CN1899384B - Medicinal composition for treating nephritis and its preparing method and use - Google Patents
Medicinal composition for treating nephritis and its preparing method and use Download PDFInfo
- Publication number
- CN1899384B CN1899384B CN2006101035380A CN200610103538A CN1899384B CN 1899384 B CN1899384 B CN 1899384B CN 2006101035380 A CN2006101035380 A CN 2006101035380A CN 200610103538 A CN200610103538 A CN 200610103538A CN 1899384 B CN1899384 B CN 1899384B
- Authority
- CN
- China
- Prior art keywords
- clear paste
- filtrate
- gained
- fine powder
- filtering residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000008383 nephritis Diseases 0.000 title claims abstract description 16
- 239000000203 mixture Substances 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title claims description 23
- 239000003814 drug Substances 0.000 claims abstract description 12
- 238000002360 preparation method Methods 0.000 claims abstract description 12
- 239000000843 powder Substances 0.000 claims description 60
- 239000000706 filtrate Substances 0.000 claims description 41
- 238000001914 filtration Methods 0.000 claims description 39
- 241000237903 Hirudo Species 0.000 claims description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 238000001035 drying Methods 0.000 claims description 19
- 239000008187 granular material Substances 0.000 claims description 16
- 238000007598 dipping method Methods 0.000 claims description 15
- 238000005325 percolation Methods 0.000 claims description 14
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 239000006187 pill Substances 0.000 claims description 8
- 239000006188 syrup Substances 0.000 claims description 7
- 235000020357 syrup Nutrition 0.000 claims description 7
- -1 mixing Substances 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000007901 soft capsule Substances 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims description 3
- 239000007766 cera flava Substances 0.000 claims description 3
- 239000000084 colloidal system Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 238000003825 pressing Methods 0.000 claims description 3
- 235000012424 soybean oil Nutrition 0.000 claims description 3
- 239000003549 soybean oil Substances 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 abstract description 11
- 239000008280 blood Substances 0.000 abstract description 11
- 206010030113 Oedema Diseases 0.000 abstract description 7
- 206010018367 Glomerulonephritis chronic Diseases 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 208000004880 Polyuria Diseases 0.000 abstract description 3
- 230000035619 diuresis Effects 0.000 abstract description 3
- 230000006870 function Effects 0.000 abstract description 3
- 230000001939 inductive effect Effects 0.000 abstract description 3
- 239000002775 capsule Substances 0.000 abstract description 2
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 abstract 1
- 241000146384 Glaux Species 0.000 abstract 1
- 241000207925 Leonurus Species 0.000 abstract 1
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 8
- 210000002700 urine Anatomy 0.000 description 7
- 238000005303 weighing Methods 0.000 description 6
- 230000017531 blood circulation Effects 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 208000006750 hematuria Diseases 0.000 description 4
- 229920001353 Dextrin Polymers 0.000 description 3
- 239000004375 Dextrin Substances 0.000 description 3
- 206010020772 Hypertension Diseases 0.000 description 3
- 206010029164 Nephrotic syndrome Diseases 0.000 description 3
- 208000017787 Paraneoplastic neurologic syndrome Diseases 0.000 description 3
- 102000007562 Serum Albumin Human genes 0.000 description 3
- 108010071390 Serum Albumin Proteins 0.000 description 3
- 238000012742 biochemical analysis Methods 0.000 description 3
- 230000023555 blood coagulation Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 235000019425 dextrin Nutrition 0.000 description 3
- 229960003444 immunosuppressant agent Drugs 0.000 description 3
- 230000001861 immunosuppressant effect Effects 0.000 description 3
- 239000003018 immunosuppressive agent Substances 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 208000017169 kidney disease Diseases 0.000 description 3
- 230000003907 kidney function Effects 0.000 description 3
- 206010001580 Albuminuria Diseases 0.000 description 2
- 208000008035 Back Pain Diseases 0.000 description 2
