is concentrated into relative density 1.15, leaves standstill more than 24 hours, get supernatant and add above-mentioned distillate just, concentrate and get dry extract broken mistake 100 mesh sieves of dried cream powder, add sucrose, dextrin to 1000g, add 70% alcohol granulation, mixing with Mel, packing, i.e. De Shange appetizing granule.
Embodiment 3
[prescription] Fructus Crataegi 250g Radix Puerariae 250g Flos Rosae Rugosae 150g
[method for making] gets the rose wate steam distillation, leaves and takes distillate 50ml just, and be standby.Medicinal residues and all the other two flavor medical materials decoct with water secondary, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1 hour, decocting liquid and residue pressed liquor merge, filter, filtrate is concentrated into relative density 1.15, leaves standstill more than 24 hours, get supernatant and add above-mentioned distillate just, concentrate and get dry extract broken mistake 100 mesh sieves of dried cream powder, add sucrose, dextrin to 1000g, add 70% alcohol granulation, mixing with Mel, encapsulated, make 1000, i.e. the De Shange appetising capsule.
Embodiment 4
[prescription] Fructus Crataegi 250g Radix Puerariae 250g Flos Rosae Rugosae 150g
[method for making] gets the rose wate steam distillation, leaves and takes distillate 50ml just, and be standby.Medicinal residues and all the other two flavor medical materials decoct with water secondary, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1 hour, decocting liquid and residue pressed liquor merge, filter, filtrate is concentrated into relative density 1.15, leaves standstill more than 24 hours, get supernatant and add above-mentioned distillate just, concentrated getting dry extract, dried cream adds an amount of carboxymethylstach sodium, granulate drying, tabletting, make 1000, the De Shange sheet that whets the appetite.
Claims (6)
1. Chinese medicine composition for the treatment of apositia is characterized in that this Chinese medicine composition is to be made by following raw medicaments in portion by weight:
Fructus Crataegi 200-300 weight portion Radix Puerariae 200-300 weight portion Flos Rosae Rugosae 200-300 weight portion.
2. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition is to be made by following raw material medicaments:
Fructus Crataegi 250 weight portion Radix Puerariaes 250 weight portion Flos Rosae Rugosaes 150 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2 is characterized in that making oral liquid, tablet, capsule, granule.
4. the preparation method of Chinese medicine composition as claimed in claim 3 is characterized in that through following process: get the rose wate steam distillation, leave and take distillate just; Medicinal residues and Fructus Crataegi, Radix Puerariae decoct with water 1-3 time, and decocting liquid is concentrated into relative density 1.05-1.25, leaves standstill, and get supernatant and add above-mentioned distillate just, concentrate extractum, add suitable adjuvant, make required dosage form.
5. the preparation method of Chinese medicine composition as claimed in claim 4 is characterized in that it being by following method preparation: get the rose wate steam distillation, leave and take distillate 50ml just; Medicinal residues and Fructus Crataegi, Radix Puerariae decoct with water 2 times, add 10 times of amounts of water for the first time, decoct 2 hours, for the second time add 8 times of amounts of water, decocted 1 hour, filtrate is concentrated into relative density 1.15, leave standstill more than 24 hours, get supernatant and add Mel 80g and above-mentioned distillate just, regulate pH value to 3.6～6.0, add water move to 1000ml, left standstill 24 hours, and filtered embedding, sterilization, promptly.
6. the application of Chinese medicine composition in the medicine of eating slow-witted few apositia is received in the preparation treatment as claimed in claim 1 or 2.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1095289A (en) * | 1993-05-14 | 1994-11-23 | 何文超 | Health-care oral liquid for children and production method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095289A (en) * | 1993-05-14 | 1994-11-23 | 何文超 | Health-care oral liquid for children and production method |
Non-Patent Citations (1)
| Title |
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| 中国医院用药评价与分析.国家药品监督管理局公布第3、4批《非处方药药品目录》.中国医院用药评价与分析.2002,2(6),374-380. * |
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