CN1879830A - An effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation and method for preparing same - Google Patents
An effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation and method for preparing same Download PDFInfo
- Publication number
- CN1879830A CN1879830A CN 200610051038 CN200610051038A CN1879830A CN 1879830 A CN1879830 A CN 1879830A CN 200610051038 CN200610051038 CN 200610051038 CN 200610051038 A CN200610051038 A CN 200610051038A CN 1879830 A CN1879830 A CN 1879830A
- Authority
- CN
- China
- Prior art keywords
- parts
- lactose
- gynecological inflammation
- filtrate
- add
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses effervescent tablets for treating gynaecologic inflammation and its preparation comprising the following steps: grilling flavescent sophora root, roor of sessile stemona, cnidium fruit, hairy vein agrimony and purple perilla, merging the grilling liquid, filtering and concentrating the filtrate into thick grease with specific gravity of 1.05-1.15 (60 deg C), stewing 24-4 hours, filtrating, reclaiming ethanol from the filtrate, concentrating to obtain clear grease, drying, disintegrating and passing through 80 mesh sieve, disintegrating other herbs and auxiliary materials, passing through 80 mesh sieves. The raw materials also include ammonia alum, sodium hydrogen carbonate, lactose, boracic acid, citric acid, hydroxypropyl cellulose, boneol, camphor and dodecyl sodium sulfate.
Description
Technical field
The invention belongs to medical technical field, relate in particular to a kind of effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation, also relate to its preparation method simultaneously.
Background technology
Vaginitis is one of gynecological's common disease, comprises mycotic, candidiasis, infusorian property, bacterial vaginitis.Vaginitis is outbreak repeatedly usually, is difficult for treatment, has a strong impact on body of women health.And the characteristics of female pathology structure have determined the universality of this class disease and multiple, cause uncomfortable even painful on the health to the patient.According to relevant bibliographical information, the stemona root and hairy vein agrimony for treating gynecological inflammation bolt is 88.24% to colpitic total effective rate, but because of suppository forms for the medical material thick paste adds the substrate moulding, easy softening transform is heated, moisture content is higher, to such an extent as to the inconvenience of usually going mouldy is preserved and difficult quality guarantee in transportation; Volatile component such as Borneolum Syntheticum is added in the high temperature matrix after with dissolve with ethanol more in addition, and volatile, active ingredient is wayward.
Summary of the invention
A kind of local application that is easy to that the objective of the invention is to overcome above-mentioned shortcoming and provide absorbs, and active ingredient is easy to control, has not only prevented that medicine from going mouldy but also reduced the effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation of production cost.
The preparation method of the effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation that provides also is provided another object of the present invention.
The selection of supplementary product kind of the present invention and consumption, be the characteristics that hygroscopicity and effervescent tablet are arranged according to stemona root and hairy vein agrimony for treating gynecological inflammation extractum, with matrine content (%) is performance assessment criteria, with 1: 1 (extractum: adjuvant) to the adjuvant test that interacts, through repetition test, filler is selected lactose, low-substituted hydroxypropyl cellulose, and effervescent is selected the acid of Chinese holly edge, sodium bicarbonate, and fluidizer is selected sodium lauryl sulphate.Result of the test shows, in the extractum matrine content with add adjuvant after, basic no change, illustrate that selected adjuvant and extractum do not have interaction, adopt different ratio component designs on this basis, through soda acid difference wet granulation, mixed pressuring plate, can increase the flowability of material like this, reduce the weight differential of tablet, phenomenon such as prevent that sticking, pine in the tabletting process from splitting.With hardness, friability, gas release is performance assessment criteria, the screening optimum formula.
Obtain thus, effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation of the present invention, each component consumption all have curative effect preferably in the scope of following weight parts:
320 parts of 320 parts of Herba Agrimoniaes of 320 parts of Fructus Cnidiis of 640 parts of Radixs Stemonae of Radix Sophorae Flavescentis
60 parts of 10 parts of boric acid of 5 parts of Camphoras of 10 parts of Borneolum Syntheticums of 320 parts of Alumens of Folium Callicarpae Formosanae
Chinese holly edge acid 90-160 part sodium bicarbonate 120-190 part hyprolose 6-72 part
12 parts of an amount of sodium lauryl sulphates of lactose.
