CN100473409C - Medicine for treating glomerular hematuria - Google Patents

Abstract

The Taiqi kidney recovering medicine liquid is prepared with pseudostellaria root, astragalus root, red sage, notoginseng, Chinese yam and other ten kinds of Chinese medicinal materials in certain weight proportion, and may be prepared into any one orally taken preparation form. The medicine of the present invention has the functions of invigorating spleen, promoting blood circulation, clearing away heat and promoting diuresis, is used in treating hematuria, and possesses high curative rate and low cost.

Description

A kind of medicine for the treatment of glomerular hematuria

Technical field

The present invention relates to a kind of is the Chinese patent medicine of feedstock production with the Chinese herbal medicine, a kind of medicine for the treatment of glomerular hematuria.

Background technology

Up to the present, by the hematuria patient due to the glomerulonephritis trend that increases is year by year arranged in the world wide.According to the investigation of the epizootic disease of my the Anshan iron and steel plant workman of institute annual test, be that 2.4% to rise to prevalence in 2002 be 7.4% from prevalence in 2000.At present Western medicine has the medicine of treatment hematurias such as hematuria ammonia, reptilase, carbazochrome salicylate, and Chinese medicine preparation mainly contains BUZHONG YIQI WAN, Xiaoji Yinzi in the recipes for Saving Lives, the medicament of treatment hematuria such as incomparable Rhizoma Dioscoreae ball, stranguria with blood in " a thousand pieces of gold ".These medicines can symptomatic treatments, but curative effect still can not be satisfactory, and the hematuria obstinate then will damage kidney, finally cause renal insufficiency, thereby its treatment is caused that not only the patient pays close attention to, and also are the major subjects that all Nephrology doctors study.The treatment of hematuria is faced with the difficult problem of society, economy and three aspects of medical treatment, must explore new treatment approach in a hurry.

Summary of the invention

The purpose of this invention is to provide a kind of medicine for the treatment of glomerular hematuria, it has gratifying curative effect, and has no side effect.

Solution of the present invention is:

According to a kind of medicine for the treatment of glomerular hematuria of the present invention, it is characterized in that it is the medicament of being made by the following weight proportion raw material,

Radix Pseudostellariae 25-35, Radix Astragali 25-35, Radix Salviae Miltiorrhizae 10-20, Radix Notoginseng 5-15,

Rhizoma Dioscoreae 10-20, Rhizoma Atractylodis Macrocephalae 5-15, Pollen Typhae 5-15, Oletum Trogopterori 5-15,

Radix Rehmanniae 10-20, Radix Angelicae Sinensis 5-15, Herba Agrimoniae 15-25, Herba Ecliptae 25-35,

Rhizoma Imperatae 35-45, Herba Taraxaci 25-35, Radix Isatidis 15-25.

The weight proportion of selected each raw material is,

Radix Pseudostellariae 28-35, Radix Astragali 28-35, Radix Salviae Miltiorrhizae 12-16, Radix Notoginseng 8-12,

Rhizoma Dioscoreae 12-16, Rhizoma Atractylodis Macrocephalae 8-12, Pollen Typhae 8-12, Oletum Trogopterori 8-12,

Radix Rehmanniae 12-16, Radix Angelicae Sinensis 8-12, Herba Agrimoniae 18-22, Herba Ecliptae 28-32,

Rhizoma Imperatae 38-42, Herba Taraxaci 28-32, Radix Isatidis 18-22.

The crude drug of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, be prepared into any peroral dosage form commonly used as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as pill, powder, tablet, capsule, oral liquid etc.

Medicine of the present invention has that spleen invigorating is invigorated blood circulation, the effect of clearing away heat-damp and promoting diuresis.Can be used for treating hematuria, adjust the blood circulation of kidney, regulate the immunocompetence of kidney, promote serum albumin synthetic, the treatment hematuria is had tangible curative effect.According to traditional Chinese medical theory, hematuria belongs to the traditional Chinese medical science " hematuria " and it " stranguria with blood " category of stranguria, and the traditional Chinese medical science thinks that this disease is divided into void, real two ends, and void is pass and spleen, kidney then; Actually be exopathogen, damp and hot, congestion is relevant.

Radix Pseudostellariae, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Notoginseng set upright spleen invigorating for monarch in the medicine of the present invention, and assistant is strengthened the power set upright with the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Radix Notoginseng, Radix Salviae Miltiorrhizae, Pollen Typhae, Oletum Trogopterori have the merit of nourshing blood and promoting blood circulation hemostasis simultaneously.Assistant is with the Radix Rehmanniae, Radix Angelicae Sinensis, Herba Agrimoniae, Herba Ecliptae, and it reaches the purpose of strengthening vital QI to eliminate pathogenic factors.Serve as that assistant makes with Rhizoma Imperatae, Herba Taraxaci, Radix Isatidis clearing away heat-damp and promoting diuresis in addition, whole body is mended and do not kept, and lives and but, and is sharp and do not hinder, and it reaches spleen invigorating sets upright, the eliminating evil purpose of invigorating blood circulation.

