CN1907269A - Aminoglucose composite effervescent preparation - Google Patents
Aminoglucose composite effervescent preparation Download PDFInfo
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- CN1907269A CN1907269A CN 200610029813 CN200610029813A CN1907269A CN 1907269 A CN1907269 A CN 1907269A CN 200610029813 CN200610029813 CN 200610029813 CN 200610029813 A CN200610029813 A CN 200610029813A CN 1907269 A CN1907269 A CN 1907269A
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Abstract
The invention discloses an effervescent and effervescent tablet based on aminoglucose and calcium agent as effective ingredient, which is characterized by the following: improving curative effect; fitting for intaking; treating arthritis.
Description
Technical field
The present invention relates to a kind of aminoglucose composite effervescent preparation that is used for, particularly relate to the composite effervescent formulation that main component is glucosamine and calcium complement agent.
Background technology
Osteoporosis is classified as one of person in middle and old age's three big diseases by WHO, has leapt to the 7th in world's common frdquently encountered disease, has surpassed 200,000,000 people before patient's total number; Wherein only just there are more than 7,500 ten thousand people in the U.S., West Europe and Japan, and annual treatment and hospitalization cost are up to 25,000,000,000 dollars.Also very serious in Chinese osteoporosis, China's patients with osteoporosis had reached more than 8,000 ten thousand in 2004, mainly was more common in middle-aged and elderly people, wherein more than 40 years old the osteoporotic incidence rate of crowd be more than 16%, 60 years old be 22.6%, 80 years old then to surpass 50%.Add that China is populous, this huge osteoporosis high-risk group is certain to bring immense pressure to China's medical care insurance and health economy.Therefore, prevention of osteoporosis disease is very important.
Bone is a kind of special connective tissue, is made up of various kinds of cell and intercellular bone matrix.Born of the same parents' composition is: osteoblast (Osteoblast), osteocyte (Osteocyte), osteoclast (Osteoclast).Bone matrix is made of organic and inanimate matter, is organicly produced by the osteocyte secretion, account for bone heavy 1/3, wherein the overwhelming majority (95%) is collagen fiber, all the other are amorphous ground substance, the gel of promptly neutral or weakly acidic glycosaminoglycan composition.Its composition is mainly proteoglycan (Proteoglycan), aminoglycan (GAG) etc.Inanimate matter mainly is a calcium salt, account for bone heavy 2/3, main component is a hydroxylapatite crystal, is a kind of insoluble neutral salt, is fine acicular, arranges along the major axis of collagen fiber.Bone is carried out calcination, remove its organic matter, though still can hold its shape and hardness, crisp and frangible.As placing strong acid to soak in bone, remove its inanimate matter (decalcification), soft and flexible though this bone is still had an original shape, can crooked even knotting, still can restore to the original state after unclamping.
Organic ratio with inanimate matter gradually changes with age growth, child's bone organic more, and pliability and elasticity are big, and is yielding, meets when violence is hit to be difficult for fractureing fully, the Ramulus Salicis Babylonicae sample often takes place fracture.Old people's organic matter decrescence, collagen fiber are aging,, the absorption of sclerotin surpasses synthetic, and osteoporosis easily takes place.Thereby sclerotin becomes fragile, and then easily fractured by violence.
Scientist finds for a long time, and glucosamine is to constitute an important component of human connective tissue and other material in conjunction with forming various biological active substanceies, is the indispensable a kind of nutritional labeling of human body.Its overwhelming majority is distributed in the skeletal tissue.Along with the variation at people's age, the glucosamine monomer can run off, and causes the cartilage degeneration, and then loses its buffering and lubricating functions.Exogenous additional glucosamine can participate in synthesizing, strengthen, repair and regeneration of cartilage as the synthetic base stock of cartilage.The main component of glucosamine is " a D-glycosamine ", and it is a kind of micromolecular compound, sees through biomembrane easily, and with cartilage in the joint very strong affinity is arranged, and combines with proteoglycan molecule in the joint.In addition, glucosamine can suppress to destroy the Elastase of cartilage, tendon and ligament, strengthens cartilage, can also effectively remove various harmful enzyme and cytokine in the articular cavity, and these materials exactly causes patient's pain and cartilage injury's key factor.Therefore, the middle-aged and elderly people that secretion " glucosamine " quantity reduces suitably replenishes some glucosamine formulations health is of great benefit to.
