CN1733017A - Effervescence tablet for treating wind-cold type cold and preparation process thereof - Google Patents
Effervescence tablet for treating wind-cold type cold and preparation process thereof Download PDFInfo
- Publication number
- CN1733017A CN1733017A CN 200510098724 CN200510098724A CN1733017A CN 1733017 A CN1733017 A CN 1733017A CN 200510098724 CN200510098724 CN 200510098724 CN 200510098724 A CN200510098724 A CN 200510098724A CN 1733017 A CN1733017 A CN 1733017A
- Authority
- CN
- China
- Prior art keywords
- cold
- inclusion complex
- radix
- effervescent
- lubricant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to an effervescent tablet for treating wind-cold type cold and preparation process, wherein the effervescent tablet comprises concrete powder for reducing cold and fever, beta-cyclodextrin inclusion, acid agent, alkaline agent, sweetener, bulking agent, lubricating agent.
Description
Technical field
Do not invent the genus field of traditional Chinese medicine pharmacy, more specifically relate to a kind of effervescence tablet for treating wind-cold type cold and preparation method thereof.
Background technology
Former preparation GANMAO QINGRE KELI has expelling wind and cold, the effect of the heat clearing away of inducing sweat, and is used for anemofrigid cold, has a headache and fever aversion to cold general pain, rhinorrhea with clear discharge, the treatment of cough dry pharynx, definite effect.But its volumes of formulation is bigger, carries inconvenience, and mouthfeel is bad.And after agent changes effervescence tablet for treating wind-cold type cold into, compare with granule, volume is little, and directly takes after the effervescent dissolving, and mouthfeel is better when taking, and stores and transport more convenient, meets the modern requirement of Chinese medicine preparation.
Effervescence tablet for treating wind-cold type cold is former dosage form GANMAO QINGRE KELI to be carried out form improvement and the effervescent tablet made.The oral administration effervescing sheet is to be the novel quick-release tablet of disintegrating agent with the effervescent, effervescent is dissolved in hot water but both have, but effervescent is dissolved in the advantage of directly taking behind the cold water again, and onset is rapid, bioavailability is high, and mouthfeel is good, is suitable for child especially, the old man takes.With GANMAO QINGRE KELI make into effervescent tablet both can keep former dosage form be easy to oral, absorb characteristics rapidly, simultaneously again because it is a solid preparation, transportation, easy to carry, steady quality, overcome the shortcoming that former preparation is preserved, carried inconvenience, meet the modern requirement of Chinese medicine preparation, have vast market prospect.
Chinese medicine effervescent tablet Chinese medicine extractum proportion is very big, difficult point is the selection of drug extract powder and pharmaceutic adjuvant kind and ratio, selected proper supplementary material and appropriate ratio, can reduce supplementary product consumption, preparation technology is simple, easy-formation, be difficult for moisture absorption, effervescent speed is fast, and effervescent is effective, medicinal liquid clarity is good behind the effervescent, no granule.
Summary of the invention
For solving not easy-formation of Chinese medicine effervescent tablet, disintegrate is slow, and clarity is bad, and problems such as poor stability the invention provides a kind of principal agent, supplementary product kind reasonable mixture ratio, forming, effervescence tablet for treating wind-cold type cold of good stability and preparation method thereof.
The present invention is implemented by the following technical programs.
A kind of effervescence tablet for treating wind-cold type cold of the present invention, it is made up of cold reducing-fever extract powder, tartaric acid, sodium bicarbonate, times its cyclodextrin inclusion complex, sweeting agent, filler, lubricant, cold reducing-fever extract powder, sour agent, alkaline agent account for sheet anharmonic ratio example altogether and are 89-97.5%, and three's ratio is 2: 1.65: 1.35; Sweeting agent, lubricant, filler, times its cyclodextrin inclusion complex account for sheet anharmonic ratio example altogether and are 2-11%, and sweeting agent is 0.5-2%, and filler is 0-6%, and lubricant is 0.5-1%, and cyclodextrin inclusion complex is 1.5-2%.