Modern theory of medicine is thought: the Radix Astragali has renal blood flow increasing, alleviates the injury of kidney of ischemia-reperfusion, accelerates the reparation of kidney.Kidney there is protective effect, can also promotes to adjust simultaneously immunity of organisms, increase the anti-immunocompetence of body.

Radix Salviae Miltiorrhizae also is that blood vessel dilating is arranged, and microcirculation improvement, anticoagulant promote fibrinolytic, anticoagulant and the effect of promotion cytothesis.

Radix Notoginseng also is that the microcirculation that improves hemorheology and kidney is arranged, and reduces albuminuria and drains, and alleviates hematuria, and renal function protecting also has antioxidant radical, regulates immune status, influences lipid metabolism, promotes the synthetic effect of serum albumin.

The clinical observation of using medicine embodiment 1 of the present invention is as follows:

Case is selected: in the past few years, select 156 examples from the glomerular hematuria patient that urinary system internal medicine is in hospital and the urinary system outpatient service is made a definite diagnosis, wherein male 98 examples, women 58 examples, age 15-81 year.

Diagnostic criteria: the glomerular hematuria diagnostic criteria by Ministry of Public Health in October, 1993 formulation is:

1. urinate outward appearance and be and wash meat water sample, blood sample, soy sauce sample, every high power field erythrocyte surpasses 3 or 1 hour urine erythrocyte and surpasses 10,000 or 12 hours urine erythrocytes and surpass 500,000 or 〉=8000/ml of cattle bag Fahrenheit calculating dial counting under the fresh Urine sediments analyzer light microscopic.

2. primary glomerulopathy position phase microscopy lopsided erythrocyte 〉=70% that has urine examined.

3. get rid of Secondary cases glomerule (lupus nephritis, purpura nephritis, infective endocarditis etc.).

4. the patient of hematuria, the continuous new explanation urine 5ml that gets more than 2 times inspected by ready samples within 2 hours, adopted the large-scale superelevation microscope of my the institute U.S. to classify the screening case as by the diagnosis of stating of closing of special messenger's check character.

5. by the hematuria case of column selection, have urine examined before and after the medication that routine is occulted blood, urine erythrocyte form, twenty-four-hour urine protein quantification, BUN, Scr, UA, ALP, albumin, plasma viscosity, platelet aggregation rate, CH, TG, IgG, IgA, IgM, C3 change.

Usage and dosage: each 100 milliliters, day clothes secondary, one after each meal.

The course of treatment and observation: one month is a course of treatment, observes for 3 courses of treatment.

Clinical observation result sees Table 1-4:

Table 1 Drug therapy hematuria front and back changes of biochemical indexes for the treatment of glomerular hematuria

Annotate: * P＜0.05 * * P＜0.01

Table 2: a kind of Drug therapy front and back BUN, Scr, UA, ALP, A that treats glomerular hematuria changes

Annotate: P 0.05 * P＜0.05

Table 3 Drug therapy front and back IgG, IgA, IgM, C3 who treats glomerular hematuria changes

Annotate: * P＜0.05 * * P＜0.01

Table 4 Drug therapy hematuria front and back plasma viscosity, platelet aggregation rate, CH, TC who treats glomerular hematuria changes

Annotate: * P＜0.05

As can be seen from Table 1: the red blood cell count(RBC) that a kind of Drug therapy hematuria for the treatment of glomerular hematuria is learned from urine routine test and urine erythrocyte position picture as can be seen, the treatment hematuria obviously is reduced to disappearance, the twenty-four-hour urine protein quantification also is reduced to disappearance thereupon, with preceding relatively P＜0.05 of treatment significant difference is arranged.

As can be seen from Table 2: the hematuria patients " renal function not only normally still is a mile abnormality; take renal function behind this medicine, the liver function no change more makes moderate progress; P〉0.05; no difference of science of statistics; point out this medicine treatment hematuria effective; and harmless to hepatic and renal function, and plasma albumin can also be protected hepatic and renal function than rising to some extent before treating.

As can be seen from Table 3: a kind of Drug therapy hematuria patient who treats glomerular hematuria; there were significant differences before plasma viscosity, platelet aggregation rate, cholesterol, triglyceride were treated; P＜0.05; point out this medicine can improve the high blood coagulation state blood fat reducing; thereby alleviate the pathology body injury of glomerule, and then renal function protecting.

As can be seen from Table 4: this medicine can also be adjusted hematuria patient immune status, and immunoglobulin is descended, and complement C3 raises, P＜0.05 and P＜0.01 before and after the treatment.

Experiment shows that the Drug therapy hematuria effective percentage of the treatment glomerular hematuria of the embodiment of the invention 1 is 92%, reduces albuminuria and reaches 90%, and blood viscosity lowering is 98%, and adjusting immune state is 90%, and total effective rate is 94%.

The specific embodiment

Embodiment 1: by following prescription is that unit takes by weighing raw material: Radix Pseudostellariae 30, the Radix Astragali 30, Radix Salviae Miltiorrhizae 15, Radix Notoginseng 10, Rhizoma Dioscoreae 15, the Rhizoma Atractylodis Macrocephalae 10, Pollen Typhae 10, Oletum Trogopterori 10, the Radix Rehmanniae 15, Radix Angelicae Sinensis 10, Herba Agrimoniae 20, Herba Ecliptae 30, Rhizoma Imperatae 40, Herba Taraxaci 30, Radix Isatidis 20 with the gram.

Preparation method: get the above-mentioned raw materials medicine and put in the extraction pot, extracting in water 2 times, each 2 hours, collecting decoction was concentrated into 200 milliliters, was distributed into 100 milliliters/bag Taiqi kidney recovery liquid.

Embodiment 2: by following prescription is that unit takes by weighing raw material: Radix Pseudostellariae 33, the Radix Astragali 33, Radix Salviae Miltiorrhizae 14, Radix Notoginseng 10, Rhizoma Dioscoreae 14, the Rhizoma Atractylodis Macrocephalae 10, Pollen Typhae 10, Oletum Trogopterori 10, the Radix Rehmanniae 14, Radix Angelicae Sinensis 10, Herba Agrimoniae 20, Herba Ecliptae 30, Rhizoma Imperatae 40, Herba Taraxaci 30, Radix Isatidis 20 with the gram.

Preparation method: get the above-mentioned raw materials medicine and put in the extraction pot, extracting in water 2 times, each 2 hours, collecting decoction was concentrated into 200 milliliters, added white sugar and heating and made it to dissolve, and filtered, and added essence, fill, gland, sterilization, made oral liquid.

Embodiment 3: by following prescription is that unit takes by weighing raw material: Radix Pseudostellariae 30, the Radix Astragali 30, Radix Salviae Miltiorrhizae 15, Radix Notoginseng 10, Rhizoma Dioscoreae 15, the Rhizoma Atractylodis Macrocephalae 10, Pollen Typhae 10, Oletum Trogopterori 10, the Radix Rehmanniae 15, Radix Angelicae Sinensis 10, Herba Agrimoniae 20, Herba Ecliptae 30, Rhizoma Imperatae 40, Herba Taraxaci 30, Radix Isatidis 20 with the gram.

Preparation method: get the above-mentioned raw materials medicine and put in the extraction pot, extracting in water 2 times, each 2 hours, collecting decoction was concentrated into thick paste, added starch, dextrin mixing, and granulation, granulate, tabletting are made tablet.

Claims (3)

1, a kind of medicine for the treatment of glomerular hematuria is characterized in that it is the medicament of being made by the following weight proportion raw material:

Radix Pseudostellariae 25-35, Radix Astragali 25-35, Radix Salviae Miltiorrhizae 10-20, Radix Notoginseng 5-15,

Rhizoma Dioscoreae 10-20, Rhizoma Atractylodis Macrocephalae 5-15, Pollen Typhae 5-15, Oletum Trogopterori 5-15,

Radix Rehmanniae 10-20, Radix Angelicae Sinensis 5-15, Herba Agrimoniae 15-25, Herba Ecliptae 25-35,

Rhizoma Imperatae 35-45, Herba Taraxaci 25-35, Radix Isatidis 15-25.

2, a kind of medicine for the treatment of glomerular hematuria according to claim 1, wherein the weight proportion of each raw material is:

Radix Pseudostellariae 28-35, Radix Astragali 28-35, Radix Salviae Miltiorrhizae 12-16, Radix Notoginseng 8-12,

Rhizoma Dioscoreae 12-16, Rhizoma Atractylodis Macrocephalae 8-12, Pollen Typhae 8-12, Oletum Trogopterori 8-12,

Radix Rehmanniae 12-16, Radix Angelicae Sinensis 8-12, Herba Agrimoniae 18-22, Herba Ecliptae 28-32,

Rhizoma Imperatae 38-42, Herba Taraxaci 28-32, Radix Isatidis 18-22.

3, a kind of medicine for the treatment of glomerular hematuria according to claim 1 and 2 is characterized in that described medicament is the above a dosage form of any pharmaceutics.