Above-mentioned effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation, the wherein preferred following dosage of adjuvant:
30 parts of 48 parts of lactose of Chinese holly edge acid 150 parts of hyprolose of 120 parts of sodium bicarbonate
12 parts of sodium lauryl sulphates.
Learn that according to long-term practice middle liquid medicine is put forward effect and is subjected to adding the doubly influence of factors such as amount, extraction time, extraction time of water.Because of extraction process in the prior art is investigated extraction time, extraction time, thus during Study on extraction, mainly investigate the reasonability of prior art, and choose and add water and doubly measure as factor, apply mechanically quadrature expression formula L
93
4The high spot reviews varying level is taken all factors into consideration in conjunction with aspects such as production cost, the energy the influence of extraction effect, selects rational extraction process.One, index is determined: extractum is the material base of solid preparation performance curative effect, and its recovery rate height directly influences preparation process, so be chosen as the extraction index; But extractum recovery rate height can not reflect active ingredient fully and extract situation, thus in selecting simultaneously to fill a prescription contained Radix Sophorae Flavescentis main component matrine content as screening index.Two, investigate test: get 1/10 formula ratio medical material (Radix Sophorae Flavescentis 64g, Radix Stemonae 32g, Fructus Cnidii 32g, Herba Agrimoniae 32g, Folium Callicarpae Formosanae 32g) and test, the aggregative weighted scoring draws, the optimised process of amount of water boils three times for adding 10 times of water yield decoctings, first and second time each 2 hours, 1 hour for the third time.Three, repeated authentication test: through 3 repeated trials, the result is that this extraction process is reasonable, and wherein the fluctuation of principal agent active ingredient matrine content is little.
Separate, concentrate and drying process: for the ease of production control, in conjunction with experience and prior art separate, concentration technology, and prove through repeatability, the basic no change of its effective component content, yield is on average 8.07%, so determine separation, the concentrated drying process that reaches be: collecting decoction, filter while hot, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (60 ℃), adds ethanol and makes and contain alcohol amount and reach 60%, leaves standstill 24 hours, its supernatant, filter, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃), drying.
In sum, the preparation method of effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation of the present invention comprises the steps:
More than nine flavor medical materials, get Radix Sophorae Flavescentis, the Radix Stemonae, Fructus Cnidii, Herba Agrimoniae, Folium Callicarpae Formosanae, add 10 times of water gagings and decoct three times, first and second time each 2 hours, 1 hour for the third time, collecting decoction, filter while hot, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (60 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, left standstill 24 hours, its supernatant filters, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃), and drying was pulverized 80 mesh sieves, be divided into 2 parts, standby; All the other medical materials and adjuvant pulverize separately are crossed 80 mesh sieves, and be standby; Get 1 part of dry extract, add Alumen, sodium bicarbonate, the lactose alcohol granulation; Getting in addition, 1 part of dry extract adds boric acid, citric acid, hyprolose alcohol granulation; Get above-mentioned two kinds of granules and add Borneolum Syntheticum, Camphora and sodium lauryl sulphate mixing, tabletting, promptly.
The present invention compared with prior art, after the moisture absorption cystose, be easy to local application and absorb; And in the prescription volatile component be ground into behind the fine powder with other granule mixing after direct compression; reduced losing of active ingredient; and make the effervescent tablet moisture content less; volume and weight reduce feasible packing after the molding, cost of transportation reduces; can also prevent to go mouldy and reduced production cost, and guarantee the therapeutical effect of medicine.