- 208000008930 Low Back Pain Diseases 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000003862 glucocorticoid Substances 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 102000007625 Hirudins Human genes 0.000 description 1
- 108010007267 Hirudins Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- CKMXBZGNNVIXHC-UHFFFAOYSA-L ammonium magnesium phosphate hexahydrate Chemical compound [NH4+].O.O.O.O.O.O.[Mg+2].[O-]P([O-])([O-])=O CKMXBZGNNVIXHC-UHFFFAOYSA-L 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
- 229960002768 dipyridamole Drugs 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 description 1
- 229940006607 hirudin Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 210000000244 kidney pelvis Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008327 renal blood flow Effects 0.000 description 1
- 201000002793 renal fibrosis Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 229910052567 struvite Inorganic materials 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 201000005665 thrombophilia Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a kind of medicinal composition for treating nephritis and its preparation process. The medicine composition is prepared with motherwort 80-1800 weight portions, leech70-1500 weight portions, and Japanese milkwort 110-2400 weight portions, and may be tablet, capsule, bolus and other orally taken preparation forms, It has the functions of promoting blood circulationto disperse blood clots and inducing diuresis to alleviate edema, and is used in treating nephritis, especially chronic nephritis.
Description
Technical field
The present invention relates to drug world, relate in particular to pharmaceutical composition of treatment nephritis and its production and application.
Background technology
Nephritis is that pathogenic microorganism is invaded matter and the caused struvite pathological changes of excess of the kidney matter between renal pelvis, kidney.In general, the common sympton of nephritis have that foam increases in edema, the urine, hematuria, waist are ached, hypertension etc.Nephritis is divided into acute and chronic two kinds: acute nephritis, but be the most common patient with the women of child-bearing age, cardinal symptom comprise hyperpyrexia, shiver with cold, lumbago, inappetence, feel sick, vomiting etc., and individual patient can have middle upper abdomen or abdomen pain entirely; Chronic nephritis generally surpasses the course of disease half a year or 1 year person and happyly is chronic nephritis, and shape is light than acute stage, can show as silent urine sometimes.
So far, treatment nephritis is mainly based on immunosuppressant class medicine.Used Chinese patent medicine, for example the patent No. is 98101633.2 Chinese patent, and it discloses a kind of medicine of mainly being made up of Chinese herbal medicine such as GULONG, HUOXUEDAN, Radix Paeoniae Rubra, Ramulus Sambuci Williamsii, Cortex Sapii Radicis, SHIZHUHUA, Radix Et Rhizoma Rhei, Herba Adonidis, Testis et Pentiss for the treatment of nephritis and kidney disease.The Chinese patent medicine that all things considered is used for treating nephritis still is fewer.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of nephritis.
The present invention also aims to provide the preparation method and the application of aforementioned pharmaceutical compositions.
Pharmaceutical composition of the present invention mainly is that the original medical material by following weight proportion is prepared from: Herba Leonuri 80-1800 part, Hirudo 70-1500 part, Herba Polygalae Japonicae 110-2400 part; Be preferably: Herba Leonuri 100-1200 part, Hirudo 90-1100 part, Herba Polygalae Japonicae 180-1500 part; More preferably: Herba Leonuri 300-500 part, Hirudo 250-450 part, Herba Polygalae Japonicae 500-650 part; Most preferably be: 443 parts of Herba Leonuris, 358 parts of Hirudos, 586 parts of Herba Polygalae Japonicae.
Aforementioned pharmaceutical compositions can be made conventional oral formulations, for example tablet, capsule, pill, drop pill, soft capsule, powder, granule, solution etc.Certainly when the concrete preparation of preparation, can add various adjuvants according to the concrete needs of every kind of preparation, for example, filler is as lactose, sucrose, dextrin, Icing Sugar etc.; Wetting agent is as distilled water, ethanol etc.; Binding agent is as syrup, hydroxypropyl cellulose, starch slurry etc.; Lubricant is as magnesium stearate etc.; Suspending agent is as vegetable oil, wax etc.
