CN1902326A - 用于癌症诊断和治疗的差异性表达的肿瘤特异性多肽 - Google Patents

用于癌症诊断和治疗的差异性表达的肿瘤特异性多肽 Download PDF

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Publication number
CN1902326A
CN1902326A CNA200480034085XA CN200480034085A CN1902326A CN 1902326 A CN1902326 A CN 1902326A CN A200480034085X A CNA200480034085X A CN A200480034085XA CN 200480034085 A CN200480034085 A CN 200480034085A CN 1902326 A CN1902326 A CN 1902326A
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cancer
protein
immunogenic membrane
steroid
polypeptide
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Chinese (zh)
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T·布施曼
N·－K·福蒂亚迪斯
M·福赫斯
S·黑姆
T·伊利尼亚
S·拉默
J·莫伊尔
K·罗特曼－科西克
V·塞伯特
S·T·佩雷斯
K·斯戴荘斯基
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Genmab AS
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Genmab AS
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CNA200480034085XA 2003-09-18 2004-09-20 用于癌症诊断和治疗的差异性表达的肿瘤特异性多肽 Pending CN1902326A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP03090307.4 2003-09-18
EP03090307 2003-09-18
US51207803P 2003-10-20 2003-10-20
US60/512,078 2003-10-20

Publications (1)

Publication Number Publication Date
CN1902326A true CN1902326A (zh) 2007-01-24

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CNA200480034085XA Pending CN1902326A (zh) 2003-09-18 2004-09-20 用于癌症诊断和治疗的差异性表达的肿瘤特异性多肽

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US (1) US20090252721A1 (enExample)
EP (2) EP1673470A2 (enExample)
JP (1) JP2007521015A (enExample)
CN (1) CN1902326A (enExample)
AU (1) AU2004272747A1 (enExample)
BR (1) BRPI0414446A (enExample)
CA (1) CA2539490A1 (enExample)
IL (1) IL174047A0 (enExample)
SG (1) SG146622A1 (enExample)
WO (1) WO2005026735A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102395682A (zh) * 2007-09-06 2012-03-28 生物治疗诊断股份有限公司 肿瘤分级和癌症预后
CN104204805A (zh) * 2012-03-14 2014-12-10 萨克生物研究学院 腺病毒肿瘤诊断法
CN109646685A (zh) * 2017-10-12 2019-04-19 北京医院 stomatin蛋白及其编码基因在肺癌诊断治疗中的应用
CN111394370A (zh) * 2020-03-03 2020-07-10 华南农业大学 一种猪RagA基因及其应用
CN114540349A (zh) * 2020-11-27 2022-05-27 中国科学院分子细胞科学卓越创新中心 结合yb-1蛋白的核酸分子
CN116482367A (zh) * 2023-05-04 2023-07-25 中国中医科学院望京医院(中国中医科学院骨伤科研究所) 一种联合mSEPT9检测和生物标志物的结直肠癌检测方法

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2599875A1 (en) * 2005-03-03 2006-09-08 Takeda Pharmaceutical Company Limited Preventive/therapeutic agent for cancer
WO2006127976A2 (en) * 2005-05-24 2006-11-30 Isis Pharmaceuticals, Inc. Compositions and their uses directed to ptpru
DE602006015508D1 (de) * 2005-11-16 2010-08-26 Pantarhei Bioscience Bv Pharmazeutische zusammensetzung zur behandlung oder prävention von ovarialkrebs
US20100028335A1 (en) * 2007-02-02 2010-02-04 Novartis Ag Compositions and Methods to Treat Bone Related Disorders
US20080299138A1 (en) * 2007-05-25 2008-12-04 Duffy Karen E Toll-Like Receptor 3 Modulators and Uses Thereof
US8158373B2 (en) * 2008-03-25 2012-04-17 Case Western Reserve University Method of detecting cancer and evaluating cancer prognosis
WO2010056993A2 (en) * 2008-11-14 2010-05-20 Emory University Prostate cancer biomarkers to predict recurrence and metastatic potential
WO2010075521A1 (en) * 2008-12-23 2010-07-01 Case Western Reserve University Compositions and methods of treating cancer
US8940826B2 (en) 2009-07-16 2015-01-27 Omnova Solutions Inc. Protective coating compositions
MY166040A (en) 2010-09-15 2018-05-21 Almac Diagnostics Ltd Molecular diagnostic test for cancer
EP2809800A1 (en) 2012-01-30 2014-12-10 VIB vzw Means and method for diagnosis and treatment of alzheimer's disease
JP6327662B2 (ja) * 2012-09-26 2018-05-23 学校法人藤田学園 細胞表面タンパクを抗原とする抗体を測定する方法
WO2016080830A2 (en) * 2014-11-18 2016-05-26 Pantarhei Bioscience B.V. Immunotherapeutic method for treating pancreatic cancer
JP2023518976A (ja) 2020-03-23 2023-05-09 エイチディーティー バイオ コーポレーション Ｒｎａを送達するための組成物および方法
AU2022351009A1 (en) 2021-09-22 2024-04-11 Hdt Bio Corp. Rna vaccines against infectious diseases
WO2023048758A1 (en) 2021-09-22 2023-03-30 Hdt Bio Corp. Dried nanoparticle compositions
KR20240099177A (ko) 2021-09-22 2024-06-28 에이치디티 바이오 코포레이션 SARS-CoV-2 RNA 백신 조성물 및 사용 방법
KR20240111819A (ko) 2021-09-22 2024-07-17 에이치디티 바이오 코포레이션 암 치료 조성물 및 이들의 용도

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003415A3 (en) 1978-01-20 1979-08-22 Glaxo Group Limited Beta-lactam compounds, processes for their preparation,compositions containing them and intermediates of use in their preparation
US4843000A (en) 1979-12-26 1989-06-27 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
US4849338A (en) 1982-07-16 1989-07-18 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4520110A (en) 1981-10-06 1985-05-28 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4542104A (en) 1983-04-06 1985-09-17 The Board Of Trustees Of The Leland Stanford Jr. Univ. Phycobiliprotein fluorescent conjugates
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5217866A (en) 1985-03-15 1993-06-08 Anti-Gene Development Group Polynucleotide assay reagent and method
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB9705949D0 (en) 1997-03-21 1997-05-07 Electrophoretics International Diagnosis of tumours and other abnormalities of body cells
US6197543B1 (en) * 1997-10-28 2001-03-06 Incyte Pharmaceuticals, Inc. Human vesicle membrane protein-like proteins
US6902898B2 (en) * 1998-11-16 2005-06-07 National Institute Of Advanced Industrial Science And Technology Human derived bradeion proteins, DNA coding for the proteins, and uses thereof
EP1033404A1 (en) * 1999-01-29 2000-09-06 F. Hoffmann-La Roche Ag New gene with down-regulated expression in metastatic human melanoma cells
US6228392B1 (en) 1999-04-29 2001-05-08 Gene Tools, Llc Osmotic delivery composition, solution, and method
CA2384713A1 (en) * 1999-09-29 2001-04-05 Human Genome Sciences, Inc. Colon and colon cancer associated polynucleotides and polypeptides
US20030104413A1 (en) * 2000-07-14 2003-06-05 Tang Y. Tom Novel Nucleic acids and polypeptides
US20030108926A1 (en) * 2000-03-15 2003-06-12 Eos Biotechnology, Inc. Novel methods of diagnosing colorectal cancer, compositions, and methods of screening for colorectal cancer modulators
JP2004512023A (ja) * 2000-06-09 2004-04-22 コリクサ　コーポレイション 結腸癌の治療および診断のための組成物および方法
AU2001285047A1 (en) * 2000-08-16 2002-02-25 Chiron Corporation Human genes and gene expression products
US20030134283A1 (en) * 2000-10-03 2003-07-17 Peterson David P. Genes regulated in dendritic cell differentiation
US20020160382A1 (en) * 2000-10-11 2002-10-31 Lasek Amy W. Genes expressed in colon cancer
WO2003029273A2 (en) * 2001-09-28 2003-04-10 Whitehead Institute For Biomedical Research Classification of lung carcinomas using gene expression analysis
EP1308459A3 (en) * 2001-11-05 2003-07-09 Research Association for Biotechnology Full-length cDNA sequences
AU2003304203A1 (en) * 2002-10-29 2005-01-04 Pharmacia Corporation Differentially expressed genes involved in cancer, the polypeptides encoded thereby, and methods of using the same

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102395682A (zh) * 2007-09-06 2012-03-28 生物治疗诊断股份有限公司 肿瘤分级和癌症预后
CN104204805A (zh) * 2012-03-14 2014-12-10 萨克生物研究学院 腺病毒肿瘤诊断法
CN104204805B (zh) * 2012-03-14 2017-08-01 萨克生物研究学院 腺病毒肿瘤诊断法
CN109646685A (zh) * 2017-10-12 2019-04-19 北京医院 stomatin蛋白及其编码基因在肺癌诊断治疗中的应用
CN111394370A (zh) * 2020-03-03 2020-07-10 华南农业大学 一种猪RagA基因及其应用
CN111394370B (zh) * 2020-03-03 2022-03-25 华南农业大学 一种猪RagA基因及其应用
CN114540349A (zh) * 2020-11-27 2022-05-27 中国科学院分子细胞科学卓越创新中心 结合yb-1蛋白的核酸分子
CN116482367A (zh) * 2023-05-04 2023-07-25 中国中医科学院望京医院(中国中医科学院骨伤科研究所) 一种联合mSEPT9检测和生物标志物的结直肠癌检测方法

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US20090252721A1 (en) 2009-10-08
SG146622A1 (en) 2008-10-30
WO2005026735A2 (en) 2005-03-24
JP2007521015A (ja) 2007-08-02
CA2539490A1 (en) 2005-03-24
IL174047A0 (en) 2006-08-01
BRPI0414446A (pt) 2006-11-14
WO2005026735A3 (en) 2005-11-03
EP1673470A2 (en) 2006-06-28
EP2050827A3 (en) 2009-09-02
EP2050827A2 (en) 2009-04-22
AU2004272747A1 (en) 2005-03-24

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