Effervescent tablet of the present invention is made by the raw material of following weight parts:
Herba Schizonepetae 3.3 Herba Menthaes 1 Radix Saposhnikoviae 1.7 Radix Bupleuri 1.7 Folium Perillaes 1 Radix Puerariae 1.7
Radix Platycodonis 1 Semen Armeniacae Amarum 1.3 Radixs Angelicae Dahuricae 1 Herba Corydalis Bungeanae 3.3 Rhizoma Phragmitiss 2.7
Its preparation method can be mainly to comprise following process steps:
(1) get Herba Schizonepetae, Herba Menthae, Folium Perillae and add 10 times of water gagings, soaked 2 hours, steam distillation extracted volatile oil in 6 hours, and the aqueous solution after distillation device is in addition collected, and medicinal residues are standby; Press volatile oil-times 1: 8: 80 inclusion volatile oil of its cyclodextrin-water, 50 ℃ were stirred 1 hour, and cold preservation is spent the night, and filters, and 40 ℃ of dryings of inclusion complex are ground into fine powder, promptly get doubly its cyclodextrin inclusion complex.
(2) eight flavors such as medicinal residues and all the other Radix Saposhnikoviaes add 12 times of water gagings, decoct secondary, and each 1.5 hours, collecting decoction, filter, filtrate and the merging of above-mentioned aqueous solution are concentrated into the thick paste that is determined as 1.25-1.30 under 60 ℃ of the relative densities, drying under reduced pressure is ground into fine powder, promptly gets the cold reducing-fever extract powder.
(3) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; Cold reducing-fever extract powder, times its cyclodextrin inclusion complex, tartaric acid, sodium bicarbonate, sweeting agent, filler are carried out proportion optimization in the ratio of above-mentioned each component of effervescent tablet, to determine optimum formula.Filler is used for regulating total amount, and sweeting agent is used for improving mouthfeel, and lubricant plays fluidizer and lubrication when tabletting.
Effervescent tablet lubricant of the present invention is selected from lubricant and is selected from a kind of in PEG6000, PEG4000, the magnesium stearate.
Effervescent tablet sweeting agent of the present invention is selected from a kind of of stevioside, betanin, Aspartane, is preferably Aspartane.
Filler of the present invention is selected from a kind of in lactose, mannitol, the xylitol, is preferably mannitol, xylitol.
Below be effervescence tablet for treating wind-cold type cold prescription screening experiment:
One, the selection of sour agent and alkaline agent
In the selection of effervescent, sodium bicarbonate is as alkali source, and consumption is few, and gas production is big, and the present invention adopts sodium bicarbonate as alkali source.Because the easy moisture absorption of Chinese medical concrete powder, viscosity is big, so the selection of acid source is very important.Take by weighing a certain amount of medicated powder and mix evenly, granulate, carry out different preparations shaping prescriptions and screen, the results are shown in Table 1 with dehydrated alcohol with acid, alkali.
The screening of the different preparations shaping soda acid of table 1 prescription
| The prescription number | Medicated powder (g) | Acid kind (g) | Alkali kind (g) | The result |
| 1 | 10 | Tartaric acid 10 | Sodium bicarbonate 10 | Granulation, tabletting, effervescent are better |
| 2 | 10 | Adipic acid 10 | Sodium bicarbonate 10 | Effervescent is too slow, and effect is bad |
| 3 | 10 | Succinic acid 10 | Sodium bicarbonate 10 | The moisture absorption can't be granulated |
| 4 | 10 | Malic acid 10 | Sodium bicarbonate 10 | The moisture absorption can't be granulated |
| 5 | 10 | Fumaric acid 10 | Sodium bicarbonate 10 | Better, effervescent is slow |
| 6 | 10 | Citric acid 10 | Sodium bicarbonate 10 | Caking can't be granulated |
The result shows: the effect of prescription 1 is better, and effervescent selects tartaric acid as acid source, and sodium bicarbonate is as carbon source.
Two, medicated powder, the screening of effervescent proportioning
To effervescent tablet quality influence maximum in the Chinese medicine effervescent tablet is soda acid ratio in effervescent and drug ratios and the effervescent, be screening formula, based on above-mentioned prescription 1, be that factor is carried out experiment sieving in soda acid ratio in the ratio of shared weight of effervescent and the effervescent.