The present invention has also improved the preparation method of aforementioned pharmaceutical compositions, and wherein a kind of method comprises: 1) with Herba Polygalae Japonicae and Herba Leonuri with water retting, decoction, filter then, filtrate is made clear paste; 2) Hirudo is used alcohol dipping, filtration, obtain filtrate and filtering residue, filtering residue is pulverized, obtain coarse powder and fine powder, coarse powder with above-mentioned filtrate percolation, is made clear paste; 3) two kinds of clear paste of gained are mixed, dry, pulverize, then with 2) in the gained fine powder mixes, granulate with syrup, drying, the adding magnesium stearate, granulate, tabletting promptly get tablet.
The present invention has also improved the preparation method of aforementioned pharmaceutical compositions, and another kind of method comprises: 1) with Herba Polygalae Japonicae and Herba Leonuri with water retting, decoction, filter then, filtrate is made clear paste; 2) Hirudo is used alcohol dipping, filtration, obtain filtrate and filtering residue, filtering residue is pulverized, obtain coarse powder and fine powder, coarse powder with above-mentioned filtrate percolation, is made clear paste; 3) two kinds of clear paste of gained are mixed, dry, pulverize, then with 2) in the gained fine powder mixes, with the syrup granulation, drying behind the granulate, incapsulates, promptly.
The present invention has also improved the preparation method of aforementioned pharmaceutical compositions, and another kind of method comprises: 1) with Herba Polygalae Japonicae and Herba Leonuri with water retting, decoction, filter then, filtrate is made clear paste; 2) Hirudo is used alcohol dipping, filtration, obtain filtrate and filtering residue, filtering residue is pulverized, obtain coarse powder and fine powder, coarse powder with above-mentioned filtrate percolation, is made clear paste; 3) two kinds of clear paste of gained are mixed, dry, pulverize, then with 2) in the gained fine powder mix, after the drying, be ground into fine powder, be binding agent with water, make pill by agitation procedure, promptly.
The present invention has also improved the preparation method of aforementioned pharmaceutical compositions, and another kind of method comprises: 1) with Herba Polygalae Japonicae and Herba Leonuri with water retting, decoction, filter then, filtrate is made clear paste; 2) Hirudo is used alcohol dipping, filtration, obtain filtrate and filtering residue, filtering residue is pulverized, obtain coarse powder and fine powder, coarse powder with above-mentioned filtrate percolation, is made clear paste; 3) two kinds of clear paste of gained are mixed, dry, pulverize, then with 2) in the gained fine powder mixes, adding drop pill substrate behind the heating and melting, splashes in the condensed fluid, after the cooling, sort out, drying, promptly.
The present invention has also improved the preparation method of aforementioned pharmaceutical compositions, and another kind of method comprises: 1) with Herba Polygalae Japonicae and Herba Leonuri with water retting, decoction, filter then, filtrate is made clear paste; 2) Hirudo is used alcohol dipping, filtration, obtain filtrate and filtering residue, filtering residue is pulverized, obtain coarse powder and fine powder, coarse powder with above-mentioned filtrate percolation, is made clear paste; 3) two kinds of clear paste of gained are mixed, dry, pulverize, then with 2) in the gained fine powder mixes, after the drying, crushing screening, with soybean oil and Cera Flava, mixing, colloid mill, prepare rubber with gelatin, G ﹠ W, make soft capsule by pressing, promptly.
Perhaps this method comprises: 1) with Herba Polygalae Japonicae and Herba Leonuri with water retting, decoction, filter then, filtrate is made clear paste; 2) Hirudo is used alcohol dipping, filtration, obtain filtrate and filtering residue, filtering residue is pulverized, obtain coarse powder and fine powder, coarse powder with above-mentioned filtrate percolation, is made clear paste; 3) two kinds of clear paste of gained are mixed, dry, pulverize, then with 2) in the gained fine powder mixes, add the excipient that suits, for example sucrose, dextrin etc. are made granule, after the drying, granulate, packing, promptly.
