CN1931006A - Feed additive for preventing H5N1 bird flu and its application - Google Patents
Feed additive for preventing H5N1 bird flu and its application Download PDFInfo
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- CN1931006A CN1931006A CNA2006101408206A CN200610140820A CN1931006A CN 1931006 A CN1931006 A CN 1931006A CN A2006101408206 A CNA2006101408206 A CN A2006101408206A CN 200610140820 A CN200610140820 A CN 200610140820A CN 1931006 A CN1931006 A CN 1931006A
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Abstract
The present invention discloses one kind of feed additive for preventing H5N1 type bird flu and its application. The feed additive for preventing H5N1 type bird flu is prepared with botanical material goldenrod and is added into feed product or feed material. Experiment proves the reliable effect of preventing H5N1 type bird flu of the feed additive.
Description
Technical field
The present invention relates to a kind of feed addictive, specifically, the present invention relates to the natural plants is the feed addictive and the application of the birds flu-preventing (H5N1) that goes out of feedstock production.
Background technology
Bird flu (H5N1) is a kind of communicable disease widely that can propagate by migratory bird, and it is very real to the potential threat of human health with to the harm of home poultry raising industry.And the mankind also do not find better prevention and treatment method so far except " slaughtering " without exception, and from 2003, the H5N1 highly pathogenic bird flu poultry farming of countries in Asia that almost has been sweeping across of hurricane type be to suffer heavy losses, and disaster was still continuing.Thereby press for can really effective, rational prevention method.
Summary of the invention
The present invention is for preventing bird flu effectively (H5N1) communicable disease its spread in china in poultry, utilization natural plants goldenrod has avian influenza virus (H5N1) significantly to be killed and rejection characteristic, has proposed the feed addictive and the application of a kind of energy birds flu-preventing (H5N1).
Technical scheme of the present invention is achieved in that
The feed addictive of a kind of birds flu-preventing (H5N1), described additive are to make by comprising following raw material: the plant goldenrod.
Described additive can also comprise Radix Glycyrrhizae or honeysuckle and Radix Isatidis; The additive that described goldenrod, Radix Glycyrrhizae are formed, its weight proportion is a goldenrod: Radix Glycyrrhizae is 1: 0.1-0.5; The additive that described goldenrod, honeysuckle, Radix Isatidis are formed, its weight proportion is a goldenrod: honeysuckle: Radix Isatidis is 1: 0.1-0.25: 0.1-0.25.
Described plant goldenrod is selected the herb goldenrod for use.
The feed addictive of described a kind of birds flu-preventing (H5N1) is preferably made extract or ultra micro pulvis.
Described extract is through supercritical CO
2Behind the fluid extraction, add pure water by 1: 50～100 by weight/volume again, blend into extract,
Described extract can also be with described additive and water by weight/volume ratio is 1: the ratio of 50-100 is put into digester and is boiled and boil 10～30 minutes, filters purifying according to a conventional method and makes.
The application of the feed addictive of described a kind of birds flu-preventing (H5N1) in the feed of preparation birds flu-preventing (H5N1).
The present invention also further provides the application of the feed addictive of described a kind of birds flu-preventing (H5N1), and with described additive extract or ultra micro pulvis and feed by weight ratio 1: 4-10 makes the feed of a kind of birds flu-preventing of the present invention (H5N1).
Described feed is commercially available finished product feedstuff.As: newly wish feed.
Described feed is to select feed prepared as required by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc.
Described extract is to adopt conventional extracting method, and conventional extracting method is roughly:
(1) digester extractive technique: equipment commonly used is to be furnished with filter bag can bear digester of air pressure etc.
Technical process: according to a conventional method raw material is put into filter bag, soaked 1～2 hour, heat, pressure rises about 1 atmospheric pressure again, the active ingredient of raw material just can parse and be dissolved in the water, leaches to get final product.
(2) existing ultramicro grinding wall breaking technology: finish by exploitation manufacturing " airslide disintegrating mill " nanoscale pulverizing of Onlly natural drug engineering Co., Ltd of Shanghai Communications University, broken wall one gas synthesis device.
