CN1695634A - Combination of medication and health products for preventing and treating osteoporosis and osteoarthritis, and preparation method - Google Patents
Combination of medication and health products for preventing and treating osteoporosis and osteoarthritis, and preparation method Download PDFInfo
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- CN1695634A CN1695634A CN 200410037729 CN200410037729A CN1695634A CN 1695634 A CN1695634 A CN 1695634A CN 200410037729 CN200410037729 CN 200410037729 CN 200410037729 A CN200410037729 A CN 200410037729A CN 1695634 A CN1695634 A CN 1695634A
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Abstract
A medicine-health-care food composition for preventing and treating osteoporosis and osteoarthritis is prepared from aminoglucose hydrochloride, ionic calcium and VD3 through grinding, wetting, drying, sieving and mixing.
Description
Technical field
The present invention relates to a kind of medicine health product compositions and preparation method, particularly relate to a kind of prevention, treatment osteoporosis, bone density improving, and medicine, Halth-care composition and the preparation method of preventing, treating osteoarthritis.
Background technology
Osteoporosis is the disease that the skeleton density that caused by a variety of causes and bone mass reduce, cause the intensity decreases fragility of skeleton to increase, cause complication such as osteodynia, limbs shortening, but at present the harm of the maximum that caused of osteoporosis is fracture, and has become China's one of reason that mainly disables.Osteoporosis pathogenic process concealment, sickness rate height in mid-aged population, sickness rate that at present should disease has leapt to the 7th of the various commonly encountered diseases sickness rate in the world.China's patients with osteoporosis reaches 6,300 ten thousand, and wherein osteoporotic fracture took place 1,500 ten thousand people, and the total incidence of China's senile osteoporosis more than 60 years old is 22.6%, and trend of rising is year by year arranged.The direct result of fracture has influenced middle-aged and elderly people orthobiosis exactly, and can bring a series of problems of family, society and economic dispatch thus, so active prevention and timely treatment osteoporosis are very important, especially all the more so concerning the high-risk group, are directed to this and produce the present invention.
(Osteoarthritis OA) is a kind of degenerative disease to osteoarthritis, mainly shows as articular cartilage Developmental and Metabolic Disorder and ossa articularia structural failure, pain, swelling, the limitation of activity in the clinical joint that can occur getting involved.Sings and symptomses such as cartilage strips off, bony spur formation can appear in end-stage patients, cause afunction when serious, even carry out prosthetic replacement's operation.The sickness rate of OA is very high, and the preliminary Epidemiological study of China shows that the knee osteoarthritis prevalence is that the crowd can reach 79% more than 9.56%, 60 years old, is modal arthropathy, and is the second largest cause of disease that causes adult's long term disability.The also harm that causes to the people of growing interest joint disease of international medical community.For this reason, how to prevent and treat OA and paid attention to by people day by day.
Osteoporosis is the special performance of biological decay.Because the absorption of osteoclast increases, the function of osteoblast decline causes proportional minimizings such as bone mineralogical composition and bone matrix, the sclerotin attenuation, and bone trabecula quantity reduces.America NI H recommended the man of over-65s and the calcium that the women should take in 1500mg every day in 1994; The intake that Chinese Soclety of Nutrition recommends to be grown up every day should be 800-1000mg, and the women is for a little higher than male of the demand of calcium, and the intake of every day should be 1000mg; According to taking in the calcium requirement every day for the postmenopausal women in " orthopaedics and tranmstology ", take in 1500mg calcium every day and just can prevent bone loss.At present, Chinese diet structure is difficult to reach this index.Milk product and green vegetable are the main sources of calcium in the food, show according to the statistical result of Chinese Soclety of Nutrition: under normal diet structure, it is many about 500mg that Chinese Youth's male takes in calcium every day, and the women is many about 400mg.