Raw materials used medical material and adjuvant can be buied at regular pharmacy.Used Herba Leonuri, Hirudo and Herba Polygalae Japonicae weight dry decoction pieces weight to buy at pharmacy.
In the pharmaceutical composition of the present invention, Herba Leonuri, hardship is let out hot loosing, the master goes into blood system, is good at the blood circulation promoting and blood stasis dispelling regulating menstruation, and the energy inducing diuresis to remove edema shows as and can improve and increase the renal blood flow amount, make the pathological changes of glomerule or renal tubules obtain repairing and regeneration, renal fibrosis is reversed,, recover renal function to eliminate albumen in inflammatory lesion and the urine; Hirudo wherein contains the hirudin that can suppress blood coagulation, thereby has effects such as removing blood stasis, removing blood stasis; Herba Polygalae Japonicae has antitussive, reduces phlegm, invigorates blood circulation, stops blooding, calms the nerves, effect such as detoxifcation.The main pharmaceutical composition of being made by Herba Leonuri, Hirudo and Herba Polygalae Japonicae has the effect of blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema, can treat nephritis, especially edema that (chronic) nephritis caused, lumbago, albuminuria, giddy, symptom such as weak can be improved and alleviate to chronic nephritis.
Patient and anemia of pregnant woman hemorrhage and menstrual period prohibit clothes pharmaceutical composition of the present invention.The instructions of taking of pharmaceutical composition of the present invention is as follows: every day 3 times, each dosage is in 5～7g raw medicinal material.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment, characteristics of the present invention and advantage will be clearer.These illustrative embodiment only be used for illustrating of the present invention; to protection scope of the present invention without any restriction; it will be understood by those skilled in the art that the substitutions and modifications of doing according to spirit of the present invention any of equal value all fall within the scope of protection of the present invention.
Embodiment 1
1) takes by weighing Herba Leonuri 443g, Hirudo 358g, Herba Polygalae Japonicae 586g;
2) with Hirudo with the alcohol dipping of 2000ml 75% 2 hours, filter, obtain filtrate and filtering residue (Hirudo after the alcohol dipping), in filtrate, add distilled water and make wherein that ethanol content is 15%, with the filtering residue vacuum drying, pulverize, cross 100 mesh sieves, the gained fine powder is standby, the gained coarse powder flooded 2 hours with above-mentioned gained filtrate according to the percolation under fluid extract and the extractum item (2000 editions first appendix IO of Chinese Pharmacopoeia), and the ethanol of reuse 15% is that solvent carries out percolation, collected percolate, decompression recycling ethanol, being concentrated into relative density is the clear paste of 1.05 (60 ℃):
3) Herba Leonuri and Herba Polygalae Japonicae are used 12000ml water retting 2.5 hours, decocted 1.5 hours, filter, repeat above-mentioned dipping, decoction and filtering operation again, merging filtrate, being evaporated to relative density is the clear paste of 1.10 (60 ℃), add ethanol and make wherein that ethanol content is 75%, left standstill 24 hours, filter, decompression filtrate recycling ethanol, being concentrated into relative density is the clear paste of 1.15 (60 ℃):
4) with two kinds of clear paste mix homogeneously of above-mentioned gained, drying is pulverized, again with above-mentioned gained fine powder mix homogeneously, cross 100 mesh sieves, granulate,, add the 28g magnesium stearate 80 ℃ of dryings with the syrup of 70ml 60%, granulate is pressed into tablet, altogether 1000, the bag film-coat gets final product.
Embodiment 2
Take by weighing Herba Leonuri 320g, Hirudo 430g, Herba Polygalae Japonicae 650g;
By with embodiment 1 in 2), 3) identical method handles Hirudo, Herba Leonuri and Herba Polygalae Japonicae, then two kinds of clear paste of gained are mixed, dry, pulverize, mixes with the gained fine powder then, with 60% syrup 70-80ml granulation, drying behind the granulate, incapsulates, promptly.