Principle: after raw material enters Jet Mill, in pulverizing chamber, there are several to pulverize nozzle, the nozzle supersonic airstream makes comminuting matter be subjected to the air-flow high speed impact and powder runs foul of each other, because fast, the big crushing effect of impact of air velocity reaches the purpose that 0.5～10 micro particles (500 nanometers～10000 nanometers) reaches physical wall breaking simultaneously, make poultry, livestock can the good absorption active principle.
(3) supercritical CO
2The fluid extraction new technology: it is strong to make " 1000L automation large and super-critical unit " extracting power by the exploitation of east, Shenyang space group, recovery rate height, quality controllable system.
Principle: CO
2Critical-temperature and critical pressure be respectively 31.05 ℃ and 7.38MPa, when being in this critical point when above, the CO of this moment
2Have gas and liquid double grading simultaneously.It both had been similar to gas, and viscosity and gas are close; Be similar to liquid again, density and liquid are close, but its diffusion coefficient is more much bigger than liquid.Be an excellent solvent, can be by intermolecular interaction and diffusion with many substance dissolves.Simultaneously, in the zone of a little higher than critical point, pressure changes slightly, promptly causes the great changes of its density, thereby causes the bigger variation of solubility.Therefore, supercritical CO
2Can from matrix, substance dissolves be come out, form supercritical CO
2The load phase reduces the pressure or the rising temperature of carrier gas, supercritical CO then
2Solubility reduce, these materials just are precipitated out (parsing) and CO
2Separate, extract the purpose of separating thereby reach.
The using method of the feed of a kind of birds flu-preventing (H5N1) of invention: both can use with the finished product feedstuff equivalent means of frequent nursing; Can divide season by the requirement of birds flu-preventing (H5N1) again, the stage uses, and as feeding 1 time winter, every day in spring, other one weeks of season feed 1～2 time.
The 8-9 page or leaf record of " Chinese medicine voluminous dictionary " (first volume) (the new medical college in Jiangsu compiles): described goldenrod is a feverfew, its herb of general using or whole herb with root.Nature and flavor are arduous, cool.The herb goldenrod contains phenolic constituent, tannin, volatile oil, saponin, flavonoids etc.Function cures mainly wind and heat dispersing, subdhing swelling and detoxicating, cold headache, abscess of throat, jaundice, pertussis, child convulsion, traumatic injury, the carbuncle carbuncle on the back that swells, the fungal infection of the hand.Staphylococcus aureus, pneumococcus, Pseudomonas aeruginosa, shigella dysenteriae etc. are all had significantly kill and inhibitory action.
Goldenrod plant wind and heat dispersing, eliminating inflammation and expelling toxin; Pharmacology is gone into liver, gallbladder channel; Property of medicine cold.
The purging intense heat and detonicating of Radix Glycyrrhizae plant, moisten the lung and relieve the cough; The pharmacology twelve channels and collaterals that passes through; Gentle, the coordinating the drug actions of a prescription of the property of medicine.
The honeysuckle plant is clearing heat and detoxicating, anti-inflammatory analgetic; Pharmacology is gone into lung, stomach, large intestine channel; The property of medicine is cold.
The cool serum fire of Radix Isatidis plant, eliminating inflammation and expelling toxin; Pharmacology is gone into the heart, lung channel; The property of medicine is cold.
Goldenrod and Radix Glycyrrhizae compatibility can be in harmonious proportion the goldenrod property of medicine, have strengthened the adaptability of medicine.
Goldenrod and honeysuckle, Radix Isatidis compatibility can improve attending effectiveness, increase the universal of medicine.
Through inventor's many decades research and the described goldenrod plant extraction liquid of multi-faceted checking or plant ultra-micropowder agent H 5 N 1 avian influenza (influenza A virus) is had and significantly to kill and inhibition and prevention effect.
The additive and the feed of a kind of birds flu-preventing (H5N1) of invention is used for birds flu-preventing (H5N1), efficiently reaches 100%.
The specific embodiment
Further specify the present invention with embodiment below.
Example 1
Prepare additive of the present invention: 100 gram goldenrods and 5000ml water are put into digester boil and boil 30 minutes, and leach according to a conventional method and can obtain described plant extraction liquid 4400ml; Prepare feed of the present invention: described plant extraction liquid is joined in 1: 4 ratio newly wish to mix in the feed, stir, feed that birds flu-preventing (H5N1) made in oven dry.Or described plant extraction liquid joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 4 ratio select feed prepared as required.