Glucosamine is mainly used in the treatment osteoarthritis at present, and osteoarthritis is the result that articular cartilage proteoglycan biosynthesis presents degeneration unusually.Glucosamine is a kind of natural amino monosaccharide, can stimulate the proteoglycan that chondrocyte produces normal polymer structure, the enzyme such as collagenase and the phospholipase A2 that suppress the damage cartilage, and can prevent the generation of the super oxyradical of damaging cells, thereby can delay the pathological process of osteoarthritis and the progress of disease, improve joint motion, alleviating pain.
Glucosamine is the structure of human body cartilaginous tissue and repairs necessary a kind of polysaccharide, it also is the synthetic precursor of multi-functional GL-PP, glucosamine can stimulate the GL-PP that chondrocyte produces normal polymer structure, promote cartilage metabolism and regeneration, remediation intensification cartilage, thereby the pathological process of blocking-up osteoarthritis, development wards off disease, improve the joint motion motility, alleviating pain is fundamentally eliminated the cause of disease that osteoarthritis takes place.It especially has special role to improving arthritis to generating cartilage, muscle tendon, ligament, joint fluid.
Glucosamine not only can improve the physiological function in joint, but also can increase the physiological action of bone density, its concrete mechanism that increases bone density is: 1) it is a nutritional labeling of synthetic bone organic substance, the aminoglycan that is used for synthetic substrate increases the organic substance in the synthetic bone tissue.2) by stimulating the synthetic collagen protein of osteocyte, promote the organic formation in the skeleton.3) the inorganic matter apatite of the synthetic main composition sclerotin of all right stimulating osteoblast.Therefore, replenish glucosamine, can increase eburnation degree, flintiness, the treatment osteoporosis.
Calcium is the maximum a kind of inorganic elements of people's in-vivo content, and calcium content 20-25 gram in the body reached the 1000-1200 gram when people was born when adult, accounted for 2% of body weight.Calcium is to constitute the various skeletons of support health and the main component of tooth; Therefore calcium is the inorganic elements extremely important in the human body, that content is the highest.Lack this important inorganic elements and must cause a series of diseases, as children rachitis, adult's osteomalacia, middle-aged and elderly people osteoporosis etc.Bone matrix is to carry out mineralising under the physiological action of hydroxyapatite (the little crystalline solid that contains the calcium phosphate of basic carbonate).Calcium is the Main Ingredients and Appearance of bone mineral hydroxyapatite, and the degree of absorption of calcium and effective rate of utilization obviously influence bone mineral content.It is a kind of factor of anti-bone resorption that competent calcium is taken in, and replenishing the calcium can delay losing of sclerotin to a certain extent.Because calcium can suppress the secretion of PTH, so have anti-bone resorption.Increase calcium intake and can also have anti-fracture effect.Especially for compatriots, most of health calcium deficiency of compatriots according to investigations.The nearly osteoporosis research heat that occurs in the whole nation during the last ten years extensively causes the upsurge that compatriots replenish the calcium.Just outside the effect of calcium in skeleton, calcium also has keeps neural and muscle normal activity; Promote the activity of various enzymes in the health, and the effects such as physiological process that participate in blood coagulation.
At present, calsium supplement is various in style, selection factor mainly contains calcium content, absorbance, safety, price etc., and wherein the characteristics of calcium carbonate are: be white powder, and water-soluble hardly, contain calcium content and reach 40%, for the highest in the calsium supplement, the human absorptivity is 39%, and calcium ion is absorbed at upper part of small intestine, side effect is little, and is cheap.
The suitable crowd of this product is a middle-aged and elderly people, because middle-aged and elderly people is easily sent out diseases such as osteoporosis, osteoarthritis, and middle-aged and elderly people stasi, the various functions of body reduce gradually, and this product is mainly used in increases the additional of these nutrient substance, the function that these of enhancing body go down.Take for a long time and can treat the various relevant skeletal diseases of prevention, promote bone health.
Summary of the invention
The invention provides a kind of aminoglucose composite effervescent preparation.
Aminoglucose composite effervescent preparation provided by the present invention, its effective ingredient are glucosamine and calcium complement agent, and all the other are the effervescent excipient.
Aminoglucose composite effervescent preparation provided by the present invention, the glucosamine in its effective ingredient are hydrochlorate, sulfate or other acceptable salt; Calcium complement agent derives from one or more of calcium carbonate, calcium citrate, calcium lactate, calcium gluconate etc.