Embodiment 3
Take by weighing Herba Leonuri 500g, Hirudo 250g, Herba Polygalae Japonicae 500g;
By with embodiment 1 in 2), 3) identical method handles Hirudo, Herba Leonuri and Herba Polygalae Japonicae, then two kinds of clear paste of gained are mixed, dry, pulverize, mix with the gained fine powder then, after the drying, being ground into 120 order fine powders, is binding agent with water, make pill by agitation procedure, promptly
Embodiment 4
Take by weighing Herba Leonuri 100g, Hirudo 90g, Herba Polygalae Japonicae 1500g;
By with embodiment 1 in 2), 3) identical method handles Hirudo, Herba Leonuri and Herba Polygalae Japonicae, then two kinds of clear paste of gained are mixed, dry, pulverize, mixes adding drop pill substrate (as PEG etc.) then with the gained fine powder, behind the heating and melting, splash in the condensed fluid, after the cooling, sort out, drying, promptly.
Embodiment 5
Take by weighing Herba Leonuri 1200g, Hirudo 90g, Herba Polygalae Japonicae 180g;
By with embodiment 1 in 2), 3) identical method handles Hirudo, Herba Leonuri and Herba Polygalae Japonicae, with two kinds of clear paste mixing of gained, dry, pulverizing, mix with middle gained fine powder then, after the drying then, pulverized 120 mesh sieves, with soybean oil 344g, Cera Flava 6g, mixing, cross colloid mill 3 times, with gelatin: glycerol: 100: 35: 95 formulation rubber of water, make soft capsule by pressing, promptly.
Embodiment 6
Take by weighing Herba Leonuri 1800g, Hirudo 70g, Herba Polygalae Japonicae 2400g;
By with embodiment 1 in 2), 3) identical method handles Hirudo, Herba Leonuri and Herba Polygalae Japonicae, then two kinds of clear paste of gained are mixed, dry, pulverize, mixes with middle gained fine powder then, adding excipient dextrin is made granule, after the drying, granulate, packing, promptly.
The test example
Use pharmaceutical composition tablet in treatment primary nephrotic syndrome of the present invention (PN) case 67 examples of the embodiment of the invention 1 gained, the result is as follows.
Data and method
1. the object of observation: PNS patient's 132 examples of being in hospital, diagnostic criteria is with reference to the academic meeting revised standard of second nephropathy in the whole nation in 1985.Wherein male 94 examples, women 38 examples; 2.5 years old～56 years old age, average (41 ± 12.7) year; Medical history 1～56 month, average (23 ± 11.2) moon.Be divided into two groups at random, 67 examples are organized in treatment, matched group 65 examples.Including case in all gets rid of the Secondary cases nephrotic syndrome and merges other kidney diseases.All accompany edema clinically, urine protein is qualitative +～+++.Hypertension person 12 examples in the treatment group, companion hematuria person 61 examples; Serum albumin (36.5 ± 8.2) g/L; Triglyceride (2.7 ± 1.86) mmol/L.Hypertension person 11 examples in the matched group, companion hematuria person 58 examples; Serum albumin (37.6 ± 7.4) g/L; Serum cholesterol (7.9 ± 1.8) mmol/L; Triglyceride (2,9 ± 1,32) mmol/L.Patient age, sex, the course of disease and the state of an illness are similar between two groups, have comparability.
2. Therapeutic Method: two groups of all oral persantin 25mg of patient, 3 times on the 1st; Look the state of an illness and use urokinase (5 ± 2) ten thousand u intravenous drips, 1 time on the 1st.The treatment group adds the tablet 2-4 sheet with embodiment 1,3 times on the 1st; Take Chinese herbal medicine decoction treatment (by what open behind the symptom Chinese medical discrimination) behind the conventional Chinese medical discrimination of matched group.Two groups all do not add with adrenal gland's glucocorticoid and other immunosuppressant.Stipulate that 12 weeks were 1 course of treatment.