Example 2
Prepare additive of the present invention: 100 gram goldenrods and 10000ml water are put into digester boil and boil 10 minutes, leach according to a conventional method and can obtain described plant extraction liquid 9800ml, prepare feed of the present invention: described plant extraction liquid is joined in 1: 6 ratio newly wish to mix in the feed, stir, feed that birds flu-preventing (H5N1) made in oven dry.Or described plant extraction liquid joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 6 ratio select feed prepared as required.
Example 3
Prepare additive of the present invention: 100 gram goldenrods and 7000ml water are put into digester boil and boil 20 minutes, leach according to a conventional method and can obtain described plant extraction liquid 6600ml, prepare feed of the present invention: described plant extraction liquid is joined in 1: 8 ratio newly wish to mix in the feed, stir, feed that birds flu-preventing (H5N1) made in oven dry.Or described plant extraction liquid joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 8 ratio select feed prepared as required.
Embodiment 4
Prepare additive of the present invention: 100 gram goldenrods, 50 gram Radix Glycyrrhizaes and 7500ml water are put into digester boil and boil 30 minutes, and leach according to a conventional method and can obtain described plant extraction liquid 6900ml, prepare feed of the present invention: described plant extraction liquid is joined in 1: 10 ratio newly wish to mix in the feed, stir, feed that birds flu-preventing (H5N1) made in oven dry.Or described plant extraction liquid joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 10 ratio select feed prepared as required.
Embodiment 5
Prepare additive of the present invention: 100 gram goldenrods, 25 gram honeysuckles, 25 gram Radix Isatidis and 7500ml water are put into digester boil and boil 30 minutes, and leach according to a conventional method and can obtain described plant extraction liquid 6900ml, prepare feed of the present invention: described plant extraction liquid is joined in 1: 9 ratio newly wish to mix in the feedstuff, stir, feed that birds flu-preventing (H5N1) made in oven dry.Or described plant extraction liquid joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 9 ratio select feed prepared as required.
Embodiment 6
Prepare additive of the present invention: 100 gram goldenrods can be obtained described plant ultra-micropowder agent through ultramicro grinding, prepare feed of the present invention: described plant ultra-micropowder agent is joined by 1: 7 ratio newly wish to mix in the feed, stir, dry the feed of making birds flu-preventing (H5N1).Or described plant ultra-micropowder agent joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 7 ratio select feed prepared as required.
Embodiment 7
Prepare additive of the present invention: 100 gram goldenrods, 50 gram Radix Glycyrrhizaes can be obtained described plant ultra-micropowder agent through ultramicro grinding, prepare feed of the present invention: described plant ultra-micropowder agent is joined by 1: 5 ratio newly wish to mix in the feed, stir, dry the feed of making birds flu-preventing (H5N1).Or described plant ultra-micropowder agent joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 5 ratio select feed prepared as required.
Embodiment 8
Prepare additive of the present invention: 100 gram goldenrods, 25 gram honeysuckles, 25 gram Radix Isatidis can be obtained described plant ultra-micropowder agent through ultramicro grinding, prepare feed of the present invention: described plant ultra-micropowder agent is joined by 1: 8 ratio newly wish to mix in the feed, stir, dry the feed of making birds flu-preventing (H5N1).Or described plant ultra-micropowder agent joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 8 ratio select feed prepared as required.
Example 9
Prepare additive of the present invention: restrain goldenrods through supercritical CO with 100
2Fluid extraction obtains the high concentration plant extraction liquid, add pure water 5000ml again, blend into the plant extraction liquid of little concentration, prepare feed of the present invention: described little concentration plant extraction liquid is joined in 1: 10 ratio newly wish to mix in the feed, stir, dry the feed of making birds flu-preventing (H5N1).Or described plant extraction liquid joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 10 ratio select feed prepared as required.