Aminoglucose composite effervescent preparation provided by the present invention, its excipient comprises: (1) acid source composition is one or more of citric acid, tartaric acid, malic acid, fumaric acid, adipic acid etc.; (2) carbon dioxide derived components is one or more of sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate; (3) filler is one or more of lactose, sucrose, maltodextrin, mannitol, sorbitol, xylitol, soluble starch, chitosan etc.; (4) binding agent or wetting agent are water, Different concentrations of alcohol, polyvinylpyrrolidone, simple syrup etc.; (5) sweeting agent is one or more of acesulfame potassium (acesulfame potassium), aspartame, cyclamate, stevioside, sucralose, saccharin sodium etc.; (6) correctives is the required edible essence of allotment taste; (7) other: effervescent formulations such as food coloring, soluble oil prepare required excipient.
Aminoglucose composite effervescent preparation provided by the present invention can be a kind of granule, and its excipient comprises: (1) acid source composition is selected from citric acid, the tartaric acid one or more; (2) carbon dioxide derived components is selected from sodium bicarbonate, the sodium carbonate one or more; (3) filler is selected from lactose, maltodextrin, the sucrose one or more; (4) binding agent or wetting agent are selected from water or Different concentrations of alcohol or polyvinylpyrrolidone; (5) sweeting agent is selected from one or more in acesulfame potassium, the aspartame; (6) correctives is selected for use from edible powdered flavor; And other effervescent granules such as food coloring prepare required excipient.
Aminoglucose composite effervescent preparation provided by the present invention, can be a kind of granule, preferably form by the glucosamine of weight content 1%～40%, 1%～40% calcium, 5%～60% citric acid, 1%～40% sodium bicarbonate, 1%～60% lactose, 0～20% maltodextrin, 0～10% polyvinylpyrrolidone, 0.1～3% aspartame, 0～3% acesulfame potassium, 0.2%～2% edible powdered essence and proper amount of edible pigment.
Aminoglucose composite effervescent preparation provided by the present invention, can be a kind of granule, most preferably form by the glucosamine of weight content 17%, 8% calcium, 37% citric acid, 4% sodium bicarbonate, 16% lactose, 2% polyvinylpyrrolidone, 0.4% acesulfame potassium, 0.4% aspartame, 0.5% edible powdered essence and proper amount of edible pigment.
Aminoglucose composite effervescent preparation provided by the present invention can be a kind of tablet, and excipient is: (1) acid source composition is selected from citric acid, the tartaric acid one or more; (2) carbon dioxide derived components is selected from sodium bicarbonate, the sodium carbonate one or more; (3) filler is selected from lactose, sucrose, sorbitol, the mannitol one or more; (4) binding agent or wetting agent are selected from water or polyvinylpyrrolidone or simple syrup; (5) sweeting agent is selected from acesulfame potassium, the aspartame one or more; (6) correctives is selected edible powdered essence for use; (7) tabletting with lubricator is selected from leucine, the polyethylene glycol 6000 one or more; (8) other effervescent tablets such as food coloring prepare required excipient.
Aminoglucose composite effervescent preparation provided by the present invention, can be a kind of tablet, preferably form by the glucosamine of weight content 1%～30%, 1%～30% calcium, 5%～60% citric acid, 1%～30% sodium bicarbonate, 1%～40% lactose, 0～40% mannitol, 0～5% polyvinylpyrrolidone, 0.1～2% aspartame, 0～2% acesulfame potassium, 0.5%～5% leucine, 0.2%～2% edible powdered essence and proper amount of edible pigment.
Aminoglucose composite effervescent preparation provided by the present invention, can be a kind of tablet, most preferably form by the glucosamine of weight content 10%, 5% calcium, 38% citric acid, 10% sodium bicarbonate, 15% lactose, 10% mannitol, 0.5% polyvinylpyrrolidone, 0.5% acesulfame potassium, 0.5% aspartame, 0.5% edible powdered essence, 1% leucine and proper amount of edible pigment.
The present invention also provides aminoglucose composite effervescent preparation to be used for the application of the health care of middle-aged and elderly people bone and arthritic health food of prophylactic treatment and medicine in preparation.