The specific embodiment
Embodiment 1
Take by weighing the following weight proportion raw material:
Radix Sophorae Flavescentis 640g Radix Stemonae 320g Fructus Cnidii 320g Herba Agrimoniae 320g
Folium Callicarpae Formosanae 320g Alumen 10g Borneolum Syntheticum 5g Camphora 10g boric acid 60g
Chinese holly edge acid 120g sodium bicarbonate 150g hyprolose 48g lactose 30g
Sodium lauryl sulphate 12g
More than nine flavor medical materials, get Radix Sophorae Flavescentis, the Radix Stemonae, Fructus Cnidii, Herba Agrimoniae, Folium Callicarpae Formosanae, add 10 times of water gagings and decoct three times, first and second time each 2 hours, 1 hour for the third time, collecting decoction, filter while hot, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (60 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, left standstill 24 hours, its supernatant filters, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃), and drying was pulverized 80 mesh sieves, be divided into 2 parts, standby; All the other medical materials and adjuvant pulverize separately are crossed 80 mesh sieves, and be standby; Get 1 part of dry extract, add Alumen, sodium bicarbonate, the lactose alcohol granulation; Getting in addition, 1 part of dry extract adds boric acid, citric acid, hyprolose alcohol granulation; Get above-mentioned two kinds of granules and add Borneolum Syntheticum, Camphora and sodium lauryl sulphate mixing, be pressed into 1000, promptly.
Embodiment 2
Take by weighing the following weight proportion raw material:
Radix Sophorae Flavescentis 640g Radix Stemonae 320g Fructus Cnidii 320g Herba Agrimoniae 320g
Folium Callicarpae Formosanae 320g Alumen 10g Borneolum Syntheticum 5g Camphora 10g boric acid 60g
Chinese holly edge acid 144g sodium bicarbonate 174g hyprolose 24g lactose 6g
Sodium lauryl sulphate 12g
More than nine flavor medical materials, get Radix Sophorae Flavescentis, the Radix Stemonae, Fructus Cnidii, Herba Agrimoniae, Folium Callicarpae Formosanae, add 10 times of water gagings and decoct three times, first and second time each 2 hours, 1 hour for the third time, collecting decoction, filter while hot, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (60 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, left standstill 24 hours, its supernatant filters, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃), and drying was pulverized 80 mesh sieves, be divided into 2 parts, standby; All the other medical materials and adjuvant pulverize separately are crossed 80 mesh sieves, and be standby; Get 1 part of dry extract, add Alumen, sodium bicarbonate, the lactose alcohol granulation; Getting in addition, 1 part of dry extract adds boric acid, citric acid, hyprolose alcohol granulation; Get above-mentioned two kinds of granules and add Borneolum Syntheticum, Camphora and sodium lauryl sulphate mixing, be pressed into 1000, promptly.
Embodiment 3
Take by weighing the following weight proportion raw material:
Radix Sophorae Flavescentis 640g Radix Stemonae 320g Fructus Cnidii 320g Herba Agrimoniae 320g
Folium Callicarpae Formosanae 320g Alumen 10g Borneolum Syntheticum 5g Camphora 10g boric acid 60g
Chinese holly edge acid 132g sodium bicarbonate 162g hyprolose 36g lactose 18g
Sodium lauryl sulphate 12g
More than nine flavor medical materials, get Radix Sophorae Flavescentis, the Radix Stemonae, Fructus Cnidii, Herba Agrimoniae, Folium Callicarpae Formosanae, add 10 times of water gagings and decoct three times, first and second time each 2 hours, 1 hour for the third time, collecting decoction, filter while hot, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (60 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, left standstill 24 hours, its supernatant filters, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃), and drying was pulverized 80 mesh sieves, be divided into 2 parts, standby; All the other medical materials and adjuvant pulverize separately are crossed 80 mesh sieves, and be standby; Get 1 part of dry extract, add Alumen, sodium bicarbonate, the lactose alcohol granulation; Getting in addition, 1 part of dry extract adds boric acid, citric acid, hyprolose alcohol granulation; Get above-mentioned two kinds of granules and add Borneolum Syntheticum, Camphora and sodium lauryl sulphate mixing, be pressed into 1000, promptly.
Embodiment 4
Take by weighing the following weight proportion raw material:
Baicao Fuyanqing effervescent tablet of the present invention is the medicament of being made by the raw material of following weight parts:
Radix Sophorae Flavescentis 640g Radix Stemonae 320g Fructus Cnidii 320g Herba Agrimoniae 320g
Folium Callicarpae Formosanae 320g Alumen 10g Borneolum Syntheticum 5g Camphora 10g boric acid 60g
Chinese holly edge acid 108g sodium bicarbonate 138g hyprolose 60g lactose 60g
Sodium lauryl sulphate 12g
The preparation method of Baicao Fuyanqing effervescent tablet of the present invention comprises the steps:
More than nine flavor medical materials, get Radix Sophorae Flavescentis, the Radix Stemonae, Fructus Cnidii, Herba Agrimoniae, Folium Callicarpae Formosanae, add 10 times of water gagings and decoct three times, first and second time each 2 hours, 1 hour for the third time, collecting decoction, filter while hot, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (60 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, left standstill 24 hours, its supernatant filters, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃), and drying was pulverized 80 mesh sieves, be divided into 2 parts, standby; All the other medical materials and adjuvant pulverize separately are crossed 80 mesh sieves, and be standby; Get 1 part of dry extract, add Alumen, sodium bicarbonate, the lactose alcohol granulation; Getting in addition, 1 part of dry extract adds boric acid, citric acid, hyprolose alcohol granulation; Get above-mentioned two kinds of granules and add Borneolum Syntheticum, Camphora and sodium lauryl sulphate mixing, be pressed into 1000, promptly.
Embodiment 5
Take by weighing the following weight proportion raw material:
Radix Sophorae Flavescentis 640g Radix Stemonae 320g Fructus Cnidii 320g Herba Agrimoniae 320g
Folium Callicarpae Formosanae 320g Alumen 10g Borneolum Syntheticum 5g Camphora 10g boric acid 60g
Chinese holly edge acid 96g sodium bicarbonate 126g hyprolose 72g lactose 72g
Sodium lauryl sulphate 12g
More than nine flavor medical materials, get Radix Sophorae Flavescentis, the Radix Stemonae, Fructus Cnidii, Herba Agrimoniae, Folium Callicarpae Formosanae, add 10 times of water gagings and decoct three times, first and second time each 2 hours, 1 hour for the third time, collecting decoction, filter while hot, filtrate is concentrated into the clear paste that relative density is 1.05-1.15 (60 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, left standstill 24 hours, its supernatant filters, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃), and drying was pulverized 80 mesh sieves, be divided into 2 parts, standby; All the other medical materials and adjuvant pulverize separately are crossed 80 mesh sieves, and be standby; Get 1 part of dry extract, add Alumen, sodium bicarbonate, the lactose alcohol granulation; Getting in addition, 1 part of dry extract adds boric acid, citric acid, hyprolose alcohol granulation; Get above-mentioned two kinds of granules and add Borneolum Syntheticum, Camphora and sodium lauryl sulphate mixing, be pressed into 1000, promptly.
Claims (3)
1, a kind of effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation is characterized in that it is to be made by following bulk drugs:
320 parts of 320 parts of Herba Agrimoniaes of 320 parts of Fructus Cnidiis of 640 parts of Radixs Stemonae of Radix Sophorae Flavescentis
60 parts of 10 parts of boric acid of 5 parts of Camphoras of 10 parts of Borneolum Syntheticums of 320 parts of Alumens of Folium Callicarpae Formosanae
Chinese holly edge acid 90-160 part sodium bicarbonate 120-190 part hyprolose 6-72 part
12 parts of an amount of sodium lauryl sulphates of lactose.
2, effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation as claimed in claim 1, wherein the consumption of adjuvant is:
30 parts of 48 parts of lactose of Chinese holly edge acid 150 parts of hyprolose of 120 parts of sodium bicarbonate
12 parts of sodium lauryl sulphates.