3. observation index: in the drug administration process, two groups of patient's measuring blood pressures in equal morning every day 1 time, the liquid 1 time of having urine examined weekly, the biochemical indicator 1 time of having a blood test in per 2 weeks.All case finishes back 6 months follow-up observation change of illness state situations 1 course of treatment.
4. statistical method: measurement data is so that (x ± s) expression adopts the t check, and enumeration data result adopts the x2 check in the literary composition.
The result
1. curative effect determinate standard
Produce effects: clinical symptoms and sign disappear, and urine detection feminine gender, biochemical analysis index be all in normal range, and renal function is normal and follow up a case by regular visits to not recurrence in 6 months; Effectively: clinical symptoms and sign disappear, urine protein ±, biochemical analysis is normal substantially, changes though follow up a case by regular visits to 6 months observation index, but still before being better than treatment; Invalid: with compare that aforementioned index does not have obvious change and/or clinical symptoms increases the weight of before the treatment.
2. after two groups of curative effects relatively finished the course of treatment, clinical symptoms and sign disappeared in the treatment group, total effective rate 95.5% (64/67), the number of days 18～54d that is in hospital, average 28d; Matched group total effective rate 69.2% (45/65), the number of days 21～57d that is in hospital, average 33d.Treatment group and matched group be P＜0.01 relatively.The biochemical all indexs of blood contrast respectively before and after the treatment, all have clear improvement.
Discuss
Nephrotic syndrome mainly is the imbalance of spleen renal function according to theory of Chinese medical science, with the passing of time causes spleen, lung, kidney all empty, because the patient immune function is low, blood flow is in hypercoagulability, and it is not smooth to circulate, the change of clinical and biochemical analysis aspect that to cause that water humidity hysteresis in the body stays etc. a series of.Pharmaceutical composition of the present invention mainly forms by pure Chinese medicine extraction such as Herba Polygalae Japonicae, Herba Leonuri, Hirudo are refining, shows that through pharmaceutical research Herba Polygalae Japonicae includes seven kinds of mucin and derivant thereof, and it has certain effect to recovering glomerule filter membrane purification function.The another kind of main component Hirudo of pharmaceutical composition of the present invention has stronger blood coagulation resisting function, therefore, the prescription of pharmaceutical composition of the present invention has blood circulation promoting and blood stasis dispelling, blood viscosity lowering, can effectively prevent and alleviate blood clotting material adventitious deposit on filter membrane, can improve the circulation of body inner blood preferably, reach the purpose of eliminating edema.Clinical trial shows, self contrasts the variation tool significant difference (P＜0.01) of the biochemical all indexs of blood before and after the treatment group is taken medicine; And compare with matched group, all better improved (P＜0.01) after finishing the course of treatment.Result of study demonstrates pharmaceutical composition of the present invention eliminating clinical symptoms, correct albuminuria, alleviating aspects such as hematuria, particularly effectively improves PNS patients serum albumin level, and its effect is better than matched group.It is worthy of note that this paper treatment group is not used glucocorticoid and other immunosuppressant, thereby also avoided the toxic and side effects of this type of medicine.It is low to take this medicine PNS healing back relapse rate, does not see obvious adverse reaction in the therapeutic process, is that pharmaceutical composition of the present invention is compared one of unique advantage with other drug.
