CN1895395A - Infantie Kechuanling decoction ointment and its preparation - Google Patents
Infantie Kechuanling decoction ointment and its preparation Download PDFInfo
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- CN1895395A CN1895395A CN 200610010142 CN200610010142A CN1895395A CN 1895395 A CN1895395 A CN 1895395A CN 200610010142 CN200610010142 CN 200610010142 CN 200610010142 A CN200610010142 A CN 200610010142A CN 1895395 A CN1895395 A CN 1895395A
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Abstract
A Chinese medicine in the form of decocted extract for treating the cough and asthma of baby and delaying sanility is prepared through decocting 5 Chinese-medicinal materials including bitter apricot kernel, gypsum, isatis root, liquorice root, etc, filtering, mixing dregs with ephedra and honeysuckle flower, decocting, filtering, collecting decoction, laying aside, taking supernatant, concentrating, adding alcohol, stirring, cold storage, taking supernatant, filtering, recovering alcohol, concentrating, mixing with honey, stirring while heating, and filling it in containers.
Description
Affiliated technical field
The present invention relates to a kind of Infantie Kechuanling decoction ointment and preparation method.
Background technology
Bronchopneumonia and acute bronchitis are to be a kind of respiratory infectious disease of primary symptom with heating, cough, dyspnea with rapid and short breath, belong to the traditional Chinese medical science " diseases caused by exogenous pathogenic factor ", " disease of breathing with cough " category, children's is the body of the young sun of young the moon, internal organs are tender and lovely, and shape gas does not fill, failure of defensive QI to protect the body against pathogen, easily be subjected on the wind and cold, in heat-transformation is gone into, or experience the how first model lung of heresy of wind heat, impairment of purifying and descending function of the lung, presenting wind heat and close the performance of lung, is main so treatment is adopted lung qi dispersing, clearing away phlegm, heat clearing away, Dingchuan mostly.The treatise on Febrile Diseases cloud: " perspiration and asthma, the having no high fever person, can with Herba Ephedrae, Semen Armeniacae Amarum, Radix Glycyrrhizae, Shigao Tang." modern age science of prescription sum up MAXINGSHIGAN TANG and cure mainly: affection due to external wind and heat, heating, thirsty, cough with dyspnea asthma; flaring of alaenasi; antiperspirant or lossless is arranged; thin white fur of tongue or Huang; slippery and rapid pulse person, and be that the oral liquid for cough and asthma of children of prescription has the effect of heat-clearing and toxic substances removing, lung qi dispersing, relieving cough and asthma with Maxingshigan Tonga flavor.Pharmacological testing proves: oral liquid for cough and asthma can produce tangible relexation to the guinea pig tracheal smooth muscle that exsomatizes, and can suppress and resist the reactivity of tracheal smooth muscle to histamine and acetylcholine.The whole guinea pig asthmatic model that histamine is caused can obviously prolong breathing heavily the phase of diving of animal, thereby illustrates that this medicine has antiasthmatic effect preferably.
Summary of the invention
The object of the present invention is to provide a kind of medicine that is applicable to treatment infant upper respiratory tract infection, tracheitis, pneumonia, cough.Another object of the present invention provides the preparation method of said preparation.
In order to achieve the above object, the technical solution used in the present invention is: it is the medicament of being made by the following weight proportion raw material
Herba Ephedrae 20～30g Flos Lonicerae 200～300g Semen Armeniacae Amarum 100～150g
Radix Isatidis 200～300g Gypsum Fibrosum 300～450g Radix Glycyrrhizae 100～150g
Fructus Trichosanthis 100～150g
Adjuvant: Mel 112.2～214.2g
Described dosage form is a soft extract.
Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Isatidis, Radix Glycyrrhizae, Fructus Trichosanthis decoct with water 1 hour, filter, and medicinal residues and Herba Ephedrae, Flos Lonicerae decoct with water 1 hour, filter, merging filtrate leaves standstill, and gets supernatant, is concentrated into fluid extract, add ethanol and make that to contain the alcohol amount be 65%, stir evenly, leave standstill cold preservation; Get supernatant, filter, reclaim ethanol, being concentrated into relative density is 1.21～1.25, and the clear paste that temperature is 80 ℃ claims to decide weight, adds Mel, and heating mixes mixing, and fill promptly.
Characteristics of the present invention:
1. be the developing history of the succession Chinese medicine of traditional medicine technology, keeping primary, traditional consciousness vestige invariably.Soft extract is to the development of water decoction and succession, and it can be added and subtracted with disease, and prescription is flexible, is not accustomed to departing from the medication in Chinese medicine.Drug level height, content are big, dissolving is fast, easily absorption, steady quality, be convenient to preserve, guarantee curative effect, safety, easily under the prerequisite, the medication that has kept traditional again is accustomed to.
2. unique characteristics to the researching human body slow down aging, improve the immune disease-resistance ability along with the development of medical career in defying age, health care, treatment chronic disease, have dropped into a large amount of financial strengths.Motherland's medical science but shows unique characteristics in this respect, and very abundant invaluable experience is arranged, and utilizes natural Chinese herb on the prevention to treat the chronic disease of various human bodies, utilizes soft extracts to grow this application method, truly have irreplaceable original effect.
3. be suitable for chronic patient to take the development of dosage form for a long time, traditional might as well, novel form might as well, safe, effectively, conveniently put in the first place medicine invariably.The use of soft extract truly have very superior condition, medicine is dense, amount is little, take after mixing it with water convert clothes all can, reduced the bitter taste of drug mouthfeel, to the patient of chronic disease is arranged, be more suitable for this dosage form of taking for a long time, giving treatment in accordance with the patient, prescription is flexible, is accepted by the people easilier.
Advantage of the present invention is:
The comprehensive clinical research result of medicine of the present invention shows that following advantage is arranged:
1, to adopt the natural edible-plant medical material be raw material in the present invention, and each component meets the Chinese Pharmacopoeia regulation.Utilize the compatibility effect of the Chinese medicine of respectively distinguishing the flavor of in the prescription to reach therapeutic purposes, and the adding of adjuvant, be that the steviosin that will derive from plant extract changes harmless Mel into, so just can not cause the harm of accumulating because of the accumulation of steviosin to human body, this product does not add preservative sodium benzoate simultaneously, has reduced the extent of injury of antiseptic to human body yet.
2, the present invention has nourishing and takes good care of, has concurrently demulcent therapeutical effect.Simultaneously to compare soft extract poor slightly for the pharmaceutically active ingredient that contains of oral liquid, and the concentration components of soft extract makes people reduce dose, but does not lessen the curative effect.
3, this product is a soft extract, identical with other SHUANGHUANLIAN class pharmaceutical preparatioies on extraction process, in preparation, adopted the preparation technology who in condensed cream, adds adjuvant-Mel, in moulding process, method with heating makes principal agent and adjuvant mix homogeneously, this kind method is also saved on the energy relatively unlike the complexity of other preparations shaping technologies, gets final product through the direct fill of soft extracts of heating mixing.
4, the present invention's epheday intermedia proportion of writing out a prescription is less, should not produce addiction.
5, child cough and panting preparation determined curative effect clinically is summarized as follows its clinical research data below:
Utilization child cough and panting preparation treatment children's bronchopneumonia, acute bronchitis patient compares with penicillin, aminophylline, and effect is more satisfied, and has carried out animal experiment study, now the result is reported as follows:
Clinical research
Clinical data 60 examples are divided into treatment group and matched group at random, each 30 example.Bronchopneumonia 12 examples wherein, acute bronchitis 18 examples, traditional Chinese medical science typing is wind heat and closes pulmonary type, and the doctor trained in Western medicine typing is light-duty.Male 17 examples in 30 examples are organized in treatment, women 13 examples, age＜1 year old 6 examples, 1～3 years old 18 example, 3
+～6 years old 6 examples; 1～3 day 13 example of the course of disease, 4～7 days 17 examples; Normal 12 examples of body temperature,＜38 ℃ of 13 example,＞38 ℃ of 5 example; Blood leukocytes sum＜5 * 10
9/ L3 example, 5～10 * 10
9/ L17 example,＞10 * 10
9/ L10 example; Male 15 examples in matched group 30 examples, women 15 examples, age＜1 year old 7 examples, 1～3 years old 17 example, 3+～6 years old 6 example; 1～3 day 14 example of the course of disease, 4～7 days 20 examples; Normal 14 examples of body temperature,＜38 ℃ of 11 example,＞38 ℃ of 5 example; Blood leukocytes sum＜5 * 10
9/ L3 example, 5～10 * 10
9/ L6 example,＞10 * 10
9/ L11 example.Two groups of data are learned by statistics and are handled there was no significant difference (P＞0.05), have comparability.
Diagnosis and curative effect determinate standard: infantile pneumonia clinical diagnosis and the curative effect judging standard of preventing and treating problem summary of a forum and Ministry of Public Health infantile pneumonia control solution formulation in 1987 according to national infantile pneumonia in 1976
Therapeutic Method and pharmaceutical formulation
1. treatment group adopts Infantie Kechuanling decoction ointment, 1 month～1 years old 5g of dosage, every day 2 times; 1～3 year old 10g, every day 2 times; 4～6 years old 10g, every day 3 times.(Infantie Kechuanling decoction ointment is by the development of Harbin City Kang Long Pharmaceutical Co., Ltd)
2. matched group is with penicillin or erythromycin (to the penicillin anaphylaxis person), aminophylline, treatment routinely.
Clinical efficacy treatment group 30 examples are cured 8 examples, produce effects 20 examples, effective 2 examples; Matched group 30 examples are cured 9 examples, produce effects 20 examples, effective 1 example.Two groups of differences do not have the significance meaning.
The specific embodiment
Below embodiments of the invention are described in further detail.
Embodiment 1,
Herba Ephedrae 20～25g Flos Lonicerae 200～250g Semen Armeniacae Amarum 100～125g
Radix Isatidis 200～250g Gypsum Fibrosum 300～375g Radix Glycyrrhizae 100～125g
Fructus Trichosanthis 100～125g
Adjuvant Mel 112.2～140.25g
Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Isatidis, Radix Glycyrrhizae, Fructus Trichosanthis decoct with water 1 hour, filter, and medicinal residues and Herba Ephedrae, Flos Lonicerae decoct with water 1 hour, filter, merging filtrate leaves standstill, and gets supernatant, is concentrated into fluid extract, add ethanol and make that to contain the alcohol amount be 65%, stir evenly, leave standstill cold preservation; Get supernatant, filter, reclaim ethanol, being concentrated into relative density is the clear paste of 1.21～1.25 (80 ℃), claims to decide weight, adds Mel, the heating mix homogeneously, and fill is promptly.
Embodiment 2,
Herba Ephedrae 25g Flos Lonicerae 250g Semen Armeniacae Amarum 125g
Radix Isatidis 250g Gypsum Fibrosum 375g Radix Glycyrrhizae 125g
Fructus Trichosanthis 125g
Adjuvant Mel 140.25～178.5g
Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Isatidis, Radix Glycyrrhizae, Fructus Trichosanthis decoct with water 1 hour, filter, and medicinal residues and Herba Ephedrae, Flos Lonicerae decoct with water 1 hour, filter, merging filtrate leaves standstill, and gets supernatant, is concentrated into fluid extract, add ethanol and make that to contain the alcohol amount be 65%, stir evenly, leave standstill cold preservation; Get supernatant, filter, reclaim ethanol, being concentrated into relative density is the clear paste of 1.21～1.25 (80 ℃), claims to decide weight, adds Mel, the heating mix homogeneously, and fill is promptly.
Embodiment 3,
Herba Ephedrae 25～30g Flos Lonicerae 250～300g Semen Armeniacae Amarum 125～150g
Radix Isatidis 250～300g Gypsum Fibrosum 375～450g Radix Glycyrrhizae 125～150g
Fructus Trichosanthis 125～150g
Adjuvant Mel 178.5～214.2g
Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Isatidis, Radix Glycyrrhizae, Fructus Trichosanthis decoct with water 1 hour, filter, and medicinal residues and Herba Ephedrae, Flos Lonicerae decoct with water 1 hour, filter, merging filtrate leaves standstill, and gets supernatant, is concentrated into fluid extract, add ethanol and make that to contain the alcohol amount be 65%, stir evenly, leave standstill cold preservation; Get supernatant, filter, reclaim ethanol, being concentrated into relative density is the clear paste of 1.21～1.25 (80 ℃), claims to decide weight, adds Mel, the heating mix homogeneously, and fill is promptly.
Claims (3)
1, a kind of Infantie Kechuanling decoction ointment: its part by weight composition is:
Herba Ephedrae 20～30g Flos Lonicerae 200～300g Semen Armeniacae Amarum 100～150g
Radix Isatidis 200～300g Gypsum Fibrosum 300～450g Radix Glycyrrhizae 100～150g
Fructus Trichosanthis 100～150g adjuvant Mel 112.2～214.2g
2, according to claim 1 it is characterized in that: described dosage form is a soft extract.
3, the preparation method of Infantie Kechuanling decoction ointment according to claim 2, it is characterized in that: Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Isatidis, Radix Glycyrrhizae, Fructus Trichosanthis decoct with water 1 hour, filter, and medicinal residues and Herba Ephedrae, Flos Lonicerae decoct with water 1 hour, filter, merging filtrate leaves standstill, and gets supernatant, be concentrated into fluid extract, add ethanol and make that to contain the alcohol amount be 65%, stir evenly, leave standstill cold preservation; Get supernatant, filter, reclaim ethanol, being concentrated into relative density is 1.21～1.25, and the clear paste that temperature is 80 ℃ claims to decide weight, adds Mel, the heating mixing, and fill is promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 200610010142 CN1895395A (en) | 2006-06-12 | 2006-06-12 | Infantie Kechuanling decoction ointment and its preparation |
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| CN 200610010142 CN1895395A (en) | 2006-06-12 | 2006-06-12 | Infantie Kechuanling decoction ointment and its preparation |
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| CN1895395A true CN1895395A (en) | 2007-01-17 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716400A (en) * | 2012-07-02 | 2012-10-10 | 罗碧 | Lung-heat clearing and cough relieving soup for babies |
| CN102716246A (en) * | 2012-06-18 | 2012-10-10 | 荣成市商贸城卫生所 | Traditional Chinese medicine composite for treating wind-heat type common cold |
| CN107773592A (en) * | 2016-08-30 | 2018-03-09 | 北京盈科瑞创新医药股份有限公司 | A kind of child cough and panting Neulized inhalation pharmaceutical solutions and preparation method thereof |
| CN112516259A (en) * | 2020-12-10 | 2021-03-19 | 新疆医科大学第一附属医院 | Pharmaceutical composition for treating pneumonia and preparation method thereof |
-
2006
- 2006-06-12 CN CN 200610010142 patent/CN1895395A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716246A (en) * | 2012-06-18 | 2012-10-10 | 荣成市商贸城卫生所 | Traditional Chinese medicine composite for treating wind-heat type common cold |
| CN102716400A (en) * | 2012-07-02 | 2012-10-10 | 罗碧 | Lung-heat clearing and cough relieving soup for babies |
| CN102716400B (en) * | 2012-07-02 | 2014-11-05 | 罗碧 | Lung-heat clearing and cough relieving soup for babies |
| CN107773592A (en) * | 2016-08-30 | 2018-03-09 | 北京盈科瑞创新医药股份有限公司 | A kind of child cough and panting Neulized inhalation pharmaceutical solutions and preparation method thereof |
| CN112516259A (en) * | 2020-12-10 | 2021-03-19 | 新疆医科大学第一附属医院 | Pharmaceutical composition for treating pneumonia and preparation method thereof |
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