Embodiment 10
Prepare additive of the present invention: restrain goldenrods through supercritical CO with 100
2Fluid extraction obtains the high concentration plant extraction liquid, add pure water 10000ml again, blend into the plant extraction liquid of little concentration, prepare feed of the present invention: described little concentration plant extraction liquid is joined in 1: 9 ratio newly wish to mix in the feedstuff, stir, dry the feed of making birds flu-preventing (H5N1).Or described little concentration plant extraction liquid joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 9 ratio select feed prepared as required.
Embodiment 11
Prepare additive of the present invention: restrain goldenrods through supercritical CO with 100
2Fluid extraction obtains the high concentration plant extraction liquid, add pure water 7000ml again, blend into the plant extraction liquid of little concentration, prepare feed of the present invention: described little concentration plant extraction liquid is joined in 1: 7 ratio newly wish to mix in the feed, stir, dry the feed of making birds flu-preventing (H5N1).Or described plant extraction liquid joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 7 ratio select feed prepared as required.
Embodiment 12
Prepare additive of the present invention: 100 gram goldenrods, 50 are restrained Radix Glycyrrhizaes through supercritical CO
2Fluid extraction obtains the high concentration plant extraction liquid, add pure water 7500ml again, blend into the plant extraction liquid of little concentration, prepare feed of the present invention: described little concentration plant extraction liquid is joined in 1: 10 ratio newly wish to mix in the feed, stir, dry the feed of making birds flu-preventing (H5N1).Or described little concentration plant extraction liquid joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 10 ratio select feed prepared as required.
Embodiment 13
Prepare additive of the present invention: 100 gram goldenrods, 25 gram honeysuckles, 25 are restrained Radix Isatidis through supercritical CO
2Fluid extraction obtains the high concentration plant extraction liquid, add pure water 7500ml again, blend into the plant extraction liquid of little concentration, prepare feed of the present invention: described little concentration plant extraction liquid is joined in 1: 8 ratio newly wish to mix in the feed, stir, dry the feed of making birds flu-preventing (H5N1).Or described little concentration plant extraction liquid joined by grain, fish meal, bone meal, worm powder, grass meal, wheat bran, rice bran and auxiliary material (amino acid, vitamin, trace element, flavor enhancement) etc. in 1: 8 ratio select feed prepared as required.
Below with putting into practice further checking effect of the present invention of observation of curative effect statistics.
1, prevent and treat process and effect: on January 13rd, 2004 the chicken phenomenon of dying of illness in a large number occurred at Dong Ting township, Guangde County, Anhui feed lot, January 16 goldenrod and water are boiled by 1: 60 concentration ratio and boil 30 minutes goldenrod extracts among preparation the present invention, infecting sick chicken to 584 gives treatment to, every sick chicken is irritated and feeds described extract 40-60ml, adds once in 2 hours; And give 242 healthy chickens being housed in together feed feed of the birds flu-preventing of the present invention (H5N1) that is prepared into by embodiment 1 and embodiment 6 of forage feed method routinely that divides into groups; Observed through 2 hours, 4 hours, 10 hours, 30 hours, 60 hours, 5 days, remove and just irritate when feeding (in 5 minutes) in the dust 26 sick chickens, the whole rehabilitations of all the other sick chickens, normally movable; Efficient reaching more than 95%; Healthy chicken all prevention effectively prevents efficiently to reach 100%.Working, everyone 300 milliliters of 1: the 100 concentration goldenrod extracts of having a drink are with pre-preventing virus infection before starting for personnel and chicken house employee, and all work personnel and chicken house employees have kept health afterwards.(it is the H5N1 highly pathogenic bird flu that the epidemic situation of Guangde County, Anhui outburst is made a definite diagnosis in Center for Disease Control of menophania country check in February)
2. control foundation is " highly pathogenic bird flu diagnostic techniques GB/T18936-2003 "
3. prevent and treat method: treatment bird flu 10 gram goldenrods add 600ml water, boil and boil 30 minutes goldenrod extracts among preparation the present invention, and sick chicken is irritated hello secondary every day, each 40-60ml, and weight person doubles, and every 2-4 hour is once.Birds flu-preventing with plant extraction liquid or plant ultra-micropowder agent in 1: the 4-10 ratio adds in the feedstuff and mixes, stirs, oven dry make birds flu-preventing (H5N1) feed routinely the forage feed method feed or with plant extraction liquid (plant ultra-micropowder agent) as additive in 1: the 4-10 ratio adds that (finished product feedstuff) newly wishes to mix in the feed to, after the stirring routinely the forage feed method feed.