Body needs vitamin D to absorb calcium, vitamin D simultaneously
3Can promote the mucous membrane of small intestine brush border that the absorption and the renal tubules of calcium are heavily absorbed calcium.But most of people lack the vitamin D of capacity, especially middle-aged and elderly people.Report according to research: the content of vitamin D is 20 years old youthful 80% in the old people's blood more than 60 years old.Great majority confine people in the family and old people's vitamin D deficiency main cause of over-65s has two: the one, and D is deficient in vitamin in the meals; The 2nd, the outdoor activities of comparing the old people with youngster are less.People such as Heikinheimo showed to Finland old people intramuscular injection vitamin D result in annual autumn that fracture rates obvious (2.9%) was lower than matched group (6.1%) in 1992.When body does not absorb enough vitamin D from food, from bone, draw calcium probably.
Glucosamine is the important composition material of cartilage matrix.Glucosamine is a kind of amino monosaccharide, derives from the chitin in the crustacean shell.With advancing age, the synthetic minimizing degraded of the cartilage in the human body increases, and cartilage can run off gradually, causes the decline of human body bone density, thereby causes multiple Senile disease, as osteoporosis, osteoarthritis etc.Scientific research shows, glucosamine extensively is present in the tissue such as cartilage, tendon and the ligament of humans and animals, be articular cartilage biosynthesis and the base substance that stimulates synthetic poly-glucosamine and hyaluronic acid skeleton, can promote the human body cartilage synthetic, increase joint flexibility and elasticity, improve joint motion.Appropriate supplement ammoniated base glucose can reduce the loss of cartilage.Modern medicine confirms that degenerative joint diseases such as osteoarthritis can influence the function of knee joint, hands, spinal column and femur, and glucosamine tool cartilage protection and repair, and replenish this class material and use nearly 30 years abroad, almost there is not untoward reaction.
Improve bone density, prevent and treat osteoporosis and can not replenish the calcium merely.The modern health theory is thought, though senile osteoporosis is feature with the calcium deficiency, from pathogenic factor and clinical manifestation, replenishing the calcium merely is not the best way, have only rehabilitation maneuver science, comprehensive to be only good plan, diet is replenished the calcium and exercise therapy is indispensable.Especially exercise therapy, as by bike, beformable body callisthenics, dancing etc., can bring into play muscle to adjusting facilitation that bone metabolism rose
[3], strengthen whole body muscle power, improve the quality of living.And glucosamine can effectively replenish cartilage, keeps the normal activity ability in whole body joint, gives full play to the forward regulating action of motion to bone density.
The patient of osteoporosis is often with the generation of osteoarthritis.Replenish the calcium at present and the preparation and the functional food of additional articular cartilage a lot, absorbance is low, effect deficiency such as single but exist mostly, and the present invention is aided with vitamin D when paying attention to calcium intake
3To promote its absorption, added glucosamine hydrochloride protection in addition, repaired the osteoarthrosis soft tissue, thereby made the middle-aged and elderly people B﹠J obtain general protection.
Summary of the invention
The object of the invention is to provide a kind of prevention, improves osteoporosis, and the compositions of preventing, treating osteoarthritis, and the object of the invention also is a kind of prevention to be provided, to improve osteoporosis, and the preparation of compositions method of preventing, treating osteoarthritis.
Clinical investigation finds that often with the generation of osteoarthritis, osteoarthritis patient often is attended by osteoporosis to the patient of osteoporosis.The product of listing is only at the calcium or calcium and the vitamin D that replenish calcium at present
3Compound preparation, and replenish cartilaginous tissue merely, be used for the glucosamine product of prophylactic treatment osteoarthritis.In the daily health caring of middle-aged and elderly people, take any product separately and all be not enough to prevention, treatment osteoporosis and osteoarthritis.
The present invention finds surprisingly, with glucosamine and ionized calcium, vitamin D
3Mix in certain proportion, can obtain a kind of compositions with unexpected effect, test confirms, gives the experimental group rat of 3.0g/kgBW said composition, and its femur calcium content is significantly higher than the calcium carbonate control group rat (P＜0.05) with dosage.The significant effect of improving osteoporosis and osteoarthritis is arranged.