On extensively having investigated both at home and abroad about enhancing bone density health promoting product market value basis, to grope through prescription screening, formulation optimization and technology, main component is glucosamine, calcium complement agent in establishment the present invention prescription, and establishes effervescent formulation preparation technology.Glucosamine is synthetic joint tissue and the necessary nutritional labeling of joint periosteum; Scientific research confirms, because calcium has facilitation to the growth promoter and the bone density of bone, calcium is easy to absorption of human body, can replenish the calcium that lacks in the vast skeleton discomfort person sclerotin, bone density improving; Two big nutrients are organically combined; not only can increase bone density; make skeleton that good compressive resistance be arranged; also can replenish articular cartilage and recover the toughness and the elasticity in joint; increase the resistance to tension of skeleton; osteoarthrosis there is the potentiation of protection, reparation and articular cartilage, regulates the immunocompetence of body, and then reduce the morbidity risk rate of osteoporosis and osteoarthritis.
At present glucosamine formulations and the calcium supplementing preparation great majority on the health-product market be tablet, capsule and plain particles agent, and form is single, and day dose more, bring inconvenience in the use to the relatively poor elderly population of function of deglutition.The advantage of the present invention on taking convenience is conspicuous, and after the reaction of calcium carbonate and effervescent, calcium is present in the aqueous solution with ionic condition, do not need to consume extra gastric acid after entering stomach, can be absorbed by the body rapidly.Simultaneously, effervescent formulation novel form, adjustable various tastes.
The salt of main component glucosamine of the present invention mainly contains glucosamine hydrochloride, glucosamine sulphate and GLUCAS AMINECP, and onset ground only is glucosamine.Special optimization selected glucosamine hydrochloride and glucosamine sulphate for use.
Main component calcium complement agent of the present invention is summarized and is divided into: 1, calcium carbonate: the calcium content height, and side effect is little, low price, the absorbance height can reach 40%; 2, other: calcium lactate, calcic 13%, good water solubility; Calcium gluconate, calcic 9%, water solublity is good, but calcium content is lower; Phosphoric acid ammonia calcium: be Japan's kind of replenishing the calcium commonly used, calcic 23.3%, higher relatively, but its shortcoming is the tablet disintegrate and absorbs difficulty that its phosphorous height is harmful to the renal dysfunction person in addition, therefore uses less; Chinese holly edge acid calcium, calcium content is 21.1%, and water solublity is better, and biological utilisation is also good than calcium phosphate, and its absorption does not rely on gastric acid, and effervescent tablet is arranged, and is more suitable for the old people and takes; Activated calcium is biological calcium (shell) high-temperature calcination and the calcium compound that forms, the calcium content height, but its aqueous solution is a strong basicity, big to gastrointestinal irritation, be not suitable for old achlorhydria person; Organic calcium: the superfluous calcium that closes of amino acid calcium and albumen has begun to use in China.Take all factors into consideration, the special optimization of the present invention selected calcium carbonate for use.
The specific embodiment
Embodiment 1 aminoglucose composite effervescent granular recipe and preparation (no cane sugar type, non-water granulating process)
Prescription 1: every bag of about 2.5g, hydrochloric glucosamine 0.5 gram, calcium carbonate 0.5 gram (being equivalent to calcium 0.2 gram).
Eating method: every day secondary, each 1 bag; In the eliminating cold for resuscitation water or cold boiled water that every bag is dissolved in about 100ml, effervescent is complete, takes after the clarification.
Per 1000 bags of consumptions
Glucosamine hydrochloride 500g
Calcium carbonate 500g
Anhydrous citric acid 920g
Sodium bicarbonate 100g
Lactose 400g
Acesulfame potassium (acesulfame potassium) 9g
Aspartame 9g
Fructus Citri tangerinae powdered flavor 0.5%
8% polyvinylpyrrolidone-dehydrated alcohol is an amount of
Preparation method: glucosamine hydrochloride (pulverizing 80 orders), calcium carbonate, anhydrous citric acid, sodium bicarbonate, lactose, acesulfame potassium are pressed the recipe quantity mix homogeneously, add 8% polyvinylpyrrolidone-ethanol solution system soft material, 18 mesh sieve system granules, 50～60 ℃ of dryings, 18 mesh sieve granulate, packing promptly behind adding aspartame, the edible essence mixing.