4. prevention effect evaluation criteria: sick fowl spirit takes a turn for the better, and is movable normal; Healthy chicken is active, in high spirits, and appetite is good.
5. prevention effect is observed: through observation in five days, all chickens of chicken group were in high spirits, and appetite is good
6. conclusion: adopt birds flu-preventing of the present invention (H5N1) feed addictive, be applied in the feed, birds flu-preventing (H5N1) is efficient to reach 100%.
Claims (10)
1. the feed addictive of a birds flu-preventing (H5N1), it is characterized in that: described additive is to make by comprising following raw material: goldenrod.
2. the feed addictive of a kind of birds flu-preventing as claimed in claim 1 (H5N1) is characterized in that: also comprise Radix Glycyrrhizae or honeysuckle and Radix Isatidis; The additive that described goldenrod, Radix Glycyrrhizae are formed, its weight proportion is a goldenrod: Radix Glycyrrhizae is 1: 0.1-0.5; The additive that described goldenrod, honeysuckle, Radix Isatidis are formed, its weight proportion is a goldenrod: honeysuckle: Radix Isatidis is 1: 0.1-0.25: 0.1-0.25.
3. the feed addictive of a kind of birds flu-preventing according to claim 1 and 2 (H5N1) is characterized in that: described plant goldenrod is selected the herb goldenrod for use.
4. the feed addictive of a kind of birds flu-preventing as claimed in claim 1 or 2 (H5N1) is characterized in that: be to make extract or ultra micro pulvis.
5. the feed addictive of a kind of birds flu-preventing as claimed in claim 4 (H5N1) is characterized in that: described extract is through supercritical CO
2Behind the fluid extraction, add pure water by 1: 50～100 by weight/volume again, blend into extract,
6. the feed addictive of a kind of birds flu-preventing as claimed in claim 4 (H5N1), it is characterized in that: described extract be with described additive and water by weight/volume ratio is 1: the ratio of 50-100 is put into digester and is boiled and boil 10～30 minutes, filters purifying according to a conventional method and makes.
7. the application of the feed addictive of the described a kind of birds flu-preventing of claim 4 (H5N1) in the feed of preparation birds flu-preventing (H5N1).
8. the application of the feed addictive of the described a kind of birds flu-preventing of claim 4 (H5N1) is characterized in that: with described additive extract or ultra micro pulvis and feed by weight ratio 1: 4-10 makes the feed of a kind of birds flu-preventing (H5N1).
9. the application of the feed addictive of the described a kind of birds flu-preventing of claim 5 (H5N1) is characterized in that: with described additive extract and feed by weight ratio 1: 4-10 makes the feed of a kind of birds flu-preventing (H5N1).
10. the application of the feed addictive of claim 8 or 9 described a kind of birds flu-preventings (H5N1), it is characterized in that: described feed is commercially available feed or feed prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101408206A CN100566587C (en) | 2006-10-11 | 2006-10-11 | The feed addictive and the application of a kind of birds flu-preventing (H5N1) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101408206A CN100566587C (en) | 2006-10-11 | 2006-10-11 | The feed addictive and the application of a kind of birds flu-preventing (H5N1) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1931006A true CN1931006A (en) | 2007-03-21 |
| CN100566587C CN100566587C (en) | 2009-12-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006101408206A Expired - Fee Related CN100566587C (en) | 2006-10-11 | 2006-10-11 | The feed addictive and the application of a kind of birds flu-preventing (H5N1) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107182911A (en) * | 2017-05-16 | 2017-09-22 | 广西习缘辣木有限公司 | A kind of cultural method of selenium-rich laying hen |
-
2006
- 2006-10-11 CN CNB2006101408206A patent/CN100566587C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107182911A (en) * | 2017-05-16 | 2017-09-22 | 广西习缘辣木有限公司 | A kind of cultural method of selenium-rich laying hen |
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| Publication number | Publication date |
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| CN100566587C (en) | 2009-12-09 |
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Granted publication date: 20091209 Termination date: 20171011 |