The glucosamine hydrochloride that said composition contains, ionized calcium, vitamin D
3Every day, the intake proportioning was 500-2000mg: 200-1200mg: a 100-550 iu, was preferably 1500mg: 600mg: 120 ius.Glucosamine, ionized calcium, vitamin D in the present composition
3Weight ratio be 5-20: 2-12: a 1-5 iu, be preferably 25: 10: 2 ius.Wherein ionized calcium can be any pharmaceutical grade calcium containing compound that can dissociate, and as calcium carbonate, calcium citrate, calcium lactate, calcium gluconate etc., and calcium carbonate calcium content height, absorbance are good, the institute that has no side effect thinks preferred; Be aided with vitamin D
3, its effect is the absorption that promotes intestinal calcium, regulates the differentiation of PTH secretion and osteocyte.Vitamin D forms 1,25 (OH) 2D behind liver, kidney hydroxylation be final active substance, participates in the metabolism of bone ore deposit directly.The general vitamin D of old people absorbs metabolism (hydroxylation) function reduction, influences the absorption of calcium, should replenish in right amount; After the glucosamine hydrochloride of Tian Jiaing absorbed in body in addition, fusion early can impel the synthetic of many saccharides in skeletal tissue's (cartilage and bone), improve the viscosity of osteoarthrosis synovial fluid, the metabolism of improvement and repairing articular cartilage.
The preparation method of the present composition: press glucosamine hydrochloride, ionized calcium, vitamin D
3Preferred every day 500 times of the intake proportioning feed intake.
Also can be made into multiple peroral dosage form according to practice of pharmacy the present invention.Said peroral dosage form comprises: conventional granulates agent, tablet, capsule, drop pill, oral liquid etc.
The present invention also can add conventional drug excipient, food additive.As: lytic agent, correctives, coloring agent, lubricant, disintegrating agent, antiseptic etc.
Compositions of the present invention preferably is prepared to effervescent granule.
Embodiment preferred of the present invention is food coloring 0.5-1g, aspartame 15-40g, lactose 400-600g and glucosamine hydrochloride cover to be ground mixing cross 20 mesh sieves three times, with flavoring pineapple essence, 50ml95% ethanol, the vitamin D of 30-80ml
3The mixed liquor moistening stir evenly, volatilize, again with calcium carbonate, malic acid 400-600g, citric acid 400-600g mixing are crossed 20 mesh sieves three times, promptly get effervescent granule.
The present invention has the effect of remarkable bone density improving and safety non-toxic, side effect, steady quality.
Those skilled in the art can select suitable additives such as excipient according to common practise when the compositions among the application adopted mode commonly used such as tablet, capsule to carry out administration, and can adjust and revise the present invention as required, these can not depart from the scope of the present invention and purport.
With the following examples the present invention is further detailed, it is not to limit the invention.
The effect of experimental example 1 bone density improving
1 experiment material and method:
1.1 supply test agent: happy outstanding board ammonia calcium D instant effervescent particles, Beijing Yangxin Science and Technology Co., ltd. provides
1.2 laboratory animal: 60 cleaning level ablactation WISTAR male rats that initial body weight is 65-75g.
1.3 key instrument: atomic absorption spectrophotometer (Varian SpectrAA 200)
Single photon bone density machine (SD-1000), animal balance, metabolism mouse cage
Precimeter, the zootomy apparatus, the one thousandth balance, ten thousand/balance,
105 ℃ of baking ovens, nitrated stove
1.4 reagent: nitric acid, perchloric acid, nicotinic acid, lanthana, it is pure to be top grade.Calcium single element titer (1000ug/ml): be stored in the polyethylene bottle, the time spent dilution is faced in 4 ℃ of preservations.
2, dosage: rat is divided into 6 groups at random, promptly low calcium feedstuff matched group, tried three dosage groups of thing (according to the average per kilogram of body weight feed of rat 100g, dosage by 0.5g/KgBW, 1.5g/KgBW, 3.0g/KgBW is mixed with semisynthetic feed), be equivalent to respectively to be grown up 5 times, 15 times, 30 times of per kilogram of body weight recommended amounts, the calcium content according to experimental group is provided with middle and high dosage calcium carbonate control group again.12 weeks of experimental period.
3, experimental technique: animal feeding sacrificed by decapitation after 12 weeks, separate the right side femur, measure femur length.Roasting to constant weight at 105 ℃ of baking ovens, the weighing bone is heavy.Measure the bone density of femur mid point and femur distal end with the SD-1000 borne densitometers.Accurately weighing is tried matter sample, animal feed 0.300-1.000g, and rat one side femur is roasting wholely to the constant weight to adopt wet method digestion, uses the atomic absorption spectrophotometry calcium content.
4, result of the test:
Result of the test shows, awards the instant effervescent particles of 1.5g/kgBW and 3.0g/kgBW, can make femur weight, calcium content of bone and the femur distal end bone density of rat be significantly higher than low calcium matched group (P＜0.05); Award the instant effervescent particles of 3.0g/kgBW, can make the femur mid point bone density of rat be significantly higher than low calcium matched group (P＜0.05).
Under the identical situation of feed calcium content, 3.0g/kgBW ammonia calcium D instant effervescent particles experimental group is compared with calcium carbonate control group, and the femur calcium content of rat is significantly higher than calcium carbonate control group (P＜0.05).
Embodiment 1
Glucosamine hydrochloride 45g calcium carbonate: 45g
Vitamin D
3: 14.4 ten thousand iu lactose: 25g
Malic acid: 500g citric acid: 500g
Aspartame: 25g
Make the 180g instant effervescent particles, every gram contains the 0.25g glucosamine hydrochloride; 0.25g calcium carbonate (being equivalent to the 100mg ionized calcium); The vitamin D of 800 ius
3Each 3g, every day 2 times.
Embodiment 2
Glucosamine hydrochloride 24g ionized calcium: 12g
Vitamin D
3: 9 million international units
Make 90 in tablet, every contains the 0.27g glucosamine hydrochloride; The 130mg ionized calcium; The vitamin D of 1000 ius
3Each 1, every day 3 times.
Embodiment 3
Glucosamine hydrochloride 66g ionized calcium: 22.5g
Vitamin D
3: 16.5 million international units
Make 180 of capsules, every contains the 0.37g glucosamine hydrochloride; The 125mg ionized calcium; 916.7 the vitamin D of iu
3Each 3, every day 2 times.
Claims (18)
1, a kind of medicine health product compositions is characterized in that said composition contains glucosamine, ionized calcium, vitamin D
3Three kinds of effective ingredient.
2, compositions as claimed in claim 1 is characterized in that ionized calcium is selected from can dissociated calcium containing compound one or more such as calcium carbonate, calcium citrate, calcium lactate, calcium gluconate.
3, compositions as claimed in claim 1 or 2 is characterized in that the ionized calcium source is preferably calcium carbonate.
4, compositions as claimed in claim 3 is characterized in that dosage every day of ionized calcium is 200-1200mg.
5, compositions as claimed in claim 1 is characterized in that glucosamine is selected from one or more in glucosamine hydrochloride, the glucosamine sulfate.
6, compositions as claimed in claim 5 is characterized in that dosage every day of glucosamine is 500-2000mg.
7, compositions as claimed in claim 1 is characterized in that glucosamine hydrochloride, ionized calcium, vitamin D that said composition contains
3Every day, the intake proportioning was 500-2000mg, 200-1200mg, a 100-550 iu.
8, compositions as claimed in claim 7 is characterized in that glucosamine hydrochloride, ionized calcium, vitamin D that said composition contains
3Preferably the intake proportioning was 1500mg: 600mg: 120 ius every day.
9,, it is characterized in that said composition can also add acceptable auxiliary, food additive or excipient on pharmacy, the food as claim 1 or 8 described compositionss.
10, compositions as claimed in claim 9 is characterized in that adjuvant, food additive or excipient are meant lytic agent, correctives, coloring agent, lubricant, disintegrating agent, antiseptic etc.
11, as claim 1 or 8 described compositionss, the dosage form that it is characterized in that said composition can be any of effervescent granule, granule, tablet, capsule, drop pill, oral liquid.
12, compositions as claimed in claim 11 is characterized in that the dosage form of making is preferably effervescent granule.
13, compositions as claimed in claim 12, it is characterized in that effervescent granule be by grinding, moistening, drying, sieve, step such as mixing packing makes.
14, compositions as claimed in claim 1 is characterized in that said glucosamine, ionized calcium, vitamin D
3Weight ratio be 5-20: 2-12: a 1-5 iu.
15, compositions as claimed in claim 14 is characterized in that said glucosamine, ionized calcium, vitamin D
3Weight ratio be 25: 10: 2 ius.
16, compositions as claimed in claim 12 is characterized in that it also comprises the flavoring pineapple essence of food coloring 0.5-1g, aspartame 15-40g, lactose 400-600g, 30-80ml, malic acid 400-600g, citric acid 400-600g.
17, compositions as claimed in claim 16, it is characterized in that it is prepared with the following method: food coloring 0.5-1g, aspartame 15-40g, lactose 400-600g and glucosamine hydrochloride cover are ground mixing cross 20 mesh sieves three times, with flavoring pineapple essence, 50ml95% ethanol, the vitamin D of 30-80ml
3The mixed liquor moistening stir evenly, volatilize, again with calcium carbonate, malic acid 400-600g, citric acid 400-600g mixing are crossed 20 mesh sieves three times, promptly get effervescent granule.
18, compositions as claimed in claim 1 is in preparation prevention, treatment osteoporosis and the medicine of osteoarthritis, the application in the health product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410037729 CN1695634A (en) | 2004-05-10 | 2004-05-10 | Combination of medication and health products for preventing and treating osteoporosis and osteoarthritis, and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410037729 CN1695634A (en) | 2004-05-10 | 2004-05-10 | Combination of medication and health products for preventing and treating osteoporosis and osteoarthritis, and preparation method |
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| CN1695634A true CN1695634A (en) | 2005-11-16 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904866A (en) * | 2010-09-07 | 2010-12-08 | 许阳 | Medicinal composition for treating osteoporosis and preparation method thereof |
| CN101537050B (en) * | 2009-05-08 | 2011-06-01 | 无锡健特药业有限公司 | Health product capable of enhancing bone density and immune function, and preparation method and applications thereof |
| CN103720710A (en) * | 2013-12-23 | 2014-04-16 | 广西博科药业有限公司 | Pharmaceutical composition capable of increasing bone density and preparation method of pharmaceutical composition |
| CN105559062A (en) * | 2015-12-20 | 2016-05-11 | 雷西云 | Health-care food with calcium supplementing function |
| CN105581329A (en) * | 2015-12-20 | 2016-05-18 | 雷西云 | Health-care food with bone strengthening function |
| CN106109490A (en) * | 2016-08-02 | 2016-11-16 | 辽宁康辰药业有限公司 | One increases bone density, prevents and treats osteoporotic tablet and preparation method thereof |
| CN109170454A (en) * | 2018-08-04 | 2019-01-11 | 安徽全康药业有限公司 | A kind of preventing bone rarefaction ammonia sugar high calcium solid beverage |
-
2004
- 2004-05-10 CN CN 200410037729 patent/CN1695634A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537050B (en) * | 2009-05-08 | 2011-06-01 | 无锡健特药业有限公司 | Health product capable of enhancing bone density and immune function, and preparation method and applications thereof |
| CN101904866A (en) * | 2010-09-07 | 2010-12-08 | 许阳 | Medicinal composition for treating osteoporosis and preparation method thereof |
| CN103720710A (en) * | 2013-12-23 | 2014-04-16 | 广西博科药业有限公司 | Pharmaceutical composition capable of increasing bone density and preparation method of pharmaceutical composition |
| CN105559062A (en) * | 2015-12-20 | 2016-05-11 | 雷西云 | Health-care food with calcium supplementing function |
| CN105581329A (en) * | 2015-12-20 | 2016-05-18 | 雷西云 | Health-care food with bone strengthening function |
| CN106109490A (en) * | 2016-08-02 | 2016-11-16 | 辽宁康辰药业有限公司 | One increases bone density, prevents and treats osteoporotic tablet and preparation method thereof |
| CN109170454A (en) * | 2018-08-04 | 2019-01-11 | 安徽全康药业有限公司 | A kind of preventing bone rarefaction ammonia sugar high calcium solid beverage |
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