Embodiment 2 aminoglucose composite effervescent granular recipes and preparation (no cane sugar type, wet granulation technology)
Prescription 2: every bag of about 2.8g, hydrochloric glucosamine 0.5 gram, calcium carbonate 0.5 gram (being equivalent to calcium 0.2 gram).
Eating method: every day secondary, each 1 bag; In the eliminating cold for resuscitation water or cold boiled water that every bag is dissolved in about 100ml, effervescent is complete, takes after the clarification.
Per 1000 bags of consumptions
Glucosamine hydrochloride 500g
Calcium carbonate 500g
Citric acid 1000g
Sodium bicarbonate 100g
Lactose 700g
Maltodextrin 50g
Lemon yellow 0.1g
Acesulfame potassium (acesulfame potassium) 9g
Aspartame 9g
Fructus Citri tangerinae powdered flavor 0.5%
10% polyvinylpyrrolidone-50% ethanol is an amount of
5% polyvinylpyrrolidone-water is an amount of
Preparation method: behind glucosamine hydrochloride and citric acid mix homogeneously, add an amount of 10% polyvinylpyrrolidone-50% alcoholic solution (partly measuring lemon yellow is dissolved in wherein in advance) system soft material, 18 mesh sieves are granulated, and wet granular is in 50～60 ℃ of dryings, 18 mesh sieve granulate get granulates; Behind calcium carbonate, sodium bicarbonate and lactose, maltodextrin, acesulfame potassium mix homogeneously, add an amount of 5% polyvinylpyrrolidone aqueous solution (partly measuring lemon yellow is dissolved in wherein in advance) system soft material, 18 mesh sieves are granulated, and wet granular is in 50～60 ℃ of dryings, 18 mesh sieves are whole, get the alkali granule; At last, the soda acid granule is even by the prescription mixed, and packing promptly behind adding aspartame, the edible essence mixing.
Embodiment 3 aminoglucose composite effervescent granular recipes and preparation (cane sugar type, non-water granulating process)
Prescription 1: every bag of about 2.5g, hydrochloric glucosamine 0.5 gram, calcium carbonate 0.5 gram (being equivalent to calcium 0.2 gram).
Eating method: every day secondary, each 1 bag; In the eliminating cold for resuscitation water or cold boiled water that every bag is dissolved in about 100ml, effervescent is complete, takes after the clarification.
Per 1000 bags of consumptions
Glucosamine hydrochloride 500g
Calcium carbonate 500g
Anhydrous citric acid 920g
Sodium bicarbonate 100g
Sucrose 400g
Aspartame 20g
Fructus Citri Limoniae powdered flavor 0.5%
8% polyvinylpyrrolidone-dehydrated alcohol is an amount of
Preparation method: with glucosamine hydrochloride (pulverizing 80 orders), calcium carbonate, anhydrous citric acid, sodium bicarbonate, sucrose, press the recipe quantity mix homogeneously, add 8% polyvinylpyrrolidone-ethanol solution system soft material, 18 mesh sieve system granules, 50～60 ℃ of dryings, 18 mesh sieve granulate, packing promptly behind adding aspartame, the edible essence mixing.
Embodiment 4 aminoglucose composite effervescent slice prescriptions and preparation technology's (no cane sugar type)
Every agreement that contracts a film or TV play to an actor or actress 4g, sulfur acid glucosamine 0.5 gram, calcium carbonate 0.5 gram (being equivalent to calcium 0.2 gram).
Eating method: every day secondary, each 1; In the eliminating cold for resuscitation water or cold boiled water that every is dissolved in about 200ml, effervescent is complete, takes after the clarification.
Prescription:
Per 1000 consumptions
Glucosamine sulfate 500g
Calcium carbonate 500g
Anhydrous citric acid 1500g
Sodium bicarbonate 400g
Lactose 600g
Mannitol 400g
Acesulfame potassium 20g
Aspartame 20g
Lemon yellow is an amount of
Sunset yellow is an amount of
5% polyvinylpyrrolidone-water is an amount of
Fructus Citri sinensis powdered flavor 0.5%
Leucine 1%
Preparation method: behind calcium carbonate and sodium bicarbonate, lactose, mannitol, acesulfame potassium mix homogeneously, add 5% polyvinylpyrrolidone aqueous solution (food coloring is dissolved in wherein in advance) system soft material, 20 mesh sieves are granulated, and wet granular is in 50～60 ℃ of dryings, 20 mesh sieve granulate; With the granule that makes and glucosamine sulfate (20～40 order), anhydrous citric acid (20～40 order) mix homogeneously, and add aspartame, edible essence and leucine, tabletting promptly behind the mix homogeneously.
Embodiment 5 aminoglucose composite effervescent slice prescriptions and preparation technology's (cane sugar type)
Every agreement that contracts a film or TV play to an actor or actress 4g, sulfur acid glucosamine 0.5 gram, calcium carbonate 0.5 gram (being equivalent to calcium 0.2 gram).
Eating method: every day secondary, each 1; In the eliminating cold for resuscitation water or cold boiled water that every is dissolved in about 200ml, effervescent is complete, takes after the clarification.
Prescription:
Per 1000 consumptions
Glucosamine sulfate 500g
Calcium carbonate 500g
Anhydrous citric acid 1500g
Sodium bicarbonate 400g
Sucrose 1000g
Aspartame 40g
Lemon yellow is an amount of
Sunset yellow is an amount of
Simple syrup is an amount of
Fructus Citri sinensis powdered flavor 0.5%
Leucine 1%
Preparation method: after closing calcium carbonate and sodium bicarbonate, sucrose evenly, add simple syrup (food coloring is dissolved in wherein in advance) system soft material, 20 mesh sieves are granulated, and wet granular is in 50～60 ℃ of dryings, 20 mesh sieve granulate; With the granule that makes and glucosamine sulfate (20～40 order), anhydrous citric acid (20～40 order) mix homogeneously, and add aspartame, edible essence and leucine, tabletting promptly behind the mix homogeneously.
The particle stabilized Journal of Sex Research of embodiment 6 aminoglucose composite effervescents
Packaged form: aminoglucose composite effervescent granule (embodiment 1) adopts two aluminum film packings, about 2.5 gram/bags; Aminoglucose composite effervescent sheet (embodiment 4) adopts the special-purpose plastic tube packaging of effervescent tablet, 10/pipe.
Stability accelerated test: the packing sample of aminoglucose composite effervescent granule and effervescent tablet is placed 40 ℃, accelerated test is 3 months in the environment of relative humidity 75%, the appearance character of results sample, moisture, effervescent response time, solution pH value, main component content equistability high spot reviews index and 0 o'clock sample measurement result are relatively, have no significant change, illustrate that sample quality is comparatively stable under this terms of packing, can satisfy the stability requirement of storage, transportation, use.Result of the test sees Table 1, table 2.
Table 1 aminoglucose composite effervescent granule stability accelerated test result
| Lot number | Time | Appearance character | Moisture (%) | Effervescent reaction settling time (branch) | The solution pH value | Glucosamine content (mg/g) | Calcium content (mg/g) |
| 050906 | 0 month | The off-white color granule | 0.63 | 3 | 4.38 | 164.9 | 79.6 |
| January | The off-white color granule | 0.68 | 3.5 | 4.42 | 165.3 | 79.8 | |
| February | The off-white color granule | 0.65 | 3 | 4.42 | 164.2 | 79.2 | |
| March | The off-white color granule | 0.69 | 3 | 4.40 | 164.5 | 79.0 | |
| 050908 | 0 month | The off-white color granule | 0.55 | 3.5 | 4.42 | 168.4 | 80.3 |
| January | The off-white color granule | 0.61 | 3 | 4.40 | 167.2 | 79.8 | |
| February | The off-white color granule | 0.57 | 3.5 | 4.39 | 168.7 | 80.6 | |
| March | The off-white color granule | 0.59 | 3 | 4.39 | 167.9 | 79.6 | |
| 050912 | 0 month | The off-white color granule | 0.70 | 2.5 | 4.40 | 165.8 | 79.4 |
| January | The off-white color granule | 0.68 | 3 | 4.42 | 166.2 | 79.8 | |
| February | The off-white color granule | 0.73 | 3 | 4.38 | 165.7 | 78.8 | |
| March | The off-white color granule | 0.75 | 2.5 | 4.39 | 165.4 | 79.1 |
Table 2 aminoglucose composite effervescent tablet stability accelerated test result
| Lot number | Time | Appearance character | Moisture (%) | Effervescent reaction settling time (branch) | The solution pH value | Glucosamine content (mg/g) | Calcium content (mg/g) |
| 051018 | 0 month | The off-white color sheet, unilateral have a light yellow speckle | 0.62 | 4 | 4.43 | 97.6 | 49.6 |
| January | The off-white color sheet, unilateral have a light yellow speckle | 0.60 | 4 | 4.42 | 98.0 | 49.8 | |
| February | The off-white color sheet, unilateral have a light yellow speckle | 0.58 | 4 | 4.40 | 98.6 | 49.2 | |
| March | The off-white color sheet, unilateral have a light yellow speckle | 0.55 | 4.5 | 4.43 | 97.1 | 49.4 | |
| 051020 | 0 month | The off-white color sheet, unilateral have | 0.57 | 3.5 | 4.37 | 97.3 | 49.3 |
| Light yellow speckle | |||||||
| January | The off-white color sheet, unilateral have a light yellow speckle | 0.61 | 4 | 4.40 | 96.8 | 49.4 | |
| February | The off-white color sheet, unilateral have a light yellow speckle | 0.55 | 3.5 | 4.39 | 97.6 | 49.6 | |
| March | The off-white color sheet, unilateral have a light yellow speckle | 0.52 | 4 | 4.39 | 96.9 | 49.2 | |
| 051024 | 0 month | The off-white color sheet, unilateral have a light yellow speckle | 0.58 | 4.5 | 4.45 | 100.4 | 50.8 |
| January | The off-white color sheet, unilateral have a light yellow speckle | 0.61 | 4.5 | 4.46 | 99.7 | 50.4 | |
| February | The off-white color sheet, unilateral have a light yellow speckle | 0.57 | 4 | 4.48 | 100.1 | 50.4 | |
| March | The off-white color sheet, unilateral have a light yellow speckle | 0.51 | 4 | 4.46 | 100.0 | 50.6 |
Embodiment 7 glucosamine and calcium complexes bone density improving animal experiment
Get cleaning level SD rat, female, body weight 60-75g is divided into five groups at random, and 10 every group, press the human body recommended dose, establish basic, normal, high three dosage, be equivalent to 5,10,30 times of human body recommended dose, establish normal feedstuff group and calcium carbonate control group simultaneously.Each group is continuous 12 weeks of feed respectively, survey every index.Result of the test shows that middle and high dosage sample sets rat body weight is apparently higher than the normal feedstuff group; The apparent absorbance of high agent sample sets is significantly higher than calcium carbonate control group; Middle and high dosage sample sets femur weight, femoral bmd, calcium content of bone are all apparently higher than the normal feedstuff group, so have the bone density improving effect.
Claims (10)
1. an aminoglucose composite effervescent preparation is characterized in that its effective ingredient is glucosamine and calcium complement agent, and all the other are the effervescent excipient.
2. aminoglucose composite effervescent preparation as claimed in claim 1 is characterized in that glucosamine is hydrochlorate, sulfate or other acceptable salt; Calcium complement agent derives from one or more of calcium carbonate, calcium citrate, calcium lactate, calcium gluconate etc.
3. aminoglucose composite effervescent preparation as claimed in claim 1 is characterized in that excipient comprises: (1) acid source composition is one or more of citric acid, tartaric acid, malic acid, fumaric acid, adipic acid etc.; (2) carbon dioxide derived components is one or more of sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate; (3) filler is one or more of lactose, sucrose, maltodextrin, mannitol, sorbitol, xylitol, soluble starch, chitosan etc.; (4) binding agent or wetting agent are water, Different concentrations of alcohol, polyvinylpyrrolidone, simple syrup etc.; (5) sweeting agent is one or more of acesulfame potassium (acesulfame potassium), aspartame, cyclamate, stevioside, sucralose, saccharin sodium etc.; (6) correctives is the required edible essence of allotment taste; (7) other: effervescent formulations such as food coloring, soluble oil prepare required excipient.
4. aminoglucose composite effervescent preparation as claimed in claim 1 is characterized in that described effervescent formulation is a kind of granule, and excipient is: (1) acid source composition is selected from citric acid, the tartaric acid one or more; (2) carbon dioxide derived components is selected from sodium bicarbonate, the sodium carbonate one or more; (3) filler is selected from lactose, maltodextrin, the sucrose one or more; (4) binding agent or wetting agent are selected from water or Different concentrations of alcohol or polyvinylpyrrolidone; (5) sweeting agent is selected from one or more in acesulfame potassium, the aspartame; (6) correctives is selected for use from edible powdered flavor; (7) other effervescent granules such as food coloring prepare required excipient.
5. aminoglucose composite effervescent preparation as claimed in claim 4 is characterized in that being made up of the glucosamine of weight content 1%～40%, 1%～40% calcium, 5%～60% citric acid, 1%～40% sodium bicarbonate, 1%～60% lactose, 0～20% maltodextrin, 0～10% polyvinylpyrrolidone, 0.1～3% aspartame, 0～3% acesulfame potassium, 0.2%～2% edible powdered essence and proper amount of edible pigment.
6. aminoglucose composite effervescent preparation as claimed in claim 4 is characterized in that being made up of the glucosamine of weight content 17%, 8% calcium, 37% citric acid, 4% sodium bicarbonate, 16% lactose, 2% polyvinylpyrrolidone, 0.4% acesulfame potassium, 0.4% aspartame, 0.5% edible powdered essence and proper amount of edible pigment.
7. aminoglucose composite effervescent preparation as claimed in claim 1 is characterized in that described effervescent formulation is a kind of tablet, and excipient is: (1) acid source composition is selected from citric acid, the tartaric acid one or more; (2) carbon dioxide derived components is selected from sodium bicarbonate, the sodium carbonate one or more; (3) filler is selected from lactose, sucrose, sorbitol, the mannitol one or more; (4) binding agent or wetting agent are selected from water or polyvinylpyrrolidone or simple syrup; (5) sweeting agent is selected from acesulfame potassium, the aspartame one or more; (6) correctives is selected edible powdered essence for use; (7) tabletting with lubricator is selected from leucine, the polyethylene glycol 6000 one or more; (8) other effervescent tablets such as food coloring prepare required excipient.
8. aminoglucose composite effervescent preparation as claimed in claim 7 is characterized in that being made up of the glucosamine of weight content 1%～30%, 1%～30% calcium, 5%～60% citric acid, 1%～30% sodium bicarbonate, 1%～40% lactose, 0～40% mannitol, 0～5% polyvinylpyrrolidone, 0.1～2% aspartame, 0～2% acesulfame potassium, 0.5%～5% leucine, 0.2%～2% edible powdered essence and proper amount of edible pigment.
9. aminoglucose composite effervescent preparation as claimed in claim 7 is characterized in that being made up of the glucosamine of weight content 10%, 5% calcium, 38% citric acid, 10% sodium bicarbonate, 15% lactose, 10% mannitol, 0.5% polyvinylpyrrolidone, 0.5% acesulfame potassium, 0.5% aspartame, 0.5% edible powdered essence, 1% leucine and proper amount of edible pigment.
10. aminoglucose composite effervescent preparation as claimed in claim 1 is used for the application of the health care of middle-aged and elderly people bone and arthritic health food of prophylactic treatment and medicine in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610029813 CN1907269A (en) | 2006-08-08 | 2006-08-08 | Aminoglucose composite effervescent preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610029813 CN1907269A (en) | 2006-08-08 | 2006-08-08 | Aminoglucose composite effervescent preparation |
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| CN1907269A true CN1907269A (en) | 2007-02-07 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102273712A (en) * | 2011-06-27 | 2011-12-14 | 桂林中族中药股份有限公司 | Momordica grosvenori chrysanthemum effervescent tablets and preparation process thereof |
| CN102415596A (en) * | 2011-10-14 | 2012-04-18 | 宁波大学 | Carbonated beverage |
| CN102578449A (en) * | 2011-11-01 | 2012-07-18 | 江苏江山制药有限公司 | Preparation technology for three-layer effervescent tablet containing glucosamine |
-
2006
- 2006-08-08 CN CN 200610029813 patent/CN1907269A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102273712A (en) * | 2011-06-27 | 2011-12-14 | 桂林中族中药股份有限公司 | Momordica grosvenori chrysanthemum effervescent tablets and preparation process thereof |
| CN102273712B (en) * | 2011-06-27 | 2012-07-18 | 桂林中族中药股份有限公司 | Momordica grosvenori chrysanthemum effervescent tablets and preparation process thereof |
| CN102415596A (en) * | 2011-10-14 | 2012-04-18 | 宁波大学 | Carbonated beverage |
| CN102578449A (en) * | 2011-11-01 | 2012-07-18 | 江苏江山制药有限公司 | Preparation technology for three-layer effervescent tablet containing glucosamine |
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