Test method: get the not commensurability medicated powder and the soda acid of different proportionings (the prescription total amount is 30g) respectively, evenly mixed, granulate with dehydrated alcohol, drying, tabletting the results are shown in Table 2.
Table 2 effervescent proportioning screening table
| Sequence number | Medicated powder accounts for sheet anharmonic ratio example | Effervescent accounts for sheet anharmonic ratio example | Acid accounts for the effervescent ratio | The effervescent effect | Disintegration time |
| 1 | 2/5 | 3/5 | 40％ | +++ | 1 minute 8 seconds |
| 2 | 2/5 | 3/5 | 45％ | +++ | 1 minute 15 seconds |
| 3 | 2/5 | 3/5 | 50％ | ++++ | 1 minute 20 seconds |
| 4 | 2/5 | 3/5 | 55％ | ++++ | 1 minute 28 seconds |
| 5 | 1/2 | 1/2 | 40％ | ++ | 3 minutes 55 seconds |
| 6 | 1/2 | 1/2 | 45％ | ++ | 4 minutes 5 seconds |
| 7 | 1/2 | 1/2 | 50％ | ++ | 4 minutes 20 seconds |
| 8 | 1/2 | 1/2 | 55％ | ++ | 4 minutes 26 seconds |
| 9 | 2/3 | 1/3 | 40％ | + | Exceed in limited time |
| 10 | 2/3 | 1/3 | 45％ | + | Exceed in limited time |
| 11 | 2/3 | 1/3 | 50％ | + | Exceed in limited time |
| 12 | 2/3 | 1/3 | 55％ | + | Exceed in limited time |
It is comprehensive that relatively the effervescent effect is moderate with 3,4,5,6 a little less than, further grope so fill a prescription 3,4.
Three, effervescent consumption screening
Know according to above-mentioned result of the test, effervescent tablet of the present invention is promptly plastic without filler, different batches Chinese crude drug paste-forming rate is variant in considering to produce, need there be 0-6% filler space to regulate total amount, simultaneously for improving mouthfeel, the sweeting agent that can add 0.5-2%, particulate flowability when increasing tabletting can add the lubricant of 0.5-1%.
Test method: every group of test all feeds intake by 100, take by weighing recipe quantity dried cream powder 110g, doubly its cyclodextrin inclusion complex mixing that adds not commensurability tartaric acid, sodium bicarbonate and an amount of filler, sweeting agent, recipe quantity, with dehydrated alcohol granulation, drying, add lubricant, mixing, tabletting, every heavy 3.0g/ sheet the results are shown in Table 3, the consumption during the consumption of table Chinese medicine powder, acid, alkali is every.
Table 3 effervescent consumption screening table
| Sequence number | Medicated powder (g) | Acid (g) | Alkali (g) | Disintegration time | Medicinal liquid evaluation behind the effervescent |
| 1 | 1.10 | 0.825 | 0.825 | 2 minutes 10 seconds | A small amount of floccule is arranged in the medicinal liquid, and mouthfeel is poor. |
| 2 | 1.10 | 0.870 | 0.780 | 1 minute 35 seconds | A small amount of floccule is arranged in the medicinal liquid, and mouthfeel is general. |
| 3 | 1.10 | 0.910 | 0.740 | 1 minute 20 seconds | The medicinal liquid clarification, mouthfeel is good. |
| 4 | 1.10 | 0.940 | 0.710 | 1 minute 44 seconds | A small amount of floccule is arranged in the medicinal liquid, and mouthfeel is poor. |
So according to table 3 result of the test as can be known, medicated powder is that 2: 1.65: 1.35 o'clock effervescent are effective with acid, alkali ratio, and disintegration rate is fast, medicinal liquid clarification behind the effervescent, and mouthfeel is good.
In order to investigate the stability of moulding process, we place 40 ℃, relative humidity with the effervescent tablet of two aluminum laminated films packings is 75% climatic chamber, places 1 month, takes out, and measures appearance character, the effervescent time of its test front and back, the results are shown in Table 4.
Comparing result before and after table 4 accelerated test
| Sample | Appearance character | The effervescent time |
| Before the test | The yellowish-brown tablet | 1 minute 15 seconds |
| After the test | The yellowish-brown tablet | 1 minute 10 seconds |
The result shows: this medicine has no significant change at aspects such as appearance color, physical behavior, effervescent times before and after the accelerated test, illustrates that this medicine is basicly stable, and moulding process is reasonable.
It is reasonable that effervescence tablet for treating wind-cold type cold principal agent of the present invention, adjuvant are formed with the proportioning selection, effervescent is effective, and medicinal liquid clarity is good behind the effervescent, volatile oil with cyclodextrin inclusion compound after, avoidable loss in the storage, and can improve slice, thin piece is risen back gained medicinal liquid at bubbly water mouthfeel.Effervescence tablet for treating wind-cold type cold preparation technology of the present invention is simple, steady quality.
The specific embodiment
The present invention is described further by embodiment.
Embodiment 1
According to the shared umber of each raw material in the effervescence tablet for treating wind-cold type cold, it is standby to get following recipe quantity raw material (by the gram number):
Herba Schizonepetae 1500g Herba Menthae 450g Radix Saposhnikoviae 750g Radix Bupleuri 750g Folium Perillae 450g
Radix Puerariae 750g Radix Platycodonis 450g Semen Armeniacae Amarum 600g Radix Angelicae Dahuricae 450g Herba Corydalis Bungeanae 1500g
Rhizoma Phragmitis 1200g
(1) get Herba Schizonepetae, Herba Menthae, Folium Perillae and add 10 times of water gagings, soaked 2 hours, steam distillation extracted volatile oil in 6 hours, and the aqueous solution after distillation device is in addition collected, and medicinal residues are standby; Press volatile oil-times 1: 8: 80 inclusion volatile oil of its cyclodextrin-water, 50 ℃ of stirrings cold preservation in 1 hour is spent the night, and filters, and 40 ℃ of dryings of inclusion complex are ground into fine powder, promptly get doubly its cyclodextrin inclusion complex.
(2) eight flavors such as medicinal residues and all the other Radix Saposhnikoviaes add 12 times of water gagings, decoct secondary, and each 1.5 hours, collecting decoction, filter, filtrate and the merging of above-mentioned aqueous solution are concentrated into the thick paste that is determined as 1.25-1.30 under 60 ℃ of the relative densities, drying under reduced pressure is ground into fine powder, promptly gets the cold reducing-fever extract powder.
(3) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With cold reducing-fever extract powder 1068g, doubly its cyclodextrin inclusion complex 60g, tartaric acid 881g, sodium bicarbonate 721g, Aspartane 60g, xylitol 180g mixing, to granulate with dehydrated alcohol, drying adds magnesium stearate 30g mixing, is pressed into 1000, promptly.
Embodiment 2
According to the shared umber of each raw material in the effervescence tablet for treating wind-cold type cold, it is standby to get following recipe quantity raw material (by the gram number):
Herba Schizonepetae 1500g Herba Menthae 450g Radix Saposhnikoviae 750g Radix Bupleuri 750g Folium Perillae 450g
Radix Puerariae 750g Radix Platycodonis 450g Semen Armeniacae Amarum 600g Radix Angelicae Dahuricae 450g Herba Corydalis Bungeanae 1500g
Rhizoma Phragmitis 1200g
(1) get Herba Schizonepetae, Herba Menthae, Folium Perillae and add 10 times of water gagings, soaked 2 hours, steam distillation extracted volatile oil in 6 hours, and the aqueous solution after distillation device is in addition collected, and medicinal residues are standby; Press volatile oil-times 1: 8: 80 inclusion volatile oil of its cyclodextrin-water, 50 ℃ of stirrings cold preservation in 1 hour is spent the night, and filters, and 40 ℃ of dryings of inclusion complex are ground into fine powder, promptly get doubly its cyclodextrin inclusion complex.
(2) eight flavors such as medicinal residues and all the other Radix Saposhnikoviaes add 12 times of water gagings, decoct secondary, and each 1.5 hours, collecting decoction, filter, filtrate and the merging of above-mentioned aqueous solution are concentrated into the thick paste that is determined as 1.25-1.30 under 60 ℃ of the relative densities, drying under reduced pressure is ground into fine powder, promptly gets the cold reducing-fever extract powder.
(3) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With cold reducing-fever extract powder 1170g, doubly its cyclodextrin inclusion complex 45g, tartaric acid 965.3g, sodium bicarbonate 789.7g, stevioside 15g mixing, to granulate with dehydrated alcohol, drying adds the PEG400015g mixing, is pressed into 1000, promptly.
Embodiment 3
According to the shared umber of each raw material in the effervescence tablet for treating wind-cold type cold, it is standby to get following recipe quantity raw material (by the gram number):
Herba Schizonepetae 1500g Herba Menthae 450g Radix Saposhnikoviae 750g Radix Bupleuri 750g Folium Perillae 450g
Radix Puerariae 750g Radix Platycodonis 450g Semen Armeniacae Amarum 600g Radix Angelicae Dahuricae 450g Herba Corydalis Bungeanae 1500g
Rhizoma Phragmitis 1200g
(1) get Herba Schizonepetae, Herba Menthae, Folium Perillae and add 10 times of water gagings, soaked 2 hours, steam distillation extracted volatile oil in 6 hours, and the aqueous solution after distillation device is in addition collected, and medicinal residues are standby; Press volatile oil-times 1: 8: 80 inclusion volatile oil of its cyclodextrin-water, 50 ℃ of stirrings cold preservation in 1 hour is spent the night, and filters, and 40 ℃ of dryings of inclusion complex are ground into fine powder, promptly get doubly its cyclodextrin inclusion complex.
(2) eight flavors such as medicinal residues and all the other Radix Saposhnikoviaes add 12 times of water gagings, decoct secondary, and each 1.5 hours, collecting decoction, filter, filtrate and the merging of above-mentioned aqueous solution are concentrated into the thick paste that is determined as 1.25-1.30 under 60 ℃ of the relative densities, drying under reduced pressure is ground into fine powder, promptly gets the cold reducing-fever extract powder.
(3) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With cold reducing-fever extract powder 1134g, doubly its cyclodextrin inclusion complex 52.5g, tartaric acid 936g, sodium bicarbonate 765g, betanin 30g, mannitol 60 mixings, to granulate with dehydrated alcohol, drying adds the PEG600022.5g mixing, is pressed into 1000, promptly.
Embodiment 4
According to the shared umber of each raw material in the effervescence tablet for treating wind-cold type cold, it is standby to get following recipe quantity raw material (by the gram number):
Herba Schizonepetae 1500g Herba Menthae 450g Radix Saposhnikoviae 750g Radix Bupleuri 750g Folium Perillae 450g
Radix Puerariae 750g Radix Platycodonis 450g Semen Armeniacae Amarum 600g Radix Angelicae Dahuricae 450g Herba Corydalis Bungeanae 1500g
Rhizoma Phragmitis 1200g
(1) get Herba Schizonepetae, Herba Menthae, Folium Perillae and add 10 times of water gagings, soaked 2 hours, steam distillation extracted volatile oil in 6 hours, and the aqueous solution after distillation device is in addition collected, and medicinal residues are standby; Press volatile oil-times 1: 8: 80 inclusion volatile oil of its cyclodextrin-water, 50 ℃ of stirrings cold preservation in 1 hour is spent the night, and filters, and 40 ℃ of dryings of inclusion complex are ground into fine powder, promptly get doubly its cyclodextrin inclusion complex.
(2) eight flavors such as medicinal residues and all the other Radix Saposhnikoviaes add 12 times of water gagings, decoct secondary, and each 1.5 hours, collecting decoction, filter, filtrate and the merging of above-mentioned aqueous solution are concentrated into the thick paste that is determined as 1.25-1.30 under 60 ℃ of the relative densities, drying under reduced pressure is ground into fine powder, promptly gets the cold reducing-fever extract powder.
(3) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With cold reducing-fever extract powder 1100g, doubly its cyclodextrin inclusion complex 54g, tartaric acid 907.5g, sodium bicarbonate 742.5g, Aspartane 21g, lactose 150g mixing is granulated with dehydrated alcohol, and drying adds magnesium stearate 25g mixing, is pressed into 1000, promptly.
Claims (4)
1, a kind of effervescence tablet for treating wind-cold type cold, it is characterized in that this effervescent tablet is by cold reducing-fever extract powder, tartaric acid, sodium bicarbonate, doubly its cyclodextrin inclusion complex, sweeting agent, filler, lubricant are formed, cold reducing-fever extract powder, tartaric acid, sodium bicarbonate account for sheet anharmonic ratio example altogether and are 89-97.5%, and three's ratio is 2: 1.65: 1.35; Sweeting agent, lubricant, filler, times its cyclodextrin inclusion complex account for sheet anharmonic ratio example altogether and are 2-11%, and sweeting agent is 0.5-2%, and filler is 0-6%, and lubricant is 0.5-1%, and cyclodextrin inclusion complex is 1.5-2%.
2, effervescence tablet for treating wind-cold type cold according to claim 1, it is characterized in that sweeting agent is selected from a kind of in stevioside, betanin, the Aspartane, filler selects a kind of in lactose, mannitol, the xylitol, lubricant to be selected from a kind of in PEG6000, PEG4000, the magnesium stearate.
3, effervescence tablet for treating wind-cold type cold according to claim 1 is characterized in that it is made by weight by following raw material:
Herba Schizonepetae 3.3 Herba Menthaes 1 Radix Saposhnikoviae 1.7 Radix Bupleuri 1.7 Folium Perillaes 1 Radix Puerariae 1.7
Radix Platycodonis 1 Semen Armeniacae Amarum 1.3 Radixs Angelicae Dahuricae 1 Herba Corydalis Bungeanae 3.3 Rhizoma Phragmitiss 2.7.
4, according to the preparation method of claim 1,2,3 described effervescence tablet for treating wind-cold type cold, it is characterized in that comprising following process steps:
(1) get Herba Schizonepetae, Herba Menthae, Folium Perillae and add 10 times of water gagings, soaked 2 hours, steam distillation extracted volatile oil in 6 hours, and the aqueous solution after distillation device is in addition collected, and medicinal residues are standby; Press volatile oil-times 1: 8: 80 inclusion volatile oil of its cyclodextrin-water, 50 ℃ were stirred 1 hour, and cold preservation is spent the night, and filters, and 40 ℃ of dryings of inclusion complex are ground into fine powder, promptly get doubly its cyclodextrin inclusion complex.
(2) eight flavors such as medicinal residues and all the other Radix Saposhnikoviaes add 12 times of water gagings, decoct secondary, and each 1.5 hours, collecting decoction, filter, filtrate and the merging of above-mentioned aqueous solution are concentrated into the thick paste that is determined as 1.25-1.30 under 60 ℃ of the relative densities, drying under reduced pressure is ground into fine powder, promptly gets the cold reducing-fever extract powder.