Claims (1)
1. method for preparing the pharmaceutical composition for the treatment of nephritis, pharmaceutical composition is prepared from by following materials of weight proportions medicine: 443 parts of Herba Leonuris, 586 parts of 358 parts of Hirudos and Herba Polygalae Japonicae; Its preparation method comprises: 1) with Herba Polygalae Japonicae and Herba Leonuri with water retting, decoction, filter then, filtrate is made clear paste; 2) Hirudo is used alcohol dipping, filtration, obtain filtrate and filtering residue, filtering residue is pulverized, obtain coarse powder and fine powder, coarse powder with above-mentioned filtrate percolation, is made clear paste; 3) two kinds of clear paste of gained are mixed, dry, pulverize, then with 2) in the gained fine powder mixes, granulate with syrup, drying, the adding magnesium stearate, granulate, tabletting promptly get tablet;
Perhaps this method comprises: 1) with Herba Polygalae Japonicae and Herba Leonuri with water retting, decoction, filter then, filtrate is made clear paste; 2) Hirudo is used alcohol dipping, filtration, obtain filtrate and filtering residue, filtering residue is pulverized, obtain coarse powder and fine powder, coarse powder with above-mentioned filtrate percolation, is made clear paste; 3) two kinds of clear paste of gained are mixed, dry, pulverize, then with 2) in the gained fine powder mixes, with the syrup granulation, drying behind the granulate, incapsulates, promptly;
Perhaps this method comprises: 1) with Herba Polygalae Japonicae and Herba Leonuri with water retting, decoction, filter then, filtrate is made clear paste; 2) Hirudo is used alcohol dipping, filtration, obtain filtrate and filtering residue, filtering residue is pulverized, obtain coarse powder and fine powder, coarse powder with above-mentioned filtrate percolation, is made clear paste; 3) two kinds of clear paste of gained are mixed, dry, pulverize, then with 2) in the gained fine powder mix, after the drying, be ground into fine powder, be binding agent with water, make pill by agitation procedure, promptly;
Perhaps this method comprises: 1) with Herba Polygalae Japonicae and Herba Leonuri with water retting, decoction, filter then, filtrate is made clear paste; 2) Hirudo is used alcohol dipping, filtration, obtain filtrate and filtering residue, filtering residue is pulverized, obtain coarse powder and fine powder, coarse powder with above-mentioned filtrate percolation, is made clear paste; 3) two kinds of clear paste of gained are mixed, dry, pulverize, then with 2) in the gained fine powder mixes, adding drop pill substrate behind the heating and melting, splashes in the condensed fluid, after the cooling, sort out, drying, promptly;
Perhaps this method comprises: 1) with Herba Polygalae Japonicae and Herba Leonuri with water retting, decoction, filter then, filtrate is made clear paste; 2) Hirudo is used alcohol dipping, filtration, obtain filtrate and filtering residue, filtering residue is pulverized, obtain coarse powder and fine powder, coarse powder with above-mentioned filtrate percolation, is made clear paste; 3) two kinds of clear paste of gained are mixed, dry, pulverize, then with 2) in the gained fine powder mixes, after the drying, crushing screening, with soybean oil, Cera Flava, mixing, colloid mill, prepare rubber with gelatin, G ﹠ W, make soft capsule by pressing, promptly;
Perhaps this method comprises: 1) with Herba Polygalae Japonicae and Herba Leonuri with water retting, decoction, filter then, filtrate is made clear paste; 2) Hirudo is used alcohol dipping, filtration, obtain filtrate and filtering residue, filtering residue is pulverized, obtain coarse powder and fine powder, coarse powder with above-mentioned filtrate percolation, is made clear paste; 3) two kinds of clear paste of gained are mixed, dry, pulverize, then with 2) in the gained fine powder mixes, add the excipient that suits, make granule, after the drying, granulate, packing, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101035380A CN1899384B (en) | 2006-07-21 | 2006-07-21 | Medicinal composition for treating nephritis and its preparing method and use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101035380A CN1899384B (en) | 2006-07-21 | 2006-07-21 | Medicinal composition for treating nephritis and its preparing method and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1899384A CN1899384A (en) | 2007-01-24 |
| CN1899384B true CN1899384B (en) | 2010-04-07 |
Family
ID=37655494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006101035380A Expired - Fee Related CN1899384B (en) | 2006-07-21 | 2006-07-21 | Medicinal composition for treating nephritis and its preparing method and use |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1899384B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101780199B (en) * | 2010-03-24 | 2011-07-27 | 安徽农业大学 | Traditional Chinese medicine breast perfusate for treating mastitis of dairy cattle and preparation method thereof |
| CN101953852B (en) * | 2010-09-16 | 2014-09-24 | 贵州信邦制药股份有限公司 | Antithrombin preparation and preparation method thereof |
-
2006
- 2006-07-21 CN CN2006101035380A patent/CN1899384B/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 国家药品监督管理局.《国家中成药标准汇编》（中成药地方标准上升国家标准部分）肾系 分册.国家药品监督管理局,2002,129. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1899384A (en) | 2007-01-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101757540A (en) | Traditional Chinese medicine composition for treating nephrotic syndrome and preparation method thereof | |
| CN102671137A (en) | Medicine composition for treating diabetic nephropathy and preparation method of medicine composition | |
| CN101007080A (en) | Chinese medicinal preparation for lowering blood fat and benefiting liver | |
| CN102631595B (en) | Medicament for treating II-type diabetes mellitus and preparation method thereof | |
| CN102716459A (en) | Chinese medicinal composition for treating senile mild cognitive impairment and preparation method thereof | |
| CN102488743A (en) | Chinese traditional medicine composition, preparation method thereof and Chinese traditional medicine preparation | |
| CN1899384B (en) | Medicinal composition for treating nephritis and its preparing method and use | |
| CN101584796B (en) | Application of traditional Chinese medicine composition in preparing medicament for treating melancholia | |
| CN1330367C (en) | Chinese medicine composition for treating premenstrual stage stress syndrome an dits prepn process | |
| CN102091306A (en) | Medicine for treating senile chronic colitis | |
| CN101618202A (en) | Medicine for treating proctitis ulcerosa and preparation method thereof | |
| CN100368008C (en) | Chinese medicine for treating gynopathy and its preparing process | |
| CN100473409C (en) | Medicine for treating glomerular hematuria | |
| CN101850063A (en) | Medicinal preparation for preventing and treating gout and preparation method | |
| CN101143181B (en) | Traditional Chinese medicinal composition for treating senile dementia and preparation method and application thereof | |
| CN103099935B (en) | Traditional Chinese medicine composition for adjusting and controlling low-density lipoprotein level | |
| CN103127358B (en) | Traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method | |
| CN101095769B (en) | Health-care food for reducing blood lipid and method for preparing the same | |
| CN109091645A (en) | A kind of pharmaceutical composition with treatment inhibition of HIV | |
| CN103877327A (en) | Pharmaceutical composition for treating nephritic syndrome, as well as preparation method and applications thereof | |
| CN101327283B (en) | Composite medicine for treating nephrosis and its preparing process | |
| CN103768412A (en) | Pure traditional Chinese medicine drug for reducing high blood pressure and high serum lipid | |
| CN101327310B (en) | Chinese medicinal composition for treating hyperlipemia and preparation thereof | |
| CN100484546C (en) | Compound medicine for treating female disintegration and its production | |
| CN102008642B (en) | Traditional Chinese medicine for treating lupus erythematosus and inhibiting glucocorticoid side effect and application of traditional Chinese medicine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HEBEI ZHAOKANG PHARMACY CO., LTD. Free format text: FORMER OWNER: LAN YUQI Effective date: 20101124 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 064400 LONGSHAN PHARMACEUTICAL, FENG AN ROAD, QIAN AN CITY, HEBEI PROVINCE TO: 064400 NO.188, ZHAOKANG STREET, QIAN AN CITY, HEBEI PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20101124 Address after: 064400, 188, Siu Kang Street, Qian'an, Hebei Patentee after: Hebei Zhaokang Pharmacy Co., Ltd. Address before: 064400 Longshan pharmaceutical, Feng an road, Qian'an, Hebei Patentee before: Lan Yuqi |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100407 Termination date: 20120721 |