3, the preparation method of effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation as claimed in claim 1 or 2 comprises the steps:
More than nine flavor medical materials, get Radix Sophorae Flavescentis, the Radix Stemonae, Fructus Cnidii, Herba Agrimoniae, Folium Callicarpae Formosanae, add 10 times of water gagings and decoct three times, first and second time each 2 hours, 1 hour for the third time, collecting decoction, filter while hot, relative density was the clear paste of 1.05-1.15 when filtrate was concentrated into 60 ℃, added ethanol and made and contain the alcohol amount and reach 60%, left standstill 24 hours, its supernatant filters, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃), and drying was pulverized 80 mesh sieves, be divided into 2 parts, standby; All the other medical materials and adjuvant pulverize separately are crossed 80 mesh sieves, and be standby; Get 1 part of dry extract, add Alumen, sodium bicarbonate, the lactose alcohol granulation; Getting in addition, 1 part of dry extract adds boric acid, citric acid, hyprolose alcohol granulation; Get above-mentioned two kinds of granules and add Borneolum Syntheticum, Camphora and sodium lauryl sulphate mixing, tabletting, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610051038 CN1879830A (en) | 2006-04-29 | 2006-04-29 | An effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation and method for preparing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610051038 CN1879830A (en) | 2006-04-29 | 2006-04-29 | An effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation and method for preparing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1879830A true CN1879830A (en) | 2006-12-20 |
Family
ID=37518331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610051038 Pending CN1879830A (en) | 2006-04-29 | 2006-04-29 | An effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation and method for preparing same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1879830A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520603A (en) * | 2013-10-11 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Fuyanling expandable vaginal suppository, and preparation method and detection method thereof |
| CN103520604A (en) * | 2013-10-11 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Baicao expandable vaginal suppository for clearing gynecologic inflammation, and preparation method and detection method thereof |
| CN103920081A (en) * | 2014-05-09 | 2014-07-16 | 任明 | Purpose of pharmaceutical composition |
-
2006
- 2006-04-29 CN CN 200610051038 patent/CN1879830A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520603A (en) * | 2013-10-11 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Fuyanling expandable vaginal suppository, and preparation method and detection method thereof |
| CN103520604A (en) * | 2013-10-11 | 2014-01-22 | 哈尔滨欧替药业有限公司 | Baicao expandable vaginal suppository for clearing gynecologic inflammation, and preparation method and detection method thereof |
| CN103920081A (en) * | 2014-05-09 | 2014-07-16 | 任明 | Purpose of pharmaceutical composition |
| CN103920081B (en) * | 2014-05-09 | 2015-01-28 | 任明 | Purpose of pharmaceutical composition |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1265715C (en) | Bitter gourd cold tea and its production method | |
| CN101129790A (en) | Compound hippophae rhamnoides lozenge method of producing the same | |
| CN1879830A (en) | An effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation and method for preparing same | |
| CN104585743A (en) | Desertliving cistanche effervescent tablet and preparation technology thereof | |
| CN101108225A (en) | Diabetes treating capsule dose and technique of preparing the same | |
| CN100339118C (en) | Summer heat clearing toxin resolving granules and its preparation method | |
| CN1943756A (en) | A Chinese traditional medicinal composite used for treatment of hypertension and its preparation method | |
| CN101473940A (en) | Functional health-care food for depression and preparation method thereof | |
| CN101301413A (en) | Cordyceps sinensis and Rhodiola rosea capsules and preparation thereof | |
| CN1985944A (en) | Chinese medicine composition for treating cutaneous pruritus, rubella and other diseases | |
| CN101036692A (en) | Application of radix codonopsis and radix astragali in the preparing of medicine for curing diabetes mellitus | |
| CN1733206A (en) | Chinese traditional medicine preparation for curing mastoplasia | |
| CN1640439A (en) | Method for preparing oral tablet | |
| CN101032524A (en) | Application of martianus dermestoides in producing oxygen-deficient resisting medicine or healthy food and the preparing method | |
| CN1698855A (en) | Powder with ass-hide glue and Chinese angelica root and its preparation method | |
| CN101062283A (en) | Tea for reducing blood sugar and its preparing method | |
| CN108837084A (en) | A kind of Chinese materia medica preparation and preparation method thereof | |
| CN1274320C (en) | Notoginseng ginkgo health care food and its preparation method | |
| CN1144123A (en) | Xinmaitai prescription and producing process thereof | |
| CN1824212A (en) | Effervescent tablet for treating elytritis and its preparation method | |
| CN1284351A (en) | Red sage containing medicine composition and its preparation and use | |
| CN105456819A (en) | Pawpaw anti-alcohol liquid and preparation process thereof | |
| CN1861158A (en) | Dispersing tablets of Liuwei-dihuang extract or its add-substract components, and its prepn. method | |
| CN1679650A (en) | Preparation of Fuyankang for gynecopathy | |
| CN1733017A (en) | Effervescence tablet for treating wind-cold type cold and preparation process thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |