CN1891222A - 含有依那普利或贝那普利和索他洛尔的药物组合物 - Google Patents
含有依那普利或贝那普利和索他洛尔的药物组合物 Download PDFInfo
- Publication number
- CN1891222A CN1891222A CNA2005100816701A CN200510081670A CN1891222A CN 1891222 A CN1891222 A CN 1891222A CN A2005100816701 A CNA2005100816701 A CN A2005100816701A CN 200510081670 A CN200510081670 A CN 200510081670A CN 1891222 A CN1891222 A CN 1891222A
- Authority
- CN
- China
- Prior art keywords
- sotalol
- enalapril
- benazepril
- hypertension
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Description
合用类型 | 合用固定剂量,mg* |
ACE抑制剂和CCBs | 氨氯地平/盐酸贝那普利(2.5/10,5/10,5/20,10/20) |
马来酸依那普利/非洛地平(5/5) | |
群多普利/维拉帕米(2/80,1/240,2/240,4/240) | |
ACE抑制剂和利尿剂 | 苯那普利/氢氯噻嗪(5/6.25,10/12.5,20/12.5,20/25) |
卡托普利/氢氯噻嗪(25/15,25/25,50/15,50/25) | |
马来酸依那普利/氢氯噻嗪(5/12.5,10/25) | |
赖诺普利/氢氯噻嗪(10/12.5,20/12.5,20/25) | |
盐酸莫昔普利/氢氯噻嗪(7.5/12.5,15/25) | |
喹那普利/氢氯噻嗪(10/12.5,20/12.5,20/25) | |
ARBs和利尿剂 | 坎地沙坦/氢氯噻嗪(16/12.5,32/12.5) |
甲磺酸依普沙坦/氢氯噻嗪(600/12.5,600/25) | |
厄贝沙坦/氢氯噻嗪(75/12.5,150/12.5,300/12.5) | |
氯沙坦/氢氯噻嗪(50/12.5,300/12.5) | |
替米沙坦/氢氯噻嗪(40/12.5,80/12.5) | |
缬沙坦/氢氯噻嗪(80/12.5,160/12.5) | |
β受体拮抗剂和利尿剂 | 阿替洛尔/氢氯噻嗪(50/25,100/25) |
比索洛尔/氢氯噻嗪(2.5/6.25,5/6.25,10/6.25) | |
普萘洛尔/氢氯噻嗪(40/25,80/25) | |
美托洛尔/氢氯噻嗪(50/25,100/25) | |
纳多洛尔/氢氯噻嗪(40/5,80/5) | |
噻吗洛尔/氢氯噻嗪(10/25) | |
中枢作用药物和利尿剂 | 甲基多巴/氢氯噻嗪(250/15,250/25,500/30,500/50) |
利血平/氯噻嗪(0.125/250,0.125/500 | |
利血平/氢氯噻嗪(0.125/25,0.125/50) | |
利尿剂和利尿剂 | 阿米洛利/氢氯噻嗪(5/50) |
螺内酯/氢氯噻嗪(25/25,50/50) | |
氨苯蝶啶/氢氯噻嗪(37.5/25,50/25,75/50) |
组别 | 剂量mg/kg | 给药前血压(mmHg) | 给药后血压(mmHg) | |||
1h | 2h | 4h | 24h | |||
正常组模型组依那普利+索他洛尔贝那普利+索他洛尔依那普利贝那普利索他洛尔 | --1+41+4114 | 93.9±6.7179.3±13.4180.7±20.2181.4±14.9179.4±13.6177.4±17.8181.3±16.4 | 94.8±5.9180.3±12.6158.2±14.4**▲152.2±13.4**▲170.2±19.9170.6±12.8167.4±17.2 | 97.4±7.3180.1±13.0140.3±12.8**▲▲143.8±9.7**▲▲165.3±14.3**160.5±10.9**165.9±15.7* | 100.5±10.6184.3±15.3130.2±12.1**▲▲127.5±12.6**▲▲148.6±13.5**150.9±12.2**164.0±18.1* | 94.4±8.2183.3±15.9140.0±9.4**▲▲145.0±13.5**▲▲165.0±12.4**164.0±14.7**176.8±13.1 |
组别 | 剂量(mg/kg) | 给药后14d血压(mmHg) | 停药后24h(mmHg) |
正常组模型组依那普利索他洛尔贝那普利索他洛尔依那普利贝那普利索他洛尔 | --1+41+4114 | 101.3±10.4179.4±13.8118.3±16.4**▲▲115.9±14.3**▲▲137.7±12.8**133.6±9.8**165.3±12.8* | 96.7±12.8176.6±15.8132.6±14.3**▲▲137.5±11.5**▲▲149.9±16.2**156.6±17.8**174.4±13.2 |
组别 | n | 剂量(mg/kg) | 给药前血压(mmHg) | 给药14天血压(mmHg) |
正常组模型组贝那普利有效组贝那普利无效组 | 10106258 | --11 | 95.6±10.8188.9±23.5192.6±26.4186.2±30.1 | 93.4±12.2193.4±27.8138.2±26.1▲▲175.6±31.5 |
组别 | n | 剂量(mg/kg) | 给药前血压(mmHg) | 给药14天血压(mmHg) |
贝那普利组依那普利组索他洛尔贝那普利+索他洛尔依那普利+索他洛尔 | 1211111212 | 1141+41+4 | 186.2±30.1186.2±29.4190.1±31.4187.7±32.3190.6±29.2 | 175.6±41.5170.6±27.8170.4±33.1139.9±26.2**136.6±30.8** |
组别 | 剂量(mg/kg) | 给药前血压(mmHg) | 连续给药14天血压(mmHg) | 停药24小时血压(mmHg) |
正常组模型组贝那普利+索他洛尔依那普利+索他洛尔西拉普利+普萘洛尔卡托普利+普萘洛尔依那普利+美托洛尔贝那普利+普萘洛尔依那普利+拉贝洛尔赖诺普利+阿替洛尔 | --1+41+40.20+210+21+2.51+21+51+2.5 | 90.4±11.3180.3±31.4178.2±17.9180.7±31.5184.0±23.6182.2±26.5177.4±31.7180.5±27.8184.6±21.5179.4±31.1 | 95.3±15.6179.2±25.6123.2±14.7**▲120.2±19.4**▲136.2±14.8**142.0±14.3144.8±20.5**136.4±16.7136.4±18.9**141.2±22.2** | 93.5±12.7183.5±27.3130.8±16.3**▲133.6±17.8**▲154.6±14.8**168.8±20.9156.4±14.6**153.4±13.3160.4±14.3*163.0±21.0 |
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