(3) the equal 80 ℃ of oven dry of used adjuvant in the prescription, sieving for standby; With cold reducing-fever extract powder, times its cyclodextrin inclusion complex, tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, to granulate with dehydrated alcohol, drying adds the lubricant mixing, tabletting, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100987245A CN100444834C (en) | 2005-09-07 | 2005-09-07 | Effervescence tablet for treating wind-cold type cold and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100987245A CN100444834C (en) | 2005-09-07 | 2005-09-07 | Effervescence tablet for treating wind-cold type cold and preparation process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1733017A true CN1733017A (en) | 2006-02-15 |
| CN100444834C CN100444834C (en) | 2008-12-24 |
Family
ID=36075772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100987245A Active CN100444834C (en) | 2005-09-07 | 2005-09-07 | Effervescence tablet for treating wind-cold type cold and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100444834C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108404140A (en) * | 2016-06-01 | 2018-08-17 | 湖南安邦制药有限公司 | A kind of clathrate process of volatile oil |
| CN108671143A (en) * | 2018-07-13 | 2018-10-19 | 安徽亳药千草国药股份有限公司 | A kind of Chinese herbal granules and preparation method with healthcare function |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1241627C (en) * | 2003-11-20 | 2006-02-15 | 张晴龙 | Effervescence tablet for treating cold and fever and its preparation |
-
2005
- 2005-09-07 CN CNB2005100987245A patent/CN100444834C/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108404140A (en) * | 2016-06-01 | 2018-08-17 | 湖南安邦制药有限公司 | A kind of clathrate process of volatile oil |
| CN108671143A (en) * | 2018-07-13 | 2018-10-19 | 安徽亳药千草国药股份有限公司 | A kind of Chinese herbal granules and preparation method with healthcare function |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100444834C (en) | 2008-12-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100342848C (en) | Effervescence tablet for reducing fever comprising tropaeolum and process for preparing the same | |
| CN1315498C (en) | Effervescence tablet for quickly allaying infantile fever and its preparation method | |
| CN1301103C (en) | Kelu drip pill used for phlegm transforming cough suppressing and its preparation method | |
| CN1315500C (en) | Effervescence tablet of Chinese globeflower and its preparation process | |
| CN1733017A (en) | Effervescence tablet for treating wind-cold type cold and preparation process thereof | |
| CN100342849C (en) | Effervescence tablet for relieving cough and asthma and its preparation process | |
| CN1315514C (en) | Heat-clearing and detoxicating effervescence tablet and its preparing process | |
| CN1733052A (en) | Effervescence tablet with honeysuckle, Chinese gold thread and forsythia fruit and its preparation process | |
| CN1264533C (en) | Radix salvia miltiorrhiza capsule compound and method for preparing same | |
| CN1857342A (en) | Seabuckthorn preparation and its preparing process | |
| CN1895355A (en) | Preparation of medicine for treating hypertension | |
| CN1634476A (en) | Chinese ephedra and almond containing cough stopping dripping pills and its preparing process | |
| CN1733044A (en) | Effervescence tablet of isatis root and its preparation process | |
| CN101822796B (en) | Silver ice buccal tablet, and preparation method and application thereof | |
| CN1879830A (en) | An effervescence tablet with stemona root and hairy vein agrimony for treating gynecological inflammation and method for preparing same | |
| CN100344314C (en) | Xinnaoshu dripping pill for invigorating qi and nourishing yin and its preparing method | |
| CN1733043A (en) | Effervescence tablet of antiviral medicine and its preparation process | |
| CN1297254C (en) | Drop pills containing bear gall and tendril-leaved fritillary bulb and preparation method thereof | |
| CN1686454A (en) | Xiaoke drip pill used for suppressing cough and transforming phlegm and its preparation method | |
| CN1682817A (en) | Throat dripping pill for clearing away heat and toxic material and its preparing method | |
| CN1284529C (en) | Compound gastrodia elata drop pills | |
| CN1634478A (en) | Tendril-leaved fritillary bulb loquat drop pills and preparation method thereof | |
| CN1682833A (en) | Ginseng and schisandra fruit dripping pill and its preparing method | |
| CN1850155A (en) | Dispersible tablet of clinopodium polycephalum, and its preparing method | |
| CN1478466A (en) | Dispersion tablet containing Chinese medicine active component |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: BEIJING TONGRENTANG HEALTH PHARMACEUTICAL CO., LT Free format text: FORMER OWNER: BEIJING INCREASE BIOPRODUCT RESEARCH INSTITUTE Effective date: 20071221 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20071221 Address after: C, building 3, building 100085, international science and Technology Pioneer Park, 2 information road, Beijing, Haidian District Applicant after: Beijing Tongrentang Health Pharmaceutical Co., Ltd. Address before: 54, building 7, gate 902, Tiantongyuan West District, Beijing, Changping District, China: 102218 Applicant before: Beijing Yinkeruisi Biological Products Research Institute |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |