CN1902181A - 可用作离子通道调控剂的苯并咪唑 - Google Patents

可用作离子通道调控剂的苯并咪唑 Download PDF

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Publication number
CN1902181A
CN1902181A CNA2004800392479A CN200480039247A CN1902181A CN 1902181 A CN1902181 A CN 1902181A CN A2004800392479 A CNA2004800392479 A CN A2004800392479A CN 200480039247 A CN200480039247 A CN 200480039247A CN 1902181 A CN1902181 A CN 1902181A
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Prior art keywords
pain
ring
independently selected
formula
group
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Chinese (zh)
Inventor
D·M·威尔森
A·P·特敏
J·E·冈萨雷斯三世
N·奇默曼
张玉莲
L·T·D·范宁
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of CN1902181A publication Critical patent/CN1902181A/zh
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Manufacturing & Machinery (AREA)
  • Ceramic Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Structural Engineering (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Materials Engineering (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
CNA2004800392479A 2003-10-28 2004-10-28 可用作离子通道调控剂的苯并咪唑 Pending CN1902181A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51508803P 2003-10-28 2003-10-28
US60/515,088 2003-10-28

Publications (1)

Publication Number Publication Date
CN1902181A true CN1902181A (zh) 2007-01-24

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ID=34549374

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CNA2004800392479A Pending CN1902181A (zh) 2003-10-28 2004-10-28 可用作离子通道调控剂的苯并咪唑

Country Status (13)

Country Link
US (2) US7309716B2 (https=)
EP (1) EP1678145A2 (https=)
JP (1) JP2007521325A (https=)
KR (1) KR20060115396A (https=)
CN (1) CN1902181A (https=)
AU (1) AU2004285053B2 (https=)
CA (1) CA2543918A1 (https=)
IL (1) IL175252A0 (https=)
NO (1) NO20062426L (https=)
NZ (1) NZ547109A (https=)
RU (1) RU2006118312A (https=)
WO (1) WO2005042497A2 (https=)
ZA (1) ZA200603864B (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104926745A (zh) * 2015-07-14 2015-09-23 佛山市赛维斯医药科技有限公司 含苯并异恶唑和末端卤代苄基类结构的化合物及其用途
CN104974103A (zh) * 2015-07-14 2015-10-14 佛山市赛维斯医药科技有限公司 一类含苯并异恶唑和烷氧苯基类结构的化合物及其用途
CN107922350A (zh) * 2015-09-11 2018-04-17 大日本住友制药株式会社 新的苯并咪唑化合物及其医药用途
CN113692276A (zh) * 2019-02-19 2021-11-23 加利福尼亚大学董事会 Nurr1受体调节剂
CN117730074A (zh) * 2021-05-12 2024-03-19 菲斯欧洲地中海大学 作为mpro蛋白酶和sars-cov-2复制的抑制剂的利尿酸衍生物
WO2025067475A1 (zh) * 2023-09-28 2025-04-03 四川大学华西医院 一类镇痛的化合物及其制备方法和用途

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FR2880889B1 (fr) * 2005-01-14 2007-04-06 Merck Sante Soc Par Actions Si Derives de l'acide 1h-indole-3-carboxylique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
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WO2007006734A1 (en) * 2005-07-12 2007-01-18 Bayer Cropscience Sa New benzoheterocyclylethylbenzamide derivatives
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EP2012774A1 (en) * 2006-03-27 2009-01-14 Wex Pharmaceuticals, Inc Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy
US7951829B2 (en) * 2006-05-03 2011-05-31 Janssen Pharmaceutica Nv Benzimidazole modulators of VR1
KR101143246B1 (ko) 2007-06-29 2012-05-18 화이자 인코포레이티드 벤즈이미다졸 유도체
CN101883760A (zh) 2007-10-11 2010-11-10 沃泰克斯药物股份有限公司 用作电压-门控钠通道抑制剂的杂芳基酰胺类
WO2009061744A2 (en) * 2007-11-06 2009-05-14 Edison Pharmaceuticals, Inc. 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases
RU2379294C1 (ru) * 2008-05-19 2010-01-20 Государственное образовательное учреждение высшего профессионального образования "Российский химико-технологический университет им. Д.И. Менделеева" (РХТУ им. Д.И. Менделеева) [2-(азол-1-ил)алкилбензимидазол-1-ил]алкановые кислоты и их эфиры, способ их получения (варианты) и рострегуляторная композиция на их основе
KR20110123253A (ko) 2009-03-05 2011-11-14 다이이찌 산쿄 가부시키가이샤 피리딘 유도체
JP2013530180A (ja) 2010-06-16 2013-07-25 パーデュー、ファーマ、リミテッド、パートナーシップ アリール置換インドールおよびその使用
RU2443690C1 (ru) * 2010-12-13 2012-02-27 Российская Федерация, От Имени Которой Выступает Министерство Образования И Науки Российской Федерации 2-(9-антрилметил)амино-1-[3-(диметиламино)пропил]бензимидазол, обладающий свойствами флуоресцентного хемосенсора на катионы h+
EP2681200A4 (en) * 2011-03-03 2015-05-27 Zalicus Pharmaceuticals Ltd INHIBITORS OF BENZIMIDAZOLE TYPE OF SODIUM CHANNEL
EP2758376A4 (en) 2011-09-19 2015-04-29 Vitas Pharma Res Private Ltd HETEROCYCLIC COMPOUNDS AS INHIBITORS OF FATTY ACID BIOSYNTHESIS FOR BACTERIAL INFECTIONS
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