CN1890221B - 1-n-苯基-氨基-1h-咪唑衍生物和含有它们的医药组合物 - Google Patents

1-n-苯基-氨基-1h-咪唑衍生物和含有它们的医药组合物 Download PDF

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Publication number
CN1890221B
CN1890221B CN200480036357.XA CN200480036357A CN1890221B CN 1890221 B CN1890221 B CN 1890221B CN 200480036357 A CN200480036357 A CN 200480036357A CN 1890221 B CN1890221 B CN 1890221B
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China
Prior art keywords
oso
derivatives
cyano
amino
hydroxyl
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Expired - Fee Related
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CN200480036357.XA
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English (en)
Chinese (zh)
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CN1890221A (zh
Inventor
让·拉费
伯努瓦·龙多
波勒·博内
蒂埃里·克莱尔
雅克利娜·希尔兹
伊戈尔·杜克
埃里克·迪朗蒂
弗朗索瓦·普乔
克里斯蒂安·布洛
菲利普·迈尔洛斯
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Laboratoire Theramex SAM
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Laboratoire Theramex SAM
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34702365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1890221(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP03293152A external-priority patent/EP1544195A1/en
Application filed by Laboratoire Theramex SAM filed Critical Laboratoire Theramex SAM
Publication of CN1890221A publication Critical patent/CN1890221A/zh
Application granted granted Critical
Publication of CN1890221B publication Critical patent/CN1890221B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200480036357.XA 2003-12-15 2004-12-15 1-n-苯基-氨基-1h-咪唑衍生物和含有它们的医药组合物 Expired - Fee Related CN1890221B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP03293152A EP1544195A1 (en) 2003-12-15 2003-12-15 1-N-phenyl-amino- 1H-imidazole derivatives and pharmaceutical compositions containing them
EP03293152.9 2003-12-15
EP04292681 2004-11-12
EP04292681.6 2004-11-12
PCT/EP2004/014847 WO2005058842A1 (en) 2003-12-15 2004-12-15 1-n-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
CN1890221A CN1890221A (zh) 2007-01-03
CN1890221B true CN1890221B (zh) 2014-07-16

Family

ID=34702365

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200480036357.XA Expired - Fee Related CN1890221B (zh) 2003-12-15 2004-12-15 1-n-苯基-氨基-1h-咪唑衍生物和含有它们的医药组合物

Country Status (18)

Country Link
US (1) US8476455B2 (enExample)
EP (1) EP1694650A1 (enExample)
JP (2) JP4834557B2 (enExample)
KR (1) KR20060123186A (enExample)
CN (1) CN1890221B (enExample)
AR (1) AR047144A1 (enExample)
AU (1) AU2004299286B2 (enExample)
BR (1) BRPI0417407A (enExample)
CA (1) CA2549603A1 (enExample)
IL (1) IL176077A0 (enExample)
MA (1) MA28286A1 (enExample)
MX (1) MXPA06006837A (enExample)
NO (1) NO20062710L (enExample)
NZ (1) NZ548399A (enExample)
OA (1) OA13336A (enExample)
RU (1) RU2365586C2 (enExample)
TW (1) TW200533668A (enExample)
WO (1) WO2005058842A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0127923D0 (en) 2001-11-21 2002-01-16 Sterix Ltd Compound
CA2656627A1 (en) * 2006-07-05 2008-01-10 Merck Patent Gesellschaft Mit Beschraenkter Haftung Sulfamatobenzothiophene derivatives
AU2007327943A1 (en) * 2006-12-04 2008-06-12 Merck Patent Gmbh Sulphamate benzothiophene derivatives
CA2698814A1 (en) 2007-09-17 2009-03-26 Preglem S.A. Treatment of oestrogen dependant conditions in pre-menopausal women
GB0914767D0 (en) * 2009-08-24 2009-09-30 Sterix Ltd Compound
HRP20221462T1 (hr) 2015-12-09 2023-01-20 The Board Of Trustees Of The University Of Illinois Selektivni nishodni regulatori receptora estrogena na bazi benzotiofena
EP3565558B1 (en) 2017-01-06 2023-12-06 G1 Therapeutics, Inc. Combination therapy with a serd compound and a cdk4/6 inhibitor for the treatment of cancer
WO2018187414A1 (en) * 2017-04-05 2018-10-11 The Regents Of The University Of California Inhibitors of mtor-rictor interactions
EP3801221A4 (en) * 2018-06-11 2022-03-30 Loma Linda University Methods of delaying and reversing alzheimer's disease progression

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071861A (en) * 1986-03-07 1991-12-10 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5674886A (en) * 1991-09-02 1997-10-07 Yamanouchi Pharmaceutical Co., Ltd. Triazolylated teritiary amine compound or salt thereof
WO2002068395A1 (en) * 2001-02-23 2002-09-06 K.U. Leuven Research & Development Hiv inhibiting n-aminoimidazole derivatives

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Publication number Priority date Publication date Assignee Title
US3558625A (en) * 1968-10-31 1971-01-26 Merck & Co Inc Pyrazinecarboxyaldehydes and method for their preparation
BE757186A (fr) 1969-10-07 1971-04-07 Bayer Ag Nouveaux esters d'acides pyridazino-thiono-phosphoriques et-phosphoniques, leur procede de preparation et leur application comme insecticides et acaricides
US4166452A (en) * 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) * 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) * 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4584302A (en) 1983-09-26 1986-04-22 Mcneilab, Inc. Methods for the treatment of ventricular dysrhythmia and prevention of ventricular fibrillation
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
DE3811574A1 (de) * 1988-03-31 1989-10-19 Schering Ag N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
JP2500849B2 (ja) * 1991-09-02 1996-05-29 山之内製薬株式会社 トリアゾリル置換３級アミノ化合物又はその塩
GB2273704B (en) * 1992-12-16 1997-01-22 Orion Yhtymae Oy Triazolyl diaryl selective aromatase inhibiting compounds
WO1996035688A1 (en) 1995-05-08 1996-11-14 Nippon Chemiphar Co., Ltd. 2,4-thiazolidinedione or oxazolidinedione derivatives and hypoglycemic agent
DE19731328A1 (de) * 1997-07-22 1999-01-28 Hoechst Ag Imidazol-Derivate mit Biphenylsulfonylcyanamid-Seitenkette, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
GB9807779D0 (en) 1998-04-09 1998-06-10 Ciba Geigy Ag Organic compounds
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
JP4320089B2 (ja) * 1999-07-06 2009-08-26 あすか製薬株式会社 フェニルスルファメート誘導体
US6436972B1 (en) 2000-04-10 2002-08-20 Dalhousie University Pyridones and their use as modulators of serine hydrolase enzymes
JP2004524289A (ja) 2000-12-22 2004-08-12 アストラゼネカ・アクチエボラーグ 治療化合物
CN1370533A (zh) 2001-02-27 2002-09-25 中国人民解放军军事医学科学院放射医学研究所 一类新的苯并噻吩类化合物在防治妇女绝经后综合症和其它与雌激素相关疾病中的用途
US7109193B2 (en) * 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
GB0127923D0 (en) * 2001-11-21 2002-01-16 Sterix Ltd Compound
BR0214373A (pt) * 2001-11-21 2004-10-13 Sterix Ltd Derivados de 1,2,4-triazol contendo um grupo sulfamato como inibidores de aromatase
US6737433B1 (en) 2002-12-16 2004-05-18 Laboratoire Theramex 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them
JP2004196795A (ja) * 2002-12-16 2004-07-15 Wyeth 外部寄生虫駆除剤としてのｎ−フェニル−３−シクロプロピルピラゾール−４−カルボニトリル
EP1644350B1 (en) 2003-05-16 2009-07-01 Laboratoire Theramex Sulfamate benzothiophene derivatives as steroid sulfatase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071861A (en) * 1986-03-07 1991-12-10 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5674886A (en) * 1991-09-02 1997-10-07 Yamanouchi Pharmaceutical Co., Ltd. Triazolylated teritiary amine compound or salt thereof
WO2002068395A1 (en) * 2001-02-23 2002-09-06 K.U. Leuven Research & Development Hiv inhibiting n-aminoimidazole derivatives

Also Published As

Publication number Publication date
OA13336A (en) 2006-04-13
CN1890221A (zh) 2007-01-03
MXPA06006837A (es) 2006-09-04
RU2365586C2 (ru) 2009-08-27
RU2006125417A (ru) 2008-01-27
EP1694650A1 (en) 2006-08-30
KR20060123186A (ko) 2006-12-01
AU2004299286A1 (en) 2005-06-30
MA28286A1 (fr) 2006-11-01
JP4834557B2 (ja) 2011-12-14
NZ548399A (en) 2011-01-28
TW200533668A (en) 2005-10-16
JP5209760B2 (ja) 2013-06-12
NO20062710L (no) 2006-06-30
US8476455B2 (en) 2013-07-02
WO2005058842A1 (en) 2005-06-30
JP2007515420A (ja) 2007-06-14
US20070112009A1 (en) 2007-05-17
BRPI0417407A (pt) 2007-04-03
AU2004299286B2 (en) 2011-06-30
IL176077A0 (en) 2006-10-05
AR047144A1 (es) 2006-01-11
JP2011190277A (ja) 2011-09-29
CA2549603A1 (en) 2005-06-30

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Granted publication date: 20140716

Termination date: 20151215

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