ZA200603864B - Benzimidazoles useful as modulators of ion channels - Google Patents
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- ZA200603864B ZA200603864B ZA200603864A ZA200603864A ZA200603864B ZA 200603864 B ZA200603864 B ZA 200603864B ZA 200603864 A ZA200603864 A ZA 200603864A ZA 200603864 A ZA200603864 A ZA 200603864A ZA 200603864 B ZA200603864 B ZA 200603864B
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- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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| DE60144284D1 (de) | 2000-11-01 | 2011-05-05 | Millennium Pharm Inc | Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung |
| FR2880889B1 (fr) * | 2005-01-14 | 2007-04-06 | Merck Sante Soc Par Actions Si | Derives de l'acide 1h-indole-3-carboxylique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique |
| GB0514018D0 (en) * | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
| WO2007006734A1 (en) * | 2005-07-12 | 2007-01-18 | Bayer Cropscience Sa | New benzoheterocyclylethylbenzamide derivatives |
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| US7816542B2 (en) * | 2005-08-15 | 2010-10-19 | Irm Llc | Compounds and compositions as TPO mimetics |
| EP2012774A1 (en) * | 2006-03-27 | 2009-01-14 | Wex Pharmaceuticals, Inc | Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy |
| US7951829B2 (en) * | 2006-05-03 | 2011-05-31 | Janssen Pharmaceutica Nv | Benzimidazole modulators of VR1 |
| KR101143246B1 (ko) | 2007-06-29 | 2012-05-18 | 화이자 인코포레이티드 | 벤즈이미다졸 유도체 |
| CN101883760A (zh) | 2007-10-11 | 2010-11-10 | 沃泰克斯药物股份有限公司 | 用作电压-门控钠通道抑制剂的杂芳基酰胺类 |
| WO2009061744A2 (en) * | 2007-11-06 | 2009-05-14 | Edison Pharmaceuticals, Inc. | 4- (p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| RU2379294C1 (ru) * | 2008-05-19 | 2010-01-20 | Государственное образовательное учреждение высшего профессионального образования "Российский химико-технологический университет им. Д.И. Менделеева" (РХТУ им. Д.И. Менделеева) | [2-(азол-1-ил)алкилбензимидазол-1-ил]алкановые кислоты и их эфиры, способ их получения (варианты) и рострегуляторная композиция на их основе |
| KR20110123253A (ko) | 2009-03-05 | 2011-11-14 | 다이이찌 산쿄 가부시키가이샤 | 피리딘 유도체 |
| JP2013530180A (ja) | 2010-06-16 | 2013-07-25 | パーデュー、ファーマ、リミテッド、パートナーシップ | アリール置換インドールおよびその使用 |
| RU2443690C1 (ru) * | 2010-12-13 | 2012-02-27 | Российская Федерация, От Имени Которой Выступает Министерство Образования И Науки Российской Федерации | 2-(9-антрилметил)амино-1-[3-(диметиламино)пропил]бензимидазол, обладающий свойствами флуоресцентного хемосенсора на катионы h+ |
| EP2681200A4 (en) * | 2011-03-03 | 2015-05-27 | Zalicus Pharmaceuticals Ltd | INHIBITORS OF BENZIMIDAZOLE TYPE OF SODIUM CHANNEL |
| EP2758376A4 (en) | 2011-09-19 | 2015-04-29 | Vitas Pharma Res Private Ltd | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF FATTY ACID BIOSYNTHESIS FOR BACTERIAL INFECTIONS |
| WO2013101911A2 (en) | 2011-12-28 | 2013-07-04 | Allergan, Inc. | Benzimidazole derivatives as selective blockers of persistent sodium current |
| WO2013101926A1 (en) | 2011-12-28 | 2013-07-04 | Allergan, Inc. | Benzimidazole derivatives as selective blockers of persistent sodium current |
| US9828348B2 (en) * | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
| US20150203812A1 (en) * | 2014-01-20 | 2015-07-23 | Francesco Tombola | Inhibitors of Voltage Gated Ion Channels |
| WO2016029146A1 (en) * | 2014-08-22 | 2016-02-25 | University Of Washington | Specific inhibitors of methionyl-trna synthetase |
| CN104974103A (zh) * | 2015-07-14 | 2015-10-14 | 佛山市赛维斯医药科技有限公司 | 一类含苯并异恶唑和烷氧苯基类结构的化合物及其用途 |
| CN104926745A (zh) * | 2015-07-14 | 2015-09-23 | 佛山市赛维斯医药科技有限公司 | 含苯并异恶唑和末端卤代苄基类结构的化合物及其用途 |
| EA201890532A1 (ru) * | 2015-08-20 | 2018-09-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые аннелированные бензамиды |
| DK3348547T3 (da) * | 2015-09-11 | 2020-09-14 | Sumitomo Dainippon Pharma Co Ltd | Benzimidazolderivater som nav 1.7 (calciumkanal, spændingsstyret, type ix, alfa undergruppe (scn9a))-inhibitorer til behandling af smerte, dysuria og multipel sclerose |
| GB201619694D0 (en) * | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
| WO2018235926A1 (ja) | 2017-06-23 | 2018-12-27 | 協和発酵キリン株式会社 | α、β不飽和アミド化合物 |
| KR101938982B1 (ko) | 2017-07-17 | 2019-01-15 | 연세대학교 산학협력단 | 자가포식 조절제를 포함하는 대사성 질환 치료용 약학 조성물 |
| KR102070882B1 (ko) * | 2017-10-17 | 2020-01-29 | 성균관대학교산학협력단 | Bietpc를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물 |
| AU2019302534B2 (en) | 2018-07-09 | 2024-10-03 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting NaV1.8 |
| AU2019301628C1 (en) | 2018-07-09 | 2025-02-06 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting NaV1.8 |
| CN120097859A (zh) * | 2019-02-19 | 2025-06-06 | 加利福尼亚大学董事会 | Nurr1受体调节剂 |
| MA53521B1 (fr) * | 2021-05-12 | 2023-03-31 | Univ Ibn Tofail | Nouveaux composés inhibiteurs de la protéase mpro et de la réplication du sars-cov2, leurs formulations et applications |
| WO2022265993A1 (en) | 2021-06-14 | 2022-12-22 | Scorpion Therapeutics, Inc. | Urea derivatives which can be used to treat cancer |
| WO2023053059A1 (en) * | 2021-09-30 | 2023-04-06 | Universidade Do Porto | Antifouling compound, method and uses thereof |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| US11478464B1 (en) | 2022-02-06 | 2022-10-25 | King Faisal University | Method for treating inflammation |
| US11786535B1 (en) | 2023-02-22 | 2023-10-17 | King Faisal University | Methods of inhibiting cyclooxygenase |
| CN120152963B (zh) * | 2023-09-28 | 2025-11-18 | 四川大学华西医院 | 一类镇痛的化合物及其制备方法和用途 |
| WO2026015548A1 (en) * | 2024-07-08 | 2026-01-15 | Convelo Therapeutics, Inc. | Cyp51 inhibitors and method of using same |
| GB202412414D0 (en) * | 2024-08-23 | 2024-10-09 | Univ Bradford | Methods for treating cancer |
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| NL280954A (https=) * | 1961-07-14 | |||
| US4088768A (en) * | 1975-05-06 | 1978-05-09 | Eli Lilly And Company | N-heterocyclic ureas as immune regulants |
| DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| EP1165518A2 (en) | 1999-04-02 | 2002-01-02 | Neurogen Corporation | Benzimidazole and imidazolopyridine derivatives, their preparation and their use as selective modulators of bradykinin b2 (= bk-2) receptors |
| CN1167686C (zh) * | 1999-06-22 | 2004-09-22 | 神经研究公司 | 苯并咪唑衍生物和包括这些化合物的药物组合物 |
| US6316474B1 (en) | 1999-10-29 | 2001-11-13 | Merck & Co., Inc. | 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists |
| JP2004503527A (ja) * | 2000-06-13 | 2004-02-05 | イーライ・リリー・アンド・カンパニー | スルホンアミド誘導体 |
| US20050113283A1 (en) * | 2002-01-18 | 2005-05-26 | David Solow-Cordero | Methods of treating conditions associated with an EDG-4 receptor |
| EP1513522A2 (en) | 2002-01-18 | 2005-03-16 | Sri International | Methods of treating conditions associated with an edg receptor |
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| US20080306129A1 (en) | 2008-12-11 |
| CA2543918A1 (en) | 2005-05-12 |
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| US7705031B2 (en) | 2010-04-27 |
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| JP2007521325A (ja) | 2007-08-02 |
| US20050209282A1 (en) | 2005-09-22 |
| AU2004285053B2 (en) | 2010-10-21 |
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| NO20062426L (no) | 2006-05-29 |
| US7309716B2 (en) | 2007-12-18 |
| IL175252A0 (en) | 2006-09-05 |
| KR20060115396A (ko) | 2006-11-08 |
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