CN102578449A - Preparation technology for three-layer effervescent tablet containing glucosamine - Google Patents
Preparation technology for three-layer effervescent tablet containing glucosamine Download PDFInfo
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- CN102578449A CN102578449A CN2011103382748A CN201110338274A CN102578449A CN 102578449 A CN102578449 A CN 102578449A CN 2011103382748 A CN2011103382748 A CN 2011103382748A CN 201110338274 A CN201110338274 A CN 201110338274A CN 102578449 A CN102578449 A CN 102578449A
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- acid
- disintegrant
- glucosamine
- sodium
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Abstract
The invention relates to a preparation technology for a three-layer effervescent tablet containing glucosamine. The preparation technology comprises the following steps of: 1) evenly mixing granules made of source acid, internally added disintegrating agent and slurry prepared by using adhesive through a wet process granulation method with glucosamine, disintegrating agent and lubricating agent, and using the mixture as a first layer for future use; 2) using materials which are used as an isolating layer as a second layer for future use; 3) evenly mixing granules made of source carbon dioxide, lactose, internally added disintegrating agent through the wet process granulation method with pigment, sweetener, disintegrating agent and lubricating agent, and using the mixture as a third layer; and 4) pressing the raw materials into three-layer tablets. The three-layer effervescent tablet produced by adopting the preparation technology has the advantages that the surface is smooth and bright, the color is even, the effervescent effect is good, the stability is good, the expansion in a high-humidity state is smaller and the tablet is convenient to carry and easy to orally taken.
Description
Technical field:
The present invention relates to field of health care food, relate in particular to a kind of preparation technology who contains three layers of effervescent tablet of Glucosamine.
Background technology:
Effervescent tablet is to be a kind of novel form that disintegrant is processed with the effervesce material; After dropping in the water; Acid source wherein and carbon dioxide source react rapidly and generate a large amount of carbon dioxides; Impel dissolving within a short period of time of whole tablet, have characteristics such as onset is rapid, bioavilability is high, easy to carry, with the characteristics of solid pharmaceutical preparation and liquid preparation.
Glucosamine, it has the important physical function to human body, participates in the detoxifcation of liver kidney, and performance anti-inflammatory liver protection effect has good curative effect to treatment rheumatism joint inflammation and gastric ulcer, is the primary raw material of synthetic antibiotic and cancer therapy drug.Glucosamine can be protected cartilaginous tissue, suppresses collagenase activity, and the formation that prevents low-density lipoprotein can effectively be alleviated the illness development to alleviate the destruction to cartilaginous tissue.It is connective tissue and cartilage cell's a main component, is the elementary cell of glycoprotein and GAG chain in the articular cartilage matrix.Additional Glucosamine can promote the glycoprotein and the GAG of cartilage cell's synthesising physiological property, to repair impaired cartilage.Also can stimulate synovial membrane to produce hyaluronic acid, interarticular lubricated to increase.
The tradition effervescent tablet mixes the back compressing tablet with effervescent couple (being acid source and carbon dioxide source) usually, and after effervescent tablet placed water, reaction generated great amount of carbon dioxide gas and disintegration rapidly by effervescent couple.Because effervescent couple mixes each other, this type effervescent tablet is easy to reaction and emits gas under super-humid conditions, not only can destroy the outward appearance of tablet, influences the disintegration of tablet, and functional component is reduced.In addition, because effervescent couple mixes each other, traditional effervescent tablet is very high to the moisture requirement of raw material, and is also very high to the humidity requirement of production environment when producing.
Summary of the invention:
The purpose of this invention is to provide a kind of preparation technology who contains three layers of effervescent tablet of Glucosamine, the product bioavilability that makes is high, has good stable property and under high wet condition, expands less.
The objective of the invention is to realize like this; A kind of preparation technology who contains three layers of effervescent tablet of Glucosamine is characterized in that: may further comprise the steps: (1) with acid source, in evenly afterwards subsequent use with Glucosamine, disintegrant, mix lubricant with disintegrant as ground floor with the particle that the slurries of adhesive preparation adopt wet granulation to make; (2) it is subsequent use as the second layer to be used as the material of interval absciss layer; (3) with carbon dioxide source, lactose, in after disintegrant wet granulation together with the particle that makes and pigment, sweetener, disintegrant, mix lubricant evenly the back as the 3rd layer; (4) be pressed into three-layer tablet together; Described acid source is citric acid, tartaric acid, fumaric acid, adipic acid or malic acid; Described disintegrant is carboxyrnethyl starch sodium, Ac-Di-Sol, PVPP or polyvinyl pyrrolidone; Described interval absciss layer is lactose, sorbierite, sweet mellow wine or glucose; Described adhesive is water, ethanol, polyvinylpyrrolidone or low-substituted hydroxypropyl cellulose; Described lubricant is dolomol, talcum powder, superfine silica gel powder, sodium stearyl fumarate, lauryl sodium sulfate, L-leucine, Macrogol 6000, Macrogol 4000 or Sodium Benzoate; Described carbon dioxide source is sodium acid carbonate, sodium carbonate or saleratus.
The product surface that the present invention makes smooth bright clean, color and luster is even, effervesce is effective, have good stable property under high wet condition, expand less, easy to carry, be easy to oral.
The specific embodiment:
Three layers of effervescent tablet main component that contain Glucosamine are: every contains carbon dioxide source 100-1600mg, acid source 100-1600mg, disintegrant 10-500mg; Lactose 10-1000mg, Glucosamine 10-2000mg, adhesive 10-500mg; Sweetener 1-100mg; Essence 1-100mg, lubricant 100-800mg, separation layer 10-600mg.
Below in conjunction with specific embodiment the present invention is further specified:
Embodiment: contain the preparation of three layers of effervescent tablet of Glucosamine
Ground floor: citric acid 1050mg
PVPP 215mg
Glucosamine 250mg
Macrogol 6000 90mg
30 POVIDONE K 30 BP/USP 30 20mg
Water is an amount of
The second layer: lactose 200mg
The 3rd layer: sodium acid carbonate 750mg
Lactose 500mg
PVPP 100mg
Aspartame 20mg
Essence 10mg
Macrogol 6000 90mg
30 POVIDONE K 30 BP/USP 30 35mg
Water is an amount of
Prepare according to following step:
1. the preparation of particulate fraction in the ground floor: using suitable quantity of water to be configured to concentration 30 POVIDONE K 30 BP/USP 30 is 5～20% binder solution, and fully stirring and dissolving is to light yellow transparent solution;
2. citric acid is pulverized, crossed 60～120 mesh sieves;
3. with stirring mixing 1～10 minute in citric acid and the partial cross-linked PVP input wet granulator;
4. the solution that adds the adhesive of the configuration in the step 1 evenly, slowly, liquid feeding is granulated while stirring, process grain after, strict control EAT, drying.Cross 12～20 mesh sieves, make the citric acid particle;
5. the particle that makes in the step 4 and Glucosamine, remaining PVPP and Macrogol 6000 are mixed, subsequent use as the ground floor material;
6. the preparation of particulate fraction in the 3rd layer: using suitable quantity of water to be configured to concentration 30 POVIDONE K 30 BP/USP 30 is 5～20% binder solution, and fully stirring and dissolving is to light yellow transparent solution;
7. sodium acid carbonate, lactose are crossed 80～120 mesh sieves;
8. sodium acid carbonate, lactose and partial cross-linked PVP are dropped in the wet granulator and stirred mixing 1～10 minute;
9. the solution that adds the adhesive of the configuration in the step 6 evenly, slowly, liquid feeding is granulated while stirring, process grain after, strict control EAT, drying.Cross 12～20 mesh sieves, make sodium bicarbonate particle;
10. the particle that makes in the step 9 and Aspartame, essence, remaining PVPP and Macrogol 6000 are mixed, subsequent use as the 3rd layer of material;
11. add the ground floor material, precompressed; Add second layer material, precompressed once more; Add the 3rd layer and directly be pressed into tablet, promptly get.
The prepared three layers of effervescent tablet smooth surface of the foregoing description bright clean, color and luster is even, effervesce is effective, taste is fit to, each item index all meets related request.
Material used in the foregoing description is crossed 60～120 mesh sieves, mix, direct tablet compressing is processed common effervescent tablet, places the container of different humidity with three layers of effervescent tablet in the foregoing description, with 7 days after take out, measure diameter, the result sees the following form.
Can be known that by last table along with the increase of humidity in the container, the diameter of three layers of effervescent tablet and common effervescent tablet all increases, tablet expands.Compare with common effervescent tablet, three layers of effervescent tablet expansion under high wet condition are less.When relative humidity in the container less than 55% the time, the outward appearance of three layers of effervescent tablet is no change almost, integrality is better.
Claims (1)
1. preparation technology who contains three layers of effervescent tablet of Glucosamine is characterized in that: may further comprise the steps: (1) with acid source, in evenly afterwards subsequent use with Glucosamine, disintegrant, mix lubricant with disintegrant as ground floor with the particle that the slurries of adhesive preparation adopt wet granulation to make; (2) it is subsequent use as the second layer to be used as the material of interval absciss layer; (3) with carbon dioxide source, lactose, in after disintegrant wet granulation together with the particle that makes and pigment, sweetener, disintegrant, mix lubricant evenly the back as the 3rd layer; (4) be pressed into three-layer tablet together; Described acid source is citric acid, tartaric acid, fumaric acid, adipic acid or malic acid; Described disintegrant is carboxyrnethyl starch sodium, Ac-Di-Sol, PVPP or polyvinyl pyrrolidone; Described interval absciss layer is lactose, sorbierite, sweet mellow wine or glucose; Described adhesive is water, ethanol, polyvinylpyrrolidone or low-substituted hydroxypropyl cellulose; Described lubricant is dolomol, talcum powder, superfine silica gel powder, sodium stearyl fumarate, lauryl sodium sulfate, L-leucine, Macrogol 6000, Macrogol 4000 or Sodium Benzoate; Described carbon dioxide source is sodium acid carbonate, sodium carbonate or saleratus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103382748A CN102578449A (en) | 2011-11-01 | 2011-11-01 | Preparation technology for three-layer effervescent tablet containing glucosamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103382748A CN102578449A (en) | 2011-11-01 | 2011-11-01 | Preparation technology for three-layer effervescent tablet containing glucosamine |
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| CN102578449A true CN102578449A (en) | 2012-07-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103382748A Pending CN102578449A (en) | 2011-11-01 | 2011-11-01 | Preparation technology for three-layer effervescent tablet containing glucosamine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523637A (en) * | 2014-11-08 | 2015-04-22 | 新疆埃乐欣药业有限公司 | Garlic capsaicin multilayer enteric-coated tablet and preparation method thereof |
| CN106937946A (en) * | 2016-01-05 | 2017-07-11 | 山东诚创医药技术开发有限公司 | Ramosetron HCl effervescent tablet and preparation method thereof |
Citations (3)
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| US5912012A (en) * | 1997-09-06 | 1999-06-15 | Carlin; Edward J. | Effervescent systems with simplified packaging requirements |
| CN1907269A (en) * | 2006-08-08 | 2007-02-07 | 上海富海科申药业有限公司 | Aminoglucose composite effervescent preparation |
| CN1947724A (en) * | 2006-03-10 | 2007-04-18 | 北京阜康仁生物制药科技有限公司 | Compound amino-glucose hydrochloride, chondroitin sulfate effervescent, tablets prepn. method and use thereof |
-
2011
- 2011-11-01 CN CN2011103382748A patent/CN102578449A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5912012A (en) * | 1997-09-06 | 1999-06-15 | Carlin; Edward J. | Effervescent systems with simplified packaging requirements |
| CN1947724A (en) * | 2006-03-10 | 2007-04-18 | 北京阜康仁生物制药科技有限公司 | Compound amino-glucose hydrochloride, chondroitin sulfate effervescent, tablets prepn. method and use thereof |
| CN1907269A (en) * | 2006-08-08 | 2007-02-07 | 上海富海科申药业有限公司 | Aminoglucose composite effervescent preparation |
Non-Patent Citations (2)
| Title |
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| 张玲玲等: "盐酸氨溴索三层泡腾片的制备及稳定性的因素考察", 《中国新药杂质》 * |
| 徐莲英等: "《现代中药制剂设计理论与实践》", 31 May 2010, 人民卫生出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523637A (en) * | 2014-11-08 | 2015-04-22 | 新疆埃乐欣药业有限公司 | Garlic capsaicin multilayer enteric-coated tablet and preparation method thereof |
| CN104523637B (en) * | 2014-11-08 | 2017-10-17 | 新疆埃乐欣药业有限公司 | Allicin multiple enteric piece and preparation method thereof |
| CN106937946A (en) * | 2016-01-05 | 2017-07-11 | 山东诚创医药技术开发有限公司 | Ramosetron HCl effervescent tablet and preparation method thereof |
| CN106937946B (en) * | 2016-01-05 | 2020-05-12 | 山东诚创医药技术开发有限公司 | Ramosetron hydrochloride effervescent tablet and preparation method thereof |
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Application publication date: 20120718 |